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Benign neoplasm of esophagus

MedGen UID:
102297
•Concept ID:
C0153942
•
Neoplastic Process
Synonyms: Benign Esophageal Neoplasm; benign esophageal neoplasm; Benign Esophageal Tumor; benign esophageal tumor; benign esophageal tumour; Benign Esophagus Neoplasm; benign esophagus neoplasm; Benign Esophagus Tumor; benign esophagus tumor; Benign Neoplasm of Esophagus; benign neoplasm of esophagus; Benign Neoplasm of the Esophagus; benign neoplasm of the esophagus; benign neoplasm of the oesophagus; benign oesophagus neoplasm; benign oesophagus tumour; Benign tumor of esophagus; Benign Tumor of Esophagus; benign tumor of esophagus; Benign Tumor of the Esophagus; benign tumor of the esophagus; benign tumour of oesophagus; benign tumour of the oesophagus; esophagus benign neoplasm; oesophagus benign neoplasm
SNOMED CT: Benign tumor of esophagus (92091003); Benign neoplasm of esophagus (92091003)
 
Monarch Initiative: MONDO:0021459

Definition

A neoplasm that arises from the esophageal wall and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.
Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Recent progress in multidisciplinary treatment for patients with esophageal cancer.
Watanabe M, Otake R, Kozuki R, Toihata T, Takahashi K, Okamura A, Imamura Y
Surg Today 2020 Jan;50(1):12-20. Epub 2019 Sep 18 doi: 10.1007/s00595-019-01878-7. PMID: 31535225Free PMC Article
Expert Consensus Contouring Guidelines for Intensity Modulated Radiation Therapy in Esophageal and Gastroesophageal Junction Cancer.
Wu AJ, Bosch WR, Chang DT, Hong TS, Jabbour SK, Kleinberg LR, Mamon HJ, Thomas CR Jr, Goodman KA
Int J Radiat Oncol Biol Phys 2015 Jul 15;92(4):911-20. Epub 2015 Apr 2 doi: 10.1016/j.ijrobp.2015.03.030. PMID: 26104943Free PMC Article

Recent clinical studies

Therapy

MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer.
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability-High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Clinical Trials.
Chao J, Fuchs CS, Shitara K, Tabernero J, Muro K, Van Cutsem E, Bang YJ, De Vita F, Landers G, Yen CJ, Chau I, Elme A, Lee J, Özgüroglu M, Catenacci D, Yoon HH, Chen E, Adelberg D, Shih CS, Shah S, Bhagia P, Wainberg ZA
JAMA Oncol 2021 Jun 1;7(6):895-902. doi: 10.1001/jamaoncol.2021.0275. PMID: 33792646Free PMC Article
Recent progress in multidisciplinary treatment for patients with esophageal cancer.
Watanabe M, Otake R, Kozuki R, Toihata T, Takahashi K, Okamura A, Imamura Y
Surg Today 2020 Jan;50(1):12-20. Epub 2019 Sep 18 doi: 10.1007/s00595-019-01878-7. PMID: 31535225Free PMC Article
Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial.
Shapiro J, van Lanschot JJB, Hulshof MCCM, van Hagen P, van Berge Henegouwen MI, Wijnhoven BPL, van Laarhoven HWM, Nieuwenhuijzen GAP, Hospers GAP, Bonenkamp JJ, Cuesta MA, Blaisse RJB, Busch ORC, Ten Kate FJW, Creemers GM, Punt CJA, Plukker JTM, Verheul HMW, Bilgen EJS, van Dekken H, van der Sangen MJC, Rozema T, Biermann K, Beukema JC, Piet AHM, van Rij CM, Reinders JG, Tilanus HW, Steyerberg EW, van der Gaast A; CROSS study group
Lancet Oncol 2015 Sep;16(9):1090-1098. Epub 2015 Aug 5 doi: 10.1016/S1470-2045(15)00040-6. PMID: 26254683
Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer.
Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, Yamanaka T, Bozonnat MC, Uitterhoeve A, Wang X, Stewart L, Arriagada R, Burdett S, Pignon JP
J Clin Oncol 2010 May 1;28(13):2181-90. Epub 2010 Mar 29 doi: 10.1200/JCO.2009.26.2543. PMID: 20351327

