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Refractory Dedifferentiated Liposarcoma

MedGen UID:
1649152
•Concept ID:
C4725859
•
Neoplastic Process

Definition

Dedifferentiated liposarcoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Dedifferentiated Liposarcoma

Professional guidelines

PubMed

A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article

Recent clinical studies

Etiology

Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib.
Endo M, Kataoka T, Fujiwara T, Tsukushi S, Takahashi M, Kobayashi E, Yamada Y, Tanaka T, Nezu Y, Hiraga H, Wasa J, Nagano A, Nakano K, Nakayama R, Hamada T, Kawano M, Torigoe T, Sakamoto A, Asanuma K, Morii T, Machida R, Sekino Y, Fukuda H, Oda Y, Ozaki T, Tanaka K
BMC Cancer 2023 Mar 8;23(1):219. doi: 10.1186/s12885-023-10693-w. PMID: 36890471Free PMC Article
Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma.
Brodowicz T, Mir O, Wallet J, Italiano A, Blay JY, Bertucci F, Eisterer W, Chevreau C, Piperno-Neumann S, Bompas E, Ryckewaert T, Liegl-Antzwager B, Thery J, Penel N, Le Cesne A, Le Deley MC
Eur J Cancer 2018 Aug;99:28-36. Epub 2018 Jun 11 doi: 10.1016/j.ejca.2018.05.008. PMID: 29902612
Sustained clinico-radiologic response to anti-cytotoxic T lymphocyte antigen 4 antibody therapy in metastatic myxoid liposarcoma.
Dasanu CA
J Oncol Pharm Pract 2017 Oct;23(7):549-551. Epub 2016 Aug 10 doi: 10.1177/1078155216664202. PMID: 27511215
A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article
Soft tissue sarcomas, a look into the future: different treatments for different subtypes.
Reichardt P
Future Oncol 2014 Jun;10(8 Suppl):s19-27. doi: 10.2217/fon.14.116. PMID: 25048045

Diagnosis

Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib.
Endo M, Kataoka T, Fujiwara T, Tsukushi S, Takahashi M, Kobayashi E, Yamada Y, Tanaka T, Nezu Y, Hiraga H, Wasa J, Nagano A, Nakano K, Nakayama R, Hamada T, Kawano M, Torigoe T, Sakamoto A, Asanuma K, Morii T, Machida R, Sekino Y, Fukuda H, Oda Y, Ozaki T, Tanaka K
BMC Cancer 2023 Mar 8;23(1):219. doi: 10.1186/s12885-023-10693-w. PMID: 36890471Free PMC Article
Head pleomorphic sarcoma showing murine double minute 2 amplification without a well-differentiated liposarcoma component in a pediatric patient.
Akaihata M, Takahashi I, Kakuda Y, Kawata T, Mukaigawa T, Onitsuka T, Murayama S, Ishida Y
Cancer Rep (Hoboken) 2023 Feb;6(2):e1774. Epub 2022 Dec 26 doi: 10.1002/cnr2.1774. PMID: 36572546Free PMC Article
A challenging diagnosis of mesenchymal neoplasm of the colon: colonic dedifferentiated liposarcoma with lymph node metastases-a case report and review of the literature.
Guadagno E, Peltrini R, Stasio L, Fiorentino F, Bucci L, Terracciano L, Insabato L
Int J Colorectal Dis 2019 Oct;34(10):1809-1814. Epub 2019 Sep 9 doi: 10.1007/s00384-019-03394-z. PMID: 31501928
REGOSARC: Regorafenib versus placebo in doxorubicin-refractory soft-tissue sarcoma-A quality-adjusted time without symptoms of progression or toxicity analysis.
Berry V, Basson L, Bogart E, Mir O, Blay JY, Italiano A, Bertucci F, Chevreau C, Clisant-Delaine S, Liegl-Antzager B, Tresch-Bruneel E, Wallet J, Taieb S, Decoupigny E, Le Cesne A, Brodowicz T, Penel N
Cancer 2017 Jun 15;123(12):2294-2302. Epub 2017 Mar 10 doi: 10.1002/cncr.30661. PMID: 28295221Free PMC Article
A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article

