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Refractory Small Intestinal Carcinoma

MedGen UID:
1660807
•Concept ID:
C4727193
•
Neoplastic Process

Definition

Small intestinal carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Small Intestinal Carcinoma

Professional guidelines

PubMed

Management of Diarrhea in Patients With Carcinoid Syndrome.
Naraev BG, Halland M, Halperin DM, Purvis AJ, OʼDorisio TM, Halfdanarson TR
Pancreas 2019 Sep;48(8):961-972. doi: 10.1097/MPA.0000000000001384. PMID: 31425482Free PMC Article
Enteroscopy and radiology for the management of celiac disease complications: Time for a pragmatic roadmap.
Branchi F, Locatelli M, Tomba C, Conte D, Ferretti F, Elli L
Dig Liver Dis 2016 Jun;48(6):578-86. Epub 2016 Mar 2 doi: 10.1016/j.dld.2016.02.015. PMID: 27012449

Recent clinical studies

Etiology

PERIPHERAL BLOOD ENDOTOXIN LEVELS ARE NOT ASSOCIATED WITH SMALL INTESTINAL BACTERIAL OVERGROWTH IN NONALCOHOLIC FATTY LIVER DISEASE WITHOUT CIRRHOSIS.
GuimarÃes VM, Santos VN, Borges PSA, DE Farias JLR, Grillo P, Parise ER
Arq Gastroenterol 2020 Oct-Dec;57(4):471-476. doi: 10.1590/S0004-2803.202000000-82. PMID: 33331479
Enteroscopy and radiology for the management of celiac disease complications: Time for a pragmatic roadmap.
Branchi F, Locatelli M, Tomba C, Conte D, Ferretti F, Elli L
Dig Liver Dis 2016 Jun;48(6):578-86. Epub 2016 Mar 2 doi: 10.1016/j.dld.2016.02.015. PMID: 27012449
Clinical Syndromes Related to Gastrointestinal Neuroendocrine Neoplasms.
Boutzios G, Kaltsas G
Front Horm Res 2015;44:40-57. Epub 2015 Aug 14 doi: 10.1159/000382053. PMID: 26303703
Small bowel adenocarcinoma in Crohn's disease.
Widmar M, Greenstein AJ, Sachar DB, Harpaz N, Bauer JJ, Greenstein AJ
J Gastrointest Surg 2011 May;15(5):797-802. Epub 2011 Feb 20 doi: 10.1007/s11605-011-1441-x. PMID: 21336499
Association of celiac disease and intestinal lymphomas and other cancers.
Catassi C, Bearzi I, Holmes GK
Gastroenterology 2005 Apr;128(4 Suppl 1):S79-86. doi: 10.1053/j.gastro.2005.02.027. PMID: 15825131

Diagnosis

Lymphoepithelioma-like carcinoma of the duodenum: a very infrequent tumor.
Chaparro Mirete M, López-López V, Robles Campos R
Rev Esp Enferm Dig 2020 Mar;112(3):239. doi: 10.17235/reed.2020.6503/2019. PMID: 32022569
Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial.
Moore KN, Secord AA, Geller MA, Miller DS, Cloven N, Fleming GF, Wahner Hendrickson AE, Azodi M, DiSilvestro P, Oza AM, Cristea M, Berek JS, Chan JK, Rimel BJ, Matei DE, Li Y, Sun K, Luptakova K, Matulonis UA, Monk BJ
Lancet Oncol 2019 May;20(5):636-648. Epub 2019 Apr 1 doi: 10.1016/S1470-2045(19)30029-4. PMID: 30948273
Enteroscopy and radiology for the management of celiac disease complications: Time for a pragmatic roadmap.
Branchi F, Locatelli M, Tomba C, Conte D, Ferretti F, Elli L
Dig Liver Dis 2016 Jun;48(6):578-86. Epub 2016 Mar 2 doi: 10.1016/j.dld.2016.02.015. PMID: 27012449
Clinical Syndromes Related to Gastrointestinal Neuroendocrine Neoplasms.
Boutzios G, Kaltsas G
Front Horm Res 2015;44:40-57. Epub 2015 Aug 14 doi: 10.1159/000382053. PMID: 26303703
Association of celiac disease and intestinal lymphomas and other cancers.
Catassi C, Bearzi I, Holmes GK
Gastroenterology 2005 Apr;128(4 Suppl 1):S79-86. doi: 10.1053/j.gastro.2005.02.027. PMID: 15825131

