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Benign thyroid gland neoplasm

MedGen UID:
102306
•Concept ID:
C0154038
•
Neoplastic Process
Synonyms: Benign Neoplasm of the Thyroid; benign neoplasm of the thyroid; Benign Neoplasm of the Thyroid Gland; benign neoplasm of the thyroid gland; Benign Neoplasm of Thyroid; benign neoplasm of thyroid; Benign neoplasm of thyroid gland; Benign Neoplasm of Thyroid Gland; benign neoplasm of thyroid gland; Benign Neoplasm of Thyroid Glands; benign neoplasm of thyroid glands; Benign Thyroid Gland Neoplasm; benign thyroid gland neoplasm; Benign Thyroid Gland Tumor; benign thyroid gland tumor; benign thyroid gland tumour; Benign Thyroid Neoplasm; benign thyroid neoplasm; Benign Thyroid Neoplasm NOS; Benign Thyroid Tumor; benign thyroid tumor; benign thyroid tumour; Benign Tumor of the Thyroid; benign tumor of the thyroid; Benign Tumor of the Thyroid Gland; benign tumor of the thyroid gland; Benign Tumor of Thyroid; benign tumor of thyroid; Benign tumor of thyroid gland; Benign Tumor of Thyroid Gland; benign tumor of thyroid gland; benign tumour of the thyroid; benign tumour of the thyroid gland; benign tumour of thyroid; benign tumour of thyroid gland; thyroid gland benign neoplasm; Thyroid Neoplasm, Benign; thyroid neoplasm, benign
SNOMED CT: Benign tumor of thyroid gland (92439006); Benign neoplasm of thyroid gland (92439006)
 
Monarch Initiative: MONDO:0006107

Definition

A neoplasm that arises from the thyroid gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management.
Durante C, Hegedüs L, Czarniecka A, Paschke R, Russ G, Schmitt F, Soares P, Solymosi T, Papini E
Eur Thyroid J 2023 Oct 1;12(5) Epub 2023 Aug 14 doi: 10.1530/ETJ-23-0067. PMID: 37358008Free PMC Article
Contemporary Thyroid Nodule Evaluation and Management.
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent clinical studies

Etiology

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Contemporary Management of Thyroid Nodules.
Kobaly K, Kim CS, Mandel SJ
Annu Rev Med 2022 Jan 27;73:517-528. Epub 2021 Aug 20 doi: 10.1146/annurev-med-042220-015032. PMID: 34416120
Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid Nodules. The Future Is Now.
Tufano RP, Pace-Asciak P, Russell JO, Suárez C, Randolph GW, López F, Shaha AR, Mäkitie A, Rodrigo JP, Kowalski LP, Zafereo M, Angelos P, Ferlito A
Front Endocrinol (Lausanne) 2021;12:698689. Epub 2021 Jun 24 doi: 10.3389/fendo.2021.698689. PMID: 34248853Free PMC Article
Thyroid nodules.
Popoveniuc G, Jonklaas J
Med Clin North Am 2012 Mar;96(2):329-49. doi: 10.1016/j.mcna.2012.02.002. PMID: 22443979Free PMC Article

Diagnosis

ThyroidPrint®: clinical utility for indeterminate thyroid cytology.
Olmos R, Domínguez JM, Vargas-Salas S, Mosso L, Fardella CE, González G, Baudrand R, Guarda F, Valenzuela F, Arteaga E, Forenzano P, Nilo F, Lustig N, Martínez A, López JM, Cruz F, Loyola S, Leon A, Droppelmann N, Montero P, Domínguez F, Camus M, Solar A, Zoroquiain P, Roa JC, Muñoz E, Bruce E, Gajardo R, Miranda G, Riquelme F, Mena N, González HE
Endocr Relat Cancer 2023 Nov 1;30(11) Epub 2023 Oct 6 doi: 10.1530/ERC-22-0409. PMID: 37671897Free PMC Article
The Future of Thyroid Nodule Risk Stratification.
Burgos N, Ospina NS, Sipos JA
Endocrinol Metab Clin North Am 2022 Jun;51(2):305-321. Epub 2022 May 4 doi: 10.1016/j.ecl.2021.12.002. PMID: 35662443Free PMC Article
Disparities in Thyroid Care.
Chen DW, Yeh MW
Endocrinol Metab Clin North Am 2022 Jun;51(2):229-241. Epub 2022 May 4 doi: 10.1016/j.ecl.2021.11.017. PMID: 35662439Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Thyroid nodules.
Popoveniuc G, Jonklaas J
Med Clin North Am 2012 Mar;96(2):329-49. doi: 10.1016/j.mcna.2012.02.002. PMID: 22443979Free PMC Article

