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Metastatic Malignant Neoplasm in the Stomach

MedGen UID:
473255
•Concept ID:
C0686068
•
Neoplastic Process
Synonyms: Cancer metastatic to stomach; Metastatic malignant neoplasm of stomach; Metastatic malignant neoplasm to stomach; Metastatic Malignant Neoplasm to the Stomach; Secondary malignant neoplasm of stomach
SNOMED CT: Secondary malignant neoplasm of stomach (94606003); Metastatic malignant neoplasm to stomach (94606003); Cancer metastatic to stomach (94606003); Metastatic malignant neoplasm of stomach (94606003)

Definition

A malignant neoplasm that has spread to the stomach from another organ or system, or from another primary gastric tumor. The primary gastric tumor is not in continuity with the metastatic lesion. Representative examples of metastatic malignant neoplasms to the stomach include breast, lung, and esophageal metastatic carcinomas and melanomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Stomach

Professional guidelines

PubMed

Gastric cancer treatment: recent progress and future perspectives.
Guan WL, He Y, Xu RH
J Hematol Oncol 2023 May 27;16(1):57. doi: 10.1186/s13045-023-01451-3. PMID: 37245017Free PMC Article
Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Fanta P, Farjah F, Gerdes H, Gibson MK, Hochwald S, Hofstetter WL, Ilson DH, Keswani RN, Kim S, Kleinberg LR, Klempner SJ, Lacy J, Ly QP, Matkowskyj KA, McNamara M, Mulcahy MF, Outlaw D, Park H, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian N, Pluchino LA
J Natl Compr Canc Netw 2022 Feb;20(2):167-192. doi: 10.6004/jnccn.2022.0008. PMID: 35130500
Current treatment and recent progress in gastric cancer.
Joshi SS, Badgwell BD
CA Cancer J Clin 2021 May;71(3):264-279. Epub 2021 Feb 16 doi: 10.3322/caac.21657. PMID: 33592120Free PMC Article

Recent clinical studies

Etiology

Health-Related Quality of Life With Nivolumab Plus Chemotherapy Versus Chemotherapy in Patients With Advanced Gastric/Gastroesophageal Junction Cancer or Esophageal Adenocarcinoma From CheckMate 649.
Moehler M, Xiao H, Blum SI, Elimova E, Cella D, Shitara K, Ajani JA, Janjigian YY, Garrido M, Shen L, Yamaguchi K, Liu T, Schenker M, Kowalyszyn R, Bragagnoli AC, Bruges R, Montesarchio V, Pazo-Cid R, Hunter S, Davenport E, Wang J, Kondo K, Li M, Wyrwicz L
J Clin Oncol 2023 Dec 10;41(35):5388-5399. Epub 2023 Sep 15 doi: 10.1200/JCO.23.00170. PMID: 37713657Free PMC Article
Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Gastritis: update on etiological features and histological practical approach.
Pennelli G, Grillo F, Galuppini F, Ingravallo G, Pilozzi E, Rugge M, Fiocca R, Fassan M, Mastracci L
Pathologica 2020 Sep;112(3):153-165. doi: 10.32074/1591-951X-163. PMID: 33179619Free PMC Article
Problems Associated with Deprescribing of Proton Pump Inhibitors.
Helgadottir H, Bjornsson ES
Int J Mol Sci 2019 Nov 2;20(21) doi: 10.3390/ijms20215469. PMID: 31684070Free PMC Article
IMMEDIATE AND LATE RESULTS OF THE COMBINED GASTRECTOMY PERFORMANCE FOR LOCALLY—SPREAD GASTRIC CANCER.
Oliynyk YY
Klin Khir 2016 Oct;(10):9-11. PMID: 30479104

Diagnosis

Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Gastritis: The clinico-pathological spectrum.
Rugge M, Savarino E, Sbaraglia M, Bricca L, Malfertheiner P
Dig Liver Dis 2021 Oct;53(10):1237-1246. Epub 2021 Mar 28 doi: 10.1016/j.dld.2021.03.007. PMID: 33785282
Gastritis: update on etiological features and histological practical approach.
Pennelli G, Grillo F, Galuppini F, Ingravallo G, Pilozzi E, Rugge M, Fiocca R, Fassan M, Mastracci L
Pathologica 2020 Sep;112(3):153-165. doi: 10.32074/1591-951X-163. PMID: 33179619Free PMC Article
Surveillance for Gastric Cancer.
Laks S, Meyers MO, Kim HJ
Surg Clin North Am 2017 Apr;97(2):317-331. Epub 2017 Feb 14 doi: 10.1016/j.suc.2016.11.007. PMID: 28325189
IMMEDIATE AND LATE RESULTS OF THE COMBINED GASTRECTOMY PERFORMANCE FOR LOCALLY—SPREAD GASTRIC CANCER.
Oliynyk YY
Klin Khir 2016 Oct;(10):9-11. PMID: 30479104

