U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Esophageal Glandular Intraepithelial Neoplasia

MedGen UID:
272587
•Concept ID:
C1333447
•
Neoplastic Process
Synonym: Esophageal Glandular Dysplasia

Definition

A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal glandular epithelium. [from NCI]

Recent clinical studies

Etiology

Submucosal gland neoplasms of the esophagus: an update and review.
Nie L, Li W, Xue L, Wang L, Shen Y, Fan X
Esophagus 2020 Oct;17(4):376-384. Epub 2020 Jul 3 doi: 10.1007/s10388-020-00758-1. PMID: 32621256Free PMC Article
Transforming human papillomavirus infection and the esophageal transformation zone: prime time for total excision/ablative therapy?
Rajendra S, Sharma P
Dis Esophagus 2019 Jul 1;32(7) doi: 10.1093/dote/doz008. PMID: 31304554
Evaluation of HER-2/neu overexpression in gastric carcinoma using a tissue microarray.
Rakhshani N, Kalantari E, Bakhti H, Sohrabi MR, Mehrazma M
Asian Pac J Cancer Prev 2014;15(18):7597-602. doi: 10.7314/apjcp.2014.15.18.7597. PMID: 25292034
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170
Barrett's oesophagus: from metaplasia to dysplasia and cancer.
Fléjou JF
Gut 2005 Mar;54 Suppl 1(Suppl 1):i6-12. doi: 10.1136/gut.2004.041525. PMID: 15711008Free PMC Article

Diagnosis

Submucosal gland neoplasms of the esophagus: an update and review.
Nie L, Li W, Xue L, Wang L, Shen Y, Fan X
Esophagus 2020 Oct;17(4):376-384. Epub 2020 Jul 3 doi: 10.1007/s10388-020-00758-1. PMID: 32621256Free PMC Article
Microscopic diffusion properties of fixed breast tissue: Preliminary findings.
Norddin N, Power C, Watson G, Cowin G, Kurniawan ND, Gluch L, Bourne RM
Magn Reson Med 2015 Dec;74(6):1733-9. Epub 2014 Dec 17 doi: 10.1002/mrm.25555. PMID: 25522006
Primary high-grade neuroendocrine carcinoma of the esophagus: a clinicopathologic and immunohistochemical study of 42 resection cases.
Huang Q, Wu H, Nie L, Shi J, Lebenthal A, Chen J, Sun Q, Yang J, Huang L, Ye Q
Am J Surg Pathol 2013 Apr;37(4):467-83. doi: 10.1097/PAS.0b013e31826d2639. PMID: 23426118
Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus.
Weimann A, Rieger A, Zimmermann M, Gross M, Hoffmann P, Slevogt H, Morawietz L
Virchows Arch 2010 Nov;457(5):537-45. Epub 2010 Sep 16 doi: 10.1007/s00428-010-0972-y. PMID: 20844891
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Therapy

Transforming human papillomavirus infection and the esophageal transformation zone: prime time for total excision/ablative therapy?
Rajendra S, Sharma P
Dis Esophagus 2019 Jul 1;32(7) doi: 10.1093/dote/doz008. PMID: 31304554
Properties of the neosquamous epithelium after radiofrequency ablation of Barrett's esophagus containing neoplasia.
Pouw RE, Gondrie JJ, Rygiel AM, Sondermeijer CM, ten Kate FJ, Odze RD, Vieth M, Krishnadath KK, Bergman JJ
Am J Gastroenterol 2009 Jun;104(6):1366-73. Epub 2009 Apr 21 doi: 10.1038/ajg.2009.88. PMID: 19491850

Prognosis

Undifferentiated carcinoma of the esophagus: a clinicopathological study of 16 cases.
Singhi AD, Seethala RR, Nason K, Foxwell TJ, Roche RL, McGrath KM, Levy RM, Luketich JD, Davison JM
Hum Pathol 2015 Mar;46(3):366-75. Epub 2014 Dec 17 doi: 10.1016/j.humpath.2014.11.021. PMID: 25582499Free PMC Article
Evaluation of HER-2/neu overexpression in gastric carcinoma using a tissue microarray.
Rakhshani N, Kalantari E, Bakhti H, Sohrabi MR, Mehrazma M
Asian Pac J Cancer Prev 2014;15(18):7597-602. doi: 10.7314/apjcp.2014.15.18.7597. PMID: 25292034
Primary high-grade neuroendocrine carcinoma of the esophagus: a clinicopathologic and immunohistochemical study of 42 resection cases.
Huang Q, Wu H, Nie L, Shi J, Lebenthal A, Chen J, Sun Q, Yang J, Huang L, Ye Q
Am J Surg Pathol 2013 Apr;37(4):467-83. doi: 10.1097/PAS.0b013e31826d2639. PMID: 23426118
Properties of the neosquamous epithelium after radiofrequency ablation of Barrett's esophagus containing neoplasia.
Pouw RE, Gondrie JJ, Rygiel AM, Sondermeijer CM, ten Kate FJ, Odze RD, Vieth M, Krishnadath KK, Bergman JJ
Am J Gastroenterol 2009 Jun;104(6):1366-73. Epub 2009 Apr 21 doi: 10.1038/ajg.2009.88. PMID: 19491850
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Clinical prediction guides

Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus.
Weimann A, Rieger A, Zimmermann M, Gross M, Hoffmann P, Slevogt H, Morawietz L
Virchows Arch 2010 Nov;457(5):537-45. Epub 2010 Sep 16 doi: 10.1007/s00428-010-0972-y. PMID: 20844891
Immunohistochemical analysis of RNA-induced silencing complex-related proteins AGO2 and TNRC6A in prostate and esophageal cancers.
Yoo NJ, Hur SY, Kim MS, Lee JY, Lee SH
APMIS 2010 Apr;118(4):271-6. doi: 10.1111/j.1600-0463.2010.02588.x. PMID: 20402672
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170
Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China.
Zhang W, Wang L, Chang A, Jin Y, Rao J
Cancer Detect Prev 2003;27(4):243-9. doi: 10.1016/s0361-090x(03)00072-2. PMID: 12893070
Coexistence of intraepithelial carcinoma and glandular differentiation in esophageal squamous cell carcinoma.
Kuwano H, Nagamatsu M, Ohno S, Matsuda H, Mori M, Sugimachi K
Cancer 1988 Oct 15;62(8):1568-72. doi: 10.1002/1097-0142(19881015)62:8<1568::aid-cncr2820620818>3.0.co;2-b. PMID: 3167769

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...