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Refractory Acute Lymphoblastic Leukemia

MedGen UID:
1612918
Concept ID:
C4521228
Neoplastic Process

Definition

Acute lymphoblastic leukemia that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Shimabukuro-Vornhagen A, Böll B, Schellongowski P, Valade S, Metaxa V, Azoulay E, von Bergwelt-Baildon M
CA Cancer J Clin 2022 Jan;72(1):78-93. Epub 2021 Oct 6 doi: 10.3322/caac.21702. PMID: 34613616
Paul S, Rausch CR, Nasnas PE, Kantarjian H, Jabbour EJ
Clin Adv Hematol Oncol 2019 Mar;17(3):166-175. PMID: 30969955
Ronson A, Tvito A, Rowe JM
Curr Oncol Rep 2016 Jun;18(6):39. doi: 10.1007/s11912-016-0519-8. PMID: 27207612

Recent clinical studies

Etiology

Myers RM, Li Y, Barz Leahy A, Barrett DM, Teachey DT, Callahan C, Fasano CC, Rheingold SR, DiNofia A, Wray L, Aplenc R, Baniewicz D, Liu H, Shaw PA, Pequignot E, Getz KD, Brogdon JL, Fesnak AD, Siegel DL, Davis MM, Bartoszek C, Lacey SF, Hexner EO, Chew A, Wertheim GB, Levine BL, June CH, Grupp SA, Maude SL
J Clin Oncol 2021 Sep 20;39(27):3044-3055. Epub 2021 Jun 22 doi: 10.1200/JCO.20.03458. PMID: 34156874Free PMC Article
Shah BD, Bishop MR, Oluwole OO, Logan AC, Baer MR, Donnellan WB, O'Dwyer KM, Holmes H, Arellano ML, Ghobadi A, Pagel JM, Lin Y, Cassaday RD, Park JH, Abedi M, Castro JE, DeAngelo DJ, Malone AK, Mawad R, Schiller GJ, Rossi JM, Bot A, Shen T, Goyal L, Jain RK, Vezan R, Wierda WG
Blood 2021 Jul 8;138(1):11-22. doi: 10.1182/blood.2020009098. PMID: 33827116Free PMC Article
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, Bader P, O'Brien MM, Brethon B, Bhojwani D, Schlegel PG, Borkhardt A, Rheingold SR, Cooper TM, Zwaan CM, Barnette P, Messina C, Michel G, DuBois SG, Hu K, Zhu M, Whitlock JA, Gore L
J Clin Oncol 2016 Dec 20;34(36):4381-4389. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.67.3301. PMID: 27998223
Kantarjian HM, DeAngelo DJ, Stelljes M, Martinelli G, Liedtke M, Stock W, Gökbuget N, O'Brien S, Wang K, Wang T, Paccagnella ML, Sleight B, Vandendries E, Advani AS
N Engl J Med 2016 Aug 25;375(8):740-53. Epub 2016 Jun 12 doi: 10.1056/NEJMoa1509277. PMID: 27292104Free PMC Article

Diagnosis

Pennesi E, Michels N, Brivio E, van der Velden VHJ, Jiang Y, Thano A, Ammerlaan AJC, Boer JM, Beverloo HB, Sleight B, Chen Y, Vormoor-Bürger B, Rives S, Bielorai B, Rössig C, Petit A, Rizzari C, Engstler G, Starý J, Bautista Sirvent FJ, Chen-Santel C, Bruno B, Bertrand Y, Rialland F, Plat G, Reinhardt D, Vinti L, Von Stackelberg A, Locatelli F, Zwaan CM
Leukemia 2022 Jun;36(6):1516-1524. Epub 2022 Apr 25 doi: 10.1038/s41375-022-01576-3. PMID: 35468945Free PMC Article
Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, Bader P, O'Brien MM, Brethon B, Bhojwani D, Schlegel PG, Borkhardt A, Rheingold SR, Cooper TM, Zwaan CM, Barnette P, Messina C, Michel G, DuBois SG, Hu K, Zhu M, Whitlock JA, Gore L
J Clin Oncol 2016 Dec 20;34(36):4381-4389. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.67.3301. PMID: 27998223
Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, White JC, Nazimuddin F, Wertheim G, Levine BL, June CH, Porter DL, Grupp SA
Cancer Discov 2016 Jun;6(6):664-79. Epub 2016 Apr 13 doi: 10.1158/2159-8290.CD-16-0040. PMID: 27076371Free PMC Article
Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, Bartido S, Stefanski J, Taylor C, Olszewska M, Borquez-Ojeda O, Qu J, Wasielewska T, He Q, Bernal Y, Rijo IV, Hedvat C, Kobos R, Curran K, Steinherz P, Jurcic J, Rosenblat T, Maslak P, Frattini M, Sadelain M
Sci Transl Med 2013 Mar 20;5(177):177ra38. doi: 10.1126/scitranslmed.3005930. PMID: 23515080Free PMC Article

