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Refractory Ovarian Adenocarcinoma

MedGen UID:
1759161
Concept ID:
C5421309
Neoplastic Process

Definition

Ovarian adenocarcinoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Young RC, Von Hoff DD, Gormley P, Makuch R, Cassidy J, Howser D, Bull JM
Cancer Treat Rep 1979 Sep-Oct;63(9-10):1539-44. PMID: 387224

Recent clinical studies

Etiology

Shimada M, Tsuji K, Shigeta S, Nagai T, Watanabe Z, Tokunaga H, Kigawa J, Yaegashi N
J Obstet Gynaecol Res 2022 Mar;48(3):576-586. Epub 2021 Dec 14 doi: 10.1111/jog.15112. PMID: 34908207
Patch AM, Christie EL, Etemadmoghadam D, Garsed DW, George J, Fereday S, Nones K, Cowin P, Alsop K, Bailey PJ, Kassahn KS, Newell F, Quinn MC, Kazakoff S, Quek K, Wilhelm-Benartzi C, Curry E, Leong HS; Australian Ovarian Cancer Study Group, Hamilton A, Mileshkin L, Au-Yeung G, Kennedy C, Hung J, Chiew YE, Harnett P, Friedlander M, Quinn M, Pyman J, Cordner S, O'Brien P, Leditschke J, Young G, Strachan K, Waring P, Azar W, Mitchell C, Traficante N, Hendley J, Thorne H, Shackleton M, Miller DK, Arnau GM, Tothill RW, Holloway TP, Semple T, Harliwong I, Nourse C, Nourbakhsh E, Manning S, Idrisoglu S, Bruxner TJ, Christ AN, Poudel B, Holmes O, Anderson M, Leonard C, Lonie A, Hall N, Wood S, Taylor DF, Xu Q, Fink JL, Waddell N, Drapkin R, Stronach E, Gabra H, Brown R, Jewell A, Nagaraj SH, Markham E, Wilson PJ, Ellul J, McNally O, Doyle MA, Vedururu R, Stewart C, Lengyel E, Pearson JV, Waddell N, deFazio A, Grimmond SM, Bowtell DD
Nature 2015 May 28;521(7553):489-94. doi: 10.1038/nature14410. PMID: 26017449
Chumworathayi B
Asian Pac J Cancer Prev 2013;14(3):1661-4. doi: 10.7314/apjcp.2013.14.3.1661. PMID: 23679252
Kim ST, Choi YJ, Park KH, Oh SC, Seo JH, Shin SW, Kim JS, Kim YH
Asia Pac J Clin Oncol 2011 Mar;7(1):82-7. Epub 2010 Dec 22 doi: 10.1111/j.1743-7563.2010.01363.x. PMID: 21332655
Utsunomiya H, Akahira J, Tanno S, Moriya T, Toyoshima M, Niikura H, Ito K, Morimura Y, Watanabe Y, Yaegashi N
Int J Gynecol Cancer 2006 Jan-Feb;16(1):52-6. doi: 10.1111/j.1525-1438.2006.00289.x. PMID: 16445610

Diagnosis

Sun Y, Patterson-Fortin J, Han S, Li Z, Nowicka Z, Hirohashi Y, Kilgas S, Yi JK, Spektor A, Fendler W, Konstantinopoulos PA, Chowdhury D
Nat Commun 2024 Aug 6;15(1):6676. doi: 10.1038/s41467-024-50999-2. PMID: 39107288Free PMC Article
Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schürer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG
Cell 2023 Aug 3;186(16):3476-3498.e35. doi: 10.1016/j.cell.2023.07.004. PMID: 37541199Free PMC Article
Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG
Cell Rep Med 2021 Dec 21;2(12):100471. doi: 10.1016/j.xcrm.2021.100471. PMID: 35028612Free PMC Article
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article
Patch AM, Christie EL, Etemadmoghadam D, Garsed DW, George J, Fereday S, Nones K, Cowin P, Alsop K, Bailey PJ, Kassahn KS, Newell F, Quinn MC, Kazakoff S, Quek K, Wilhelm-Benartzi C, Curry E, Leong HS; Australian Ovarian Cancer Study Group, Hamilton A, Mileshkin L, Au-Yeung G, Kennedy C, Hung J, Chiew YE, Harnett P, Friedlander M, Quinn M, Pyman J, Cordner S, O'Brien P, Leditschke J, Young G, Strachan K, Waring P, Azar W, Mitchell C, Traficante N, Hendley J, Thorne H, Shackleton M, Miller DK, Arnau GM, Tothill RW, Holloway TP, Semple T, Harliwong I, Nourse C, Nourbakhsh E, Manning S, Idrisoglu S, Bruxner TJ, Christ AN, Poudel B, Holmes O, Anderson M, Leonard C, Lonie A, Hall N, Wood S, Taylor DF, Xu Q, Fink JL, Waddell N, Drapkin R, Stronach E, Gabra H, Brown R, Jewell A, Nagaraj SH, Markham E, Wilson PJ, Ellul J, McNally O, Doyle MA, Vedururu R, Stewart C, Lengyel E, Pearson JV, Waddell N, deFazio A, Grimmond SM, Bowtell DD
Nature 2015 May 28;521(7553):489-94. doi: 10.1038/nature14410. PMID: 26017449

