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Head and neck neoplasm

MedGen UID:: 6728
•Concept ID:: C0018671
•: Neoplastic Process

Synonyms:	Head and Neck Neoplasms; Neoplasm of head and neck
SNOMED CT:	Neoplasm of head and neck (255055008); Neoplasm of head AND/OR neck (255055008); Tumor of head and neck (255055008)

HPO:	HP:0012288
Monarch Initiative:	MONDO:0005586

Definition

A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Head and neck neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Head and Neck Disorder
        Head and neck neoplasm
        Benign Head and Neck Neoplasm
        Benign carotid body paraganglioma
        Benign neoplasm of ear
        Benign External Ear Neoplasm
        Benign Inner Ear Neoplasm
        Benign neoplasm of middle ear
        Ear Polyp
        Benign neoplasm of neck
        Benign laryngeal neoplasm
        Benign neoplasm of parathyroid gland
        Benign neoplasm of pharynx
        Benign Parapharyngeal Neoplasm
        Benign Retropharyngeal Neoplasm
        Benign thyroid gland neoplasm
        Schwannoma of jugular foramen
        Benign neoplasm of oral cavity
        Benign neoplasm of buccal mucosa
        Benign neoplasm of floor of mouth
        Benign neoplasm of gum
        Benign neoplasm of hard palate
        Benign neoplasm of lip
        Benign neoplasm of tongue
        Benign neoplasm of tonsil
        Benign Odontogenic Neoplasm
        Benign Oral Cavity Soft Tissue Neoplasm
        Oral Cavity Adenoma
        Oral Cavity Benign Granular Cell Tumor
        Benign neoplasm of salivary gland
        Benign neoplasm of major salivary gland
        Benign neoplasm of minor salivary gland
        Pleomorphic adenoma of salivary gland
        Salivary Gland Cystadenoma
        Salivary Gland Ductal Papilloma
        Salivary Gland Hemangioma
        Salivary Gland Lipoma
        Salivary Gland Lymphadenoma
        Salivary Gland Monomorphic Adenoma
        Salivary Gland Myoepithelioma
        Salivary Gland Nodular Fasciitis
        Sclerosing Polycystic Adenosis
        Sialolipoma
        Warthin tumor
        Benign Orbit Neoplasm
        Hemangioma of orbit
        Orbit Dermoid Cyst
        Benign Sinonasal Neoplasm
        Benign neoplasm of nasal cavity
        Benign Paranasal Sinus Neoplasm
        Benign Sinonasal Soft Tissue Neoplasm
        Sinonasal Neurofibroma
        Sinonasal Papilloma
        Sinonasal Pleomorphic Adenoma
        Sinonasal Schwannoma
        Benign Skull Neoplasm
        Benign Maxillofacial Neoplasm
        Benign Skull Base Neoplasm
        Ossifying Fibroma
        Skull Osteoma
        Head and Neck Nevus
        Facial neoplasm
        Eyelid neoplasm
        Benign eyelid neoplasm
        Eyelid cancer
        Head and neck cancer
        Head and neck carcinoma
        Ear Carcinoma
        Head and Neck Heterotopia-Associated Carcinoma
        Head and Neck Neuroendocrine Carcinoma
        Head and Neck NUT Carcinoma
        Head and Neck Sebaceous Carcinoma
        Lip and oral cavity carcinoma
        Localized Head and Neck Carcinoma
        Metastatic Head and Neck Carcinoma
        Nasal cavity and paranasal sinus carcinoma
        Neck Carcinoma
        Recurrent Head and Neck Carcinoma
        Refractory Head and Neck Carcinoma
        Salivary gland carcinoma
        Squamous cell carcinoma of the head and neck
        Unresectable Head and Neck Carcinoma
        Head and Neck Follicular Dendritic Cell Sarcoma
        Thyroid Gland Follicular Dendritic Cell Sarcoma
        Head and Neck Sarcoma
        Laryngeal sarcoma
        Major Salivary Gland Sarcoma
        Maxillofacial Sarcoma
        Oral Cavity Sarcoma
        Orbit sarcoma
        Sinonasal Sarcoma
        Thyroid sarcoma
