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Nasopharyngeal neoplasm

MedGen UID:
6526
Concept ID:
C0027439
Neoplastic Process
Synonyms: Nasopharyngeal Neoplasms; Neoplasia of the nasopharynx
SNOMED CT: Tumor of nasopharynx (126680004); Tumor of postnasal space (126680004); Neoplasm of nasopharynx (126680004)
 
HPO: HP:0100630
Monarch Initiative: MONDO:0005375

Definition

A benign or malignant neoplasm affecting the nasopharynx. Representative examples of benign neoplasms include angiofibroma and squamous papilloma. Representative examples of malignant neoplasms include keratinizing squamous cell carcinoma and nonkeratinizing carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Nasopharyngeal neoplasm

Conditions with this feature

Nasopharyngeal carcinoma
MedGen UID:
419909
Concept ID:
C2931822
Neoplastic Process
Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated (Tse et al., 2009). Genetic Heterogeneity of Susceptibility to Nasopharyngeal Carcinoma NPCA1 maps to chromosome 4p. NPCA2 (161550) maps to chromosome 6p21. NPCA3 (617075) is associated with variation in the MST1R gene (600168) on chromosome 3p21. Somatic mutations have been found in the TP53 gene (191170) in nasopharyngeal carcinoma tumors.
Nasopharyngeal carcinoma, susceptibility to, 3
MedGen UID:
934696
Concept ID:
C4310729
Finding
Nasopharyngeal carcinoma (NPCA) is a malignant tumor that emerges from the epithelium of the nasopharynx. It has a high incidence in southern China, and evidence suggests that there may be a genetic component that underlies familial clustering. Some patients have onset before 20 years of age (summary by Dai et al., 2016) For a general phenotypic description and a discussion of genetic heterogeneity of susceptibility to nasopharyngeal carcinoma, see NPCA1 (607107).

Professional guidelines

PubMed

Sharma M, Bartlett E, Yu E
Expert Rev Anticancer Ther 2010 Nov;10(11):1703-6. doi: 10.1586/era.10.159. PMID: 21080798

Recent clinical studies

Etiology

Spadarella G, Calareso G, Garanzini E, Ugga L, Cuocolo A, Cuocolo R
Eur J Radiol 2021 Jul;140:109744. Epub 2021 Apr 30 doi: 10.1016/j.ejrad.2021.109744. PMID: 33962253
Wu Z, Wang L, Xie DH, Lv SW, Su Y, Shi YR
Asia Pac J Clin Oncol 2021 Aug;17(4):330-337. Epub 2020 Oct 20 doi: 10.1111/ajco.13475. PMID: 33079493
Lastrucci L, Bertocci S, Bini V, Borghesi S, De Majo R, Rampini A, Pernici P, Gennari PG
Radiol Med 2017 Apr;122(4):303-308. Epub 2017 Jan 9 doi: 10.1007/s11547-016-0722-6. PMID: 28070838
Fangzheng W, Chuner J, Lei W, Weijun C, Min X, Quanquan S, Tongxin L, Aizawa R, Sakamoto M, Zhenfu F
Oncotarget 2017 Jun 13;8(24):39756-39765. doi: 10.18632/oncotarget.14403. PMID: 28055973Free PMC Article
Lu T, Guo Q, Cui X, Chen Z, Lin S, Xu L, Lin J, Zong J, Pan J
Yonsei Med J 2016 Jul;57(4):840-5. doi: 10.3349/ymj.2016.57.4.840. PMID: 27189275Free PMC Article

Diagnosis

Liu Z, Jin C, Zhang Y, Jiang Y, Wang J, Zheng L
World J Surg Oncol 2023 May 24;21(1):158. doi: 10.1186/s12957-023-03036-3. PMID: 37221610Free PMC Article
Shen CH, Chang SL, Chang ST
Medicine (Baltimore) 2021 Nov 5;100(44):e27729. doi: 10.1097/MD.0000000000027729. PMID: 34871272Free PMC Article
Darouassi Y, Aljalil A, Hanine A, Enneouali A, Bouaity B, Touati MM, Ammar H
Pan Afr Med J 2019;33:150. Epub 2019 Jun 27 doi: 10.11604/pamj.2019.33.150.15892. PMID: 31558947Free PMC Article
Fangzheng W, Chuner J, Lei W, Weijun C, Min X, Quanquan S, Tongxin L, Aizawa R, Sakamoto M, Zhenfu F
Oncotarget 2017 Jun 13;8(24):39756-39765. doi: 10.18632/oncotarget.14403. PMID: 28055973Free PMC Article
Burkey B, Koopmann CF, Brunberg J
Int J Pediatr Otorhinolaryngol 1990 Nov;20(2):169-79. doi: 10.1016/0165-5876(90)90083-4. PMID: 1962762

