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Refractory Malignant Brain Neoplasm

MedGen UID:: 1667258
•Concept ID:: C4727431
•: Neoplastic Process

Definition

A malignant brain neoplasm that is resistant to treatment. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRefractory Malignant Brain Neoplasm

Disorder of nervous system
- Disorder of the central nervous system
  - Neoplasm of the central nervous system
    - Intracranial Neoplasm
      - Malignant Intracranial Neoplasm
        Malignant neoplasm of brain
        Refractory Malignant Brain Neoplasm
        Refractory Diffuse Intrinsic Pontine Glioma
        Refractory Medulloblastoma
        Refractory Medulloblastoma, SHH-Activated
        Refractory Medulloblastoma, WNT-Activated

Professional guidelines

PubMed

Palliative treatment of germ cell cancer.

Oing C, Giannatempo P, Honecker F, Oechsle K, Bokemeyer C, Beyer J
Cancer Treat Rev 2018 Dec;71:102-107. Epub 2018 Oct 22 doi: 10.1016/j.ctrv.2018.10.007. PMID: 30415106

Clinical Assessment and Management of Delirium in the Palliative Care Setting.

Bush SH, Tierney S, Lawlor PG
Drugs 2017 Oct;77(15):1623-1643. doi: 10.1007/s40265-017-0804-3. PMID: 28864877 Free PMC Article

Management of Intracranial Pressure.

Freeman WD
Continuum (Minneap Minn) 2015 Oct;21(5 Neurocritical Care):1299-323. doi: 10.1212/CON.0000000000000235. PMID: 26426232

See all (160)

Recent clinical studies

Etiology

Central Nervous System Prophylaxis and Treatment in Acute Leukemias.

Wu SY, Short NJ, Nasr L, Dabaja BS, Fang PQ
Curr Treat Options Oncol 2022 Dec;23(12):1829-1844. Epub 2022 Dec 13 doi: 10.1007/s11864-022-01032-5. PMID: 36510037 Free PMC Article

Childhood Medulloblastoma: An Overview.

Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683

Therapeutic Opportunities in Neuroblastoma Using Nanotechnology.

Rodríguez-Nogales C, Noguera R, Couvreur P, Blanco-Prieto MJ
J Pharmacol Exp Ther 2019 Sep;370(3):625-635. Epub 2019 Jan 11 doi: 10.1124/jpet.118.255067. PMID: 30635473

Brain Tumors.

McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158

Tumors in Epilepsy.

Nowell M, Miserocchi A, McEvoy AW
Semin Neurol 2015 Jun;35(3):209-17. Epub 2015 Jun 10 doi: 10.1055/s-0035-1552628. PMID: 26060900

See all (600)

Diagnosis

An update on, and genetics of refractory adenomas of childhood.

Stratakis CA
Pituitary 2023 Jun;26(3):281-287. Epub 2023 Jun 15 doi: 10.1007/s11102-023-01327-2. PMID: 37318708

Somatostatin Analogs in Clinical Practice: a Review.

Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432 Free PMC Article

Brain Tumors.

McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158

Tumors in Epilepsy.

Nowell M, Miserocchi A, McEvoy AW
Semin Neurol 2015 Jun;35(3):209-17. Epub 2015 Jun 10 doi: 10.1055/s-0035-1552628. PMID: 26060900

Cerebellar seizures.

Boop S, Wheless J, Van Poppel K, McGregor A, Boop FA
J Neurosurg Pediatr 2013 Sep;12(3):288-92. Epub 2013 Jun 28 doi: 10.3171/2013.5.PEDS1394. PMID: 23808728

See all (632)

Therapy

Tovorafenib: First Approval.

Dhillon S
Drugs 2024 Aug;84(8):985-993. Epub 2024 Jul 5 doi: 10.1007/s40265-024-02069-6. PMID: 38967715

Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators.

Segura-Collar B, Hiller-Vallina S, de Dios O, Caamaño-Moreno M, Mondejar-Ruescas L, Sepulveda-Sanchez JM, Gargini R
Acta Neuropathol Commun 2023 May 10;11(1):79. doi: 10.1186/s40478-023-01569-y. PMID: 37165457 Free PMC Article

Therapeutic Opportunities in Neuroblastoma Using Nanotechnology.

Rodríguez-Nogales C, Noguera R, Couvreur P, Blanco-Prieto MJ
J Pharmacol Exp Ther 2019 Sep;370(3):625-635. Epub 2019 Jan 11 doi: 10.1124/jpet.118.255067. PMID: 30635473

Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.

Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896

Cerebellar seizures.

Boop S, Wheless J, Van Poppel K, McGregor A, Boop FA
J Neurosurg Pediatr 2013 Sep;12(3):288-92. Epub 2013 Jun 28 doi: 10.3171/2013.5.PEDS1394. PMID: 23808728

See all (948)

Prognosis

Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators.

Childhood Medulloblastoma: An Overview.

Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683

Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.

Tumors in Epilepsy.

