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Benign neoplasm of buccal mucosa

MedGen UID:
91046
•Concept ID:
C0345566
•
Neoplastic Process
Synonyms: Benign Buccal Mucosa Neoplasm; benign buccal mucosa neoplasm; Benign Buccal Mucosa Tumor; benign buccal mucosa tumor; benign buccal mucosa tumour; Benign Neoplasm of Buccal Mucosa; benign neoplasm of buccal mucosa; Benign neoplasm of cheek mucosa; Benign Neoplasm of the Buccal Mucosa; benign neoplasm of the buccal mucosa; Benign tumor of buccal mucosa; Benign Tumor of Buccal Mucosa; benign tumor of buccal mucosa; Benign tumor of cheek mucosa; Benign tumor of internal cheek; Benign Tumor of the Buccal Mucosa; benign tumor of the buccal mucosa; benign tumour of buccal mucosa; benign tumour of the buccal mucosa; buccal mucosa benign neoplasm
SNOMED CT: Benign neoplasm of buccal mucosa (92039003); Benign neoplasm of cheek mucosa (92039003); Benign tumor of buccal mucosa (92039003); Benign tumor of cheek mucosa (92039003); Benign tumor of internal cheek (92039003)
 
Monarch Initiative: MONDO:0021524

Definition

A neoplasm that arises from the buccal mucosa and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of buccal mucosa

Professional guidelines

PubMed

Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Pathogenesis and Treatment of Pancreatic Cancer Related Pain.
Lohse I, Brothers SP
Anticancer Res 2020 Apr;40(4):1789-1796. doi: 10.21873/anticanres.14133. PMID: 32234867Free PMC Article
Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048

Recent clinical studies

Etiology

Oral verruciform xanthoma in chronic graft-versus-host disease patients.
Bar O, Elad S, Avni B, Abu-Tair J, Zaharia B, Hanut A, Zadik Y
Support Care Cancer 2021 Jan;29(1):79-84. Epub 2020 Aug 15 doi: 10.1007/s00520-020-05681-w. PMID: 32803727
Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis.
Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M
Int J Environ Res Public Health 2020 Dec 8;17(24) doi: 10.3390/ijerph17249160. PMID: 33302498Free PMC Article
Black and Brown Oro-facial Mucocutaneous Neoplasms.
Natarajan E
Head Neck Pathol 2019 Mar;13(1):56-70. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01008-2. PMID: 30693458Free PMC Article
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Oral mucositis.
Raber-Durlacher JE, Elad S, Barasch A
Oral Oncol 2010 Jun;46(6):452-6. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.03.012. PMID: 20403721

Diagnosis

Synchronous Multifocal Canalicular Adenomas.
Sultan AS, Chang FS, Cooper T, Jessri M
Head Neck Pathol 2021 Sep;15(3):945-949. Epub 2021 Feb 5 doi: 10.1007/s12105-021-01293-w. PMID: 33544378Free PMC Article
Oral verruciform xanthoma in chronic graft-versus-host disease patients.
Bar O, Elad S, Avni B, Abu-Tair J, Zaharia B, Hanut A, Zadik Y
Support Care Cancer 2021 Jan;29(1):79-84. Epub 2020 Aug 15 doi: 10.1007/s00520-020-05681-w. PMID: 32803727
Black and Brown Oro-facial Mucocutaneous Neoplasms.
Natarajan E
Head Neck Pathol 2019 Mar;13(1):56-70. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01008-2. PMID: 30693458Free PMC Article
Multifocal Epithelial Hyperplasia.
Agnew C, Alexander S, Prabhu N
J Dent Child (Chic) 2017 Jan 15;84(1):47-49. PMID: 28387191
Oral compound nevus.
Cardoso LB, Consalaro A, da Silva Santos PS, da Silva Sampieri MB, Tinoco-Araújo JE
Dermatol Online J 2014 Feb 18;20(2) PMID: 24612575

Therapy

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies.
Elad S, Yarom N, Zadik Y, Kuten-Shorrer M, Sonis ST
CA Cancer J Clin 2022 Jan;72(1):57-77. Epub 2021 Oct 29 doi: 10.3322/caac.21704. PMID: 34714553
Oral health-related quality of life in oral cancer patients: systematic review and meta-analysis.
Yuwanati M, Gondivkar S, Sarode SC, Gadbail A, Desai A, Mhaske S, Pathak SK, N Khatib M
Future Oncol 2021 Mar;17(8):979-990. Epub 2021 Feb 5 doi: 10.2217/fon-2020-0881. PMID: 33541115
The Oral Microbiota May Have Influence on Oral Cancer.
Zhang L, Liu Y, Zheng HJ, Zhang CP
Front Cell Infect Microbiol 2019;9:476. Epub 2020 Jan 15 doi: 10.3389/fcimb.2019.00476. PMID: 32010645Free PMC Article
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H
Cancer Discov 2019 Jul;9(7):852-871. Epub 2019 May 3 doi: 10.1158/2159-8290.CD-18-1522. PMID: 31053628
Oral mucositis.
Raber-Durlacher JE, Elad S, Barasch A
Oral Oncol 2010 Jun;46(6):452-6. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.03.012. PMID: 20403721

Prognosis

Carcinosarcoma of buccal mucosa: A case report.
Daljit T, Melgandi W, Ansari FA, Rathi AK, Singh K
J Cancer Res Ther 2023 Apr;19(Supplement):S0. doi: 10.4103/jcrt.jcrt_1536_22. PMID: 37147972
Long term outcomes of Carcinoma Buccal Mucosa treated with High Dose Rate Interstitial Brachytherapy.
Bajwa HK, Singareddy R, Raju AK
Brachytherapy 2022 Mar-Apr;21(2):224-228. Epub 2021 Dec 6 doi: 10.1016/j.brachy.2021.10.004. PMID: 34876359
Comprehensive characterization of pleomorphic adenoma at intraoral unusual sites.
Li Y, Xiao N, Dai Y, Guo S, Zhang Y, Wang D, Cheng J
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jan;133(1):21-27. Epub 2021 May 24 doi: 10.1016/j.oooo.2021.05.006. PMID: 34511341
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Lingua plicata.
Nisa L, Giger R
CMAJ 2012 Mar 6;184(4):E241. Epub 2012 Jan 30 doi: 10.1503/cmaj.111255. PMID: 22291178Free PMC Article

Clinical prediction guides

Occurrence of field cancerization in clinically normal oral mucosa: A systematic review and meta-analysis.
Peralta-Mamani M, Terrero-Pérez Á, Tucunduva RMA, Rubira CMF, Santos PSDS, Honório HM, Rubira-Bullen IRF
Arch Oral Biol 2022 Nov;143:105544. Epub 2022 Sep 14 doi: 10.1016/j.archoralbio.2022.105544. PMID: 36126567
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H
Cancer Discov 2019 Jul;9(7):852-871. Epub 2019 May 3 doi: 10.1158/2159-8290.CD-18-1522. PMID: 31053628
Immunoexpression of SOX-2 in oral leukoplakia.
Luiz ST, Modolo F, Mozzer I, Dos Santos EC, Nagashima S, Camargo Martins AP, de Azevedo MLV, Azevedo Alanis LR, Hardy AMTG, de Moraes RS, Aguiar MCF, Ignácio SA, Jham BC, Noronha L, Johann ACBR
Oral Dis 2018 Nov;24(8):1449-1457. Epub 2018 Jul 18 doi: 10.1111/odi.12922. PMID: 29938872
Clinical application of micronucleus test in exfoliated buccal cells: A systematic review and metanalysis.
Bolognesi C, Bonassi S, Knasmueller S, Fenech M, Bruzzone M, Lando C, Ceppi M
Mutat Res Rev Mutat Res 2015 Oct-Dec;766:20-31. Epub 2015 Aug 5 doi: 10.1016/j.mrrev.2015.07.002. PMID: 26596545
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203

Recent systematic reviews

The use of E-cigarettes as a risk factor for oral potentially malignant disorders and oral cancer: a rapid review of clinical evidence.
Gallagher KP, Vargas PA, Santos-Silva AR
Med Oral Patol Oral Cir Bucal 2024 Jan 1;29(1):e18-e26. doi: 10.4317/medoral.26042. PMID: 37992145Free PMC Article
Benign fibrous histiocytoma of the oral and maxillofacial region: A systematic review.
Kirschnick LB, Schuch LF, Silveira FM, Só BB, Martins MAT, Lopes MA, Vargas PA, Santos-Silva AR, Carrard VC, Vasconcelos ACU, Wagner VP, Martins MD
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Feb;133(2):e43-e56. Epub 2021 Jul 15 doi: 10.1016/j.oooo.2021.07.003. PMID: 34511357
Oral Mucosal Melanoma.
Nisi M, Izzetti R, Gennai S, Pucci A, Lenzi C, Graziani F
J Craniofac Surg 2022 May 1;33(3):830-834. Epub 2021 Jul 30 doi: 10.1097/SCS.0000000000008054. PMID: 34334749
Oral health-related quality of life in oral cancer patients: systematic review and meta-analysis.
Yuwanati M, Gondivkar S, Sarode SC, Gadbail A, Desai A, Mhaske S, Pathak SK, N Khatib M
Future Oncol 2021 Mar;17(8):979-990. Epub 2021 Feb 5 doi: 10.2217/fon-2020-0881. PMID: 33541115
Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.
Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

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