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Refractory Neuroendocrine Carcinoma

MedGen UID:
1719330
•Concept ID:
C5237419
•
Neoplastic Process

Definition

Neuroendocrine carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

The Evolving Treatment Landscape of Merkel Cell Carcinoma.
Singh N, McClure EM, Akaike T, Park SY, Huynh ET, Goff PH, Nghiem P
Curr Treat Options Oncol 2023 Sep;24(9):1231-1258. Epub 2023 Jul 5 doi: 10.1007/s11864-023-01118-8. PMID: 37403007Free PMC Article
Merkel cell carcinoma: a review of clinical management with focus on Asian patients.
Nakano E, Ogata D, Namikawa K, Yamazaki N
Jpn J Clin Oncol 2023 Jul 31;53(8):673-679. doi: 10.1093/jjco/hyad059. PMID: 37288476
Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300

Recent clinical studies

Etiology

Response to Combined Peptide Receptor Radionuclide Therapy and Checkpoint Immunotherapy with Ipilimumab Plus Nivolumab in Metastatic Merkel Cell Carcinoma.
Ferdinandus J, Fendler WP, Lueckerath K, Berliner C, Kurzidem S, Hadaschik E, Klode J, Zimmer L, Livingstone E, Schadendorf D, Herrmann K, Becker JC, Ugurel S
J Nucl Med 2022 Mar;63(3):396-398. Epub 2021 Sep 2 doi: 10.2967/jnumed.121.262344. PMID: 34475234
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Avelumab: A Review in Metastatic Merkel Cell Carcinoma.
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096
Islet cell tumors of the pancreas.
Bieligk S, Jaffe BM
Surg Clin North Am 1995 Oct;75(5):1025-40. doi: 10.1016/s0039-6109(16)46744-7. PMID: 7660247

Diagnosis

DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Merkel cell carcinoma.
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article
Avelumab and other recent advances in Merkel cell carcinoma.
Bommareddy PK, Kaufman HL
Future Oncol 2017 Dec;13(30):2771-2783. Epub 2017 Oct 4 doi: 10.2217/fon-2017-0305. PMID: 28976209
Current Advances in Thyroid Cancer Management. Are We Ready for the Epidemic Rise of Diagnoses?
Rusinek D, Chmielik E, Krajewska J, Jarzab M, Oczko-Wojciechowska M, Czarniecka A, Jarzab B
Int J Mol Sci 2017 Aug 22;18(8) doi: 10.3390/ijms18081817. PMID: 28829399Free PMC Article
Aggressive variants of castration-resistant prostate cancer.
Beltran H, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA
Clin Cancer Res 2014 Jun 1;20(11):2846-50. Epub 2014 Apr 11 doi: 10.1158/1078-0432.CCR-13-3309. PMID: 24727321Free PMC Article

Therapy

Immunotherapy for Non-melanoma Skin Cancer.
Shalhout SZ, Emerick KS, Kaufman HL, Miller DM
Curr Oncol Rep 2021 Aug 27;23(11):125. doi: 10.1007/s11912-021-01120-z. PMID: 34448958Free PMC Article
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Avelumab: A Review in Metastatic Merkel Cell Carcinoma.
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096
Avelumab for the treatment of metastatic Merkel cell carcinoma.
Cordes LM, Gulley JL
Drugs Today (Barc) 2017 Jul;53(7):377-383. doi: 10.1358/dot.2017.53.7.2654888. PMID: 28837181Free PMC Article
New therapeutic options for advanced forms of thyroid cancer.
Bernet V, Smallridge R
Expert Opin Emerg Drugs 2014 Jun;19(2):225-41. Epub 2014 Mar 3 doi: 10.1517/14728214.2014.894017. PMID: 24588376

