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Refractory Bladder Carcinoma

MedGen UID:
1664919
•Concept ID:
C4725675
•
Neoplastic Process

Definition

Bladder carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Antibody-Based Therapeutics for the Treatment of Renal Cell Carcinoma: Challenges and Opportunities.
Mahmoud AM, Nabavizadeh R, Rodrigues Pessoa R, Garg I, Orme J, Costello BA, Cheville J, Lucien F
Oncologist 2023 Apr 6;28(4):297-308. doi: 10.1093/oncolo/oyac263. PMID: 36745503Free PMC Article
Treatment Strategies and Metabolic Pathway Regulation in Urothelial Cell Carcinoma: A Comprehensive Review.
Yang HY, Wu CY, Chen JJ, Lee TH
Int J Mol Sci 2020 Nov 26;21(23) doi: 10.3390/ijms21238993. PMID: 33256165Free PMC Article
Erdafitinib for the treatment of metastatic bladder cancer.
Montazeri K, Bellmunt J
Expert Rev Clin Pharmacol 2020 Jan;13(1):1-6. Epub 2019 Dec 22 doi: 10.1080/17512433.2020.1702025. PMID: 31810398

Recent clinical studies

Etiology

Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
SIU-ICUD recommendations on bladder cancer: systemic therapy for metastatic bladder cancer.
Merseburger AS, Apolo AB, Chowdhury S, Hahn NM, Galsky MD, Milowsky MI, Petrylak D, Powles T, Quinn DI, Rosenberg JE, Siefker-Radtke A, Sonpavde G, Sternberg CN
World J Urol 2019 Jan;37(1):95-105. Epub 2018 Sep 20 doi: 10.1007/s00345-018-2486-1. PMID: 30238401Free PMC Article
New agents for bacillus Calmette-Guérin-refractory nonmuscle invasive bladder cancer.
Ahn JJ, Ghandour RA, McKiernan JM
Curr Opin Urol 2014 Sep;24(5):540-5. doi: 10.1097/MOU.0000000000000088. PMID: 24921906
Radical cystectomy and the implications of comorbidity.
Mayr R, Fritsche HM, Pycha A, Pycha A
Expert Rev Anticancer Ther 2014 Mar;14(3):289-95. Epub 2014 Jan 8 doi: 10.1586/14737140.2014.868775. PMID: 24397794
The management of superficial bladder cancer.
Dalbagni G
Nat Clin Pract Urol 2007 May;4(5):254-60. doi: 10.1038/ncpuro0784. PMID: 17483810

Diagnosis

Poly (ADP-Ribose) Polymerase Inhibitors in Patients With Urothelial Cancer.
Gamba T, Paparo J, Panepinto O, Dionisio R, Di Maio M, Vignani F
Clin Genitourin Cancer 2023 Oct;21(5):509-516. Epub 2023 Jul 20 doi: 10.1016/j.clgc.2023.07.009. PMID: 37500375
TROP2 Expression Across Molecular Subtypes of Urothelial Carcinoma and Enfortumab Vedotin-resistant Cells.
Chou J, Trepka K, Sjöström M, Egusa EA, Chu CE, Zhu J, Chan E, Gibb EA, Badura ML, Contreras-Sanz A, Stohr BA, Meng MV, Pruthi RS, Lotan Y, Black PC, Porten SP, Koshkin VS, Friedlander TW, Feng FY
Eur Urol Oncol 2022 Dec;5(6):714-718. Epub 2022 Feb 23 doi: 10.1016/j.euo.2021.11.005. PMID: 35216942Free PMC Article
Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin.
Chu CE, Sjöström M, Egusa EA, Gibb EA, Badura ML, Zhu J, Koshkin VS, Stohr BA, Meng MV, Pruthi RS, Friedlander TW, Lotan Y, Black PC, Porten SP, Feng FY, Chou J
Clin Cancer Res 2021 Sep 15;27(18):5123-5130. Epub 2021 Jun 9 doi: 10.1158/1078-0432.CCR-20-4175. PMID: 34108177Free PMC Article
The management of superficial bladder cancer.
Dalbagni G
Nat Clin Pract Urol 2007 May;4(5):254-60. doi: 10.1038/ncpuro0784. PMID: 17483810
Future directions for gemcitabine in the treatment of genitourinary cancer.
Vogelzang NJ
Semin Oncol 2002 Feb;29(1 Suppl 3):40-5. doi: 10.1053/sonc.2002.30755. PMID: 11894007

Therapy

Novel uses of complement inhibitors in myasthenia gravis-Two case reports.
Zadeh S, Price H, Drews R, Bouffard MA, Young LH, Narayanaswami P
Muscle Nerve 2024 Mar;69(3):368-372. Epub 2024 Jan 11 doi: 10.1002/mus.28037. PMID: 38205840
Targeting the FGFR Pathway in Urothelial Carcinoma: the Future Is Now.
Peng J, Sridhar S, Siefker-Radtke AO, Selvarajah S, Jiang DM
Curr Treat Options Oncol 2022 Sep;23(9):1269-1287. Epub 2022 Aug 13 doi: 10.1007/s11864-022-01009-4. PMID: 35962938
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
A good start of immunotherapy in esophageal cancer.
Zhao Q, Yu J, Meng X
Cancer Med 2019 Aug;8(10):4519-4526. Epub 2019 Jun 23 doi: 10.1002/cam4.2336. PMID: 31231980Free PMC Article
Farnesyltransferase inhibitors.
Sebti SM, Adjei AA
Semin Oncol 2004 Feb;31(1 Suppl 1):28-39. doi: 10.1053/j.seminoncol.2003.12.012. PMID: 14981578

