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Benign Orbit Neoplasm

MedGen UID:
102304
•Concept ID:
C0154023
•
Neoplastic Process
Synonyms: Benign neoplasm of orbit; Benign Neoplasm of Orbit; Benign Neoplasm of the Orbit; Benign Orbit Tumor; Benign Orbital Neoplasm; Benign orbital tumor; Benign Orbital Tumor; Benign tumor of orbit; Benign Tumor of Orbit; Benign Tumor of the Orbit
SNOMED CT: Benign tumor of orbit (92258000); Benign orbital tumor (92258000); Benign neoplasm of orbit (92258000)

Definition

A neoplasm that arises from the orbit and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Treatment of intraorbital lesions using the Accuray CyberKnife system.
Hirschbein MJ, Collins S, Jean WC, Chang SD, Adler JR Jr
Orbit 2008;27(2):97-105. doi: 10.1080/01676830601177471. PMID: 18415869
Management of orbital tumors.
Char DH
Mayo Clin Proc 1993 Nov;68(11):1081-96. doi: 10.1016/s0025-6196(12)60902-1. PMID: 8231272

Recent clinical studies

Etiology

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Dermoscopy of atypical pigmented lesions of the face: Variation according to facial areas.
Tognetti L, Cartocci A, Cinotti E, D'Onghia M, Żychowska M, Moscarella E, Dika E, Farnetani F, Guida S, Paoli J, Lallas A, Tiodorovic D, Stanganelli I, Longo C, Suppa M, Zalaudek I, Argenziano G, Perrot JL, Rubegni G, Cataldo G, Rubegni P
Exp Dermatol 2023 Dec;32(12):2166-2172. Epub 2023 Sep 28 doi: 10.1111/exd.14941. PMID: 37770421
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Imaging of orbital disorders.
Cunnane MB, Curtin HD
Handb Clin Neurol 2016;135:659-672. doi: 10.1016/B978-0-444-53485-9.00031-3. PMID: 27432687
Maxillary ameloblastoma.
Bozza F, Marcelli VA, Pistilli R, Govoni FA, Marsico C
Minerva Stomatol 2006 Apr;55(4):215-22. PMID: 16618996

Diagnosis

Orbital dermoid cyst.
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Imaging of orbital disorders.
Cunnane MB, Curtin HD
Handb Clin Neurol 2016;135:659-672. doi: 10.1016/B978-0-444-53485-9.00031-3. PMID: 27432687
Tumor pathology of the orbit.
Héran F, Bergès O, Blustajn J, Boucenna M, Charbonneau F, Koskas P, Lafitte F, Nau E, Roux P, Sadik JC, Savatovsky J, Williams M
Diagn Interv Imaging 2014 Oct;95(10):933-44. Epub 2014 Sep 5 doi: 10.1016/j.diii.2014.08.002. PMID: 25195185
IgG4-associated sialadenitis.
Geyer JT, Deshpande V
Curr Opin Rheumatol 2011 Jan;23(1):95-101. doi: 10.1097/BOR.0b013e3283413011. PMID: 21124091
Orbital pseudotumor.
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455

Therapy

Sebaceous Carcinoma: A Review of the Scientific Literature.
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210
Characterization of orbital masses by multiparametric MRI.
Ro SR, Asbach P, Siebert E, Bertelmann E, Hamm B, Erb-Eigner K
Eur J Radiol 2016 Feb;85(2):324-36. Epub 2015 Dec 4 doi: 10.1016/j.ejrad.2015.11.041. PMID: 26781137
Radiation therapy: posterior segment complications.
Seregard S, Pelayes DE, Singh AD
Dev Ophthalmol 2013;52:114-23. Epub 2013 Aug 26 doi: 10.1159/000351088. PMID: 23989132
Orbital pseudotumor.
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455
Green bone.
Boulos PR, Knoepp SM, Rubin PA
Arch Ophthalmol 2007 Mar;125(3):380-6. doi: 10.1001/archopht.125.3.380. PMID: 17353410