Therapy

MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer.
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer.
Janjigian YY, Kawazoe A, Yañez P, Li N, Lonardi S, Kolesnik O, Barajas O, Bai Y, Shen L, Tang Y, Wyrwicz LS, Xu J, Shitara K, Qin S, Van Cutsem E, Tabernero J, Li L, Shah S, Bhagia P, Chung HC
Nature 2021 Dec;600(7890):727-730. Epub 2021 Dec 15 doi: 10.1038/s41586-021-04161-3. PMID: 34912120Free PMC Article
KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma.
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article
Problems Associated with Deprescribing of Proton Pump Inhibitors.
Helgadottir H, Bjornsson ES
Int J Mol Sci 2019 Nov 2;20(21) doi: 10.3390/ijms20215469. PMID: 31684070Free PMC Article
A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study.
Türeci O, Sahin U, Schulze-Bergkamen H, Zvirbule Z, Lordick F, Koeberle D, Thuss-Patience P, Ettrich T, Arnold D, Bassermann F, Al-Batran SE, Wiechen K, Dhaene K, Maurus D, Gold M, Huber C, Krivoshik A, Arozullah A, Park JW, Schuler M
Ann Oncol 2019 Sep 1;30(9):1487-1495. doi: 10.1093/annonc/mdz199. PMID: 31240302Free PMC Article

Prognosis

Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Pan-cancer analysis of prognostic metastatic phenotypes.
Zaorsky NG, Wang X, Garrett SM, Lehrer EJ, Lin C, DeGraff DJ, Spratt DE, Trifiletti DM, Kishan AU, Showalter TN, Park HS, Yang JT, Chinchilli VM, Wang M
Int J Cancer 2022 Jan 1;150(1):132-141. Epub 2021 Aug 27 doi: 10.1002/ijc.33744. PMID: 34287840Free PMC Article
The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis.
Zhou K, Wang A, Ao S, Chen J, Ji K, He Q, Ji X, Wu X, Zhang J, Li Z, Bu Z, Ji J
BMC Cancer 2020 Jul 17;20(1):671. doi: 10.1186/s12885-020-07031-9. PMID: 32680468Free PMC Article
Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial.
Li WQ, Zhang JY, Ma JL, Li ZX, Zhang L, Zhang Y, Guo Y, Zhou T, Li JY, Shen L, Liu WD, Han ZX, Blot WJ, Gail MH, Pan KF, You WC
BMJ 2019 Sep 11;366:l5016. doi: 10.1136/bmj.l5016. PMID: 31511230Free PMC Article
Novel Targeted Therapies for Esophagogastric Cancer.
Maron SB, Catenacci DV
Surg Oncol Clin N Am 2017 Apr;26(2):293-312. doi: 10.1016/j.soc.2016.10.002. PMID: 28279470Free PMC Article

Clinical prediction guides

First-line nivolumab plus chemotherapy vs chemotherapy in patients with advanced gastric, gastroesophageal junction and esophageal adenocarcinoma: CheckMate 649 Chinese subgroup analysis.
Liu T, Bai Y, Lin X, Li W, Wang J, Zhang X, Pan H, Bai C, Bai L, Cheng Y, Zhang J, Zhong H, Ba Y, Hu W, Xu R, Guo W, Qin S, Yang N, Lu J, Shitara K, Lei M, Li M, Bao N, Chen T, Shen L
Int J Cancer 2023 Feb 15;152(4):749-760. Epub 2022 Oct 31 doi: 10.1002/ijc.34296. PMID: 36121651Free PMC Article
Recent progress and current challenges of immunotherapy in advanced/metastatic esophagogastric adenocarcinoma.
Moehler M, Högner A, Wagner AD, Obermannova R, Alsina M, Thuss-Patience P, van Laarhoven H, Smyth E
Eur J Cancer 2022 Nov;176:13-29. Epub 2022 Sep 29 doi: 10.1016/j.ejca.2022.08.023. PMID: 36183651
Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Gastritis: update on etiological features and histological practical approach.
Pennelli G, Grillo F, Galuppini F, Ingravallo G, Pilozzi E, Rugge M, Fiocca R, Fassan M, Mastracci L
Pathologica 2020 Sep;112(3):153-165. doi: 10.32074/1591-951X-163. PMID: 33179619Free PMC Article

Recent systematic reviews

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Primary gastric melanoma in adult population: a systematic review of the literature.
Schizas D, Tomara N, Katsaros I, Sakellariou S, Machairas N, Paspala A, Tsilimigras DI, Papanikolaou IS, Mantas D
ANZ J Surg 2021 Mar;91(3):269-275. Epub 2020 Jul 20 doi: 10.1111/ans.16160. PMID: 32687691
Risk Factors for Gastric Cancer: A Systematic Review.
Yusefi AR, Bagheri Lankarani K, Bastani P, Radinmanesh M, Kavosi Z
Asian Pac J Cancer Prev 2018 Mar 27;19(3):591-603. doi: 10.22034/APJCP.2018.19.3.591. PMID: 29579788Free PMC Article
Staging and surgical approaches in gastric cancer: A systematic review.
Coburn N, Cosby R, Klein L, Knight G, Malthaner R, Mamazza J, Mercer CD, Ringash J
Cancer Treat Rev 2018 Feb;63:104-115. Epub 2017 Dec 13 doi: 10.1016/j.ctrv.2017.12.006. PMID: 29275224

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