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Refractory Lung Small Cell Carcinoma

MedGen UID:
1662162
Concept ID:
C4743561
Neoplastic Process
Synonym: Refractory Small Cell Lung Carcinoma

Definition

Small cell lung carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Lung Small Cell Carcinoma

Professional guidelines

PubMed

Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, Cauquil C, Chanson P, Collins M, Durrbach A, Ederhy S, Feuillet S, François H, Lazarovici J, Le Pavec J, De Martin E, Mateus C, Michot JM, Samuel D, Soria JC, Robert C, Eggermont A, Marabelle A
Ann Oncol 2016 Apr;27(4):559-74. Epub 2015 Dec 28 doi: 10.1093/annonc/mdv623. PMID: 26715621

Recent clinical studies

Etiology

Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazières J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Pérol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Jänne PA; DESTINY-Lung01 Trial Investigators
N Engl J Med 2022 Jan 20;386(3):241-251. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112431. PMID: 34534430Free PMC Article
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Camidge DR, Kim HR, Ahn MJ, Yang JC, Han JY, Lee JS, Hochmair MJ, Li JY, Chang GC, Lee KH, Gridelli C, Delmonte A, Garcia Campelo R, Kim DW, Bearz A, Griesinger F, Morabito A, Felip E, Califano R, Ghosh S, Spira A, Gettinger SN, Tiseo M, Gupta N, Haney J, Kerstein D, Popat S
N Engl J Med 2018 Nov 22;379(21):2027-2039. Epub 2018 Sep 25 doi: 10.1056/NEJMoa1810171. PMID: 30280657
Suresh K, Naidoo J, Lin CT, Danoff S
Chest 2018 Dec;154(6):1416-1423. Epub 2018 Sep 4 doi: 10.1016/j.chest.2018.08.1048. PMID: 30189190Free PMC Article

Diagnosis

Wang XS, Bai YF, Verma V, Yu RL, Tian W, Ao R, Deng Y, Zhu XQ, Liu H, Pan HX, Yang L, Bai HS, Luo X, Guo Y, Zhou MX, Sun YM, Zhang ZC, Li SM, Cheng X, Tan BX, Han LF, Liu YY, Zhang K, Zeng FX, Jia L, Hao XB, Wang YY, Feng G, Xie K, Lu Y, Zeng M
J Natl Cancer Inst 2023 Jun 8;115(6):742-748. doi: 10.1093/jnci/djac015. PMID: 35094066Free PMC Article
Wang S, Zimmermann S, Parikh K, Mansfield AS, Adjei AA
Mayo Clin Proc 2019 Aug;94(8):1599-1622. doi: 10.1016/j.mayocp.2019.01.034. PMID: 31378235
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Adjei AA
J Thorac Oncol 2008 Jun;3(6 Suppl 2):S160-3. doi: 10.1097/JTO.0b013e318174dbf9. PMID: 18520303
Dancey JE
Cancer Cell 2004 May;5(5):411-5. doi: 10.1016/s1535-6108(04)00122-9. PMID: 15144948

Therapy

Mathew D, Marmarelis ME, Foley C, Bauml JM, Ye D, Ghinnagow R, Ngiow SF, Klapholz M, Jun S, Zhang Z, Zorc R, Davis CW, Diehn M, Giles JR, Huang AC, Hwang WT, Zhang NR, Schoenfeld AJ, Carpenter EL, Langer CJ, Wherry EJ, Minn AJ
Science 2024 Jun 21;384(6702):eadf1329. doi: 10.1126/science.adf1329. PMID: 38900877Free PMC Article
Paz-Ares L, Champiat S, Lai WV, Izumi H, Govindan R, Boyer M, Hummel HD, Borghaei H, Johnson ML, Steeghs N, Blackhall F, Dowlati A, Reguart N, Yoshida T, He K, Gadgeel SM, Felip E, Zhang Y, Pati A, Minocha M, Mukherjee S, Goldrick A, Nagorsen D, Hashemi Sadraei N, Owonikoko TK
J Clin Oncol 2023 Jun 1;41(16):2893-2903. Epub 2023 Jan 23 doi: 10.1200/JCO.22.02823. PMID: 36689692Free PMC Article
Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Markham A
Drugs 2021 Nov;81(17):2063-2068. doi: 10.1007/s40265-021-01628-5. PMID: 34709602
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article

