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Refractory Prostate Carcinoma

MedGen UID:
1710824
•Concept ID:
C5238404
•
Neoplastic Process

Definition

Prostate carcinoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Society of Urologic Oncology position statement: redefining the management of hormone-refractory prostate carcinoma.
Chang SS, Benson MC, Campbell SC, Crook J, Dreicer R, Evans CP, Hall MC, Higano C, Kelly WK, Sartor O, Smith JA Jr; Society of Urologic Oncology, Shaumberg, Illinois
Cancer 2005 Jan 1;103(1):11-21. doi: 10.1002/cncr.20726. PMID: 15558815
Contemporary chemotherapeutic approaches for the treatment of hormone-refractory prostate carcinoma.
Walther PJ
World J Urol 2000 Jun;18(3):216-21. doi: 10.1007/s003450000126. PMID: 10926086
Treatment of hormone-refractory prostate carcinoma.
Fournier G
Eur Urol 1996;30 Suppl 1:32-7. doi: 10.1159/000474243. PMID: 8977988

Recent clinical studies

Etiology

Radiotherapy and concurrent metronomic chemotherapy in hormone-refractory prostate carcinoma: a Phase I study.
Morganti AG, Massaccesi M, Caravatta L, Macchia G, Picardi V, Deodato F, Ippolito E, Mignogna S, Ferro M, Cilla S, Mattiucci GC, Valentini V
Anticancer Res 2013 Oct;33(10):4585-9. PMID: 24123034
Targeting the endothelin axis in prostate carcinoma.
Pinto A, Merino M, Zamora P, Redondo A, Castelo B, Espinosa E
Tumour Biol 2012 Apr;33(2):421-6. Epub 2011 Dec 29 doi: 10.1007/s13277-011-0299-6. PMID: 22203496
Diethylstilboestrol versus bicalutamide in hormone refractory prostate carcinoma: a prospective randomized trial.
Manikandan R, Srirangam SJ, Pearson E, Brown SC, O'Reilly P, Collins GN
Urol Int 2005;75(3):217-21. doi: 10.1159/000087797. PMID: 16215308
Hormone therapy for patients with prostate carcinoma.
Klotz L
Cancer 2000 Jun 15;88(12 Suppl):3009-14. doi: 10.1002/1097-0142(20000615)88:12+<3009::aid-cncr17>3.3.co;2-5. PMID: 10898345
A study of aminoglutethemide and hydrocortisone in patients with advanced and refractory prostate carcinoma.
Chang AY, Bennett JM, Pandya KJ, Asbury R, McCune C
Am J Clin Oncol 1989 Aug;12(4):358-60. doi: 10.1097/00000421-198908000-00017. PMID: 2474242

Diagnosis

Study and detection of potential markers for predicting metastasis into lymph nodes in prostate cancer.
Papasotiriou I, Apostolou P, Ntanovasilis DA, Parsonidis P, Osmonov D, Jünemann KP
Biomark Med 2020 Oct;14(14):1317-1327. Epub 2020 Aug 17 doi: 10.2217/bmm-2020-0372. PMID: 32799659
Phase II trial of oral uracil/tegafur plus leucovorin in patients with hormone-refractory prostate carcinoma.
Bhandari MS, Pienta KJ, Fardig J, Olson K, Smith DC
Cancer 2006 Apr 15;106(8):1715-21. doi: 10.1002/cncr.21815. PMID: 16534795
Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models.
Zuco V, Supino R, De Cesare M, Carenini N, Perego P, Gatti L, Pratesi G, Pisano C, Martinelli R, Bucci F, Zanier R, Carminati P, Zunino F
Biochem Pharmacol 2003 Apr 15;65(8):1281-94. doi: 10.1016/s0006-2952(03)00079-0. PMID: 12694869
Hormone therapy for patients with prostate carcinoma.
Klotz L
Cancer 2000 Jun 15;88(12 Suppl):3009-14. doi: 10.1002/1097-0142(20000615)88:12+<3009::aid-cncr17>3.3.co;2-5. PMID: 10898345
Enhanced in vitro cytotoxicity of idarubicin compared to epirubicin and doxorubicin in rat prostate carcinoma cells.
Siegsmund MJ, Stendler A, Kreukler C, Köhrmann KU, Alken P
Eur Urol 1997;31(3):365-70. doi: 10.1159/000474485. PMID: 9129933

