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Head and Neck Langerhans Cell Histiocytosis

MedGen UID:
1756757
•Concept ID:
C5420232
•
Neoplastic Process

Definition

Langerhans cell histiocytosis involving the head and neck. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and Neck Langerhans Cell Histiocytosis

Professional guidelines

PubMed

Primary head and neck Langerhans cell histiocytosis in children.
Buchmann L, Emami A, Wei JL
Otolaryngol Head Neck Surg 2006 Aug;135(2):312-7. doi: 10.1016/j.otohns.2006.03.019. PMID: 16890089

Recent clinical studies

Etiology

Langerhans Cell Histiocytosis of the Head and Neck: Experience at a Rural Tertiary Referral Center.
Schwartz TR, Elliott LA, Fenley H, Ramdas J, Scott Greene J
Ann Otol Rhinol Laryngol 2023 Apr;132(4):431-439. Epub 2022 Jun 3 doi: 10.1177/00034894221098466. PMID: 35656804
Head and Neck Langerhans Cell Histiocytosis in Children.
Xu J, Gilbert JR, Sutton KS, Goudy SL, Abramowicz S
J Oral Maxillofac Surg 2022 Mar;80(3):545-552. Epub 2021 Nov 5 doi: 10.1016/j.joms.2021.10.014. PMID: 34852246
Juvenile xanthogranulomas in Asian children.
Wee LWY, Ling HY, Ho VPY, Foong AYW, Koh MJA
Dermatol Ther 2022 Feb;35(2):e15224. Epub 2021 Dec 4 doi: 10.1111/dth.15224. PMID: 34820973
Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.
Chen T, Ashman PE, Bojrab DI 2nd, Johnson AP, Benson B, Hong RS, Svider PF
Otolaryngol Head Neck Surg 2022 Jan;166(1):48-59. Epub 2021 May 4 doi: 10.1177/01945998211004590. PMID: 33945752
Pediatric maxillary and mandibular tumors.
Trosman SJ, Krakovitz PR
Otolaryngol Clin North Am 2015 Feb;48(1):101-19. doi: 10.1016/j.otc.2014.09.008. PMID: 25442129

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.
Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735Free PMC Article
Head and Neck Langerhans Cell Histiocytosis in Children.
Xu J, Gilbert JR, Sutton KS, Goudy SL, Abramowicz S
J Oral Maxillofac Surg 2022 Mar;80(3):545-552. Epub 2021 Nov 5 doi: 10.1016/j.joms.2021.10.014. PMID: 34852246
Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.
Chen T, Ashman PE, Bojrab DI 2nd, Johnson AP, Benson B, Hong RS, Svider PF
Otolaryngol Head Neck Surg 2022 Jan;166(1):48-59. Epub 2021 May 4 doi: 10.1177/01945998211004590. PMID: 33945752
US of Pediatric Superficial Masses of the Head and Neck.
Bansal AG, Oudsema R, Masseaux JA, Rosenberg HK
Radiographics 2018 Jul-Aug;38(4):1239-1263. doi: 10.1148/rg.2018170165. PMID: 29995618
Pediatric maxillary and mandibular tumors.
Trosman SJ, Krakovitz PR
Otolaryngol Clin North Am 2015 Feb;48(1):101-19. doi: 10.1016/j.otc.2014.09.008. PMID: 25442129

Therapy

Cochlear Implantation After Head and Neck Radiation: A Case Series, Systematic Review, and Meta-analysis.
Ahmad JG, Lovin BD, Lee A, Nader ME, Gidley PW
Otol Neurotol 2024 Apr 1;45(4):352-361. Epub 2024 Feb 15 doi: 10.1097/MAO.0000000000004127. PMID: 38361317Free PMC Article
Langerhans cell sarcoma: a systematic review.
Howard JE, Dwivedi RC, Masterson L, Jani P
Cancer Treat Rev 2015 Apr;41(4):320-31. Epub 2015 Mar 9 doi: 10.1016/j.ctrv.2015.02.011. PMID: 25805533
Head and neck manifestation and prognosis of Langerhans' cell histiocytosis in children.
Nicollas R, Rome A, Belaïch H, Roman S, Volk M, Gentet JC, Michel G, Triglia JM
Int J Pediatr Otorhinolaryngol 2010 Jun;74(6):669-73. Epub 2010 Apr 2 doi: 10.1016/j.ijporl.2010.03.017. PMID: 20363036
Langerhans' cell histiocytosis of the head and neck in children.
Angeli SI, Alcalde J, Hoffman HT, Smith RJ
Ann Otol Rhinol Laryngol 1995 Mar;104(3):173-80. doi: 10.1177/000348949510400301. PMID: 7872599
Histiocytosis X.
Nolph MB, Luikin GA
Otolaryngol Clin North Am 1982 Aug;15(3):635-48. PMID: 6752826

Prognosis

Langerhans cell histiocytosis of the head and neck in the pediatric population in a tertiary center: Clinical presentation, classification and treatment.
García Díaz MP, De Luca Sologaistoa A, De Paula Vernetta C, Moreno MA, Galeano Paniagua LA, Fernández MM, Carceller MA
Int J Pediatr Otorhinolaryngol 2022 Apr;155:111073. Epub 2022 Feb 19 doi: 10.1016/j.ijporl.2022.111073. PMID: 35220158
Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.
Chen T, Ashman PE, Bojrab DI 2nd, Johnson AP, Benson B, Hong RS, Svider PF
Otolaryngol Head Neck Surg 2022 Jan;166(1):48-59. Epub 2021 May 4 doi: 10.1177/01945998211004590. PMID: 33945752
Langerhans cell sarcoma: a systematic review.
Howard JE, Dwivedi RC, Masterson L, Jani P
Cancer Treat Rev 2015 Apr;41(4):320-31. Epub 2015 Mar 9 doi: 10.1016/j.ctrv.2015.02.011. PMID: 25805533
Pediatric maxillary and mandibular tumors.
Trosman SJ, Krakovitz PR
Otolaryngol Clin North Am 2015 Feb;48(1):101-19. doi: 10.1016/j.otc.2014.09.008. PMID: 25442129
Head and neck manifestation and prognosis of Langerhans' cell histiocytosis in children.
Nicollas R, Rome A, Belaïch H, Roman S, Volk M, Gentet JC, Michel G, Triglia JM
Int J Pediatr Otorhinolaryngol 2010 Jun;74(6):669-73. Epub 2010 Apr 2 doi: 10.1016/j.ijporl.2010.03.017. PMID: 20363036

Clinical prediction guides

Cochlear Implantation After Head and Neck Radiation: A Case Series, Systematic Review, and Meta-analysis.
Ahmad JG, Lovin BD, Lee A, Nader ME, Gidley PW
Otol Neurotol 2024 Apr 1;45(4):352-361. Epub 2024 Feb 15 doi: 10.1097/MAO.0000000000004127. PMID: 38361317Free PMC Article
Langerhans cell histiocytosis of the head and neck in the pediatric population in a tertiary center: Clinical presentation, classification and treatment.
García Díaz MP, De Luca Sologaistoa A, De Paula Vernetta C, Moreno MA, Galeano Paniagua LA, Fernández MM, Carceller MA
Int J Pediatr Otorhinolaryngol 2022 Apr;155:111073. Epub 2022 Feb 19 doi: 10.1016/j.ijporl.2022.111073. PMID: 35220158
Clinicopathological and Immunohistochemical Study of Head and Neck Langerhans Cell Histiocytosis from Latin America.
Bedran NR, Carlos R, de Andrade BAB, Bueno APS, Romañach MJ, Milito CB
Head Neck Pathol 2018 Dec;12(4):431-439. Epub 2017 Nov 21 doi: 10.1007/s12105-017-0867-1. PMID: 29164473Free PMC Article
Differentiating Pediatric Rhabdomyosarcoma and Langerhans Cell Histiocytosis of the Temporal Bone by Imaging Appearance.
Chevallier KM, Wiggins RH, Quinn NA, Gurgel RK
AJNR Am J Neuroradiol 2016 Jun;37(6):1185-9. Epub 2016 Feb 11 doi: 10.3174/ajnr.A4676. PMID: 26869468Free PMC Article
Isolated Langerhans Cell Histiocytosis Bone Lesion in Pediatric Patients: Systematic Review and Treatment Algorithm.
Bezdjian A, Alarfaj AA, Varma N, Daniel SJ
Otolaryngol Head Neck Surg 2015 Nov;153(5):751-7. Epub 2015 Aug 4 doi: 10.1177/0194599815598969. PMID: 26243026

Recent systematic reviews

Cochlear Implantation After Head and Neck Radiation: A Case Series, Systematic Review, and Meta-analysis.
Ahmad JG, Lovin BD, Lee A, Nader ME, Gidley PW
Otol Neurotol 2024 Apr 1;45(4):352-361. Epub 2024 Feb 15 doi: 10.1097/MAO.0000000000004127. PMID: 38361317Free PMC Article
Oral juvenile xanthogranuloma: An unusual presentation in an adult patient and a systematic analysis of published cases.
Gioco G, Rupe C, Basco A, Contaldo M, Gallenzi P, Lajolo C
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jan;133(1):42-49. Epub 2021 Oct 8 doi: 10.1016/j.oooo.2021.09.015. PMID: 34736900
Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.
Chen T, Ashman PE, Bojrab DI 2nd, Johnson AP, Benson B, Hong RS, Svider PF
Otolaryngol Head Neck Surg 2022 Jan;166(1):48-59. Epub 2021 May 4 doi: 10.1177/01945998211004590. PMID: 33945752
Isolated Langerhans Cell Histiocytosis Bone Lesion in Pediatric Patients: Systematic Review and Treatment Algorithm.
Bezdjian A, Alarfaj AA, Varma N, Daniel SJ
Otolaryngol Head Neck Surg 2015 Nov;153(5):751-7. Epub 2015 Aug 4 doi: 10.1177/0194599815598969. PMID: 26243026
Langerhans cell sarcoma: a systematic review.
Howard JE, Dwivedi RC, Masterson L, Jani P
Cancer Treat Rev 2015 Apr;41(4):320-31. Epub 2015 Mar 9 doi: 10.1016/j.ctrv.2015.02.011. PMID: 25805533

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