Prognosis

Singhal A, Li BT, O'Reilly EM
Nat Med 2024 Apr;30(4):969-983. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02903-0. PMID: 38637634
LaMarche NM, Hegde S, Park MD, Maier BB, Troncoso L, Le Berichel J, Hamon P, Belabed M, Mattiuz R, Hennequin C, Chin T, Reid AM, Reyes-Torres I, Nemeth E, Zhang R, Olson OC, Doroshow DB, Rohs NC, Gomez JE, Veluswamy R, Hall N, Venturini N, Ginhoux F, Liu Z, Buckup M, Figueiredo I, Roudko V, Miyake K, Karasuyama H, Gonzalez-Kozlova E, Gnjatic S, Passegué E, Kim-Schulze S, Brown BD, Hirsch FR, Kim BS, Marron TU, Merad M
Nature 2024 Jan;625(7993):166-174. Epub 2023 Dec 6 doi: 10.1038/s41586-023-06797-9. PMID: 38057662Free PMC Article
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazières J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Pérol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Jänne PA; DESTINY-Lung01 Trial Investigators
N Engl J Med 2022 Jan 20;386(3):241-251. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112431. PMID: 34534430Free PMC Article
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article

Clinical prediction guides

LaMarche NM, Hegde S, Park MD, Maier BB, Troncoso L, Le Berichel J, Hamon P, Belabed M, Mattiuz R, Hennequin C, Chin T, Reid AM, Reyes-Torres I, Nemeth E, Zhang R, Olson OC, Doroshow DB, Rohs NC, Gomez JE, Veluswamy R, Hall N, Venturini N, Ginhoux F, Liu Z, Buckup M, Figueiredo I, Roudko V, Miyake K, Karasuyama H, Gonzalez-Kozlova E, Gnjatic S, Passegué E, Kim-Schulze S, Brown BD, Hirsch FR, Kim BS, Marron TU, Merad M
Nature 2024 Jan;625(7993):166-174. Epub 2023 Dec 6 doi: 10.1038/s41586-023-06797-9. PMID: 38057662Free PMC Article
Passaro A, Wang J, Wang Y, Lee SH, Melosky B, Shih JY, Wang J, Azuma K, Juan-Vidal O, Cobo M, Felip E, Girard N, Cortot AB, Califano R, Cappuzzo F, Owen S, Popat S, Tan JL, Salinas J, Tomasini P, Gentzler RD, William WN Jr, Reckamp KL, Takahashi T, Ganguly S, Kowalski DM, Bearz A, MacKean M, Barala P, Bourla AB, Girvin A, Greger J, Millington D, Withelder M, Xie J, Sun T, Shah S, Diorio B, Knoblauch RE, Bauml JM, Campelo RG, Cho BC; MARIPOSA-2 Investigators
Ann Oncol 2024 Jan;35(1):77-90. Epub 2023 Oct 23 doi: 10.1016/j.annonc.2023.10.117. PMID: 37879444
Parisi C, Mahjoubi L, Gazzah A, Barlesi F
Cancer Treat Rev 2023 Jul;118:102572. Epub 2023 May 19 doi: 10.1016/j.ctrv.2023.102572. PMID: 37230055
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Li BT, Smit EF, Goto Y, Nakagawa K, Udagawa H, Mazières J, Nagasaka M, Bazhenova L, Saltos AN, Felip E, Pacheco JM, Pérol M, Paz-Ares L, Saxena K, Shiga R, Cheng Y, Acharyya S, Vitazka P, Shahidi J, Planchard D, Jänne PA; DESTINY-Lung01 Trial Investigators
N Engl J Med 2022 Jan 20;386(3):241-251. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112431. PMID: 34534430Free PMC Article

Recent systematic reviews

Zhao Y, He Y, Wang W, Cai Q, Ge F, Chen Z, Zheng J, Zhang Y, Deng H, Chen Y, Lao S, Liang H, Liang W, He J
Lancet Oncol 2024 Oct;25(10):1347-1356. Epub 2024 Aug 16 doi: 10.1016/S1470-2045(24)00379-6. PMID: 39159630
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Parisi C, Mahjoubi L, Gazzah A, Barlesi F
Cancer Treat Rev 2023 Jul;118:102572. Epub 2023 May 19 doi: 10.1016/j.ctrv.2023.102572. PMID: 37230055
Yu G, Shen Y, Xu X, Zhong F
PLoS One 2020;15(11):e0242982. Epub 2020 Nov 30 doi: 10.1371/journal.pone.0242982. PMID: 33253313Free PMC Article

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