        Malignant carotid body paraganglioma
        Malignant ear neoplasm
        External ear cancer
        Malignant Inner Ear Neoplasm
        Middle ear cancer
        Malignant jugulotympanic paraganglioma
        Malignant Sinonasal Neoplasm
        Malignant Sinonasal Soft Tissue Neoplasm
        Nasal cavity cancer
        Paranasal sinus cancer
        Sinonasal Lymphoma
        Sinonasal Mucosal Melanoma
        Sinonasal Olfactory Neuroblastoma
        Sinonasal Plasmacytoma
        Sinonasal Teratocarcinosarcoma
        Malignant tumor of neck
        Larynx cancer
        Malignant Parapharyngeal Neoplasm
        Malignant Retropharyngeal Neoplasm
        Malignant tumor of parathyroid gland
        Malignant tumor of thyroid gland
        Metastatic Malignant Neoplasm in the Neck
        Pharynx cancer
        Metastatic Malignant Head and Neck Neoplasm
        Advanced Malignant Head and Neck Neoplasm
        Locally Advanced Malignant Head and Neck Neoplasm
        Metastatic Malignant Neoplasm in the Parathyroid Glands
        Metastatic Malignant Neoplasm in the Head and Neck
        Head and Neck Carcinoma of Unknown Primary
        Metastatic Malignant Neoplasm in the Lip
        Metastatic Malignant Neoplasm in the Orbit
        Metastatic Malignant Neoplasm in the Sellar Region
        Mucosal Melanoma of the Head and Neck
        Mucosal Melanoma of the Head and Neck by AJCC v7 Stage
        Oral Cavity Mucosal Melanoma
        Pharyngeal Melanoma
        Oral cavity cancer
        Cheek mucosa cancer
        Gingival cancer
        Lip cancer
        Malignant Odontogenic Neoplasm
        Malignant Palate Neoplasm
        Malignant tumor of floor of mouth
        Oral cavity carcinoma
        Oral Cavity Myeloid Sarcoma
        Recurrent Malignant Oral Neoplasm
        Refractory Malignant Oral Neoplasm
        Tongue cancer
        Tonsil cancer
        Orbital cancer
        Orbital lymphoma
        Orbital Melanoma
        Recurrent Malignant Head and Neck Neoplasm
        Recurrent Malignant Pharyngeal Neoplasm
        Recurrent Malignant Salivary Gland Neoplasm
        Recurrent Malignant Thyroid Gland Neoplasm
        Recurrent Neck Squamous Cell Carcinoma of Unknown Primary
        Refractory Malignant Head and Neck Neoplasm
        Refractory Malignant Pharyngeal Neoplasm
        Refractory Malignant Salivary Gland Neoplasm
        Refractory Malignant Thyroid Gland Neoplasm
        Salivary gland cancer
        Major salivary gland cancer
        Malignant Mixed Tumor of the Salivary Gland
        Malignant tumor of minor salivary gland
        Salivary Gland Lymphoma
        Skull cancer
        Malignant Skull Base Neoplasm
        Head and Neck Histiocytic and Dendritic Cell Neoplasm
        Head and Neck Langerhans Cell Histiocytosis
        Oral Mucosa Langerhans Cell Histiocytosis
        Thyroid Gland Langerhans Cell Histiocytosis
        Thyroid Gland Histiocytic and Dendritic Cell Neoplasm
        Head and Neck Melanocytic Neoplasm
        Juvenile nasopharyngeal angiofibroma
        Nasal cavity and paranasal sinus neoplasm
        Nasal cavity neoplasm
        Paranasal sinus neoplasm
        Ethmoidal sinus neoplasm
        Frontal sinus neoplasm
        Maxillary sinus neoplasm
        Sphenoidal sinus neoplasm
        Primary Sinonasal Meningioma
        Ethmoid sinus ectopic meningioma
        Sinonasal Ameloblastoma
        Sinonasal Soft Tissue Neoplasm
        Intermediate Sinonasal Soft Tissue Neoplasm
        Neoplasm of esophagus
        Barrett esophagus
        Refractory Barrett Esophagus
        Benign neoplasm of esophagus
        Esophageal Fibroma
        Esophageal hemangioma
        Esophageal lipoma
        Esophageal Polyp
        Esophageal Schwannoma
        Esophagus leiomyoma