Therapy

Targeting the endothelin axis in prostate carcinoma.
Pinto A, Merino M, Zamora P, Redondo A, Castelo B, Espinosa E
Tumour Biol 2012 Apr;33(2):421-6. Epub 2011 Dec 29 doi: 10.1007/s13277-011-0299-6. PMID: 22203496
Effect of extracellular ATP on the growth of hormone-refractory prostate cancer in vivo.
Shabbir M, Thompson C, Jarmulowiczc M, Mikhailidis D, Burnstock G
BJU Int 2008 Jul;102(1):108-12. Epub 2008 Mar 5 doi: 10.1111/j.1464-410X.2008.07578.x. PMID: 18325054
Hormone therapy for patients with prostate carcinoma.
Klotz L
Cancer 2000 Jun 15;88(12 Suppl):3009-14. doi: 10.1002/1097-0142(20000615)88:12+<3009::aid-cncr17>3.3.co;2-5. PMID: 10898345
Weekly chemotherapeutic regimen in metastatic prostate cancer.
Burk K
Prog Clin Biol Res 1990;350:187-200. PMID: 2201043
Weekly chemotherapeutic regimen in metastatic prostate cancer.
Burk K
Prog Clin Biol Res 1989;303:261-75. PMID: 2674989

Prognosis

Study and detection of potential markers for predicting metastasis into lymph nodes in prostate cancer.
Papasotiriou I, Apostolou P, Ntanovasilis DA, Parsonidis P, Osmonov D, Jünemann KP
Biomark Med 2020 Oct;14(14):1317-1327. Epub 2020 Aug 17 doi: 10.2217/bmm-2020-0372. PMID: 32799659
Diethylstilboestrol versus bicalutamide in hormone refractory prostate carcinoma: a prospective randomized trial.
Manikandan R, Srirangam SJ, Pearson E, Brown SC, O'Reilly P, Collins GN
Urol Int 2005;75(3):217-21. doi: 10.1159/000087797. PMID: 16215308
Weekly 1-hour infusion of paclitaxel. Clinical feasibility and efficacy in patients with hormone-refractory prostate carcinoma.
Trivedi C, Redman B, Flaherty LE, Kucuk O, Du W, Heilbrun LK, Hussain M
Cancer 2000 Jul 15;89(2):431-6. doi: 10.1002/1097-0142(20000715)89:2<431::aid-cncr31>3.0.co;2-b. PMID: 10918176
Estramustine-based chemotherapy.
Hudes G
Semin Urol Oncol 1997 Feb;15(1):13-9. PMID: 9050135
Weekly chemotherapeutic regimen in metastatic prostate cancer.
Burk K
Prog Clin Biol Res 1990;350:187-200. PMID: 2201043

Clinical prediction guides

Study and detection of potential markers for predicting metastasis into lymph nodes in prostate cancer.
Papasotiriou I, Apostolou P, Ntanovasilis DA, Parsonidis P, Osmonov D, Jünemann KP
Biomark Med 2020 Oct;14(14):1317-1327. Epub 2020 Aug 17 doi: 10.2217/bmm-2020-0372. PMID: 32799659
Anti-tumor activity of non-nucleosidic reverse transcriptase inhibitors.
Landriscina M, Spadafora C, Cignarelli M, Barone C
Curr Pharm Des 2007;13(7):737-47. doi: 10.2174/138161207780249191. PMID: 17346188
Weekly administration of docetaxel for symptomatic metastatic hormone-refractory prostate carcinoma.
Gravis G, Bladou F, Salem N, Macquart-Moulin G, Serment G, Camerlo J, Genre D, Bardou VJ, Maraninchi D, Viens P
Cancer 2003 Oct 15;98(8):1627-34. doi: 10.1002/cncr.11687. PMID: 14534878
Estramustine-based chemotherapy.
Hudes G
Semin Urol Oncol 1997 Feb;15(1):13-9. PMID: 9050135
A study of aminoglutethemide and hydrocortisone in patients with advanced and refractory prostate carcinoma.
Chang AY, Bennett JM, Pandya KJ, Asbury R, McCune C
Am J Clin Oncol 1989 Aug;12(4):358-60. doi: 10.1097/00000421-198908000-00017. PMID: 2474242

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