Therapy

Emmanuelli A, Salvagno C, Hwang SM, Awasthi D, Sandoval TA, Chae CS, Cheong JG, Tan C, Iwawaki T, Cubillos-Ruiz JR
Oncoimmunology 2024;13(1):2411070. Epub 2024 Oct 2 doi: 10.1080/2162402X.2024.2411070. PMID: 39364290Free PMC Article
Ma B, Zhao L, Zhang Y, Zhang F, Gao Q
Immunotherapy 2022 Oct;14(15):1205-1209. Epub 2022 Aug 31 doi: 10.2217/imt-2021-0328. PMID: 36043370
Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG
Cell Rep Med 2021 Dec 21;2(12):100471. doi: 10.1016/j.xcrm.2021.100471. PMID: 35028612Free PMC Article
Bourbon E, Ghesquières H, Bachy E
Bull Cancer 2021 Oct;108(10S):S4-S17. doi: 10.1016/j.bulcan.2021.02.017. PMID: 34920806
Morello A, Sadelain M, Adusumilli PS
Cancer Discov 2016 Feb;6(2):133-46. Epub 2015 Oct 26 doi: 10.1158/2159-8290.CD-15-0583. PMID: 26503962Free PMC Article

Prognosis

Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schürer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG
Cell 2023 Aug 3;186(16):3476-3498.e35. doi: 10.1016/j.cell.2023.07.004. PMID: 37541199Free PMC Article
Giucca A, Morrison H, Wilson T, Cossburn M
BMJ Case Rep 2023 May 3;16(5) doi: 10.1136/bcr-2022-251277. PMID: 37137547Free PMC Article
Ma B, Zhao L, Zhang Y, Zhang F, Gao Q
Immunotherapy 2022 Oct;14(15):1205-1209. Epub 2022 Aug 31 doi: 10.2217/imt-2021-0328. PMID: 36043370
Hsu YH, Wang PH, Chang AC
Int J Environ Res Public Health 2020 Jun 2;17(11) doi: 10.3390/ijerph17113951. PMID: 32498447Free PMC Article
Chumworathayi B
Asian Pac J Cancer Prev 2013;14(3):1661-4. doi: 10.7314/apjcp.2013.14.3.1661. PMID: 23679252

Clinical prediction guides

Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schürer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG
Cell 2023 Aug 3;186(16):3476-3498.e35. doi: 10.1016/j.cell.2023.07.004. PMID: 37541199Free PMC Article
Lin C, Ying Z, Sijing C
Medicine (Baltimore) 2019 Mar;98(10):e14530. doi: 10.1097/MD.0000000000014530. PMID: 30855437Free PMC Article
Patch AM, Christie EL, Etemadmoghadam D, Garsed DW, George J, Fereday S, Nones K, Cowin P, Alsop K, Bailey PJ, Kassahn KS, Newell F, Quinn MC, Kazakoff S, Quek K, Wilhelm-Benartzi C, Curry E, Leong HS; Australian Ovarian Cancer Study Group, Hamilton A, Mileshkin L, Au-Yeung G, Kennedy C, Hung J, Chiew YE, Harnett P, Friedlander M, Quinn M, Pyman J, Cordner S, O'Brien P, Leditschke J, Young G, Strachan K, Waring P, Azar W, Mitchell C, Traficante N, Hendley J, Thorne H, Shackleton M, Miller DK, Arnau GM, Tothill RW, Holloway TP, Semple T, Harliwong I, Nourse C, Nourbakhsh E, Manning S, Idrisoglu S, Bruxner TJ, Christ AN, Poudel B, Holmes O, Anderson M, Leonard C, Lonie A, Hall N, Wood S, Taylor DF, Xu Q, Fink JL, Waddell N, Drapkin R, Stronach E, Gabra H, Brown R, Jewell A, Nagaraj SH, Markham E, Wilson PJ, Ellul J, McNally O, Doyle MA, Vedururu R, Stewart C, Lengyel E, Pearson JV, Waddell N, deFazio A, Grimmond SM, Bowtell DD
Nature 2015 May 28;521(7553):489-94. doi: 10.1038/nature14410. PMID: 26017449
Woopen H, Pietzner K, Darb-Esfahani S, Oskay-Oezcelik G, Sehouli J
Med Oncol 2012 Dec;29(5):3416-20. Epub 2012 Jun 29 doi: 10.1007/s12032-012-0285-x. PMID: 22744709
Kim ST, Choi YJ, Park KH, Oh SC, Seo JH, Shin SW, Kim JS, Kim YH
Asia Pac J Clin Oncol 2011 Mar;7(1):82-7. Epub 2010 Dec 22 doi: 10.1111/j.1743-7563.2010.01363.x. PMID: 21332655

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