        Neurofibroma of the esophagus
        Carcinoma of esophagus
        Adenocarcinoma of esophagus
        Carcinoma of esophagus, salivary gland type
        Childhood Esophageal Carcinoma
        Esophageal adenoid cystic carcinoma
        Esophageal adenosquamous carcinoma
        Esophageal Cancer by AJCC v6 Stage
        Esophageal Cancer by AJCC v7 Stage
        Esophageal Cancer by AJCC v8 Stage
        Esophageal Mixed Adenoneuroendocrine Carcinoma
        Esophageal Neuroendocrine Carcinoma
        Esophageal squamous cell carcinoma
        Localized Esophageal Carcinoma
        Metastatic Esophageal Carcinoma
        Mucoepidermoid esophageal carcinoma
        Recurrent Esophageal Carcinoma
        Refractory Esophageal Carcinoma
        Undifferentiated carcinoma of esophagus
        Unresectable Esophageal Carcinoma
        Esophageal dysplasia
        Esophageal Glandular Intraepithelial Neoplasia
        Esophageal High Grade Intraepithelial Neoplasia
        Esophageal Squamous Intraepithelial Neoplasia
        Mild esophageal dysplasia
        Esophageal granular cell tumor
        Esophageal Neuroendocrine Neoplasm
        Esophageal neuroendocrine tumor
        Esophageal Soft Tissue Neoplasm
        Esophageal Gastrointestinal Stromal Tumor
        Esophagus sarcoma
        Esophageal squamous papilloma
        Malignant tumor of esophagus
        Esophageal melanoma
        Esophagus lymphoma
        Malignant Esophageal Neoplasm by Anatomic Region
        Malignant Esophageal Neoplasm by Topographic Region
        Metastatic Malignant Neoplasm in the Esophagus
        Neoplasm of neck
        Ectopic Cervical Thymoma
        Jugular Foramen Neoplasm
        Jugular foramen meningioma
        Neoplasm of the larynx
        Glottis neoplasm
        Laryngeal carcinoma
        Laryngeal neuroendocrine neoplasm
        Laryngeal papillomatosis
        Laryngeal Soft Tissue Neoplasm
        Subglottis neoplasm
        Supraglottis neoplasm
        Neoplasm of the pharynx
        Nasopharyngeal neoplasm
        Neoplasm of hypopharynx
        Neoplasm of oropharynx
        Pharyngeal myxoma
        Parapharyngeal Neoplasm
        Primary Parapharyngeal Meningioma
        Retropharyngeal Neoplasm
        Thyroid tumor
        Intrathyroidal Thymoma
        Neoplastic C-Cell Hyperplasia
        Papillary thyroid carcinoma
        Thyroid adenoma
        Thyroid gland atypical follicular adenoma
        Thyroid gland carcinoma
        Thyroid Gland Follicular Tumor of Uncertain Malignant Potential
        Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features
        Thyroid Gland Oncocytic Neoplasm
        Thyroid Gland Paraganglioma
        Thyroid Gland Solitary Fibrous Tumor
        Thyroid Gland Teratoma
        Thyroid hyalinizing trabecular adenoma
        Thyroid lymphoma
        Thyroid nodule
        Tumor of parathyroid gland
        Parathyroid carcinoma
        Parathyroid gland adenoma
        Neoplasm of the ear
        External ear neoplasm
        Ceruminous Neoplasm
        External Ear Actinic Keratosis
        Neoplasm of the inner ear
        Endolymphatic sac tumor
        Neoplasm of the middle ear
        Aggressive Papillary Tumor
        Cholesteatoma
        Middle Ear Paraganglioma
        Primary Middle Ear Meningioma
        Neoplasm of the outer ear
        Basalioma of the outer ear
        Neoplasm of the ceruminal gland
        Neoplasm of the oral cavity
        Buccal mucosa neoplasm
        Epignathus
        Gingival neoplasm
        Neoplasm of floor of mouth
        Neoplasm of the lip
        Neoplasm of the tongue
        Anterior Tongue Neoplasm
        Hamartoma of tongue
        Lipoma of the tongue
        Posterior Tongue Neoplasm