Therapy

Radiofrequency ablation and thyroid nodules: updated systematic review.
Muhammad H, Santhanam P, Russell JO
Endocrine 2021 Jun;72(3):619-632. Epub 2021 Jan 15 doi: 10.1007/s12020-020-02598-6. PMID: 33449296
Effectiveness of Molecular Testing Techniques for Diagnosis of Indeterminate Thyroid Nodules: A Randomized Clinical Trial.
Livhits MJ, Zhu CY, Kuo EJ, Nguyen DT, Kim J, Tseng CH, Leung AM, Rao J, Levin M, Douek ML, Beckett KR, Cheung DS, Gofnung YA, Smooke-Praw S, Yeh MW
JAMA Oncol 2021 Jan 1;7(1):70-77. doi: 10.1001/jamaoncol.2020.5935. PMID: 33300952Free PMC Article
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM
Thyroid 2009 Nov;19(11):1167-214. doi: 10.1089/thy.2009.0110. PMID: 19860577
Thyroid nodules.
Welker MJ, Orlov D
Am Fam Physician 2003 Feb 1;67(3):559-66. PMID: 12588078
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Prognosis

Ultrasound Follow-Up of Benign Thyroid Nodules: A Scoping Review.
Chou R, Dana T, Mayson SE, Cibas ES, Durante C, Solórzano CC, Mandel SJ, Orloff LA
Thyroid 2023 Apr;33(4):420-427. Epub 2023 Mar 17 doi: 10.1089/thy.2022.0692. PMID: 36800900
The role of heavy metals in thyroid cancer: A meta-analysis.
van Gerwen M, Alerte E, Alsen M, Little C, Sinclair C, Genden E
J Trace Elem Med Biol 2022 Jan;69:126900. Epub 2021 Nov 12 doi: 10.1016/j.jtemb.2021.126900. PMID: 34798515
Computed Tomography and MR Imaging of Thyroid Disease.
Traylor KS
Radiol Clin North Am 2020 Nov;58(6):1059-1070. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.004. PMID: 33040848
Ultrasound of Thyroid Nodules.
Bojunga J
Ultraschall Med 2018 Oct;39(5):488-511. Epub 2018 Sep 3 doi: 10.1055/a-0659-2350. PMID: 30176696
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article

Clinical prediction guides

Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study.
Steward DL, Carty SE, Sippel RS, Yang SP, Sosa JA, Sipos JA, Figge JJ, Mandel S, Haugen BR, Burman KD, Baloch ZW, Lloyd RV, Seethala RR, Gooding WE, Chiosea SI, Gomes-Lima C, Ferris RL, Folek JM, Khawaja RA, Kundra P, Loh KS, Marshall CB, Mayson S, McCoy KL, Nga ME, Ngiam KY, Nikiforova MN, Poehls JL, Ringel MD, Yang H, Yip L, Nikiforov YE
JAMA Oncol 2019 Feb 1;5(2):204-212. doi: 10.1001/jamaoncol.2018.4616. PMID: 30419129Free PMC Article
Ultrasound of Thyroid Nodules.
Bojunga J
Ultraschall Med 2018 Oct;39(5):488-511. Epub 2018 Sep 3 doi: 10.1055/a-0659-2350. PMID: 30176696
The 2017 Bethesda System for Reporting Thyroid Cytopathology.
Cibas ES, Ali SZ
Thyroid 2017 Nov;27(11):1341-1346. doi: 10.1089/thy.2017.0500. PMID: 29091573
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent systematic reviews

Liquid biopsies in thyroid cancers: a systematic review and meta-analysis.
Zeyghami W, Hansen MU, Jakobsen KK, Groenhøj C, Feldt-Rasmussen U, von Buchwald C, Hahn CH
Endocr Relat Cancer 2023 Dec 1;30(12) Epub 2023 Oct 26 doi: 10.1530/ERC-23-0002. PMID: 37882489
Facelift thyroid surgery: a systematic review of indications, surgical and functional outcomes.
Lechien JR, Fisichella PM, Dapri G, Russell JO, Hans S
J Otolaryngol Head Neck Surg 2023 Apr 10;52(1):25. doi: 10.1186/s40463-023-00624-x. PMID: 37038204Free PMC Article
Radiofrequency ablation and thyroid nodules: updated systematic review.
Muhammad H, Santhanam P, Russell JO
Endocrine 2021 Jun;72(3):619-632. Epub 2021 Jan 15 doi: 10.1007/s12020-020-02598-6. PMID: 33449296
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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