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Refractory Childhood Malignant Solid Neoplasm

MedGen UID:
1644994
•Concept ID:
C4688334
•
Neoplastic Process
Synonyms: Childhood Refractory Malignant Solid Neoplasm; Childhood Refractory Malignant Solid Tumor

Definition

A childhood malignant solid neoplasm that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Childhood Malignant Solid Neoplasm

Professional guidelines

PubMed

Bevacizumab-containing treatment for relapsed or refractory Wilms tumor.
Al-Jilaihawi S, Spreafico F, Mavinkurve-Groothuis A, Drost J, Perotti D, Koenig C, Brok J
Expert Rev Anticancer Ther 2024 Sep;24(9):837-843. Epub 2024 Jul 23 doi: 10.1080/14737140.2024.2381537. PMID: 39016020
Personalized Treatment Response Assessment for Rare Childhood Tumors Using Microcalorimetry-Exemplified by Use of Carbonic Anhydrase IX and Aquaporin 1 Inhibitors.
Gros SJ, Holland-Cunz SG, Supuran CT, Braissant O
Int J Mol Sci 2019 Oct 9;20(20) doi: 10.3390/ijms20204984. PMID: 31600976Free PMC Article
Epipodophyllotoxins in the treatment of childhood cancer.
Rivera GK, Pui CH, Santana VM, Pratt CB, Crist WM
Cancer Chemother Pharmacol 1994;34 Suppl:S89-95. doi: 10.1007/BF00684870. PMID: 8070034

Recent clinical studies

Etiology

Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial.
Glade Bender JL, Pinkney K, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
Oncologist 2024 Jul 5;29(7):638-e952. doi: 10.1093/oncolo/oyae096. PMID: 38815151Free PMC Article
Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations.
Pastorino F, Capasso M, Brignole C, Giglio S, Bensa V, Cantalupo S, Lasorsa VA, Tondo A, Mura R, Sementa AR, Garaventa A, Ponzoni M, Amoroso L
Int J Mol Sci 2022 Sep 23;23(19) doi: 10.3390/ijms231911236. PMID: 36232538Free PMC Article
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Actionable Tumor Alterations and Treatment Protocol Enrollment of Pediatric and Young Adult Patients With Refractory Cancers in the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial.
Parsons DW, Janeway KA, Patton DR, Winter CL, Coffey B, Williams PM, Roy-Chowdhuri S, Tsongalis GJ, Routbort M, Ramirez NC, Saguilig L, Piao J, Alonzo TA, Berg SL, Fox E, Hawkins DS, Abrams JS, Mooney M, Takebe N, Tricoli JV, Seibel NL; NCI-COG Pediatric MATCH Team
J Clin Oncol 2022 Jul 10;40(20):2224-2234. Epub 2022 Mar 30 doi: 10.1200/JCO.21.02838. PMID: 35353553Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article

Diagnosis

Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial.
Glade Bender JL, Pinkney K, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
Oncologist 2024 Jul 5;29(7):638-e952. doi: 10.1093/oncolo/oyae096. PMID: 38815151Free PMC Article
Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations.
Pastorino F, Capasso M, Brignole C, Giglio S, Bensa V, Cantalupo S, Lasorsa VA, Tondo A, Mura R, Sementa AR, Garaventa A, Ponzoni M, Amoroso L
Int J Mol Sci 2022 Sep 23;23(19) doi: 10.3390/ijms231911236. PMID: 36232538Free PMC Article
Catecholamines in neuroblastoma: Driver of hypertension, or solely a marker of disease?
Harding M, Deyell RJ, Blydt-Hansen T
Cancer Rep (Hoboken) 2022 Aug;5(8):e1569. Epub 2021 Oct 6 doi: 10.1002/cnr2.1569. PMID: 34612613Free PMC Article
4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells.
Alshangiti AM, Tuboly E, Hegarty SV, McCarthy CM, Sullivan AM, O'Keeffe GW
Oxid Med Cell Longev 2019;2019:1670759. Epub 2019 Dec 5 doi: 10.1155/2019/1670759. PMID: 31885773Free PMC Article
Treatment of childhood sarcoma with irinotecan: bilirubin level as a predictor of gastrointestinal toxicity.
Ruggiero A, Coccia P, Scalzone M, Attinà G, Riccardi R
J Chemother 2009 Dec;21(6):693-7. doi: 10.1179/joc.2009.21.6.693. PMID: 20071295

