U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neoplasm of neck

MedGen UID:
10279
•Concept ID:
C0027533
•
Neoplastic Process
Synonyms: Neck Neoplasm; Neck Neoplasms; Neoplasm, Neck; Neoplasms, Neck
SNOMED CT: Neoplasm of neck (126635000); Tumor of neck (126635000)
 
Monarch Initiative: MONDO:0021351

Definition

A benign or malignant neoplasm that affects the neck region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of neck

Professional guidelines

PubMed

2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management.
Durante C, Hegedüs L, Czarniecka A, Paschke R, Russ G, Schmitt F, Soares P, Solymosi T, Papini E
Eur Thyroid J 2023 Oct 1;12(5) Epub 2023 Aug 14 doi: 10.1530/ETJ-23-0067. PMID: 37358008Free PMC Article
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Oral Cancer.
Wong T, Wiesenfeld D
Aust Dent J 2018 Mar;63 Suppl 1:S91-S99. doi: 10.1111/adj.12594. PMID: 29574808
Overview of the 8th Edition TNM Classification for Head and Neck Cancer.
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375
Essentials of oral cancer.
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Diagnosis

SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Head and Neck Cancer.
Chow LQM
N Engl J Med 2020 Jan 2;382(1):60-72. doi: 10.1056/NEJMra1715715. PMID: 31893516
Oral Cancer.
Wong T, Wiesenfeld D
Aust Dent J 2018 Mar;63 Suppl 1:S91-S99. doi: 10.1111/adj.12594. PMID: 29574808
Overview of the 8th Edition TNM Classification for Head and Neck Cancer.
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Therapy

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Nivolumab vs Pembrolizumab for Treatment of US Patients With Platinum-Refractory Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Network Meta-analysis and Cost-effectiveness Analysis.
Pei R, Shi Y, Lv S, Dai T, Zhang F, Liu S, Wu B
JAMA Netw Open 2021 May 3;4(5):e218065. doi: 10.1001/jamanetworkopen.2021.8065. PMID: 33956130Free PMC Article
Treatment of inoperable elderly head and neck cancer patients.
Guigay J, Le Caer H, Ortholan C, Aupérin A, Michel C, Mertens C
Curr Opin Oncol 2019 May;31(3):152-159. doi: 10.1097/CCO.0000000000000526. PMID: 30985496
Quality of head and neck radiotherapy reporting in randomized controlled trials.
Tseng M, Tan TH, Zheng H, Soon YY, Tey J
Head Neck 2018 Aug;40(8):1854-1860. Epub 2018 Mar 25 doi: 10.1002/hed.25133. PMID: 29575476
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Prognosis

Extranodal Head and Neck Mantle Cell Lymphoma: Characteristics, Treatment, and Survival.
Breen CT, Chao J, Mehra S, Kohli N
Ann Otol Rhinol Laryngol 2022 Apr;131(4):412-419. Epub 2021 Jun 17 doi: 10.1177/00034894211025171. PMID: 34137303
Epidemiological Trends of Head and Neck Cancer: A Population-Based Study.
Guo K, Xiao W, Chen X, Zhao Z, Lin Y, Chen G
Biomed Res Int 2021;2021:1738932. Epub 2021 Jul 14 doi: 10.1155/2021/1738932. PMID: 34337000Free PMC Article
Incidence and survival of head and neck cancer in the Faroe Islands.
Olsen SH, Friborg J, Ellefsen B, Jakobsen KK, Aanæs K
Int J Circumpolar Health 2021 Dec;80(1):1894697. doi: 10.1080/22423982.2021.1894697. PMID: 33719929Free PMC Article
Epidemiology and Demographics of the Head and Neck Cancer Population.
Cohen N, Fedewa S, Chen AY
Oral Maxillofac Surg Clin North Am 2018 Nov;30(4):381-395. Epub 2018 Aug 3 doi: 10.1016/j.coms.2018.06.001. PMID: 30078696
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226

Clinical prediction guides

Overview of the 8th Edition TNM Classification for Head and Neck Cancer.
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375
Response Evaluation in Head and Neck Oncology: Definition and Prediction.
Hoffmann TK, Schuler PJ, Laban S, Grässlin R, Beer M, Beer AJ, Friebe-Hoffmann U, Bullinger L, Möller P, Wiegel T
ORL J Otorhinolaryngol Relat Spec 2017;79(1-2):14-23. Epub 2017 Feb 24 doi: 10.1159/000455726. PMID: 28231577
Morphological and functional imaging of neck paragangliomas.
Guichard JP, Fakhry N, Franc J, Herman P, Righini CA, Taieb D
Eur Ann Otorhinolaryngol Head Neck Dis 2017 Sep;134(4):243-248. Epub 2016 Nov 23 doi: 10.1016/j.anorl.2016.10.003. PMID: 27887852
CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
Brouwer CL, Steenbakkers RJ, Bourhis J, Budach W, Grau C, Grégoire V, van Herk M, Lee A, Maingon P, Nutting C, O'Sullivan B, Porceddu SV, Rosenthal DI, Sijtsema NM, Langendijk JA
Radiother Oncol 2015 Oct;117(1):83-90. Epub 2015 Aug 13 doi: 10.1016/j.radonc.2015.07.041. PMID: 26277855
Management of metastatic neck disease--summary of the 11th Evidence Based Management Day.
O'Hara J, Simo R, McQueen A, Andi K, Lester S, Giddings C, Repanos C, Moor J, Kelly C, Jennings C, Wilson J, Paleri V
Clin Otolaryngol 2014 Feb;39(1):3-5. doi: 10.1111/coa.12218. PMID: 24575924

Recent systematic reviews

Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
A systematic review of validated assessments methods for head and neck lymphedema.
Arends CR, Lindhout JE, van der Molen L, Wilthagen EA, van den Brekel MWM, Stuiver MM
Eur Arch Otorhinolaryngol 2023 Jun;280(6):2653-2661. Epub 2023 Feb 10 doi: 10.1007/s00405-023-07841-0. PMID: 36763153Free PMC Article
Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review.
Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702Free PMC Article
Exercise and Nutrition Interventions in Patients with Head and Neck Cancer during Curative Treatment: A Systematic Review and Meta-Analysis.
Bye A, Sandmael JA, Stene GB, Thorsen L, Balstad TR, Solheim TS, Pripp AH, Oldervoll LM
Nutrients 2020 Oct 22;12(11) doi: 10.3390/nu12113233. PMID: 33105699Free PMC Article
Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis.
Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A
Medicina (Kaunas) 2019 Jan 22;55(2) doi: 10.3390/medicina55020025. PMID: 30678228Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...