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Metastatic Paraganglioma

MedGen UID:
288558
Concept ID:
C1533592
Neoplastic Process
Synonyms: Malignant Neoplasm of Paraganglion; Malignant Neoplasm of the Paraganglion; Malignant paraganglioma; Malignant Paraganglioma; Malignant Paraganglion Neoplasm; Malignant Paraganglion Tumor; Malignant Paraganglionic Neoplasm; Malignant Paraganglionic Tumor; Malignant Tumor of Paraganglion; Malignant Tumor of the Paraganglion; Paraganglioma, malignant; Paraganglion Neoplasm, Malignant
SNOMED CT: Malignant paraganglioma (9903002); Paraganglioma, malignant (9903002)

Definition

A paraganglioma that metastasizes to regional or distant anatomic sites. Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas. Common sites of metastasis include the lymph nodes, lungs, bones, and liver. [from NCI]

Professional guidelines

PubMed

Jimenez C, Xu G, Varghese J, Graham PH, Campbell MT, Lu Y
Curr Oncol Rep 2022 Jan;24(1):89-98. Epub 2022 Jan 21 doi: 10.1007/s11912-022-01197-0. PMID: 35061191
Jasim S, Jimenez C
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101354. Epub 2019 Oct 24 doi: 10.1016/j.beem.2019.101354. PMID: 31685417
Jia Q, Yin H, Yang J, Wu Z, Yan W, Zhou W, Yang X, Xiao J
Eur Spine J 2018 Apr;27(4):859-867. Epub 2017 Jun 26 doi: 10.1007/s00586-017-5140-5. PMID: 28653097

Recent clinical studies

Etiology

Lundholm MD, Marquard J, Rao PP
J Med Case Rep 2023 Apr 7;17(1):124. doi: 10.1186/s13256-023-03871-8. PMID: 37024931Free PMC Article
Chan EY, Ali A, Umana JP, Nguyen DT, Hamilton DJ, Graviss EA, Ravi V, MacGillivray TE, Reardon MJ
J Thorac Cardiovasc Surg 2022 Jul;164(1):158-166.e1. Epub 2020 Oct 3 doi: 10.1016/j.jtcvs.2020.09.100. PMID: 33148444
Parghane RV, Talole S, Basu S
Ann Nucl Med 2021 Jan;35(1):92-101. Epub 2020 Nov 1 doi: 10.1007/s12149-020-01541-z. PMID: 33135123
Jia Q, Yin H, Yang J, Wu Z, Yan W, Zhou W, Yang X, Xiao J
Eur Spine J 2018 Apr;27(4):859-867. Epub 2017 Jun 26 doi: 10.1007/s00586-017-5140-5. PMID: 28653097
de Leon D, Walton K, Sokumbi O
Am J Dermatopathol 2017 Sep;39(9):700-703. doi: 10.1097/DAD.0000000000000965. PMID: 28763336

Diagnosis

Harmsworth D, Mallia A, DeGaetano J, Cassar PJ
BMJ Case Rep 2023 Jan 17;16(1) doi: 10.1136/bcr-2022-252449. PMID: 36653043Free PMC Article
Kakodkar P, Houlihan LM, Preul M, Bermingham N, Lim C
Br J Neurosurg 2023 Oct;37(5):967-975. Epub 2021 Mar 19 doi: 10.1080/02688697.2021.1902477. PMID: 33739182
Urquhart C, Fleming B, Harper I, Aloj L, Armstrong R, Hook L, Long AM, Jackson C, Gallagher FA, McLean MA, Tarpey P, Kosmoliaptsis V, Nicholson J, Hendriks AEJ, Casey RT
Front Endocrinol (Lausanne) 2022;13:1066208. Epub 2022 Nov 9 doi: 10.3389/fendo.2022.1066208. PMID: 36440187Free PMC Article
de Leon D, Walton K, Sokumbi O
Am J Dermatopathol 2017 Sep;39(9):700-703. doi: 10.1097/DAD.0000000000000965. PMID: 28763336
Fliedner SM, Lehnert H, Pacak K
Semin Oncol 2010 Dec;37(6):627-37. doi: 10.1053/j.seminoncol.2010.10.017. PMID: 21167381Free PMC Article

