U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Proliferative Verrucous Leukoplakia

MedGen UID:
785040
•Concept ID:
C3697776
•
Neoplastic Process
Synonyms: Papillary Leukoplakia; Proliferative verrucous leukoplakia; Proliferative verrucous oral leukoplakia; Verrucous Oral Leukoplakia
SNOMED CT: Proliferative verrucous leukoplakia (698010001); Proliferative verrucous oral leukoplakia (698010001)

Definition

Warty leukoplakia on the oral mucosa. It is associated with a high risk for malignant transformation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferative Verrucous Leukoplakia

Professional guidelines

PubMed

Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting.
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Proliferative verrucous leukoplakia: diagnosis, management and current advances.
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article

Recent clinical studies

Etiology

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting.
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Diagnosis

Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting.
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Proliferative verrucous leukoplakia: diagnosis, management and current advances.
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article

Therapy

Laser-assisted photodynamic therapy in proliferative verrucous oral leukoplakia.
Yan Y, Li Z, Tian X, Zeng X, Chen Q, Wang J
Photodiagnosis Photodyn Ther 2022 Sep;39:103002. Epub 2022 Jul 6 doi: 10.1016/j.pdpdt.2022.103002. PMID: 35809828
Malignant development of proliferative verrucous/multifocal leukoplakia: A critical systematic review, meta-analysis and proposal of diagnostic criteria.
Lafuente Ibáñez de Mendoza I, Lorenzo Pouso AI, Aguirre Urízar JM, Barba Montero C, Blanco Carrión A, Gándara Vila P, Pérez Sayáns M
J Oral Pathol Med 2022 Jan;51(1):30-38. Epub 2021 Oct 13 doi: 10.1111/jop.13246. PMID: 34558734
Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta-analysis.
Ramos-García P, González-Moles MÁ, Mello FW, Bagan JV, Warnakulasuriya S
Oral Dis 2021 Nov;27(8):1896-1907. Epub 2021 May 19 doi: 10.1111/odi.13831. PMID: 34009718
Recurrences following treatment of proliferative verrucous leukoplakia: A systematic review and meta-analysis.
Proaño-Haro A, Bagan L, Bagan JV
J Oral Pathol Med 2021 Sep;50(8):820-828. Epub 2021 Apr 13 doi: 10.1111/jop.13178. PMID: 33765364
Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature.
Cabay RJ, Morton TH Jr, Epstein JB
J Oral Pathol Med 2007 May;36(5):255-61. doi: 10.1111/j.1600-0714.2007.00506.x. PMID: 17448134

Prognosis

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta-analysis.
Ramos-García P, González-Moles MÁ, Mello FW, Bagan JV, Warnakulasuriya S
Oral Dis 2021 Nov;27(8):1896-1907. Epub 2021 May 19 doi: 10.1111/odi.13831. PMID: 34009718
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Proliferative verrucous leukoplakia: An update.
Munde A, Karle R
J Cancer Res Ther 2016 Apr-Jun;12(2):469-73. doi: 10.4103/0973-1482.151443. PMID: 27461595

Clinical prediction guides

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting.
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Proliferative verrucous leukoplakia: An update.
Munde A, Karle R
J Cancer Res Ther 2016 Apr-Jun;12(2):469-73. doi: 10.4103/0973-1482.151443. PMID: 27461595
Proliferative verrucous leukoplakia: recognition and differentiation from conventional leukoplakia and mimics.
Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK
Head Neck 2014 Nov;36(11):1662-8. Epub 2014 Aug 28 doi: 10.1002/hed.23505. PMID: 24115154

Recent systematic reviews

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta-analysis.
Ramos-García P, González-Moles MÁ, Mello FW, Bagan JV, Warnakulasuriya S
Oral Dis 2021 Nov;27(8):1896-1907. Epub 2021 May 19 doi: 10.1111/odi.13831. PMID: 34009718
Recurrences following treatment of proliferative verrucous leukoplakia: A systematic review and meta-analysis.
Proaño-Haro A, Bagan L, Bagan JV
J Oral Pathol Med 2021 Sep;50(8):820-828. Epub 2021 Apr 13 doi: 10.1111/jop.13178. PMID: 33765364
Clinical manifestations of oral proliferative verrucous leukoplakia: A systematic review.
Torrejon-Moya A, Jané-Salas E, López-López J
J Oral Pathol Med 2020 May;49(5):404-408. Epub 2020 Feb 9 doi: 10.1111/jop.12999. PMID: 31990082
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta-analysis.
Rintala M, Vahlberg T, Salo T, Rautava J
Head Neck 2019 May;41(5):1499-1507. Epub 2018 Dec 11 doi: 10.1002/hed.25569. PMID: 30536498

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...