Nowell M, Miserocchi A, McEvoy AW
Semin Neurol 2015 Jun;35(3):209-17. Epub 2015 Jun 10 doi: 10.1055/s-0035-1552628. PMID: 26060900

Dietary therapies for epilepsy.

Kossoff EH, Wang HS
Biomed J 2013 Jan-Feb;36(1):2-8. doi: 10.4103/2319-4170.107152. PMID: 23515147

See all (618)

Clinical prediction guides

Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1.

Cornel AM, van der Sman L, van Dinter JT, Arrabito M, Dunnebach E, van Hoesel M, Kluiver TA, Lopes AP, Dautzenberg NMM, Dekker L, van Rijn JM, van den Beemt DAMH, Buhl JL, du Chatinier A, Barneh F, Lu Y, Lo Nigro L, Krippner-Heidenreich A, Sebestyén Z, Kuball J, Hulleman E, Drost J, van Heesch S, Heidenreich OT, Peng WC, Nierkens S
J Immunother Cancer 2024 Mar 21;12(3) doi: 10.1136/jitc-2023-007538. PMID: 38519054 Free PMC Article

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.

LaMarche NM, Hegde S, Park MD, Maier BB, Troncoso L, Le Berichel J, Hamon P, Belabed M, Mattiuz R, Hennequin C, Chin T, Reid AM, Reyes-Torres I, Nemeth E, Zhang R, Olson OC, Doroshow DB, Rohs NC, Gomez JE, Veluswamy R, Hall N, Venturini N, Ginhoux F, Liu Z, Buckup M, Figueiredo I, Roudko V, Miyake K, Karasuyama H, Gonzalez-Kozlova E, Gnjatic S, Passegué E, Kim-Schulze S, Brown BD, Hirsch FR, Kim BS, Marron TU, Merad M
Nature 2024 Jan;625(7993):166-174. Epub 2023 Dec 6 doi: 10.1038/s41586-023-06797-9. PMID: 38057662 Free PMC Article

B7-H3 in Brain Malignancies: Immunology and Immunotherapy.

Guo X, Chang M, Wang Y, Xing B, Ma W
Int J Biol Sci 2023;19(12):3762-3780. Epub 2023 Jul 24 doi: 10.7150/ijbs.85813. PMID: 37564196 Free PMC Article

Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators.

Evaluation of immunotherapy efficacy in gynecologic cancer.

Jiang G, Wu Q, Li B
Front Immunol 2023;14:1061761. Epub 2023 Jan 31 doi: 10.3389/fimmu.2023.1061761. PMID: 36793735 Free PMC Article

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Recent systematic reviews

A Systematic Review Informing the Management of Symptomatic Brain Radiation Necrosis After Stereotactic Radiosurgery and International Stereotactic Radiosurgery Society Recommendations.

Vellayappan B, Lim-Fat MJ, Kotecha R, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan JP, Suh JH, Yomo S, Sahgal A
Int J Radiat Oncol Biol Phys 2024 Jan 1;118(1):14-28. Epub 2023 Jul 22 doi: 10.1016/j.ijrobp.2023.07.015. PMID: 37482137

Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways.

Serioli S, Agostini L, Pietrantoni A, Valeri F, Costanza F, Chiloiro S, Buffoli B, Piazza A, Poliani PL, Peris-Celda M, Iavarone F, Gaudino S, Gessi M, Schinzari G, Mattogno PP, Giampietro A, De Marinis L, Pontecorvi A, Fontanella MM, Lauretti L, Rindi G, Olivi A, Bianchi A, Doglietto F
Int J Mol Sci 2023 Oct 29;24(21) doi: 10.3390/ijms242115719. PMID: 37958702 Free PMC Article

The role of bevacizumab for treatment-refractory intracranial meningiomas: a single institution's experience and a systematic review of the literature.

Alexander AY, Onyedimma C, Bhandarkar AR, Yolcu YU, Michalopoulos GD, Bydon M, Link MJ
Acta Neurochir (Wien) 2022 Nov;164(11):3011-3023. Epub 2022 Sep 19 doi: 10.1007/s00701-022-05348-x. PMID: 36117185

Somatostatin analogues in treatment-refractory meningioma: a systematic review with meta-analysis of individual patient data.

Jensen LR, Maier AD, Lomstein A, Graillon T, Hrachova M, Bota D, Ruiz-Patiño A, Arrieta O, Cardona AF, Rudà R, Furtner J, Roeckle U, Clement P, Preusser M, Scheie D, Broholm H, Kristensen BW, Skjøth-Rasmussen J, Ziebell M, Munch TN, Fugleholm K, Walter MA, Mathiesen T, Mirian C
Neurosurg Rev 2022 Oct;45(5):3067-3081. Epub 2022 Aug 19 doi: 10.1007/s10143-022-01849-6. PMID: 35984552

Gene expression in prolactinomas: a systematic review.

Seltzer J, Scotton TC, Kang K, Zada G, Carmichael JD
Pituitary 2016 Feb;19(1):93-104. doi: 10.1007/s11102-015-0674-1. PMID: 26238304

See all (18)

MedGen

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Refractory Malignant Brain Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity