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Endometrioid adenocarcinoma

MedGen UID:
293976
•Concept ID:
C1569637
•
Neoplastic Process
Synonyms: Adenocarcinoma, Endometrioid; Adenocarcinomas, Endometrioid; Endometrioid Adenocarcinoma; Endometrioid Adenocarcinomas
SNOMED CT: Endometrioid adenocarcinoma (30289006); Endometrioid cystadenocarcinoma (30289006)
 
Monarch Initiative: MONDO:0005026

Definition

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Endometrioid adenocarcinoma

Professional guidelines

PubMed

Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?
Mahdi H, Ray-Coquard I, Lorusso D, Mirza MR, Monk BJ, Slomovitz B
Int J Gynecol Cancer 2023 Nov 6;33(11):1675-1681. doi: 10.1136/ijgc-2023-004454. PMID: 37640446Free PMC Article
Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Therapeutic options for management of endometrial hyperplasia.
Chandra V, Kim JJ, Benbrook DM, Dwivedi A, Rai R
J Gynecol Oncol 2016 Jan;27(1):e8. Epub 2015 Dec 1 doi: 10.3802/jgo.2016.27.e8. PMID: 26463434Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024

Recent clinical studies

Etiology

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Endometrium and steroids, a pathologic overview.
Plaza-Parrochia F, Romero C, Valladares L, Vega M
Steroids 2017 Oct;126:85-91. Epub 2017 Aug 18 doi: 10.1016/j.steroids.2017.08.007. PMID: 28827068
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256

Diagnosis

Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Endometrium and steroids, a pathologic overview.
Plaza-Parrochia F, Romero C, Valladares L, Vega M
Steroids 2017 Oct;126:85-91. Epub 2017 Aug 18 doi: 10.1016/j.steroids.2017.08.007. PMID: 28827068
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256

Therapy

Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?
Mahdi H, Ray-Coquard I, Lorusso D, Mirza MR, Monk BJ, Slomovitz B
Int J Gynecol Cancer 2023 Nov 6;33(11):1675-1681. doi: 10.1136/ijgc-2023-004454. PMID: 37640446Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Therapeutic options for management of endometrial hyperplasia.
Chandra V, Kim JJ, Benbrook DM, Dwivedi A, Rai R
J Gynecol Oncol 2016 Jan;27(1):e8. Epub 2015 Dec 1 doi: 10.3802/jgo.2016.27.e8. PMID: 26463434Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Pathology and physiopathology of adenomyosis.
Bergeron C, Amant F, Ferenczy A
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):511-21. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.016. PMID: 16563870

Prognosis

Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Management and prognosis of endometrioid borderline tumors of the ovary.
Uzan C, Berretta R, Rolla M, Gouy S, Fauvet R, Darai E, Duvillard P, Morice P
Surg Oncol 2012 Sep;21(3):178-84. Epub 2012 Mar 13 doi: 10.1016/j.suronc.2012.02.002. PMID: 22418038
Pathology and physiopathology of adenomyosis.
Bergeron C, Amant F, Ferenczy A
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):511-21. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.016. PMID: 16563870

Clinical prediction guides

Clinical and multiparametric MRI features for differentiating uterine carcinosarcoma from endometrioid adenocarcinoma.
Chen X, Guo Q, Chen X, Zheng W, Kang Y, Cao D
BMC Med Imaging 2024 Feb 19;24(1):48. doi: 10.1186/s12880-024-01225-4. PMID: 38373912Free PMC Article
vNOTES Hysterectomy: What about Obese Patients?
Bouchez MC, Delporte V, Delplanque S, Leroy M, Vandendriessche D, Rubod C, Cosson M, Giraudet G
J Minim Invasive Gynecol 2023 Jul;30(7):569-575. Epub 2023 Mar 25 doi: 10.1016/j.jmig.2023.03.014. PMID: 36966918
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Malignant Transformation of Vaginal Endometriosis - A Review of Literature.
Cozzolino M, Nasioudis D, Sisti G, Coccia ME
Gynecol Obstet Invest 2017;82(2):105-112. Epub 2016 Sep 13 doi: 10.1159/000449198. PMID: 27618565
MRI for differentiating ovarian endometrioid adenocarcinoma from high-grade serous adenocarcinoma.
Li HM, Qiang JW, Xia GL, Zhao SH, Ma FH, Cai SQ, Feng F, Fu AY
J Ovarian Res 2015 Apr 30;8:26. doi: 10.1186/s13048-015-0154-2. PMID: 25926038Free PMC Article

Recent systematic reviews

Endometrial cancer after endometrial ablation: a systematic review.
Oderkerk TJ, van de Kar MRD, Cornel KMC, Bongers MY, Geomini PMAJ
Int J Gynecol Cancer 2022 Dec 5;32(12):1555-1560. doi: 10.1136/ijgc-2022-003866. PMID: 36375895
Minimally invasive surgery versus open surgery in high-risk histologic endometrial cancer patients: A meta-analysis.
Kim NR, Lee AJ, Yang EJ, So KA, Lee SJ, Kim TJ, Shim SH
Gynecol Oncol 2022 Aug;166(2):236-244. Epub 2022 Jun 17 doi: 10.1016/j.ygyno.2022.06.004. PMID: 35725657
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Malignant transformation of abdominal wall endometriosis: A systematic review of the epidemiology, diagnosis, treatment, and outcomes.
Liu G, Wang Y, Chen Y, Ren F
Eur J Obstet Gynecol Reprod Biol 2021 Sep;264:363-367. Epub 2021 Aug 8 doi: 10.1016/j.ejogrb.2021.08.006. PMID: 34391052
Endometriosis-associated malignant transformation in abdominal surgical scar: A PRISMA-compliant systematic review.
Mihailovici A, Rottenstreich M, Kovel S, Wassermann I, Smorgick N, Vaknin Z
Medicine (Baltimore) 2017 Dec;96(49):e9136. doi: 10.1097/MD.0000000000009136. PMID: 29245355Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024

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