Prognosis

Merkel cell carcinoma.
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article
Avelumab and other recent advances in Merkel cell carcinoma.
Bommareddy PK, Kaufman HL
Future Oncol 2017 Dec;13(30):2771-2783. Epub 2017 Oct 4 doi: 10.2217/fon-2017-0305. PMID: 28976209
Current Advances in Thyroid Cancer Management. Are We Ready for the Epidemic Rise of Diagnoses?
Rusinek D, Chmielik E, Krajewska J, Jarzab M, Oczko-Wojciechowska M, Czarniecka A, Jarzab B
Int J Mol Sci 2017 Aug 22;18(8) doi: 10.3390/ijms18081817. PMID: 28829399Free PMC Article
Aggressive variants of castration-resistant prostate cancer.
Beltran H, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA
Clin Cancer Res 2014 Jun 1;20(11):2846-50. Epub 2014 Apr 11 doi: 10.1158/1078-0432.CCR-13-3309. PMID: 24727321Free PMC Article
New therapeutic options for advanced forms of thyroid cancer.
Bernet V, Smallridge R
Expert Opin Emerg Drugs 2014 Jun;19(2):225-41. Epub 2014 Mar 3 doi: 10.1517/14728214.2014.894017. PMID: 24588376

Clinical prediction guides

Phase I study of the (177)Lu-DOTA(0)-Tyr(3)-Octreotate (lutathera) in combination with nivolumab in patients with neuroendocrine tumors of the lung.
Kim C, Liu SV, Subramaniam DS, Torres T, Loda M, Esposito G, Giaccone G
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-000980. PMID: 32616557Free PMC Article
Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
Avelumab: A Review in Metastatic Merkel Cell Carcinoma.
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096
Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma.
Sakaida E, Ebata T, Iwasawa S, Kurimoto R, Yonemori S, Ota S, Nakatani Y, Sekine I, Takiguchi Y
Intern Med 2017;56(5):567-570. Epub 2017 Mar 1 doi: 10.2169/internalmedicine.56.7675. PMID: 28250307Free PMC Article
Islet cell tumors of the pancreas: the medical oncologist's perspective.
Brentjens R, Saltz L
Surg Clin North Am 2001 Jun;81(3):527-42. doi: 10.1016/s0039-6109(05)70141-9. PMID: 11459269

Recent systematic reviews

Efficacy and Safety of Multikinase Inhibitors for Patients With Refractory Thyroid Cancer: Systematic Review and Network Meta-Analysis.
Jing R, Wu N, Wu Y, Zhang Q, Liang Q, Huang P, Yi S
J Clin Endocrinol Metab 2024 Sep 16;109(10):2658-2672. doi: 10.1210/clinem/dgae454. PMID: 38970485
Cabozantinib for different endocrine tumours: killing two birds with one stone. A systematic review of the literature.
Zago E, Galluzzo A, Pradella S, Antonuzzo L, Maggi M, Petrone L, Sparano C
Endocrine 2024 Jan;83(1):26-40. Epub 2023 Oct 18 doi: 10.1007/s12020-023-03526-0. PMID: 37851242Free PMC Article
Efficacy and safety of peptide receptor radionuclide therapy in advanced radioiodine-refractory differentiated thyroid cancer and metastatic medullary thyroid cancer: a systematic review.
Maghsoomi Z, Emami Z, Malboosbaf R, Malek M, Khamseh ME
BMC Cancer 2021 May 20;21(1):579. doi: 10.1186/s12885-021-08257-x. PMID: 34016077Free PMC Article
Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR: a systematic literature review.
Broder MS, Beenhouwer D, Strosberg JR, Neary MP, Cherepanov D
World J Gastroenterol 2015 Feb 14;21(6):1945-55. doi: 10.3748/wjg.v21.i6.1945. PMID: 25684964Free PMC Article
New therapeutic options for advanced forms of thyroid cancer.
Bernet V, Smallridge R
Expert Opin Emerg Drugs 2014 Jun;19(2):225-41. Epub 2014 Mar 3 doi: 10.1517/14728214.2014.894017. PMID: 24588376

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