Therapy

Urquhart C, Fleming B, Harper I, Aloj L, Armstrong R, Hook L, Long AM, Jackson C, Gallagher FA, McLean MA, Tarpey P, Kosmoliaptsis V, Nicholson J, Hendriks AEJ, Casey RT
Front Endocrinol (Lausanne) 2022;13:1066208. Epub 2022 Nov 9 doi: 10.3389/fendo.2022.1066208. PMID: 36440187Free PMC Article
Parghane RV, Talole S, Basu S
Ann Nucl Med 2021 Jan;35(1):92-101. Epub 2020 Nov 1 doi: 10.1007/s12149-020-01541-z. PMID: 33135123
Jasim S, Jimenez C
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101354. Epub 2019 Oct 24 doi: 10.1016/j.beem.2019.101354. PMID: 31685417
Toledo R, Jimenez C
F1000Res 2018;7 Epub 2018 Jul 30 doi: 10.12688/f1000research.13995.1. PMID: 30109021Free PMC Article
Kong G, Grozinsky-Glasberg S, Hofman MS, Callahan J, Meirovitz A, Maimon O, Pattison DA, Gross DJ, Hicks RJ
J Clin Endocrinol Metab 2017 Sep 1;102(9):3278-3287. doi: 10.1210/jc.2017-00816. PMID: 28605448

Prognosis

Bellerive C, Biscotti CV, Singh N, Singh AD
Can J Ophthalmol 2019 Dec;54(6):694-698. Epub 2019 May 31 doi: 10.1016/j.jcjo.2019.03.016. PMID: 31836102
Jia Q, Yin H, Yang J, Wu Z, Yan W, Zhou W, Yang X, Xiao J
Eur Spine J 2018 Apr;27(4):859-867. Epub 2017 Jun 26 doi: 10.1007/s00586-017-5140-5. PMID: 28653097
Kong G, Grozinsky-Glasberg S, Hofman MS, Callahan J, Meirovitz A, Maimon O, Pattison DA, Gross DJ, Hicks RJ
J Clin Endocrinol Metab 2017 Sep 1;102(9):3278-3287. doi: 10.1210/jc.2017-00816. PMID: 28605448
Niemeijer ND, Rijken JA, Eijkelenkamp K, van der Horst-Schrivers ANA, Kerstens MN, Tops CMJ, van Berkel A, Timmers HJLM, Kunst HPM, Leemans CR, Bisschop PH, Dreijerink KMA, van Dooren MF, Bayley JP, Pereira AM, Jansen JC, Hes FJ, Hensen EF, Corssmit EPM
Eur J Endocrinol 2017 Aug;177(2):115-125. Epub 2017 May 10 doi: 10.1530/EJE-17-0074. PMID: 28490599
Lau D, La Marca F, Camelo-Piragua S, Park P
Clin Neurol Neurosurg 2013 Sep;115(9):1571-4. Epub 2013 Feb 9 doi: 10.1016/j.clineuro.2013.01.006. PMID: 23398849

Clinical prediction guides

Bellerive C, Biscotti CV, Singh N, Singh AD
Can J Ophthalmol 2019 Dec;54(6):694-698. Epub 2019 May 31 doi: 10.1016/j.jcjo.2019.03.016. PMID: 31836102
Niemeijer ND, Rijken JA, Eijkelenkamp K, van der Horst-Schrivers ANA, Kerstens MN, Tops CMJ, van Berkel A, Timmers HJLM, Kunst HPM, Leemans CR, Bisschop PH, Dreijerink KMA, van Dooren MF, Bayley JP, Pereira AM, Jansen JC, Hes FJ, Hensen EF, Corssmit EPM
Eur J Endocrinol 2017 Aug;177(2):115-125. Epub 2017 May 10 doi: 10.1530/EJE-17-0074. PMID: 28490599
Bryant BH, Zenali MJ, Swanson PE, Upton MP, Yeh MM, Cuevas C, Park JO, Westerhoff M
Am J Clin Pathol 2016 Aug;146(2):254-61. Epub 2016 May 31 doi: 10.1093/ajcp/aqw056. PMID: 27247379
Feng N, Li X, Gao HD, Liu ZL, Shi LJ, Liu WZ
Chin J Cancer 2013 Nov;32(11):624-8. Epub 2013 May 14 doi: 10.5732/cjc.012.10317. PMID: 23668927Free PMC Article
Bourcier ME, Vinik AI
Pancreas 2013 Mar;42(2):348-52. doi: 10.1097/MPA.0b013e31825c53fa. PMID: 23407483

Recent systematic reviews

Kakodkar P, Houlihan LM, Preul M, Bermingham N, Lim C
Br J Neurosurg 2023 Oct;37(5):967-975. Epub 2021 Mar 19 doi: 10.1080/02688697.2021.1902477. PMID: 33739182

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