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Carcinosarcoma

MedGen UID:
2876
•Concept ID:
C0007140
•
Neoplastic Process
Synonym: Carcinosarcomas
SNOMED CT: Carcinosarcoma (63264007)
 
Monarch Initiative: MONDO:0002928

Definition

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. [from NCI]

Professional guidelines

PubMed

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120

Recent clinical studies

Etiology

Frontiers of Ovarian Carcinosarcoma.
Ismail A, Choi S, Boussios S
Curr Treat Options Oncol 2023 Dec;24(12):1667-1682. Epub 2023 Nov 8 doi: 10.1007/s11864-023-01138-4. PMID: 37938504Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Uterine sarcoma 2008.
Lin JF, Slomovitz BM
Curr Oncol Rep 2008 Nov;10(6):512-8. doi: 10.1007/s11912-008-0077-9. PMID: 18928666

Diagnosis

Frontiers of Ovarian Carcinosarcoma.
Ismail A, Choi S, Boussios S
Curr Treat Options Oncol 2023 Dec;24(12):1667-1682. Epub 2023 Nov 8 doi: 10.1007/s11864-023-01138-4. PMID: 37938504Free PMC Article
Uterine carcinosarcoma: An overview.
Pezzicoli G, Moscaritolo F, Silvestris E, Silvestris F, Cormio G, Porta C, D'Oronzo S
Crit Rev Oncol Hematol 2021 Jul;163:103369. Epub 2021 May 27 doi: 10.1016/j.critrevonc.2021.103369. PMID: 34051304
Sinonasal teratocarcinosarcoma.
Sobani ZA, Akhtar S, Junaid M, Salahuddin I
J Pak Med Assoc 2012 Jun;62(6):633-5. PMID: 22755362
Gallbladder carcinosarcoma.
Pu JJ, Wu W
BMJ Case Rep 2011 Apr 1;2011 doi: 10.1136/bcr.05.2010.3009. PMID: 22700610Free PMC Article
Uterine carcinosarcoma.
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326

Therapy

Top advances of the year: Ovarian cancer.
Lumish MA, Kohn EC, Tew WP
Cancer 2024 Mar 15;130(6):837-845. Epub 2023 Dec 15 doi: 10.1002/cncr.35135. PMID: 38100616
Endometrial carcinosarcoma.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Caruso G, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher DM, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Ramirez PT, Mariani A, Leitao M, Makker V, Abu-Rustum NR, Vergote I, Zannoni G, Tan D, McCormack M, Paolini B, Bini M, Raspagliesi F, Benedetti Panici P, Di Donato V, Muzii L, Colombo N, Pignata S, Scambia G, Monk BJ
Int J Gynecol Cancer 2023 Feb 6;33(2):147-174. doi: 10.1136/ijgc-2022-004073. PMID: 36585027
Randomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial.
Powell MA, Filiaci VL, Hensley ML, Huang HQ, Moore KN, Tewari KS, Copeland LJ, Secord AA, Mutch DG, Santin A, Warshal DP, Spirtos NM, DiSilvestro PA, Ioffe OB, Miller DS
J Clin Oncol 2022 Mar 20;40(9):968-977. Epub 2022 Jan 10 doi: 10.1200/JCO.21.02050. PMID: 35007153Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465

Prognosis

Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120
Bronchial carcinosarcoma.
Carcano C, Savage E, Diacovo MJ, Kirsch J
J Radiol Case Rep 2012 Oct;6(10):26-31. Epub 2012 Oct 1 doi: 10.3941/jrcr.v6i10.1049. PMID: 23378874Free PMC Article

Clinical prediction guides

Germline drivers of gynecologic carcinosarcomas.
Sia TY, Gordhandas SB, Birsoy O, Kemel Y, Maio A, Salo-Mullen E, Sheehan M, Hensley ML, Rubinstein M, Makker V, Grisham RN, O'Cearbhaill RE, Roche KL, Mueller JJ, Leitao MM Jr, Sonoda Y, Chi DS, Abu-Rustum NR, Berger MF, Ellenson LH, Latham A, Stadler Z, Offit K, Aghajanian C, Weigelt B, Mandelker D, Liu YL
Gynecol Oncol 2023 Jul;174:34-41. Epub 2023 May 5 doi: 10.1016/j.ygyno.2023.04.024. PMID: 37149903Free PMC Article
Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial.
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Epidemiology and prediction model of patients with carcinosarcoma in the United States.
Chen M, He X, Yang Q, Zhang J, Peng J, Wang D, Tong K, Huang W
Front Public Health 2022;10:1038211. Epub 2022 Nov 28 doi: 10.3389/fpubh.2022.1038211. PMID: 36518582Free PMC Article
Genomics of gynaecological carcinosarcomas and future treatment options.
Barker HE, Scott CL
Semin Cancer Biol 2020 Apr;61:110-120. Epub 2019 Oct 14 doi: 10.1016/j.semcancer.2019.10.006. PMID: 31622660
Sarcomatoid Carcinoma of the Urinary Bladder.
Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715

Recent systematic reviews

Clinicopathological characteristics of odontogenic carcinosarcoma: A systematic review.
da Silveira KG, de Almeida Souto Montenegro L, de Albuquerque DS, do Lago CAP, Laureano Filho JR, de Vasconcellos RJH
J Oral Pathol Med 2024 Jan;53(1):20-30. Epub 2024 Jan 1 doi: 10.1111/jop.13502. PMID: 38164057
Pancreatic carcinosarcoma: An orthogonal analysis.
Fleming AM, Hendrick LE, Glazer ES, Murphy AJ, Dickson PV, Shibata D, Yakoub D, Deneve JL
Surgery 2023 Oct;174(4):907-915. Epub 2023 Jul 29 doi: 10.1016/j.surg.2023.06.039. PMID: 37524640
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Prognostic value of the TCGA molecular classification in uterine carcinosarcoma.
Travaglino A, Raffone A, Raimondo D, Arciuolo D, Angelico G, Valente M, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Santoro A, Seracchioli R, Franco Zannoni G
Int J Gynaecol Obstet 2022 Jul;158(1):13-20. Epub 2021 Oct 11 doi: 10.1002/ijgo.13937. PMID: 34536971Free PMC Article
Odontogenic carcinosarcoma: A systematic review.
Schuch LF, de Arruda JAA, Silva LVO, Abreu LG, Silva TA, Mesquita RA
Oral Oncol 2018 Oct;85:52-59. Epub 2018 Aug 30 doi: 10.1016/j.oraloncology.2018.08.017. PMID: 30220320

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