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Thyroid Gland Paraganglioma

MedGen UID:
328114
•Concept ID:
C1710416
•
Neoplastic Process

Definition

A rare, circumscribed or encapsulated neuroendocrine tumor arising from the thyroid gland. Microscopically, it is characterized by the presence of tumor cells arranged in a nesting (Zellballen) growth pattern. The reported cases have followed a benign clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Paraganglioma

Professional guidelines

PubMed

Genetic evaluation of patients and families with concern for hereditary endocrine tumor syndromes.
Anderson JL, Pilarski R, Kirschner L, Brock P
Fam Cancer 2022 Jan;21(1):93-100. Epub 2021 Jan 7 doi: 10.1007/s10689-020-00222-0. PMID: 33409929
PET/Computed Tomography in Neuroendocrine Tumor: Value to Patient Management and Survival Outcomes.
Shamim SA, Kumar A, Kumar R
PET Clin 2015 Jul;10(3):411-21. Epub 2015 Apr 14 doi: 10.1016/j.cpet.2015.03.005. PMID: 26099675
Genetics, diagnosis, and management of medullary thyroid carcinoma and pheochromocytoma/paraganglioma.
Moraitis AG, Martucci VL, Pacak K
Endocr Pract 2014 Feb;20(2):176-87. doi: 10.4158/EP13268.RA. PMID: 24449662

Recent clinical studies

Etiology

Updates on the genetics of multiple endocrine neoplasia.
Sahakian N, Castinetti F, Romanet P, Reznik Y, Brue T
Ann Endocrinol (Paris) 2024 Apr;85(2):127-135. Epub 2024 Feb 5 doi: 10.1016/j.ando.2023.11.005. PMID: 38325596
Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations.
Chevalier B, Dupuis H, Jannin A, Lemaitre M, Do Cao C, Cardot-Bauters C, Espiard S, Vantyghem MC
Front Endocrinol (Lausanne) 2021;12:678869. Epub 2021 May 6 doi: 10.3389/fendo.2021.678869. PMID: 34025587Free PMC Article
Endocrine oncology in pregnancy.
Lansdown A, Rees DA
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):911-26. doi: 10.1016/j.beem.2011.06.011. PMID: 22115166
Multiple endocrine neoplasia.
Caruso DR, O'Dorisio TM, Mazzaferri EL
Curr Opin Oncol 1991 Feb;3(1):103-8. doi: 10.1097/00001622-199102000-00015. PMID: 1675123

Diagnosis

Anesthesia for Endocrine Emergencies.
Peramunage D, Nikravan S
Anesthesiol Clin 2020 Mar;38(1):149-163. Epub 2020 Jan 2 doi: 10.1016/j.anclin.2019.10.006. PMID: 32008649
Surgical approaches in hereditary endocrine tumors.
Iacobone M, Citton M, Viel G, Schiavone D, Torresan F
Updates Surg 2017 Jun;69(2):181-191. Epub 2017 Apr 28 doi: 10.1007/s13304-017-0451-y. PMID: 28455835
Genetics, diagnosis, and management of medullary thyroid carcinoma and pheochromocytoma/paraganglioma.
Moraitis AG, Martucci VL, Pacak K
Endocr Pract 2014 Feb;20(2):176-87. doi: 10.4158/EP13268.RA. PMID: 24449662
Multiple endocrine neoplasia.
Caruso DR, O'Dorisio TM, Mazzaferri EL
Curr Opin Oncol 1991 Feb;3(1):103-8. doi: 10.1097/00001622-199102000-00015. PMID: 1675123
Neurofibromatosis update.
Riccardi VM
Neurofibromatosis 1989;2(5-6):284-91. PMID: 2518510