Therapy

Myositis and myasteniform syndrome related to pembrolizumab.
Sanchez-Sancho P, Selva-O'Callaghan A, Trallero-Araguás E, Ros J, Montoro B
BMJ Case Rep 2021 Jul 21;14(7) doi: 10.1136/bcr-2021-241766. PMID: 34290006Free PMC Article
Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma.
Brodowicz T, Mir O, Wallet J, Italiano A, Blay JY, Bertucci F, Eisterer W, Chevreau C, Piperno-Neumann S, Bompas E, Ryckewaert T, Liegl-Antzwager B, Thery J, Penel N, Le Cesne A, Le Deley MC
Eur J Cancer 2018 Aug;99:28-36. Epub 2018 Jun 11 doi: 10.1016/j.ejca.2018.05.008. PMID: 29902612
REGOSARC: Regorafenib versus placebo in doxorubicin-refractory soft-tissue sarcoma-A quality-adjusted time without symptoms of progression or toxicity analysis.
Berry V, Basson L, Bogart E, Mir O, Blay JY, Italiano A, Bertucci F, Chevreau C, Clisant-Delaine S, Liegl-Antzager B, Tresch-Bruneel E, Wallet J, Taieb S, Decoupigny E, Le Cesne A, Brodowicz T, Penel N
Cancer 2017 Jun 15;123(12):2294-2302. Epub 2017 Mar 10 doi: 10.1002/cncr.30661. PMID: 28295221Free PMC Article
A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article
Ultra-low dose ketamine and memantine treatment for pain in an opioid-tolerant oncology patient.
Grande LA, O'Donnell BR, Fitzgibbon DR, Terman GW
Anesth Analg 2008 Oct;107(4):1380-3. doi: 10.1213/ane.0b013e3181733ddd. PMID: 18806055

Prognosis

Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.
Gounder MM, Razak AA, Somaiah N, Chawla S, Martin-Broto J, Grignani G, Schuetze SM, Vincenzi B, Wagner AJ, Chmielowski B, Jones RL, Riedel RF, Stacchiotti S, Loggers ET, Ganjoo KN, Le Cesne A, Italiano A, Garcia Del Muro X, Burgess M, Piperno-Neumann S, Ryan C, Mulcahy MF, Forscher C, Penel N, Okuno S, Elias A, Hartner L, Philip T, Alcindor T, Kasper B, Reichardt P, Lapeire L, Blay JY, Chevreau C, Valverde Morales CM, Schwartz GK, Chen JL, Deshpande H, Davis EJ, Nicholas G, Gröschel S, Hatcher H, Duffaud F, Herráez AC, Beveridge RD, Badalamenti G, Eriksson M, Meyer C, von Mehren M, Van Tine BA, Götze K, Mazzeo F, Yakobson A, Zick A, Lee A, Gonzalez AE, Napolitano A, Dickson MA, Michel D, Meng C, Li L, Liu J, Ben-Shahar O, Van Domelen DR, Walker CJ, Chang H, Landesman Y, Shah JJ, Shacham S, Kauffman MG, Attia S
J Clin Oncol 2022 Aug 1;40(22):2479-2490. Epub 2022 Apr 8 doi: 10.1200/JCO.21.01829. PMID: 35394800Free PMC Article
Establishment and characterization of NCC-DDLPS3-C1: a novel patient-derived cell line of dedifferentiated liposarcoma.
Tsuchiya R, Yoshimatsu Y, Noguchi R, Ono T, Sei A, Takeshita F, Sugaya J, Fukushima S, Yoshida A, Ohtori S, Kawai A, Kondo T
Hum Cell 2021 May;34(3):1008-1018. Epub 2021 Mar 6 doi: 10.1007/s13577-021-00515-1. PMID: 33677797
Establishment and characterization of NCC-DDLPS1-C1: a novel patient-derived cell line of dedifferentiated liposarcoma.
Tsuchiya R, Yoshimatsu Y, Noguchi R, Sei A, Takeshita F, Sugaya J, Fukushima S, Yoshida A, Ohtori S, Kawai A, Kondo T
Hum Cell 2021 Jan;34(1):260-270. Epub 2020 Sep 19 doi: 10.1007/s13577-020-00436-5. PMID: 32949334
Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma.
Brodowicz T, Mir O, Wallet J, Italiano A, Blay JY, Bertucci F, Eisterer W, Chevreau C, Piperno-Neumann S, Bompas E, Ryckewaert T, Liegl-Antzwager B, Thery J, Penel N, Le Cesne A, Le Deley MC
Eur J Cancer 2018 Aug;99:28-36. Epub 2018 Jun 11 doi: 10.1016/j.ejca.2018.05.008. PMID: 29902612
A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article