Therapy

Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial.
Glade Bender JL, Pinkney K, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
Oncologist 2024 Jul 5;29(7):638-e952. doi: 10.1093/oncolo/oyae096. PMID: 38815151Free PMC Article
Cardiotoxicity of Targeted Therapies in Children with Haematological Malignancies and Solid Tumors.
Bangeas A, Tragiannidis A
Anticancer Agents Med Chem 2023;23(15):1702-1709. doi: 10.2174/1871520623666230525162147. PMID: 37231721
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Actionable Tumor Alterations and Treatment Protocol Enrollment of Pediatric and Young Adult Patients With Refractory Cancers in the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial.
Parsons DW, Janeway KA, Patton DR, Winter CL, Coffey B, Williams PM, Roy-Chowdhuri S, Tsongalis GJ, Routbort M, Ramirez NC, Saguilig L, Piao J, Alonzo TA, Berg SL, Fox E, Hawkins DS, Abrams JS, Mooney M, Takebe N, Tricoli JV, Seibel NL; NCI-COG Pediatric MATCH Team
J Clin Oncol 2022 Jul 10;40(20):2224-2234. Epub 2022 Mar 30 doi: 10.1200/JCO.21.02838. PMID: 35353553Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article

Prognosis

Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial.
Glade Bender JL, Pinkney K, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
Oncologist 2024 Jul 5;29(7):638-e952. doi: 10.1093/oncolo/oyae096. PMID: 38815151Free PMC Article
Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations.
Pastorino F, Capasso M, Brignole C, Giglio S, Bensa V, Cantalupo S, Lasorsa VA, Tondo A, Mura R, Sementa AR, Garaventa A, Ponzoni M, Amoroso L
Int J Mol Sci 2022 Sep 23;23(19) doi: 10.3390/ijms231911236. PMID: 36232538Free PMC Article
The dawn of "immune-revolution" in children: early experiences with checkpoint inhibitors in childhood malignancies.
Lucchesi M, Sardi I, Puppo G, Chella A, Favre C
Cancer Chemother Pharmacol 2017 Dec;80(6):1047-1053. Epub 2017 Oct 24 doi: 10.1007/s00280-017-3450-2. PMID: 29067473
Treatment of childhood sarcoma with irinotecan: bilirubin level as a predictor of gastrointestinal toxicity.
Ruggiero A, Coccia P, Scalzone M, Attinà G, Riccardi R
J Chemother 2009 Dec;21(6):693-7. doi: 10.1179/joc.2009.21.6.693. PMID: 20071295
Phase II trail cisplatin in refractory childhood cancer: Children's Cancer Study Group Report.
Baum ES, Gaynon P, Greenberg L, Krivit W, Hammond D
Cancer Treat Rep 1981 Sep-Oct;65(9-10):815-22. PMID: 6944156

Clinical prediction guides

Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial.
Glade Bender JL, Pinkney K, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Fox E, Weigel BJ, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
Oncologist 2024 Jul 5;29(7):638-e952. doi: 10.1093/oncolo/oyae096. PMID: 38815151Free PMC Article
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Treatment of persistent Mongolian spots with Q-switched alexandrite laser.
Kagami S, Asahina A, Uwajima Y, Miyamoto A, Yamada D, Shibata S, Yamamoto M, Masui Y, Sato S
Lasers Med Sci 2012 Nov;27(6):1229-32. Epub 2012 May 8 doi: 10.1007/s10103-012-1113-4. PMID: 22565344
Treatment of childhood sarcoma with irinotecan: bilirubin level as a predictor of gastrointestinal toxicity.
Ruggiero A, Coccia P, Scalzone M, Attinà G, Riccardi R
J Chemother 2009 Dec;21(6):693-7. doi: 10.1179/joc.2009.21.6.693. PMID: 20071295

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