Prognosis

Bronchoesophageal Fistula.
di Mauro P, Ferrari V
N Engl J Med 2020 Dec 17;383(25):e137. doi: 10.1056/NEJMicm2018535. PMID: 33326718
Neoplastic and pre-neoplastic lesions of the oesophagus and gastro-oesophageal junction.
Grillo F, Mastracci L, Saragoni L, Vanoli A, Limarzi F, Gullo I, Ferro J, Paudice M, Parente P, Fassan M
Pathologica 2020 Sep;112(3):138-152. doi: 10.32074/1591-951X-164. PMID: 33179618Free PMC Article
The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus.
Bleaney CW, Barrow M, Hayes S, Ang Y
J Clin Pathol 2018 Mar;71(3):201-206. Epub 2017 Dec 6 doi: 10.1136/jclinpath-2017-204863. PMID: 29212656
Barrett's oesophagus: Current controversies.
Amadi C, Gatenby P
World J Gastroenterol 2017 Jul 28;23(28):5051-5067. doi: 10.3748/wjg.v23.i28.5051. PMID: 28811703Free PMC Article
Examination of Surgical Specimens of the Esophagus.
Bejarano PA, Berho M
Arch Pathol Lab Med 2015 Nov;139(11):1446-54. doi: 10.5858/arpa.2014-0506-RA. PMID: 26516942

Clinical prediction guides

The Tissue Systems Pathology Test Outperforms Pathology Review in Risk Stratifying Patients With Low-Grade Dysplasia.
Khoshiwal AM, Frei NF, Pouw RE; TissueCypher SURF LGD Study Pathologists Consortium, Smolko C, Arora M, Siegel JJ, Duits LC, Critchley-Thorne RJ, Bergman JJGHM
Gastroenterology 2023 Nov;165(5):1168-1179.e6. Epub 2023 Aug 30 doi: 10.1053/j.gastro.2023.07.029. PMID: 37657759
What Makes an Expert Barrett's Histopathologist?
van der Wel MJ, Jansen M, Vieth M, Meijer SL
Adv Exp Med Biol 2016;908:137-59. doi: 10.1007/978-3-319-41388-4_8. PMID: 27573771
Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.
Naini BV, Souza RF, Odze RD
Am J Surg Pathol 2016 May;40(5):e45-66. doi: 10.1097/PAS.0000000000000598. PMID: 26813745Free PMC Article
Capsule endoscopy--not just for the small bowel: a review.
Parker CE, Spada C, McAlindon M, Davison C, Panter S
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):79-89. Epub 2014 Dec 8 doi: 10.1586/17474124.2014.934357. PMID: 25484107
Endocytoscopy in esophageal cancer.
Tomizawa Y, Abdulla HM, Prasad GA, Wong Kee Song LM, Lutzke LS, Borkenhagen LS, Wang KK
Gastrointest Endosc Clin N Am 2009 Apr;19(2):273-81. doi: 10.1016/j.giec.2009.02.006. PMID: 19423024Free PMC Article

Recent systematic reviews

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
EBioMedicine 2022 Aug;82:104154. Epub 2022 Jul 8 doi: 10.1016/j.ebiom.2022.104154. PMID: 35816897Free PMC Article
Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality.
Kerr AJ, Dodwell D, McGale P, Holt F, Duane F, Mannu G, Darby SC, Taylor CW
Cancer Treat Rev 2022 Apr;105:102375. Epub 2022 Mar 4 doi: 10.1016/j.ctrv.2022.102375. PMID: 35367784Free PMC Article
Work stress and the risk of cancer: A meta-analysis of observational studies.
Yang T, Qiao Y, Xiang S, Li W, Gan Y, Chen Y
Int J Cancer 2019 May 15;144(10):2390-2400. Epub 2018 Dec 8 doi: 10.1002/ijc.31955. PMID: 30484859

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