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Refractory malignant neoplasm

MedGen UID:
146772
Concept ID:
C0677936
Neoplastic Process
Synonyms: clinical resistance; Refractory Cancer; refractory cancer; Refractory Malignant Neoplasm; refractory malignant neoplasm; resistant cancer
 
Monarch Initiative: MONDO:0036501

Definition

A malignant neoplasm that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory malignant neoplasm

Professional guidelines

PubMed

Ansell SM
Am J Hematol 2022 Nov;97(11):1478-1488. Epub 2022 Sep 19 doi: 10.1002/ajh.26717. PMID: 36215668
Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ
Nat Rev Gastroenterol Hepatol 2020 Sep;17(9):557-588. Epub 2020 Jun 30 doi: 10.1038/s41575-020-0310-z. PMID: 32606456Free PMC Article
Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network
J Clin Oncol 2018 Jun 10;36(17):1714-1768. Epub 2018 Feb 14 doi: 10.1200/JCO.2017.77.6385. PMID: 29442540Free PMC Article

Recent clinical studies

Etiology

Wang JZ, Nassiri F, Bi L, Zadeh G
Adv Exp Med Biol 2023;1416:189-198. doi: 10.1007/978-3-031-29750-2_14. PMID: 37432628
Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Berdelou A, Lamartina L, Klain M, Leboulleux S, Schlumberger M
Endocr Relat Cancer 2018 Apr;25(4):R209-R223. Epub 2018 Jan 25 doi: 10.1530/ERC-17-0542. PMID: 29371330
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455

Diagnosis

Panch SR, Guo L, Vassallo R
Blood Rev 2023 Nov;62:101135. Epub 2023 Oct 2 doi: 10.1016/j.blre.2023.101135. PMID: 37805287
Shen F, Shen W
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106563. doi: 10.1177/15330338221106563. PMID: 35903924Free PMC Article
Kamijo H, Miyagaki T
Curr Treat Options Oncol 2021 Jan 7;22(2):10. doi: 10.1007/s11864-020-00809-w. PMID: 33415447
Boumahdi S, de Sauvage FJ
Nat Rev Drug Discov 2020 Jan;19(1):39-56. Epub 2019 Oct 10 doi: 10.1038/s41573-019-0044-1. PMID: 31601994
Payandeh Z, Noori E, Khalesi B, Mard-Soltani M, Abdolalizadeh J, Khalili S
Biotechnol Lett 2018 Dec;40(11-12):1459-1466. Epub 2018 Oct 6 doi: 10.1007/s10529-018-2612-6. PMID: 30293139

Therapy

Chin RI, Wu FS, Menda Y, Kim H
Semin Radiat Oncol 2021 Jan;31(1):60-70. doi: 10.1016/j.semradonc.2020.07.007. PMID: 33246637
Barbui T, Tefferi A, Vannucchi AM, Passamonti F, Silver RT, Hoffman R, Verstovsek S, Mesa R, Kiladjian JJ, Hehlmann R, Reiter A, Cervantes F, Harrison C, Mc Mullin MF, Hasselbalch HC, Koschmieder S, Marchetti M, Bacigalupo A, Finazzi G, Kroeger N, Griesshammer M, Birgegard G, Barosi G
Leukemia 2018 May;32(5):1057-1069. Epub 2018 Feb 27 doi: 10.1038/s41375-018-0077-1. PMID: 29515238Free PMC Article
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article
Baekelandt M
Curr Opin Investig Drugs 2002 Oct;3(10):1517-26. PMID: 12431030
Cheson B
Curr Opin Investig Drugs 2002 Jan;3(1):165-70. PMID: 12054068

Prognosis

Martinelli G, Boissel N, Chevallier P, Ottmann O, Gökbuget N, Rambaldi A, Ritchie EK, Papayannidis C, Tuglus CA, Morris JD, Stein A
Eur J Cancer 2021 Mar;146:107-114. Epub 2021 Feb 13 doi: 10.1016/j.ejca.2020.12.022. PMID: 33588145
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
Salles G, Duell J, González Barca E, Tournilhac O, Jurczak W, Liberati AM, Nagy Z, Obr A, Gaidano G, André M, Kalakonda N, Dreyling M, Weirather J, Dirnberger-Hertweck M, Ambarkhane S, Fingerle-Rowson G, Maddocks K
Lancet Oncol 2020 Jul;21(7):978-988. Epub 2020 Jun 5 doi: 10.1016/S1470-2045(20)30225-4. PMID: 32511983
Cordeiro A, Bezerra ED, Hirayama AV, Hill JA, Wu QV, Voutsinas J, Sorror ML, Turtle CJ, Maloney DG, Bar M
Biol Blood Marrow Transplant 2020 Jan;26(1):26-33. Epub 2019 Aug 13 doi: 10.1016/j.bbmt.2019.08.003. PMID: 31419568Free PMC Article
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article

Clinical prediction guides

Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schürer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG
Cell 2023 Aug 3;186(16):3476-3498.e35. doi: 10.1016/j.cell.2023.07.004. PMID: 37541199Free PMC Article
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Chang Y, Jeong SW, Young Jang J, Jae Kim Y
Int J Mol Sci 2020 Oct 31;21(21) doi: 10.3390/ijms21218165. PMID: 33142892Free PMC Article
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
Zikich D, Schachter J, Besser MJ
Immunotherapy 2016;8(1):35-43. Epub 2015 Dec 10 doi: 10.2217/imt.15.99. PMID: 26653685

Recent systematic reviews

Mc Donald D, Drake MT, Crowley RK
Clin Med (Lond) 2023 Sep;23(5):503-507. Epub 2023 Sep 29 doi: 10.7861/clinmed.2023-0227. PMID: 37775175Free PMC Article
Patell K, Kurian M, Garcia JA, Mendiratta P, Barata PC, Jia AY, Spratt DE, Brown JR
Expert Rev Anticancer Ther 2023 Jul;23(7):731-744. Epub 2023 May 24 doi: 10.1080/14737140.2023.2213892. PMID: 37194261
Nabizadeh F, Balabandian M, Sodeifian F, Rezaei N, Rostami MR, Naser Moghadasi A
Mult Scler Relat Disord 2022 Jun;62:103795. Epub 2022 Apr 6 doi: 10.1016/j.msard.2022.103795. PMID: 35472834Free PMC Article
Chen J, Wei Z, Fu K, Duan Y, Zhang M, Li K, Guo T, Yin R
Biomed Pharmacother 2022 Jun;150:112929. Epub 2022 Apr 13 doi: 10.1016/j.biopha.2022.112929. PMID: 35429741
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article

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