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Refractory Malignant Glioma

MedGen UID:
1635459
•Concept ID:
C4684868
•
Neoplastic Process

Definition

Malignant glioma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Role of tyrosine kinase inhibitors in the management of high-grade gliomas.
Ahluwalia MS, Patel M, Peereboom DM
Expert Rev Anticancer Ther 2011 Nov;11(11):1739-48. doi: 10.1586/era.11.166. PMID: 22050023
Blood-brain barrier and chemotherapeutic treatment of brain tumors.
de Vries NA, Beijnen JH, Boogerd W, van Tellingen O
Expert Rev Neurother 2006 Aug;6(8):1199-209. doi: 10.1586/14737175.6.8.1199. PMID: 16893347

Recent clinical studies

Etiology

Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Maurizi P, Ridola V, Mastrangelo S, Migliorati R, Bertolini P, Colosimo C, Riccardi R
J Neurooncol 2013 Jul;113(3):513-8. Epub 2013 May 12 doi: 10.1007/s11060-013-1145-z. PMID: 23666235
Extended-schedule dose-dense temozolomide in refractory gliomas.
Berrocal A, Perez Segura P, Gil M, Balaña C, Garcia Lopez J, Yaya R, Rodríguez J, Reynes G, Gallego O, Iglesias L; GENOM Cooperative Group
J Neurooncol 2010 Feb;96(3):417-22. Epub 2009 Aug 8 doi: 10.1007/s11060-009-9980-7. PMID: 19669096Free PMC Article

Diagnosis

Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors.
Hyman DM, Rizvi N, Natale R, Armstrong DK, Birrer M, Recht L, Dotan E, Makker V, Kaley T, Kuruvilla D, Gribbin M, McDevitt J, Lai DW, Dar M
Clin Cancer Res 2018 Jun 15;24(12):2749-2757. Epub 2018 Mar 20 doi: 10.1158/1078-0432.CCR-17-1775. PMID: 29559563Free PMC Article
Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Maurizi P, Ridola V, Mastrangelo S, Migliorati R, Bertolini P, Colosimo C, Riccardi R
J Neurooncol 2013 Jul;113(3):513-8. Epub 2013 May 12 doi: 10.1007/s11060-013-1145-z. PMID: 23666235
New approaches for temozolomide therapy: use in newly diagnosed glioma.
Stupp R, Newlands E
Semin Oncol 2001 Aug;28(4 Suppl 13):19-23. doi: 10.1016/s0093-7754(01)90067-3. PMID: 11550135

Therapy

Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors.
Hyman DM, Rizvi N, Natale R, Armstrong DK, Birrer M, Recht L, Dotan E, Makker V, Kaley T, Kuruvilla D, Gribbin M, McDevitt J, Lai DW, Dar M
Clin Cancer Res 2018 Jun 15;24(12):2749-2757. Epub 2018 Mar 20 doi: 10.1158/1078-0432.CCR-17-1775. PMID: 29559563Free PMC Article
Predictive significance of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab: preliminary report.
Nagane M, Kobayashi K, Tanaka M, Tsuchiya K, Shishido-Hara Y, Shimizu S, Shiokawa Y
Int J Clin Oncol 2014 Feb;19(1):16-23. Epub 2013 Jan 26 doi: 10.1007/s10147-013-0517-x. PMID: 23354833
Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Maurizi P, Ridola V, Mastrangelo S, Migliorati R, Bertolini P, Colosimo C, Riccardi R
J Neurooncol 2013 Jul;113(3):513-8. Epub 2013 May 12 doi: 10.1007/s11060-013-1145-z. PMID: 23666235
Extended-schedule dose-dense temozolomide in refractory gliomas.
Berrocal A, Perez Segura P, Gil M, Balaña C, Garcia Lopez J, Yaya R, Rodríguez J, Reynes G, Gallego O, Iglesias L; GENOM Cooperative Group
J Neurooncol 2010 Feb;96(3):417-22. Epub 2009 Aug 8 doi: 10.1007/s11060-009-9980-7. PMID: 19669096Free PMC Article
New approaches for temozolomide therapy: use in newly diagnosed glioma.
Stupp R, Newlands E
Semin Oncol 2001 Aug;28(4 Suppl 13):19-23. doi: 10.1016/s0093-7754(01)90067-3. PMID: 11550135

Prognosis

Predictive significance of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab: preliminary report.
Nagane M, Kobayashi K, Tanaka M, Tsuchiya K, Shishido-Hara Y, Shimizu S, Shiokawa Y
Int J Clin Oncol 2014 Feb;19(1):16-23. Epub 2013 Jan 26 doi: 10.1007/s10147-013-0517-x. PMID: 23354833
Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Maurizi P, Ridola V, Mastrangelo S, Migliorati R, Bertolini P, Colosimo C, Riccardi R
J Neurooncol 2013 Jul;113(3):513-8. Epub 2013 May 12 doi: 10.1007/s11060-013-1145-z. PMID: 23666235
New approaches for temozolomide therapy: use in newly diagnosed glioma.
Stupp R, Newlands E
Semin Oncol 2001 Aug;28(4 Suppl 13):19-23. doi: 10.1016/s0093-7754(01)90067-3. PMID: 11550135

Clinical prediction guides

Predictive significance of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab: preliminary report.
Nagane M, Kobayashi K, Tanaka M, Tsuchiya K, Shishido-Hara Y, Shimizu S, Shiokawa Y
Int J Clin Oncol 2014 Feb;19(1):16-23. Epub 2013 Jan 26 doi: 10.1007/s10147-013-0517-x. PMID: 23354833
Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors.
Ruggiero A, Rizzo D, Attinà G, Lazzareschi I, Maurizi P, Ridola V, Mastrangelo S, Migliorati R, Bertolini P, Colosimo C, Riccardi R
J Neurooncol 2013 Jul;113(3):513-8. Epub 2013 May 12 doi: 10.1007/s11060-013-1145-z. PMID: 23666235
Phase I study of phenylacetate administered twice daily to patients with cancer.
Thibault A, Samid D, Cooper MR, Figg WD, Tompkins AC, Patronas N, Headlee DJ, Kohler DR, Venzon DJ, Myers CE
Cancer 1995 Jun 15;75(12):2932-8. doi: 10.1002/1097-0142(19950615)75:12<2932::aid-cncr2820751221>3.0.co;2-p. PMID: 7773944

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