        Squamous cell carcinoma of the tongue
        Odontogenic neoplasm
        Ameloblastoma
        Calcifying Cystic Odontogenic Tumor
        Cementoma
        Odontogenic keratocysts of the jaw
        Odontoma
        Squamous Odontogenic Tumor
        Oral Cavity Granular Cell Tumor
        Oral Cavity Soft Tissue Neoplasm
        Oral Cavity Soft Tissue Sarcoma
        Oral Intraepithelial Neoplasia
        Oral mucosa leukoplakia
        Aneuploid Dysplastic Oral Leukoplakia
        Erythroleukoplakia
        Leukoplakia of gingiva
        Leukoplakia of Lip
        Leukoplakia of Tongue
        Mouth Mucous Membrane Leukoplakia
        Oral hairy leukoplakia
        Proliferative Verrucous Leukoplakia
        Speckled Oral Leukoplakia
        Ulcerated Oral Leukoplakia
        Ossifying fibroma of the jaw
        Palate neoplasm
        Benign Palate Neoplasm
        Palatine myxoma
        Salivary gland neoplasm
        Hybrid Salivary Gland Tumor
        Neoplasm of major salivary gland
        Neoplasm of minor salivary gland
        Parotid adenoma
        Parotid gland neoplasm
        Pleomorphic adenoma
        Salivary basal cell adenoma
        Salivary Gland Myoepithelial Tumor
        Salivary gland oncocytoma
        Sialoblastoma
        Sublingual gland neoplasm
        Submandibular gland neoplasm
        Tonsil neoplasm
        Neoplasm of the pituitary gland
        ACTH-producing pituitary gland adenoma
        Crooke Cell Tumor
        Nelson Syndrome
        Non-Functioning Corticotroph Pituitary Neuroendocrine Tumor
        Anterior Pituitary Gland Neoplasm
        Pituitary blastoma
        Recurrent Anterior Pituitary Gland Neoplasm
        Benign neoplasm of pituitary gland
        Neoplasm of the anterior pituitary
        Pituitary adenoma
        Pituitary carcinoma
        Pituitary spindle cell oncocytoma
        Neoplasm of the posterior pituitary
        Ependymal Pituicytoma
        Neurohypophysis granular cell tumor
        Pituicytoma
        Spindle cell oncocytoma
        Pituitary cancer
        Metastatic Malignant Neoplasm in the Pituitary Gland
        Pituitary Gland Non-Hodgkin Lymphoma
        Prolactin-producing pituitary gland adenoma
        Densely Granulated Lactotroph Pituitary Neuroendocrine Tumor
        Macroprolactinoma
        Microprolactinoma
        Sparsely Granulated Lactotroph Pituitary Neuroendocrine Tumor
        Sellar Paraganglioma
        Somatotroph Pituitary Neuroendocrine Tumor
        Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor
        Sparsely Granulated Somatotroph Pituitary Neuroendocrine Tumor
        Neoplasm of the trachea
        Benign neoplasm of trachea
        Trachea leiomyoma
        Tracheal cancer
        Metastatic Malignant Neoplasm in the Trachea
        Trachea carcinoma
        Trachea sarcoma
        Tracheal lymphoma
        Tracheal papilloma
        Orbit neoplasm
        Intraorbital meningioma
        Periocular meningioma
        Orbit Paraganglioma
        Otorhinolaryngologic Neoplasms
        Acoustic neuroma
        Bilateral vestibular schwannoma
        Neurofibromatosis, type 2
        Unilateral vestibular schwannoma
        Neoplasm of the nose
        Paraganglioma of head and neck
        Carotid body paraganglioma
        Glomus jugular tumor
        Laryngeal Paraganglioma
        Nasopharyngeal Paraganglioma
        Tympanic paraganglioma
        Vagal paraganglioma
        Parotid gland adenocarcinoma
        Parotid gland acinic cell carcinoma
        Recurrent Parotid Gland Acinic Cell Carcinoma
        Skull neoplasm
        Jaw neoplasm
        Maxillary neoplasm
        Neoplasm of mandible
        Maxillofacial Neoplasm
        Skull base neoplasm
        Sella turcica neoplasm
        Skull base meningioma