Prognosis

Efficacy and safety of pembrolizumab in metastatic urothelial carcinoma: results from KEYNOTE-045 and KEYNOTE-052 after up to 5 years of follow-up.
Balar AV, Castellano DE, Grivas P, Vaughn DJ, Powles T, Vuky J, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Necchi A, Petrylak DP, Plimack ER, Xu JZ, Imai K, Moreno BH, Bellmunt J, de Wit R, O'Donnell PH
Ann Oncol 2023 Mar;34(3):289-299. Epub 2022 Dec 6 doi: 10.1016/j.annonc.2022.11.012. PMID: 36494006
New agents for bacillus Calmette-Guérin-refractory nonmuscle invasive bladder cancer.
Ahn JJ, Ghandour RA, McKiernan JM
Curr Opin Urol 2014 Sep;24(5):540-5. doi: 10.1097/MOU.0000000000000088. PMID: 24921906
Radical cystectomy and the implications of comorbidity.
Mayr R, Fritsche HM, Pycha A, Pycha A
Expert Rev Anticancer Ther 2014 Mar;14(3):289-95. Epub 2014 Jan 8 doi: 10.1586/14737140.2014.868775. PMID: 24397794
Novel strategies for treating relapsed/refractory urothelial carcinoma.
Iyer G, Milowsky MI, Bajorin DF
Expert Rev Anticancer Ther 2010 Dec;10(12):1917-32. doi: 10.1586/era.10.182. PMID: 21110758Free PMC Article
The management of superficial bladder cancer.
Dalbagni G
Nat Clin Pract Urol 2007 May;4(5):254-60. doi: 10.1038/ncpuro0784. PMID: 17483810

Clinical prediction guides

Enhancing immune checkpoint blockade therapy of genitourinary malignancies by co-targeting PMN-MDSCs.
Lu X, Lu X
Biochim Biophys Acta Rev Cancer 2022 May;1877(3):188702. Epub 2022 Feb 25 doi: 10.1016/j.bbcan.2022.188702. PMID: 35227829Free PMC Article
Efficacy of enfortumab vedotin in advanced urothelial cancer: Analysis from the Urothelial Cancer Network to Investigate Therapeutic Experiences (UNITE) study.
Koshkin VS, Henderson N, James M, Natesan D, Freeman D, Nizam A, Su CT, Khaki AR, Osterman CK, Glover MJ, Chiang R, Makrakis D, Talukder R, Lemke E, Olsen TA, Jain J, Jang A, Ali A, Jindal T, Chou J, Friedlander TW, Hoimes C, Basu A, Zakharia Y, Barata PC, Bilen MA, Emamekhoo H, Davis NB, Shah SA, Milowsky MI, Gupta S, Campbell MT, Grivas P, Sonpavde GP, Kilari D, Alva AS
Cancer 2022 Mar 15;128(6):1194-1205. Epub 2021 Dec 9 doi: 10.1002/cncr.34057. PMID: 34882781
A rare case of large cell neuroendocrine carcinoma.
Lin D, Tan AJ, De Sousa AF, Singh-Rai R
BMJ Case Rep 2014 Oct 19;2014 doi: 10.1136/bcr-2014-206403. PMID: 25331150Free PMC Article
Cyclophosphamide therapy in pediatric multiple sclerosis.
Makhani N, Gorman MP, Branson HM, Stazzone L, Banwell BL, Chitnis T
Neurology 2009 Jun 16;72(24):2076-82. Epub 2009 May 13 doi: 10.1212/WNL.0b013e3181a8164c. PMID: 19439723Free PMC Article
Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.
Del Sal G, Collavin L, Ruaro ME, Edomi P, Saccone S, Valle GD, Schneider C
Proc Natl Acad Sci U S A 1994 Mar 1;91(5):1848-52. doi: 10.1073/pnas.91.5.1848. PMID: 8127893Free PMC Article

Recent systematic reviews

Programmed Death 1 and Programmed Death Ligand 1 Inhibitors in Advanced and Recurrent Urothelial Carcinoma: Meta-analysis of Single-Agent Studies.
Tafuri A, Smith DD, Cacciamani GE, Cole S, Shakir A, Sadeghi S, Vogelzang NJ, Quinn D, Gill PS, Gill IS
Clin Genitourin Cancer 2020 Oct;18(5):351-360.e3. Epub 2020 Jan 31 doi: 10.1016/j.clgc.2020.01.004. PMID: 32146152Free PMC Article
Extended versus standard lymph node dissection for urothelial carcinoma of the bladder in patients undergoing radical cystectomy.
Hwang EC, Sathianathen NJ, Imamura M, Kuntz GM, Risk MC, Dahm P
Cochrane Database Syst Rev 2019 May 14;5(5):CD013336. doi: 10.1002/14651858.CD013336. PMID: 31111956Free PMC Article
Treatment Strategy for Newly Diagnosed T1 High-grade Bladder Urothelial Carcinoma: New Insights and Updated Recommendations.
Klaassen Z, Kamat AM, Kassouf W, Gontero P, Villavicencio H, Bellmunt J, van Rhijn BWG, Hartmann A, Catto JWF, Kulkarni GS
Eur Urol 2018 Nov;74(5):597-608. Epub 2018 Jul 13 doi: 10.1016/j.eururo.2018.06.024. PMID: 30017405
Intravesical gemcitabine therapy for non-muscle invasive bladder cancer (NMIBC): a systematic review.
Shelley MD, Jones G, Cleves A, Wilt TJ, Mason MD, Kynaston HG
BJU Int 2012 Feb;109(4):496-505. doi: 10.1111/j.1464-410X.2011.10880.x. PMID: 22313502

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