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Platinum-Refractory Ovarian Carcinoma

MedGen UID:
1791636
•Concept ID:
C5555195
•
Neoplastic Process

Definition

Ovarian carcinoma that progresses during platinum therapy or within one month of completing the last platinum therapy. [from NCI]

Professional guidelines

PubMed

A brief review of the management of platinum-resistant-platinum-refractory ovarian cancer.
Oronsky B, Ray CM, Spira AI, Trepel JB, Carter CA, Cottrill HM
Med Oncol 2017 Jun;34(6):103. Epub 2017 Apr 25 doi: 10.1007/s12032-017-0960-z. PMID: 28444622
Olaparib for the treatment of BRCA-mutated advanced ovarian cancer.
Munroe M, Kolesar J
Am J Health Syst Pharm 2016 Jul 15;73(14):1037-41. doi: 10.2146/ajhp150550. PMID: 27385701
Treatment of advanced ovarian cancer.
du Bois A
Eur J Cancer 2001 Dec;37 Suppl 9:S1-7. doi: 10.1016/s0959-8049(01)00328-8. PMID: 11741767

Recent clinical studies

Etiology

Efficacy and safety of low-dose apatinib in ovarian cancer patients with platinum-resistance or platinum-refractoriness: A single-center retrospective study.
Chen W, Li Z, Zheng Z, Wu X
Cancer Med 2020 Aug;9(16):5899-5907. Epub 2020 Jul 6 doi: 10.1002/cam4.3282. PMID: 32627959Free PMC Article
Phase II trial of CI-958 in recurrent platinum-refractory ovarian carcinoma. A Gynecologic Oncology Group Study.
Hoffman MA, Blessing JA, Morgan M
Gynecol Oncol 2000 Dec;79(3):463-5. doi: 10.1006/gyno.2000.5984. PMID: 11104620
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia.
Slichenmyer WJ, Donehower RC, Chen TL, Bowling MK, McGuire WP, Rowinsky EK
Cancer Chemother Pharmacol 1995;36(3):227-32. PMID: 7781143

Therapy

Efficacy and safety of low-dose apatinib in ovarian cancer patients with platinum-resistance or platinum-refractoriness: A single-center retrospective study.
Chen W, Li Z, Zheng Z, Wu X
Cancer Med 2020 Aug;9(16):5899-5907. Epub 2020 Jul 6 doi: 10.1002/cam4.3282. PMID: 32627959Free PMC Article
Matched unrelated donor bone marrow transplantation for the treatment of platinum refractory ovarian carcinoma: a case report.
Donato ML, Levenback C, Gershenson DM, McMeekin S, Champlin RE
Gynecol Oncol 2004 Jan;92(1):365-7. doi: 10.1016/j.ygyno.2003.09.004. PMID: 14751187
Phase II trial of CI-958 in recurrent platinum-refractory ovarian carcinoma. A Gynecologic Oncology Group Study.
Hoffman MA, Blessing JA, Morgan M
Gynecol Oncol 2000 Dec;79(3):463-5. doi: 10.1006/gyno.2000.5984. PMID: 11104620
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia.
Slichenmyer WJ, Donehower RC, Chen TL, Bowling MK, McGuire WP, Rowinsky EK
Cancer Chemother Pharmacol 1995;36(3):227-32. PMID: 7781143
Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.
Rowinsky EK, Grochow LB, Hendricks CB, Ettinger DS, Forastiere AA, Hurowitz LA, McGuire WP, Sartorius SE, Lubejko BG, Kaufmann SH
J Clin Oncol 1992 Apr;10(4):647-56. doi: 10.1200/JCO.1992.10.4.647. PMID: 1312588

Prognosis

Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia.
Slichenmyer WJ, Donehower RC, Chen TL, Bowling MK, McGuire WP, Rowinsky EK
Cancer Chemother Pharmacol 1995;36(3):227-32. PMID: 7781143
Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.
Rowinsky EK, Grochow LB, Hendricks CB, Ettinger DS, Forastiere AA, Hurowitz LA, McGuire WP, Sartorius SE, Lubejko BG, Kaufmann SH
J Clin Oncol 1992 Apr;10(4):647-56. doi: 10.1200/JCO.1992.10.4.647. PMID: 1312588

Clinical prediction guides

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.
Rowinsky EK, Grochow LB, Hendricks CB, Ettinger DS, Forastiere AA, Hurowitz LA, McGuire WP, Sartorius SE, Lubejko BG, Kaufmann SH
J Clin Oncol 1992 Apr;10(4):647-56. doi: 10.1200/JCO.1992.10.4.647. PMID: 1312588

Supplemental Content

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