Professional guidelines

PubMed

Pentoxifylline and tocopherol (vitamin E) with/without clodronate for the management of osteoradionecrosis: A scoping review.

Banjar A, Patel V, Abed H
Oral Dis 2023 Jan;29(1):29-39. Epub 2021 Nov 6 doi: 10.1111/odi.14058. PMID: 34695271

Challenges in diagnosing head and neck cancer in primary health care.

Nieminen M, Aro K, Mäkitie A, Harlin V, Kainulainen S, Jouhi L, Atula T
Ann Med 2021 Dec;53(1):26-33. Epub 2020 Aug 5 doi: 10.1080/07853890.2020.1802060. PMID: 32746635 Free PMC Article

Head and neck teratoma: from diagnosis to treatment.

Kadlub N, Touma J, Leboulanger N, Garel C, Soupre V, L'Herminé AC, Vazquez MP, Picard A
J Craniomaxillofac Surg 2014 Dec;42(8):1598-603. Epub 2014 May 2 doi: 10.1016/j.jcms.2014.04.028. PMID: 24954765

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Recent clinical studies

Etiology

Prognostic role of surgical margins in patients undergoing transoral robotic surgery after neo-adjuvant chemotherapy.

Costantino A, Sampieri C, Pirola F, Kim DH, Lee K, Park YM, De Virgilio A, Kim SH
Eur J Surg Oncol 2023 Jul;49(7):1171-1176. Epub 2023 Mar 15 doi: 10.1016/j.ejso.2023.03.217. PMID: 36997412

Outcome of multidisciplinary treatment in laryngeal cancer. Retrospective study with 10-years follow-up.

Gurrola-Machuca H, Miranda-Aguirre AP, Villavicencio-Quejeiro M, Nuñez-Guardado G, Juárez-Ramiro A
Cir Cir 2020;88(4):461-466. doi: 10.24875/CIRU.19001540. PMID: 32567606

Salvage surgery for recurrent larynx cancer.

Mimica X, Hanson M, Patel SG, McGill M, McBride S, Lee N, Dunn LA, Cracchiolo JR, Shah JP, Wong RJ, Ganly I, Cohen MA
Head Neck 2019 Nov;41(11):3906-3915. Epub 2019 Aug 21 doi: 10.1002/hed.25925. PMID: 31433540 Free PMC Article

Oral cancers: Current status.

D'Cruz AK, Vaish R, Dhar H
Oral Oncol 2018 Dec;87:64-69. Epub 2018 Oct 24 doi: 10.1016/j.oraloncology.2018.10.013. PMID: 30527245

Raman Spectroscopy for Inverted Papilloma: A Proof-of-Concept Study.

Mascarella MA, Alrasheed A, Fnais N, Gourgas O, Jalani G, Cerruti M, Tewfik MA
Otolaryngol Head Neck Surg 2018 Sep;159(3):587-589. Epub 2018 May 15 doi: 10.1177/0194599818776640. PMID: 29763337

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Diagnosis

Prognostic role of surgical margins in patients undergoing transoral robotic surgery after neo-adjuvant chemotherapy.