Prognosis

Evaluation of orbital lesions with DCE-MRI: a literature review.
Ang T, Juniat V, Patel S, Selva D
Orbit 2024 Jun;43(3):408-416. Epub 2022 Nov 27 doi: 10.1080/01676830.2022.2149819. PMID: 36437715
Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Sebaceous Carcinoma: A Review of the Scientific Literature.
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210
Genetic testing in orbital tumors.
Khong JJ, Moore S, Prabhakaran VC, Selva D
Orbit 2009;28(2-3):88-97. doi: 10.1080/08820530802506094. PMID: 19839890
Intraosseous hemangiomas.
Valentini V, Nicolai G, Lorè B, Aboh IV
J Craniofac Surg 2008 Nov;19(6):1459-64. doi: 10.1097/SCS.0b013e318188a030. PMID: 19098533

Clinical prediction guides

Orbital resection by intranasal technique (ORBIT): A new classification system for reporting endoscopically resectable primary benign orbital tumors.
Jafari A, Adappa ND, Anagnos VJ, Campbell RG, Castelnuovo P, Chalian A, Chambers CB, Chitguppi C, Dallan I, El Rassi E, Freitag SK, Fernandez Miranda JC, Ferreira M Jr, Gardner PA, Gudis DA, Harvey RJ, Huang Q, Humphreys IM, Kennedy DW, Lee JYK, Lehmann AE, Locatelli D, McKinney KA, Moreau A, Nyquist G, Palmer JN, Prepageran N, Pribitkin EA, Rabinowitz MR, Rosen MR, Sacks R, Sharma D, Snyderman CH, Tonya Stefko S, Stokken JK, Wang EW, Workman AD, Wu AW, Yu JY, Zhang MM, Zhou B, Bleier BS
Int Forum Allergy Rhinol 2023 Oct;13(10):1852-1863. Epub 2023 Mar 2 doi: 10.1002/alr.23141. PMID: 36808854
Primary Intrabulbar Neurofibroma.
Furdová A, Babál P
Cesk Slov Oftalmol 2020 Spring;76(2):62-67. doi: 10.31348/2020/13. PMID: 33126800
Benign Tumors of the Anterior Cranial Base.
Snyderman CH, Lavigne P
Adv Otorhinolaryngol 2020;84:106-113. Epub 2020 Jul 30 doi: 10.1159/000457930. PMID: 32731223
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513

Recent systematic reviews

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review.
Rafizadeh SM, Ghahvehchian H, Rajabi MT, Heidari M, Rahmanikhah E
Ophthalmic Plast Reconstr Surg 2024 May-Jun 01;40(3):235-244. Epub 2023 Sep 18 doi: 10.1097/IOP.0000000000002520. PMID: 37721309
A Systematic Review of Nasal Chondromesenchymal Hamartoma (NCMH) with a New Case Report.
Javadirad E, Azimivaghar J, Montazer S, Sharafi S
Head Neck Pathol 2022 Dec;16(4):1172-1184. Epub 2022 May 4 doi: 10.1007/s12105-022-01452-7. PMID: 35507301Free PMC Article
Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta-analysis.
Jafari A, von Sneidern M, Lehmann AE, Shen SA, Shishido S, Freitag SK, Bleier BS
Int Forum Allergy Rhinol 2021 May;11(5):924-934. Epub 2020 Dec 22 doi: 10.1002/alr.22745. PMID: 33350602
Pediatric Benign Paranasal Sinus Osteoneogenic Tumors: A Case Series and Systematic Review of Outcomes, Techniques, and a Multiportal Approach.
Badran KW, Suh JD, Namiri N, Wrobel B, Ference EH
Am J Rhinol Allergy 2018 Nov;32(6):465-472. Epub 2018 Aug 22 doi: 10.1177/1945892418793475. PMID: 30132339
Purely endoscopic trans-nasal management of orbital intraconal cavernous haemangiomas: a systematic review of the literature.
Lenzi R, Bleier BS, Felisati G, Muscatello L
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2319-22. Epub 2015 Jul 26 doi: 10.1007/s00405-015-3733-3. PMID: 26210157

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