Clinical prediction guides

Head pleomorphic sarcoma showing murine double minute 2 amplification without a well-differentiated liposarcoma component in a pediatric patient.
Akaihata M, Takahashi I, Kakuda Y, Kawata T, Mukaigawa T, Onitsuka T, Murayama S, Ishida Y
Cancer Rep (Hoboken) 2023 Feb;6(2):e1774. Epub 2022 Dec 26 doi: 10.1002/cnr2.1774. PMID: 36572546Free PMC Article
Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.
Gounder MM, Razak AA, Somaiah N, Chawla S, Martin-Broto J, Grignani G, Schuetze SM, Vincenzi B, Wagner AJ, Chmielowski B, Jones RL, Riedel RF, Stacchiotti S, Loggers ET, Ganjoo KN, Le Cesne A, Italiano A, Garcia Del Muro X, Burgess M, Piperno-Neumann S, Ryan C, Mulcahy MF, Forscher C, Penel N, Okuno S, Elias A, Hartner L, Philip T, Alcindor T, Kasper B, Reichardt P, Lapeire L, Blay JY, Chevreau C, Valverde Morales CM, Schwartz GK, Chen JL, Deshpande H, Davis EJ, Nicholas G, Gröschel S, Hatcher H, Duffaud F, Herráez AC, Beveridge RD, Badalamenti G, Eriksson M, Meyer C, von Mehren M, Van Tine BA, Götze K, Mazzeo F, Yakobson A, Zick A, Lee A, Gonzalez AE, Napolitano A, Dickson MA, Michel D, Meng C, Li L, Liu J, Ben-Shahar O, Van Domelen DR, Walker CJ, Chang H, Landesman Y, Shah JJ, Shacham S, Kauffman MG, Attia S
J Clin Oncol 2022 Aug 1;40(22):2479-2490. Epub 2022 Apr 8 doi: 10.1200/JCO.21.01829. PMID: 35394800Free PMC Article
Establishment and characterization of NCC-DDLPS3-C1: a novel patient-derived cell line of dedifferentiated liposarcoma.
Tsuchiya R, Yoshimatsu Y, Noguchi R, Ono T, Sei A, Takeshita F, Sugaya J, Fukushima S, Yoshida A, Ohtori S, Kawai A, Kondo T
Hum Cell 2021 May;34(3):1008-1018. Epub 2021 Mar 6 doi: 10.1007/s13577-021-00515-1. PMID: 33677797
Multiple modes of action of eribulin mesylate: Emerging data and clinical implications.
Cortes J, Schöffski P, Littlefield BA
Cancer Treat Rev 2018 Nov;70:190-198. Epub 2018 Aug 21 doi: 10.1016/j.ctrv.2018.08.008. PMID: 30243063
Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma.
Brodowicz T, Mir O, Wallet J, Italiano A, Blay JY, Bertucci F, Eisterer W, Chevreau C, Piperno-Neumann S, Bompas E, Ryckewaert T, Liegl-Antzwager B, Thery J, Penel N, Le Cesne A, Le Deley MC
Eur J Cancer 2018 Aug;99:28-36. Epub 2018 Jun 11 doi: 10.1016/j.ejca.2018.05.008. PMID: 29902612

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