Costantino A, Sampieri C, Pirola F, Kim DH, Lee K, Park YM, De Virgilio A, Kim SH
Eur J Surg Oncol 2023 Jul;49(7):1171-1176. Epub 2023 Mar 15 doi: 10.1016/j.ejso.2023.03.217. PMID: 36997412

Branchial cleft cyst and branchial cleft cyst carcinoma, or cystic lymph node and cystic nodal metastasis?

Stefanicka P, Profant M
J Laryngol Otol 2023 Jan;137(1):31-36. Epub 2022 Jun 17 doi: 10.1017/S0022215122001293. PMID: 35712979 Free PMC Article

Oral cancers: Current status.

D'Cruz AK, Vaish R, Dhar H
Oral Oncol 2018 Dec;87:64-69. Epub 2018 Oct 24 doi: 10.1016/j.oraloncology.2018.10.013. PMID: 30527245

Raman Spectroscopy for Inverted Papilloma: A Proof-of-Concept Study.

Mascarella MA, Alrasheed A, Fnais N, Gourgas O, Jalani G, Cerruti M, Tewfik MA
Otolaryngol Head Neck Surg 2018 Sep;159(3):587-589. Epub 2018 May 15 doi: 10.1177/0194599818776640. PMID: 29763337

Imaging appearances for recurrent nasopharyngeal carcinoma and post-salvage nasopharyngectomy.

Teo PT, Tan NC, Khoo JB
Clin Radiol 2013 Nov;68(11):e629-38. Epub 2013 Aug 12 doi: 10.1016/j.crad.2013.06.003. PMID: 23937825

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Therapy

Antibiotic prophylaxis in head and neck cancer surgery: Systematic review and Bayesian network meta-analysis.

Iocca O, Copelli C, Ramieri G, Zocchi J, Savo M, Di Maio P
Head Neck 2022 Jan;44(1):254-261. Epub 2021 Nov 6 doi: 10.1002/hed.26908. PMID: 34741354

Head and Neck Cancer Treatments through Chemotherapy to Magnetic Systems: Perspectives and Challenges.

de Lima NRB, de Souza Junior FG, Roullin VG, Pal K, da Silva ND
Curr Radiopharm 2022;15(1):2-20. doi: 10.2174/1874471014999210128183231. PMID: 33511961

Outcome of multidisciplinary treatment in laryngeal cancer. Retrospective study with 10-years follow-up.

Gurrola-Machuca H, Miranda-Aguirre AP, Villavicencio-Quejeiro M, Nuñez-Guardado G, Juárez-Ramiro A
Cir Cir 2020;88(4):461-466. doi: 10.24875/CIRU.19001540. PMID: 32567606

Oral cancers: Current status.

D'Cruz AK, Vaish R, Dhar H
Oral Oncol 2018 Dec;87:64-69. Epub 2018 Oct 24 doi: 10.1016/j.oraloncology.2018.10.013. PMID: 30527245

Intra-abdominal spilled gallstones simulating peritoneal metastasis: CT and MR imaging features (2008: 1b).

Karabulut N, Tavasli B, Kiroğlu Y
Eur Radiol 2008 Apr;18(4):851-4. Epub 2008 Mar 20 doi: 10.1007/s00330-007-0703-1. PMID: 18351358

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Prognosis

Antibiotic prophylaxis in head and neck cancer surgery: Systematic review and Bayesian network meta-analysis.

Iocca O, Copelli C, Ramieri G, Zocchi J, Savo M, Di Maio P
Head Neck 2022 Jan;44(1):254-261. Epub 2021 Nov 6 doi: 10.1002/hed.26908. PMID: 34741354

Outcome of multidisciplinary treatment in laryngeal cancer. Retrospective study with 10-years follow-up.

Gurrola-Machuca H, Miranda-Aguirre AP, Villavicencio-Quejeiro M, Nuñez-Guardado G, Juárez-Ramiro A
Cir Cir 2020;88(4):461-466. doi: 10.24875/CIRU.19001540. PMID: 32567606

Salvage surgery for recurrent larynx cancer.