Therapy

Laetsch TW, Maude SL, Rives S, Hiramatsu H, Bittencourt H, Bader P, Baruchel A, Boyer M, De Moerloose B, Qayed M, Buechner J, Pulsipher MA, Myers GD, Stefanski HE, Martin PL, Nemecek E, Peters C, Yanik G, Khaw SL, Davis KL, Krueger J, Balduzzi A, Boissel N, Tiwari R, O'Donovan D, Grupp SA
J Clin Oncol 2023 Mar 20;41(9):1664-1669. Epub 2022 Nov 18 doi: 10.1200/JCO.22.00642. PMID: 36399695Free PMC Article
Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
Pullarkat VA, Lacayo NJ, Jabbour E, Rubnitz JE, Bajel A, Laetsch TW, Leonard J, Colace SI, Khaw SL, Fleming SA, Mattison RJ, Norris R, Opferman JT, Roberts KG, Zhao Y, Qu C, Badawi M, Schmidt M, Tong B, Pesko JC, Sun Y, Ross JA, Vishwamitra D, Rosenwinkel L, Kim SY, Jacobson A, Mullighan CG, Alexander TB, Stock W
Cancer Discov 2021 Jun;11(6):1440-1453. Epub 2021 Feb 16 doi: 10.1158/2159-8290.CD-20-1465. PMID: 33593877Free PMC Article
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
Kantarjian HM, DeAngelo DJ, Stelljes M, Martinelli G, Liedtke M, Stock W, Gökbuget N, O'Brien S, Wang K, Wang T, Paccagnella ML, Sleight B, Vandendries E, Advani AS
N Engl J Med 2016 Aug 25;375(8):740-53. Epub 2016 Jun 12 doi: 10.1056/NEJMoa1509277. PMID: 27292104Free PMC Article

Prognosis

Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Gu R, Liu F, Zou D, Xu Y, Lu Y, Liu B, Liu W, Chen X, Liu K, Guo Y, Gong X, Lv R, Chen X, Zhou C, Zhong M, Wang H, Wei H, Mi Y, Qiu L, Lv L, Wang M, Wang Y, Zhu X, Wang J
J Hematol Oncol 2020 Sep 7;13(1):122. doi: 10.1186/s13045-020-00953-8. PMID: 32894185Free PMC Article
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, Bader P, O'Brien MM, Brethon B, Bhojwani D, Schlegel PG, Borkhardt A, Rheingold SR, Cooper TM, Zwaan CM, Barnette P, Messina C, Michel G, DuBois SG, Hu K, Zhu M, Whitlock JA, Gore L
J Clin Oncol 2016 Dec 20;34(36):4381-4389. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.67.3301. PMID: 27998223
Kantarjian HM, DeAngelo DJ, Stelljes M, Martinelli G, Liedtke M, Stock W, Gökbuget N, O'Brien S, Wang K, Wang T, Paccagnella ML, Sleight B, Vandendries E, Advani AS
N Engl J Med 2016 Aug 25;375(8):740-53. Epub 2016 Jun 12 doi: 10.1056/NEJMoa1509277. PMID: 27292104Free PMC Article

Clinical prediction guides

Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
Pullarkat VA, Lacayo NJ, Jabbour E, Rubnitz JE, Bajel A, Laetsch TW, Leonard J, Colace SI, Khaw SL, Fleming SA, Mattison RJ, Norris R, Opferman JT, Roberts KG, Zhao Y, Qu C, Badawi M, Schmidt M, Tong B, Pesko JC, Sun Y, Ross JA, Vishwamitra D, Rosenwinkel L, Kim SY, Jacobson A, Mullighan CG, Alexander TB, Stock W
Cancer Discov 2021 Jun;11(6):1440-1453. Epub 2021 Feb 16 doi: 10.1158/2159-8290.CD-20-1465. PMID: 33593877Free PMC Article
Pasquini MC, Hu ZH, Curran K, Laetsch T, Locke F, Rouce R, Pulsipher MA, Phillips CL, Keating A, Frigault MJ, Salzberg D, Jaglowski S, Sasine JP, Rosenthal J, Ghosh M, Landsburg D, Margossian S, Martin PL, Kamdar MK, Hematti P, Nikiforow S, Turtle C, Perales MA, Steinert P, Horowitz MM, Moskop A, Pacaud L, Yi L, Chawla R, Bleickardt E, Grupp S
Blood Adv 2020 Nov 10;4(21):5414-5424. doi: 10.1182/bloodadvances.2020003092. PMID: 33147337Free PMC Article
Gu R, Liu F, Zou D, Xu Y, Lu Y, Liu B, Liu W, Chen X, Liu K, Guo Y, Gong X, Lv R, Chen X, Zhou C, Zhong M, Wang H, Wei H, Mi Y, Qiu L, Lv L, Wang M, Wang Y, Zhu X, Wang J
J Hematol Oncol 2020 Sep 7;13(1):122. doi: 10.1186/s13045-020-00953-8. PMID: 32894185Free PMC Article
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article

Recent systematic reviews

Zhai Y, Hong J, Wang J, Jiang Y, Wu W, Lv Y, Guo J, Tian L, Sun H, Li Y, Li C, Zhan H, Zhao Z
Expert Rev Hematol 2024 Jan-Mar;17(1-3):67-76. Epub 2024 Jan 4 doi: 10.1080/17474086.2023.2298732. PMID: 38135295
Jeha S, Goto H, Baruchel A, Boëlle-Le Corfec E, Geffriaud-Ricouard C, Pieters R, Shin HY
Adv Ther 2023 Dec;40(12):5447-5463. Epub 2023 Oct 11 doi: 10.1007/s12325-023-02696-7. PMID: 37819554Free PMC Article
Elsallab M, Ellithi M, Hempel S, Abdel-Azim H, Abou-El-Enein M
Cancer Gene Ther 2023 Jun;30(6):845-854. Epub 2023 Feb 7 doi: 10.1038/s41417-023-00593-3. PMID: 36750666Free PMC Article
Liu H, Xi R, Mao D, Zhao X, Wu T
Clin Lymphoma Myeloma Leuk 2023 Mar;23(3):e139-e149. Epub 2022 Dec 17 doi: 10.1016/j.clml.2022.12.009. PMID: 36593170
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914

Supplemental Content

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