Therapy

Liu Z, Jin C, Zhang Y, Jiang Y, Wang J, Zheng L
World J Surg Oncol 2023 May 24;21(1):158. doi: 10.1186/s12957-023-03036-3. PMID: 37221610Free PMC Article
Wang L, Wu Z, Xie D, Lv S, Xia L, Su Y
Radiat Oncol 2020 Jul 2;15(1):160. doi: 10.1186/s13014-020-01594-4. PMID: 32615984Free PMC Article
Zhai XM, Hu QC, Gu K, Wang JP, Zhang JN, Wu YW
Asia Pac J Clin Oncol 2016 Mar;12(1):e125-32. Epub 2013 Aug 5 doi: 10.1111/ajco.12117. PMID: 23910235
Goh YH, Chong VF, Low WK
J Laryngol Otol 1999 Mar;113(3):222-8. doi: 10.1017/s0022215100143622. PMID: 10435128

Prognosis

Shen CH, Chang SL, Chang ST
Medicine (Baltimore) 2021 Nov 5;100(44):e27729. doi: 10.1097/MD.0000000000027729. PMID: 34871272Free PMC Article
Spadarella G, Calareso G, Garanzini E, Ugga L, Cuocolo A, Cuocolo R
Eur J Radiol 2021 Jul;140:109744. Epub 2021 Apr 30 doi: 10.1016/j.ejrad.2021.109744. PMID: 33962253
Wu Z, Wang L, Xie DH, Lv SW, Su Y, Shi YR
Asia Pac J Clin Oncol 2021 Aug;17(4):330-337. Epub 2020 Oct 20 doi: 10.1111/ajco.13475. PMID: 33079493
Lastrucci L, Bertocci S, Bini V, Borghesi S, De Majo R, Rampini A, Pernici P, Gennari PG
Radiol Med 2017 Apr;122(4):303-308. Epub 2017 Jan 9 doi: 10.1007/s11547-016-0722-6. PMID: 28070838
Lu T, Guo Q, Cui X, Chen Z, Lin S, Xu L, Lin J, Zong J, Pan J
Yonsei Med J 2016 Jul;57(4):840-5. doi: 10.3349/ymj.2016.57.4.840. PMID: 27189275Free PMC Article

Clinical prediction guides

Liu Z, Jin C, Zhang Y, Jiang Y, Wang J, Zheng L
World J Surg Oncol 2023 May 24;21(1):158. doi: 10.1186/s12957-023-03036-3. PMID: 37221610Free PMC Article
Spadarella G, Calareso G, Garanzini E, Ugga L, Cuocolo A, Cuocolo R
Eur J Radiol 2021 Jul;140:109744. Epub 2021 Apr 30 doi: 10.1016/j.ejrad.2021.109744. PMID: 33962253
Wang L, Wu Z, Xie D, Lv S, Xia L, Su Y
Radiat Oncol 2020 Jul 2;15(1):160. doi: 10.1186/s13014-020-01594-4. PMID: 32615984Free PMC Article
Darouassi Y, Aljalil A, Hanine A, Enneouali A, Bouaity B, Touati MM, Ammar H
Pan Afr Med J 2019;33:150. Epub 2019 Jun 27 doi: 10.11604/pamj.2019.33.150.15892. PMID: 31558947Free PMC Article
Lastrucci L, Bertocci S, Bini V, Borghesi S, De Majo R, Rampini A, Pernici P, Gennari PG
Radiol Med 2017 Apr;122(4):303-308. Epub 2017 Jan 9 doi: 10.1007/s11547-016-0722-6. PMID: 28070838

Recent systematic reviews

Spadarella G, Calareso G, Garanzini E, Ugga L, Cuocolo A, Cuocolo R
Eur J Radiol 2021 Jul;140:109744. Epub 2021 Apr 30 doi: 10.1016/j.ejrad.2021.109744. PMID: 33962253

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