Therapy

Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Histone deacetylase inhibitors as a novel therapeutic approach for pheochromocytomas and paragangliomas.
Manta A, Kazanas S, Karamaroudis S, Gogas H, Ziogas DC
Oncol Res 2022;30(5):211-219. Epub 2023 Feb 3 doi: 10.32604/or.2022.026913. PMID: 37305348Free PMC Article
The role of an anti-diabetic drug metformin in the treatment of endocrine tumors.
Thakur S, Daley B, Klubo-Gwiezdzinska J
J Mol Endocrinol 2019 Aug;63(2):R17-R35. doi: 10.1530/JME-19-0083. PMID: 31307011Free PMC Article
Endocrine oncology in pregnancy.
Lansdown A, Rees DA
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):911-26. doi: 10.1016/j.beem.2011.06.011. PMID: 22115166
Multidirectional differentiation in neuroendocrine neoplasms.
DeLellis RA, Tischler AS, Wolfe HJ
J Histochem Cytochem 1984 Aug;32(8):899-904. doi: 10.1177/32.8.6146648. PMID: 6146648

Prognosis

Updates on the genetics of multiple endocrine neoplasia.
Sahakian N, Castinetti F, Romanet P, Reznik Y, Brue T
Ann Endocrinol (Paris) 2024 Apr;85(2):127-135. Epub 2024 Feb 5 doi: 10.1016/j.ando.2023.11.005. PMID: 38325596
Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations.
Chevalier B, Dupuis H, Jannin A, Lemaitre M, Do Cao C, Cardot-Bauters C, Espiard S, Vantyghem MC
Front Endocrinol (Lausanne) 2021;12:678869. Epub 2021 May 6 doi: 10.3389/fendo.2021.678869. PMID: 34025587Free PMC Article
Applications of Immunohistochemistry to Endocrine Pathology.
Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042
Endocrine oncology in pregnancy.
Lansdown A, Rees DA
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):911-26. doi: 10.1016/j.beem.2011.06.011. PMID: 22115166

Clinical prediction guides

Updates on the genetics of multiple endocrine neoplasia.
Sahakian N, Castinetti F, Romanet P, Reznik Y, Brue T
Ann Endocrinol (Paris) 2024 Apr;85(2):127-135. Epub 2024 Feb 5 doi: 10.1016/j.ando.2023.11.005. PMID: 38325596
Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Applications of Immunohistochemistry to Endocrine Pathology.
Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042
Multidirectional differentiation in neuroendocrine neoplasms.
DeLellis RA, Tischler AS, Wolfe HJ
J Histochem Cytochem 1984 Aug;32(8):899-904. doi: 10.1177/32.8.6146648. PMID: 6146648

Recent systematic reviews

Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article
Thyroid paraganglioma: A case-based systematic review of literature.
Mishra P, Padhi S, Behera G
J Cancer Res Ther 2020 Dec;16(Supplement):S11-S21. doi: 10.4103/jcrt.JCRT_713_18. PMID: 33380646
Ki67 in endocrine neoplasms: to count or not to count, this is the question! A systematic review from the English language literature.
Guadagno E, D'Avella E, Cappabianca P, Colao A, Del Basso De Caro M
J Endocrinol Invest 2020 Oct;43(10):1429-1445. Epub 2020 May 15 doi: 10.1007/s40618-020-01275-9. PMID: 32415572
Thyroid Paraganglioma: Our Experience and Systematic Review of the Literature on a Rare Tumor.
Pelizzo MR, Conti C, Pennelli G, Bellan E, Cook GJ, Wong KK, Colletti PM, Merante Boschin I, Rubello D
Am J Clin Oncol 2018 Apr;41(4):416-423. doi: 10.1097/COC.0000000000000295. PMID: 27163832
Efficacy and Safety of Everolimus in Extrapancreatic Neuroendocrine Tumor: A Comprehensive Review of Literature.
Faggiano A, Malandrino P, Modica R, Agrimi D, Aversano M, Bassi V, Giordano EA, Guarnotta V, Logoluso FA, Messina E, Nicastro V, Nuzzo V, Sciaraffia M, Colao A
Oncologist 2016 Jul;21(7):875-86. Epub 2016 Apr 6 doi: 10.1634/theoncologist.2015-0420. PMID: 27053503Free PMC Article

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