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Refractory Spindle Cell Sarcoma

MedGen UID:
1676240
•Concept ID:
C4764230
•
Neoplastic Process

Definition

Spindle cell sarcoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Spindle Cell Sarcoma

Professional guidelines

PubMed

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Surgical treatment of pulmonary metastases in pediatric solid tumors.
Heaton TE, Davidoff AM
Semin Pediatr Surg 2016 Oct;25(5):311-317. Epub 2016 Sep 3 doi: 10.1053/j.sempedsurg.2016.09.001. PMID: 27955735Free PMC Article
Ifosfamide in the treatment of malignant epithelial ovarian tumors.
Lissoni AA, Fei F, Rossi R, Fruscio R, Villa A, Zani G
Oncology 2003;65 Suppl 2:59-62. doi: 10.1159/000073361. PMID: 14586150

Recent clinical studies

Etiology

Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts.
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Naxitamab: First Approval.
Markham A
Drugs 2021 Feb;81(2):291-296. doi: 10.1007/s40265-021-01467-4. PMID: 33616889
Progress Update in Pediatric Renal Tumors.
Jain J, Sutton KS, Hong AL
Curr Oncol Rep 2021 Feb 16;23(3):33. doi: 10.1007/s11912-021-01016-y. PMID: 33591402
SMARCB1/INI1-deficient tumors of adulthood.
Parker NA, Al-Obaidi A, Deutsch JM
F1000Res 2020;9:662. Epub 2020 Jun 30 doi: 10.12688/f1000research.24808.2. PMID: 33796273Free PMC Article
Alitretinoin.
Cheer SM, Foster RH
Am J Clin Dermatol 2000 Sep-Oct;1(5):307-14; discussion 315-6. doi: 10.2165/00128071-200001050-00005. PMID: 11702321

Diagnosis

A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase trials.
Hernando-Calvo A, Vila-Casadesús M, Bareche Y, Gonzalez-Medina A, Abbas-Aghababazadeh F, Lo Giacco D, Martin A, Saavedra O, Brana I, Vieito M, Fasani R, Stagg J, Mancuso F, Haibe-Kains B, Han M, Berche R, Pugh TJ, Mirallas O, Jimenez J, Gonzalez NS, Valverde C, Muñoz-Couselo E, Suarez C, Diez M, Élez E, Capdevila J, Oaknin A, Saura C, Macarulla T, Galceran JC, Felip E, Dienstmann R, Bedard PL, Nuciforo P, Seoane J, Tabernero J, Garralda E, Vivancos A
Med 2023 Oct 13;4(10):710-727.e5. Epub 2023 Aug 11 doi: 10.1016/j.medj.2023.07.006. PMID: 37572657
Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts.
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Progress Update in Pediatric Renal Tumors.
Jain J, Sutton KS, Hong AL
Curr Oncol Rep 2021 Feb 16;23(3):33. doi: 10.1007/s11912-021-01016-y. PMID: 33591402
SMARCB1/INI1-deficient tumors of adulthood.
Parker NA, Al-Obaidi A, Deutsch JM
F1000Res 2020;9:662. Epub 2020 Jun 30 doi: 10.12688/f1000research.24808.2. PMID: 33796273Free PMC Article
Global Health Perspective in Sarcomas and Other Rare Cancers.
Florou V, Nascimento AG, Gulia A, de Lima Lopes G Jr
Am Soc Clin Oncol Educ Book 2018 May 23;38:916-924. doi: 10.1200/EDBK_200589. PMID: 30231406

Therapy

Naxitamab: First Approval.
Markham A
Drugs 2021 Feb;81(2):291-296. doi: 10.1007/s40265-021-01467-4. PMID: 33616889
Precision Medicine in Osteosarcoma: MATCH Trial and Beyond.
Tirtei E, Campello A, Asaftei SD, Mareschi K, Cereda M, Fagioli F
Cells 2021 Jan 31;10(2) doi: 10.3390/cells10020281. PMID: 33572496Free PMC Article
Progress and opportunities for immune therapeutics in osteosarcoma.
Lettieri CK, Appel N, Labban N, Lussier DM, Blattman JN, Hingorani P
Immunotherapy 2016 Oct;8(10):1233-44. doi: 10.2217/imt-2016-0048. PMID: 27605071
Future directions in the treatment of osteosarcoma.
Bishop MW, Janeway KA, Gorlick R
Curr Opin Pediatr 2016 Feb;28(1):26-33. doi: 10.1097/MOP.0000000000000298. PMID: 26626558Free PMC Article
Alitretinoin.
Cheer SM, Foster RH
Am J Clin Dermatol 2000 Sep-Oct;1(5):307-14; discussion 315-6. doi: 10.2165/00128071-200001050-00005. PMID: 11702321

