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Refractory Ampulla of Vater Carcinoma

MedGen UID:
1786845
•Concept ID:
C5446519
•
Neoplastic Process

Definition

Ampulla of Vater carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ampulla of Vater Carcinoma

Professional guidelines

PubMed

Futibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives.
Rizzo A, Ricci AD, Brandi G
Expert Opin Investig Drugs 2021 Apr;30(4):317-324. Epub 2020 Oct 25 doi: 10.1080/13543784.2021.1837774. PMID: 33054456

Recent clinical studies

Diagnosis

Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine.
Ikeda M, Ioka T, Fukutomi A, Morizane C, Kasuga A, Takahashi H, Todaka A, Okusaka T, Creasy CL, Gorman S, Felitsky DJ, Kobayashi M, Zhang F, Furuse J
Cancer Sci 2018 Jan;109(1):215-224. Epub 2017 Dec 9 doi: 10.1111/cas.13438. PMID: 29121415Free PMC Article
Myelodysplastic syndrome progresses rapidly into erythroleukemia associated with synchronous double cancers of the stomach and the papilla of Vater.
Takahashi T, Kazama Y, Shimizu H, Yoshimoto M, Tsujisaki M, Aoki S, Imai K
Int J Hematol 2001 Jul;74(1):64-9. doi: 10.1007/BF02982551. PMID: 11530807

Therapy

Futibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives.
Rizzo A, Ricci AD, Brandi G
Expert Opin Investig Drugs 2021 Apr;30(4):317-324. Epub 2020 Oct 25 doi: 10.1080/13543784.2021.1837774. PMID: 33054456
Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine.
Ikeda M, Ioka T, Fukutomi A, Morizane C, Kasuga A, Takahashi H, Todaka A, Okusaka T, Creasy CL, Gorman S, Felitsky DJ, Kobayashi M, Zhang F, Furuse J
Cancer Sci 2018 Jan;109(1):215-224. Epub 2017 Dec 9 doi: 10.1111/cas.13438. PMID: 29121415Free PMC Article
Myelodysplastic syndrome progresses rapidly into erythroleukemia associated with synchronous double cancers of the stomach and the papilla of Vater.
Takahashi T, Kazama Y, Shimizu H, Yoshimoto M, Tsujisaki M, Aoki S, Imai K
Int J Hematol 2001 Jul;74(1):64-9. doi: 10.1007/BF02982551. PMID: 11530807

Prognosis

Futibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives.
Rizzo A, Ricci AD, Brandi G
Expert Opin Investig Drugs 2021 Apr;30(4):317-324. Epub 2020 Oct 25 doi: 10.1080/13543784.2021.1837774. PMID: 33054456
Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.
Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, Arai E, Sugiyama Y, Matsuzaki J, Uchida R, Yoshikawa N, Furukawa R, Saito H
Cell Rep 2019 Apr 23;27(4):1265-1276.e4. doi: 10.1016/j.celrep.2019.03.088. PMID: 31018139

Clinical prediction guides

Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine.
Ikeda M, Ioka T, Fukutomi A, Morizane C, Kasuga A, Takahashi H, Todaka A, Okusaka T, Creasy CL, Gorman S, Felitsky DJ, Kobayashi M, Zhang F, Furuse J
Cancer Sci 2018 Jan;109(1):215-224. Epub 2017 Dec 9 doi: 10.1111/cas.13438. PMID: 29121415Free PMC Article
Myelodysplastic syndrome progresses rapidly into erythroleukemia associated with synchronous double cancers of the stomach and the papilla of Vater.
Takahashi T, Kazama Y, Shimizu H, Yoshimoto M, Tsujisaki M, Aoki S, Imai K
Int J Hematol 2001 Jul;74(1):64-9. doi: 10.1007/BF02982551. PMID: 11530807

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