Therapy

Management of Diarrhea in Patients With Carcinoid Syndrome.
Naraev BG, Halland M, Halperin DM, Purvis AJ, OʼDorisio TM, Halfdanarson TR
Pancreas 2019 Sep;48(8):961-972. doi: 10.1097/MPA.0000000000001384. PMID: 31425482Free PMC Article
Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial.
Moore KN, Secord AA, Geller MA, Miller DS, Cloven N, Fleming GF, Wahner Hendrickson AE, Azodi M, DiSilvestro P, Oza AM, Cristea M, Berek JS, Chan JK, Rimel BJ, Matei DE, Li Y, Sun K, Luptakova K, Matulonis UA, Monk BJ
Lancet Oncol 2019 May;20(5):636-648. Epub 2019 Apr 1 doi: 10.1016/S1470-2045(19)30029-4. PMID: 30948273
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study.
Doi T, Shitara K, Naito Y, Shimomura A, Fujiwara Y, Yonemori K, Shimizu C, Shimoi T, Kuboki Y, Matsubara N, Kitano A, Jikoh T, Lee C, Fujisaki Y, Ogitani Y, Yver A, Tamura K
Lancet Oncol 2017 Nov;18(11):1512-1522. Epub 2017 Oct 13 doi: 10.1016/S1470-2045(17)30604-6. PMID: 29037983
ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients.
Wilson BJ, Schatton T, Zhan Q, Gasser M, Ma J, Saab KR, Schanche R, Waaga-Gasser AM, Gold JS, Huang Q, Murphy GF, Frank MH, Frank NY
Cancer Res 2011 Aug 1;71(15):5307-16. Epub 2011 Jun 7 doi: 10.1158/0008-5472.CAN-11-0221. PMID: 21652540Free PMC Article
Malignant complications of coeliac disease.
Brousse N, Meijer JW
Best Pract Res Clin Gastroenterol 2005 Jun;19(3):401-12. doi: 10.1016/j.bpg.2005.02.002. PMID: 15925845

Prognosis

Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study.
Doi T, Shitara K, Naito Y, Shimomura A, Fujiwara Y, Yonemori K, Shimizu C, Shimoi T, Kuboki Y, Matsubara N, Kitano A, Jikoh T, Lee C, Fujisaki Y, Ogitani Y, Yver A, Tamura K
Lancet Oncol 2017 Nov;18(11):1512-1522. Epub 2017 Oct 13 doi: 10.1016/S1470-2045(17)30604-6. PMID: 29037983
Dynamics of occurrence of refractory coeliac disease and associated complications over 25 years.
Eigner W, Bashir K, Primas C, Kazemi-Shirazi L, Wrba F, Trauner M, Vogelsang H
Aliment Pharmacol Ther 2017 Jan;45(2):364-372. Epub 2016 Nov 25 doi: 10.1111/apt.13867. PMID: 27885681
Enteroscopy and radiology for the management of celiac disease complications: Time for a pragmatic roadmap.
Branchi F, Locatelli M, Tomba C, Conte D, Ferretti F, Elli L
Dig Liver Dis 2016 Jun;48(6):578-86. Epub 2016 Mar 2 doi: 10.1016/j.dld.2016.02.015. PMID: 27012449
Low incidence but poor prognosis of complicated coeliac disease: a retrospective multicentre study.
Biagi F, Gobbi P, Marchese A, Borsotti E, Zingone F, Ciacci C, Volta U, Caio G, Carroccio A, Ambrosiano G, Mansueto P, Corazza GR
Dig Liver Dis 2014 Mar;46(3):227-30. Epub 2013 Nov 20 doi: 10.1016/j.dld.2013.10.010. PMID: 24268568
Small bowel adenocarcinoma in Crohn's disease.
Widmar M, Greenstein AJ, Sachar DB, Harpaz N, Bauer JJ, Greenstein AJ
J Gastrointest Surg 2011 May;15(5):797-802. Epub 2011 Feb 20 doi: 10.1007/s11605-011-1441-x. PMID: 21336499

Clinical prediction guides

Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial.
Moore KN, Secord AA, Geller MA, Miller DS, Cloven N, Fleming GF, Wahner Hendrickson AE, Azodi M, DiSilvestro P, Oza AM, Cristea M, Berek JS, Chan JK, Rimel BJ, Matei DE, Li Y, Sun K, Luptakova K, Matulonis UA, Monk BJ
Lancet Oncol 2019 May;20(5):636-648. Epub 2019 Apr 1 doi: 10.1016/S1470-2045(19)30029-4. PMID: 30948273
Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine.
Ikeda M, Ioka T, Fukutomi A, Morizane C, Kasuga A, Takahashi H, Todaka A, Okusaka T, Creasy CL, Gorman S, Felitsky DJ, Kobayashi M, Zhang F, Furuse J
Cancer Sci 2018 Jan;109(1):215-224. Epub 2017 Dec 9 doi: 10.1111/cas.13438. PMID: 29121415Free PMC Article
Small bowel adenocarcinoma complicating Crohn's disease: a single-centre experience emphasizing the importance of screening for dysplasia.
Grolleau C, Pote NM, Guedj NS, Zappa M, Theou-Anton N, Bouhnik Y, Panis Y, Cazals-Hatem DL
Virchows Arch 2017 Nov;471(5):611-617. Epub 2017 Apr 18 doi: 10.1007/s00428-017-2125-z. PMID: 28421339
A case of acute respiratory distress syndrome responsive to methylene blue during a carcinoid crisis.
van Diepen S, Sobey A, Lewanczuk R, Singh G, Sidhu S, Zibdawi M, Mullen JC
Can J Anaesth 2013 Nov;60(11):1085-8. Epub 2013 Sep 14 doi: 10.1007/s12630-013-0026-4. PMID: 24037749
Intravenous vincristine infusion: phase I trial.
Jackson DV Jr, Sethi VS, Spurr CL, Willard V, White DR, Richards F 2nd, Stuart JJ, Muss HB, Cooper MR, Homesley HD, Jobson VW, Castle MC
Cancer 1981 Dec 15;48(12):2559-64. doi: 10.1002/1097-0142(19811215)48:12<2559::aid-cncr2820481203>3.0.co;2-6. PMID: 7306914

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