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Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder

MedGen UID:
1683202
•Concept ID:
C4763646
•
Neoplastic Process

Definition

A monomorphic post-transplant lymphoproliferative disorder that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Monomorphic Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders.
Ohmoto A, Fuji S
Blood Rev 2021 Sep;49:100807. Epub 2021 Feb 6 doi: 10.1016/j.blre.2021.100807. PMID: 33579543

Recent clinical studies

Etiology

Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD.
McKenna M, Epperla N, Ghobadi A, Liu J, Lazaryan A, Ibrahim U, Jacobson CA, Naik SG, Nastoupil L, Chowdhury SM, Voorhees TJ, Jacobs MT, Farooq U, Osman K, Olszewski AJ, Ahmed S, Evens AM
Br J Haematol 2023 Jul;202(2):248-255. Epub 2023 May 2 doi: 10.1111/bjh.18828. PMID: 37129856
Presentation and outcomes of post-transplant lymphoproliferative disorder at a single institution pediatric transplant center.
Ramos-Gonzalez G, Crum R, Allain A, Agur T, O'Melia L, Staffa S, Burchett SK, Siegele B, Weinberg O, Rodig NM, Fawaz R, Singh TP, Freiberger DA, Bae Kim H
Pediatr Transplant 2022 Aug;26(5):e14268. Epub 2022 Mar 19 doi: 10.1111/petr.14268. PMID: 35304794
CD30 expression and survival in posttransplant lymphoproliferative disorders.
Kinch A, Amini RM, Hollander P, Molin D, Sundström C, Enblad G
Acta Oncol 2020 Jun;59(6):673-680. Epub 2020 Feb 27 doi: 10.1080/0284186X.2020.1731924. PMID: 32102582
Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397

Diagnosis

Monomorphic T-cell post-transplant lymphoproliferative disorder with features of HHV8-negative primary effusion lymphoma: an autopsy case and review of the literature.
Hosaka N, Hashimura M, Mugitani A, Hamaguchi M, Kubo Y, Nakatsuka SI
Med Mol Morphol 2024 Sep;57(3):226-232. Epub 2024 May 23 doi: 10.1007/s00795-024-00388-x. PMID: 38780761Free PMC Article
Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD.
McKenna M, Epperla N, Ghobadi A, Liu J, Lazaryan A, Ibrahim U, Jacobson CA, Naik SG, Nastoupil L, Chowdhury SM, Voorhees TJ, Jacobs MT, Farooq U, Osman K, Olszewski AJ, Ahmed S, Evens AM
Br J Haematol 2023 Jul;202(2):248-255. Epub 2023 May 2 doi: 10.1111/bjh.18828. PMID: 37129856
Presentation and outcomes of post-transplant lymphoproliferative disorder at a single institution pediatric transplant center.
Ramos-Gonzalez G, Crum R, Allain A, Agur T, O'Melia L, Staffa S, Burchett SK, Siegele B, Weinberg O, Rodig NM, Fawaz R, Singh TP, Freiberger DA, Bae Kim H
Pediatr Transplant 2022 Aug;26(5):e14268. Epub 2022 Mar 19 doi: 10.1111/petr.14268. PMID: 35304794
EBV-specific cytotoxic T lymphocytes for refractory EBV-associated post-transplant lymphoproliferative disorder in solid organ transplant recipients: a systematic review.
Liu JY, Zhang JM, Zhan HS, Sun LY, Wei L
Transpl Int 2021 Dec;34(12):2483-2493. Epub 2021 Oct 28 doi: 10.1111/tri.14107. PMID: 34510581

Therapy

Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD.
McKenna M, Epperla N, Ghobadi A, Liu J, Lazaryan A, Ibrahim U, Jacobson CA, Naik SG, Nastoupil L, Chowdhury SM, Voorhees TJ, Jacobs MT, Farooq U, Osman K, Olszewski AJ, Ahmed S, Evens AM
Br J Haematol 2023 Jul;202(2):248-255. Epub 2023 May 2 doi: 10.1111/bjh.18828. PMID: 37129856
Presentation and outcomes of post-transplant lymphoproliferative disorder at a single institution pediatric transplant center.
Ramos-Gonzalez G, Crum R, Allain A, Agur T, O'Melia L, Staffa S, Burchett SK, Siegele B, Weinberg O, Rodig NM, Fawaz R, Singh TP, Freiberger DA, Bae Kim H
Pediatr Transplant 2022 Aug;26(5):e14268. Epub 2022 Mar 19 doi: 10.1111/petr.14268. PMID: 35304794
Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders.
Ohmoto A, Fuji S
Blood Rev 2021 Sep;49:100807. Epub 2021 Feb 6 doi: 10.1016/j.blre.2021.100807. PMID: 33579543
CD30 expression and survival in posttransplant lymphoproliferative disorders.
Kinch A, Amini RM, Hollander P, Molin D, Sundström C, Enblad G
Acta Oncol 2020 Jun;59(6):673-680. Epub 2020 Feb 27 doi: 10.1080/0284186X.2020.1731924. PMID: 32102582

Prognosis

Late-Onset Hemophagocytic Lymphohistiocytosis in a Lung Transplant Patient: A Case of T-Cell Post-Transplant Lymphoproliferative Disorder.
Leclercq C, Sansen PY, Collinge E, Thirionet R, Evrard P, Planté-Bordeneuve T, Fervaille C, Pouplard M, Dumonceaux M, Sonet A, Carlier FM
Am J Case Rep 2024 Oct 16;25:e944761. doi: 10.12659/AJCR.944761. PMID: 39410671Free PMC Article
Monomorphic T-cell post-transplant lymphoproliferative disorder with features of HHV8-negative primary effusion lymphoma: an autopsy case and review of the literature.
Hosaka N, Hashimura M, Mugitani A, Hamaguchi M, Kubo Y, Nakatsuka SI
Med Mol Morphol 2024 Sep;57(3):226-232. Epub 2024 May 23 doi: 10.1007/s00795-024-00388-x. PMID: 38780761Free PMC Article
Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.
Weinberg OK, Pinkus GC, Ramos-Gonzalez GJ, Agur T, Rodig NM
Clin Transplant 2023 Dec;37(12):e15134. Epub 2023 Sep 29 doi: 10.1111/ctr.15134. PMID: 37772613
Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397

Clinical prediction guides

Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD.
McKenna M, Epperla N, Ghobadi A, Liu J, Lazaryan A, Ibrahim U, Jacobson CA, Naik SG, Nastoupil L, Chowdhury SM, Voorhees TJ, Jacobs MT, Farooq U, Osman K, Olszewski AJ, Ahmed S, Evens AM
Br J Haematol 2023 Jul;202(2):248-255. Epub 2023 May 2 doi: 10.1111/bjh.18828. PMID: 37129856
Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders.
Ohmoto A, Fuji S
Blood Rev 2021 Sep;49:100807. Epub 2021 Feb 6 doi: 10.1016/j.blre.2021.100807. PMID: 33579543
Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience.
Marino D, Burra P, Boccagni P, Calabrese F, Canova F, Trentin C, Boso C, Soldà C, Angeli P, Aversa SM
Anticancer Res 2010 Jun;30(6):2383-91. PMID: 20651397

Recent systematic reviews

EBV-specific cytotoxic T lymphocytes for refractory EBV-associated post-transplant lymphoproliferative disorder in solid organ transplant recipients: a systematic review.
Liu JY, Zhang JM, Zhan HS, Sun LY, Wei L
Transpl Int 2021 Dec;34(12):2483-2493. Epub 2021 Oct 28 doi: 10.1111/tri.14107. PMID: 34510581

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