Sex disparities in salivary malignancies: Does female sex impact oncological outcome?

Mimica X, McGill M, Hay A, Zanoni DK, Shah JP, Wong RJ, Ho AL, Cohen MA, Patel SG, Ganly I
Oral Oncol 2019 Jul;94:86-92. Epub 2019 May 22 doi: 10.1016/j.oraloncology.2019.05.017. PMID: 31178218 Free PMC Article

Cardiac metastasis after squamous cell carcinoma of the base of tongue.

Hans S, Chauvet D, Sadoughi B, Brasnu DF
Am J Otolaryngol 2009 May-Jun;30(3):206-8. Epub 2008 Oct 1 doi: 10.1016/j.amjoto.2008.03.008. PMID: 19410127

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Clinical prediction guides

Transoral versus transfacial surgical approach to maxillary tumors: evaluation of outcomes and perspectives.

Pucci R, Cassoni A, Weyh A, Mangini N, Della Monaca M, Battisti A, Fernandes R, Valentini V
Int J Oral Maxillofac Surg 2024 Feb;53(2):101-108. Epub 2023 Jun 2 doi: 10.1016/j.ijom.2023.05.006. PMID: 37271627

Prognostic role of surgical margins in patients undergoing transoral robotic surgery after neo-adjuvant chemotherapy.

Costantino A, Sampieri C, Pirola F, Kim DH, Lee K, Park YM, De Virgilio A, Kim SH
Eur J Surg Oncol 2023 Jul;49(7):1171-1176. Epub 2023 Mar 15 doi: 10.1016/j.ejso.2023.03.217. PMID: 36997412

Salvage surgery for recurrent larynx cancer.

Papillary carcinoma arising in a submental-intralingual thyroglossal duct cyst.

Mesolella M, Ricciardiello F, Cavaliere M, Iengo M, Galli V, Galli J
Acta Otorhinolaryngol Ital 2010 Dec;30(6):313-6. PMID: 21808454 Free PMC Article

Cervical metastases from pulmonary epidermoid carcinoma.

Maremonti P, Zupi A, Buono U, Califano L
Acta Stomatol Belg 1997 Mar;94(1):29-31. PMID: 9923108

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Recent systematic reviews

The accuracy of Fiber-Optic Raman Spectroscopy in the detection and diagnosis of head and neck neoplasm in vivo: a systematic review and meta-analysis.

Chen W, Chen Y, Wu C, Zhang X, Huang X
PeerJ 2023;11:e16536. Epub 2023 Dec 11 doi: 10.7717/peerj.16536. PMID: 38099303 Free PMC Article

Antibiotic prophylaxis in head and neck cancer surgery: Systematic review and Bayesian network meta-analysis.

Iocca O, Copelli C, Ramieri G, Zocchi J, Savo M, Di Maio P
Head Neck 2022 Jan;44(1):254-261. Epub 2021 Nov 6 doi: 10.1002/hed.26908. PMID: 34741354

Multimodal Analgesia in Head and Neck Free Flap Reconstruction: A Systematic Review.

Go BC, Go CC, Chorath K, Moreira A, Rajasekaran K
Otolaryngol Head Neck Surg 2022 May;166(5):820-831. Epub 2021 Aug 10 doi: 10.1177/01945998211032910. PMID: 34372726

Immunonutrition in head and neck cancer: Systematic review and metanalysis of its clinical and nutritional effects.

Lyra MMF, Meira JEC, Guedes GDS, Bueno NB
Clin Nutr ESPEN 2021 Feb;41:30-41. Epub 2021 Jan 11 doi: 10.1016/j.clnesp.2020.12.014. PMID: 33487281

E-cigarettes and head and neck cancers: A systematic review of the current literature.

Flach S, Maniam P, Manickavasagam J
Clin Otolaryngol 2019 Sep;44(5):749-756. Epub 2019 Jul 23 doi: 10.1111/coa.13384. PMID: 31148389

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Head and neck neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

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