Prognosis

A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase trials.
Hernando-Calvo A, Vila-Casadesús M, Bareche Y, Gonzalez-Medina A, Abbas-Aghababazadeh F, Lo Giacco D, Martin A, Saavedra O, Brana I, Vieito M, Fasani R, Stagg J, Mancuso F, Haibe-Kains B, Han M, Berche R, Pugh TJ, Mirallas O, Jimenez J, Gonzalez NS, Valverde C, Muñoz-Couselo E, Suarez C, Diez M, Élez E, Capdevila J, Oaknin A, Saura C, Macarulla T, Galceran JC, Felip E, Dienstmann R, Bedard PL, Nuciforo P, Seoane J, Tabernero J, Garralda E, Vivancos A
Med 2023 Oct 13;4(10):710-727.e5. Epub 2023 Aug 11 doi: 10.1016/j.medj.2023.07.006. PMID: 37572657
Strategies to Overcome Resistance to Immune-Based Therapies in Osteosarcoma.
Hattinger CM, Salaroglio IC, Fantoni L, Godel M, Casotti C, Kopecka J, Scotlandi K, Ibrahim T, Riganti C, Serra M
Int J Mol Sci 2023 Jan 2;24(1) doi: 10.3390/ijms24010799. PMID: 36614241Free PMC Article
Progress Update in Pediatric Renal Tumors.
Jain J, Sutton KS, Hong AL
Curr Oncol Rep 2021 Feb 16;23(3):33. doi: 10.1007/s11912-021-01016-y. PMID: 33591402
SMARCB1/INI1-deficient tumors of adulthood.
Parker NA, Al-Obaidi A, Deutsch JM
F1000Res 2020;9:662. Epub 2020 Jun 30 doi: 10.12688/f1000research.24808.2. PMID: 33796273Free PMC Article
Future directions in the treatment of osteosarcoma.
Bishop MW, Janeway KA, Gorlick R
Curr Opin Pediatr 2016 Feb;28(1):26-33. doi: 10.1097/MOP.0000000000000298. PMID: 26626558Free PMC Article

Clinical prediction guides

First-in-Human Stage III/IV Melanoma Clinical Trial of Immune Priming Agent IFx-Hu2.0.
Markowitz J, Shamblott M, Brohl AS, Sarnaik AA, Eroglu Z, Khushalani NI, Dukes CW, Chamizo A, Bastawrous M, Garcia ET, Dehlawi A, Chen PL, De Aquino DB, Sondak VK, Tarhini AA, Kim Y, Lawman P, Pilon-Thomas S
Mol Cancer Ther 2024 Aug 1;23(8):1139-1143. doi: 10.1158/1535-7163.MCT-23-0652. PMID: 38657233Free PMC Article
Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities.
Venkataramany AS, Schieffer KM, Lee K, Cottrell CE, Wang PY, Mardis ER, Cripe TP, Chandler DS
Ann Oncol 2022 Jun;33(6):578-592. Epub 2022 Mar 23 doi: 10.1016/j.annonc.2022.03.011. PMID: 35339647
Drug resistance-related microRNAs in osteosarcoma: Translating basic evidence into therapeutic strategies.
Chen R, Wang G, Zheng Y, Hua Y, Cai Z
J Cell Mol Med 2019 Apr;23(4):2280-2292. Epub 2019 Feb 5 doi: 10.1111/jcmm.14064. PMID: 30724027Free PMC Article
Gemcitabine in the treatment of soft tissue sarcomas.
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353
Alitretinoin.
Cheer SM, Foster RH
Am J Clin Dermatol 2000 Sep-Oct;1(5):307-14; discussion 315-6. doi: 10.2165/00128071-200001050-00005. PMID: 11702321

Recent systematic reviews

The efficacy of gemcitabine and docetaxel chemotherapy for the treatment of relapsed and refractory osteosarcoma: A systematic review and pre-clinical study.
Low K, Foulkes P, Hills F, Roberts HC, Stordal B
Cancer Med 2024 Sep;13(18):e70248. doi: 10.1002/cam4.70248. PMID: 39315544Free PMC Article
A systematic review of combined surgery and brachytherapy approaches for children and young people with relapsed and refractory rhabdomyosarcoma (Local-REFoRMS).
Ballantyne E, Evans C, Shepherd L, Fulbright H, Wakeling S, Phillips B, Morgan JE
Pediatr Blood Cancer 2024 Jun;71(6):e30952. Epub 2024 Apr 2 doi: 10.1002/pbc.30952. PMID: 38566349
High-dose chemotherapy for Ewing sarcoma and Rhabdomyosarcoma: A systematic review by the Australia and New Zealand sarcoma association clinical practice guidelines working party.
Ramamurthy A, Connolly EA, Mar J, Lewin J, Bhadri VA, Phillips MB, Winstanley M, Orme LM, Grimison P, Connor J, Lazarakis S, Hong AM, Omer N, Cayrol J
Cancer Treat Rev 2024 Mar;124:102694. Epub 2024 Feb 2 doi: 10.1016/j.ctrv.2024.102694. PMID: 38325070
A systematic review of early phase studies for children and young people with relapsed and refractory rhabdomyosarcoma: The REFoRMS-SR project.
Evans C, Shepherd L, Bryan G, Fulbright H, Crowther S, Wakeling S, Stewart A, Stewart C, Chisholm J, Gibson F, Phillips B, Morgan JE
Int J Cancer 2024 Apr 1;154(7):1235-1260. Epub 2023 Dec 10 doi: 10.1002/ijc.34808. PMID: 38071594
Systematic review of phase-I/II trials enrolling refractory and recurrent Ewing sarcoma: Actual knowledge and future directions to optimize the research.
Felix A, Berlanga P, Toulmonde M, Landman-Parker J, Dumont S, Vassal G, Le Deley MC, Gaspar N
Cancer Med 2021 Mar;10(5):1589-1604. Epub 2021 Jan 15 doi: 10.1002/cam4.3712. PMID: 33452711Free PMC Article

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