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Refractory Endometrial Adenocarcinoma

MedGen UID:
1714709
•Concept ID:
C5237060
•
Neoplastic Process
Synonyms: Refractory Endometrial Adenocarcinoma, NOS; Refractory Endometrial Adenocarcinoma, Not Otherwise Specified

Definition

Endometrial adenocarcinoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Nuclear PTEN Localization Contributes to DNA Damage Response in Endometrial Adenocarcinoma and Could Have a Diagnostic Benefit for Therapeutic Management of the Disease.
Mukherjee A, Patterson AL, George JW, Carpenter TJ, Madaj ZB, Hostetter G, Risinger JI, Teixeira JM
Mol Cancer Ther 2018 Sep;17(9):1995-2003. Epub 2018 Jun 13 doi: 10.1158/1535-7163.MCT-17-1255. PMID: 29898896
Quality of life in ovarian cancer patients choosing to receive salvage chemotherapy or palliative treatment.
Srisuttayasathien M, Khemapech N
Asian Pac J Cancer Prev 2013;14(12):7669-74. doi: 10.7314/apjcp.2013.14.12.7669. PMID: 24460351

Recent clinical studies

Etiology

Paclitaxel and carboplatin with amifostine in advanced, recurrent, or refractory endometrial adenocarcinoma: a phase II study of the Southwest Oncology Group.
Scudder SA, Liu PY, Wilczynski SP, Smith HO, Jiang C, Hallum AV 3rd, Smith GB, Hannigan EV, Markman M, Alberts DS; Southwest Oncology Group
Gynecol Oncol 2005 Mar;96(3):610-5. doi: 10.1016/j.ygyno.2004.11.024. PMID: 15721401
Phase II trial of oral etoposide in recurrent or refractory endometrial adenocarcinoma: a southwest oncology group study.
Poplin EA, Liu PY, Delmore JE, Wilczynski S, Moore DF Jr, Potkul RK, Fine BA, Hannigan EV, Alberts DS
Gynecol Oncol 1999 Sep;74(3):432-5. doi: 10.1006/gyno.1999.5461. PMID: 10479505

Therapy

Paclitaxel and carboplatin with amifostine in advanced, recurrent, or refractory endometrial adenocarcinoma: a phase II study of the Southwest Oncology Group.
Scudder SA, Liu PY, Wilczynski SP, Smith HO, Jiang C, Hallum AV 3rd, Smith GB, Hannigan EV, Markman M, Alberts DS; Southwest Oncology Group
Gynecol Oncol 2005 Mar;96(3):610-5. doi: 10.1016/j.ygyno.2004.11.024. PMID: 15721401
Phase II trial of oral etoposide in recurrent or refractory endometrial adenocarcinoma: a southwest oncology group study.
Poplin EA, Liu PY, Delmore JE, Wilczynski S, Moore DF Jr, Potkul RK, Fine BA, Hannigan EV, Alberts DS
Gynecol Oncol 1999 Sep;74(3):432-5. doi: 10.1006/gyno.1999.5461. PMID: 10479505
A trial of continuous-infusion vinblastine in refractory endometrial adenocarcinoma.
Kavanagh JJ, Saul PB, Wharton JT, Rutledge FN
Gynecol Oncol 1987 Feb;26(2):236-9. doi: 10.1016/0090-8258(87)90279-4. PMID: 3804040

Clinical prediction guides

Phase II trial of oral etoposide in recurrent or refractory endometrial adenocarcinoma: a southwest oncology group study.
Poplin EA, Liu PY, Delmore JE, Wilczynski S, Moore DF Jr, Potkul RK, Fine BA, Hannigan EV, Alberts DS
Gynecol Oncol 1999 Sep;74(3):432-5. doi: 10.1006/gyno.1999.5461. PMID: 10479505

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