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Malignant Melanoma in Precancerous Melanosis

MedGen UID:
96555
•Concept ID:
C0431098
•
Neoplastic Process
Synonyms: Malignant melanoma in melanosis; Malignant melanoma in precancerous melanosis
SNOMED CT: Malignant melanoma in melanosis (18450009); Malignant melanoma in precancerous melanosis (18450009)

Definition

A melanoma arising from an atypical intraepithelial melanocytic hyperplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Melanoma in Precancerous Melanosis

Professional guidelines

PubMed

Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Congenital melanocytic nevi: treatment modalities and management options.
Marghoob AA, Borrego JP, Halpern AC
Semin Cutan Med Surg 2003 Mar;22(1):21-32. doi: 10.1053/sder.2003.50002. PMID: 12773011
Treatment of lentigo maligna and lentigo maligna melanoma.
Coleman WP 3rd, Davis RS, Reed RJ, Krementz ET
J Dermatol Surg Oncol 1980 Jun;6(6):476-9. doi: 10.1111/j.1524-4725.1980.tb00900.x. PMID: 7391322

Recent clinical studies

Etiology

The Evaluation of the Malignant Characteristics of Conjunctival Lesions Based on the Dermatoscopic Algorithm.
DĘbicka-Kumela M, Romanowska-Dixon B, Karska-Basta I, Kowal J, Markiewicz A
Anticancer Res 2021 Feb;41(2):895-903. doi: 10.21873/anticanres.14842. PMID: 33517295
Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Lentiginous melanoma.
King R
Arch Pathol Lab Med 2011 Mar;135(3):337-41. doi: 10.5858/2009-0538-RA.1. PMID: 21366457
Conjunctival melanosis and melanoma.
Folberg R, McLean IW, Zimmerman LE
Ophthalmology 1984 Jun;91(6):673-8. doi: 10.1016/s0161-6420(84)34245-2. PMID: 6462625

Diagnosis

Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Vulvar Neoplasms, Benign and Malignant.
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Lentiginous melanoma.
King R
Arch Pathol Lab Med 2011 Mar;135(3):337-41. doi: 10.5858/2009-0538-RA.1. PMID: 21366457
Primary acquired melanosis of the conjunctiva is melanoma in situ.
Ackerman AB, Sood R, Koenig M
Mod Pathol 1991 Mar;4(2):253-63. PMID: 2047386

Therapy

Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Senile lentigo--cosmetic or medical issue of the elderly population.
Situm M, Bulat V, Buljan M, Puljiz Z, Situm V, Bolanca Z
Coll Antropol 2010 Apr;34 Suppl 2:85-8. PMID: 21302707
Histological criteria for grading of atypia in melanocytic conjunctival lesions.
Maly A, Epstein D, Meir K, Pe'er J
Pathology 2008 Dec;40(7):676-81. doi: 10.1080/00313020802436428. PMID: 18985522
Atypical junctional melanocytic proliferations in benign lichenoid keratosis.
Dalton SR, Fillman EP, Altman CE, Gardner TL, Davis TL, Bastian BC, Libow LF, Elston DM
Hum Pathol 2003 Jul;34(7):706-9. doi: 10.1016/s0046-8177(03)00234-x. PMID: 12874767
Benign melanocytic lesions: risk markers or precursors of cutaneous melanoma?
Skender-Kalnenas TM, English DR, Heenan PJ
J Am Acad Dermatol 1995 Dec;33(6):1000-7. doi: 10.1016/0190-9622(95)90294-5. PMID: 7490345

Prognosis

Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
BRAF mutations in conjunctival melanoma: investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions.
Larsen AC, Dahl C, Dahmcke CM, Lade-Keller J, Siersma VD, Toft PB, Coupland SE, Prause JU, Guldberg P, Heegaard S
Acta Ophthalmol 2016 Aug;94(5):463-70. Epub 2016 Mar 24 doi: 10.1111/aos.13007. PMID: 27009410
Conjunctival melanosis and melanoma.
Folberg R, McLean IW, Zimmerman LE
Ophthalmology 1984 Jun;91(6):673-8. doi: 10.1016/s0161-6420(84)34245-2. PMID: 6462625
Conjunctival melanoma.
Jakobiec FA
Arch Ophthalmol 1980 Aug;98(8):1378-84. doi: 10.1001/archopht.1980.01020040230003. PMID: 6998439

Clinical prediction guides

The Evaluation of the Malignant Characteristics of Conjunctival Lesions Based on the Dermatoscopic Algorithm.
DĘbicka-Kumela M, Romanowska-Dixon B, Karska-Basta I, Kowal J, Markiewicz A
Anticancer Res 2021 Feb;41(2):895-903. doi: 10.21873/anticanres.14842. PMID: 33517295
Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Oral melanotic macule and primary oral malignant melanoma: epidemiology, location involved, and clinical implications.
Shen ZY, Liu W, Bao ZX, Zhou ZT, Wang LZ
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jul;112(1):e21-5. doi: 10.1016/j.tripleo.2011.02.040. PMID: 21669356
Malignant melanoma in xeroderma pigmentosum: search for a precursor lesion.
Stern JB, Peck GL, Haupt HM, Hollingsworth HC, Beckerman T
J Am Acad Dermatol 1993 Apr;28(4):591-4. doi: 10.1016/0190-9622(93)70079-9. PMID: 8463460
Conjunctival melanosis and melanoma.
Folberg R, McLean IW, Zimmerman LE
Ophthalmology 1984 Jun;91(6):673-8. doi: 10.1016/s0161-6420(84)34245-2. PMID: 6462625

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