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Comedocarcinoma

MedGen UID:
90773
•Concept ID:
C0334370
•
Neoplastic Process
Synonyms: comedo carcinoma; Comedo-Type Adenocarcinoma; comedocarcinoma
SNOMED CT: Comedocarcinoma (36425007)
 
Monarch Initiative: MONDO:0003575

Definition

A high grade carcinoma characterized by the presence of comedo-type tumor cell necrosis in which the necrotic areas are surrounded by a solid proliferation of malignant pleomorphic cells. [from NCI]

Professional guidelines

PubMed

Local recurrence after ductal carcinoma in situ breast conserving treatment. Analysis of 195 cases.
Cutuli B, Lemanski C, Le Blanc-Onfroy M, de Lafontan B, Cohen-Solal-Le-Nir C, Fondrinier E, Mignotte H, Giard S, Charra-Brunaud C, Auvray H, Gonzague-Casabianca L, Quétin P, Fay R
Cancer Radiother 2013 Jun;17(3):196-201. Epub 2013 Mar 26 doi: 10.1016/j.canrad.2013.01.011. PMID: 23538041
Surgical management of ductal carcinoma in situ in Australia in 1995.
Shugg D, White VM, Kitchen PR, Pruden M, Collins JP, Hill DJ
ANZ J Surg 2002 Oct;72(10):708-15. doi: 10.1046/j.1445-2197.2002.02532.x. PMID: 12534380
Nonpalpable in situ ductal carcinoma of the breast. Predictors of multicentricity and microinvasion and implications for treatment.
Schwartz GF, Patchefsky AS, Finklestein SD, Sohn SH, Prestipino A, Feig SA, Singer JS
Arch Surg 1989 Jan;124(1):29-32. doi: 10.1001/archsurg.1989.01410010035007. PMID: 2535928

Recent clinical studies

Therapy

Ductal carcinoma in situ of the breast: our experience.
Ruggiero R, Procaccini E, Sanguinetti A, Cremone C, Gili S, Docimo G, Docimo L, Sparavigna L, Gubitosi A, Parmeggiani D, Avenia N
G Chir 2009 Mar;30(3):121-4. PMID: 19351465
Breast-conserving therapy for ductal carcinoma in situ of the breast: the French Cancer Centers' experience.
Cutuli B, Cohen-Solal-le Nir C, de Lafontan B, Mignotte H, Fichet V, Fay R, Servent V, Giard S, Charra-Brunaud C, Lemanski C, Auvray H, Jacquot S, Charpentier JC
Int J Radiat Oncol Biol Phys 2002 Jul 15;53(4):868-79. doi: 10.1016/s0360-3016(02)02834-1. PMID: 12095552
External beam irradiation plus (192)Ir implant after breast-preserving surgery in women with early breast cancer.
Moreno F, Guedea F, Lopez Y, Ferrer F, Gutierrez C, Petriz L, Pera J
Int J Radiat Oncol Biol Phys 2000 Oct 1;48(3):757-65. doi: 10.1016/s0360-3016(00)00676-3. PMID: 11020573
Radiation therapy for intraductal carcinoma. Is it an equal alternative?
Silverstein MJ, Waisman JR, Gierson ED, Colburn W, Gamagami P, Lewinsky BS
Arch Surg 1991 Apr;126(4):424-8. PMID: 1848972
Diagnostic problems in tissues previously sampled by fine-needle aspiration.
Tabbara SO, Frierson HF Jr, Fechner RE
Am J Clin Pathol 1991 Jul;96(1):76-80. doi: 10.1093/ajcp/96.1.76. PMID: 1648878

Prognosis

Prognostic significance of morphological patterns of Gleason grade 5 prostatic adenocarcinoma diagnosed on needle biopsy.
Franklin A, Delahunt B, Egevad L, Yaxley J, Johannsen S, Gianduzzo T, Ganter J, Pecoraro C, Thunders M, Samaratunga H
Pathology 2021 Feb;53(2):199-204. Epub 2020 Dec 29 doi: 10.1016/j.pathol.2020.10.009. PMID: 33386122
Local recurrence after ductal carcinoma in situ breast conserving treatment. Analysis of 195 cases.
Cutuli B, Lemanski C, Le Blanc-Onfroy M, de Lafontan B, Cohen-Solal-Le-Nir C, Fondrinier E, Mignotte H, Giard S, Charra-Brunaud C, Auvray H, Gonzague-Casabianca L, Quétin P, Fay R
Cancer Radiother 2013 Jun;17(3):196-201. Epub 2013 Mar 26 doi: 10.1016/j.canrad.2013.01.011. PMID: 23538041
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000
Surgical treatment of ductal carcinoma in situ of the breast. 10- to 20-year follow-up.
Simpson T, Thirlby RC, Dail DH
Arch Surg 1992 Apr;127(4):468-72. doi: 10.1001/archsurg.1992.01420040114020. PMID: 1313671
Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma.
Currin SM, Lee SE, Walther PJ
J Urol 1988 Jul;140(1):96-100. doi: 10.1016/s0022-5347(17)41496-0. PMID: 2837590

Clinical prediction guides

Prognostic significance of morphological patterns of Gleason grade 5 prostatic adenocarcinoma diagnosed on needle biopsy.
Franklin A, Delahunt B, Egevad L, Yaxley J, Johannsen S, Gianduzzo T, Ganter J, Pecoraro C, Thunders M, Samaratunga H
Pathology 2021 Feb;53(2):199-204. Epub 2020 Dec 29 doi: 10.1016/j.pathol.2020.10.009. PMID: 33386122
Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.
Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V
Mod Pathol 2015 Sep;28(9):1249-64. Epub 2015 Jun 26 doi: 10.1038/modpathol.2015.61. PMID: 26111977
Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: an interobserver reproducibility study among urologic pathologists.
Shah RB, Li J, Cheng L, Egevad L, Deng FM, Fine SW, Kunju LP, Melamed J, Mehra R, Osunkoya AO, Paner GP, Shen SS, Tsuzuki T, Trpkov K, Tian W, Yang XJ, Zhou M
Am J Surg Pathol 2015 Sep;39(9):1242-9. doi: 10.1097/PAS.0000000000000442. PMID: 25929349
Local recurrence after ductal carcinoma in situ breast conserving treatment. Analysis of 195 cases.
Cutuli B, Lemanski C, Le Blanc-Onfroy M, de Lafontan B, Cohen-Solal-Le-Nir C, Fondrinier E, Mignotte H, Giard S, Charra-Brunaud C, Auvray H, Gonzague-Casabianca L, Quétin P, Fay R
Cancer Radiother 2013 Jun;17(3):196-201. Epub 2013 Mar 26 doi: 10.1016/j.canrad.2013.01.011. PMID: 23538041
Histopathological review of sebaceous carcinoma of the eyelid.
Pereira PR, Odashiro AN, Rodrigues-Reyes AA, Correa ZM, de Souza Filho JP, Burnier MN Jr
J Cutan Pathol 2005 Aug;32(7):496-501. doi: 10.1111/j.0303-6987.2005.00371.x. PMID: 16008694

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