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Anterior Pituitary Gland Neoplasm

MedGen UID:
310471
•Concept ID:
C1706819
•
Neoplastic Process
Synonym: Neoplasm of the Anterior Lobe of the Pituitary Gland

Definition

A neoplasm arising from the anterior lobe of the pituitary gland. The vast majority are pituitary neuroendocrine tumors (formerly pituitary adenomas). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior Pituitary Gland Neoplasm

Professional guidelines

PubMed

Progress, challenges and perspectives in the management of hypopituitarism.
Boguszewski CL, Neggers S
Rev Endocr Metab Disord 2024 Jun;25(3):453-455. Epub 2024 May 27 doi: 10.1007/s11154-024-09889-7. PMID: 38801648
Diagnosis and Treatment of Parasellar Lesions.
Gatto F, Perez-Rivas LG, Olarescu NC, Khandeva P, Chachlaki K, Trivellin G, Gahete MD, Cuny T; on behalf of the ENEA Young Researchers Committee (EYRC)
Neuroendocrinology 2020;110(9-10):728-739. Epub 2020 Mar 4 doi: 10.1159/000506905. PMID: 32126547
Treatment of acromegaly with dopamine agonists.
Jaffe CA, Barkan AL
Endocrinol Metab Clin North Am 1992 Sep;21(3):713-35. PMID: 1355728

Recent clinical studies

Etiology

Refractory Pit1 plurihormonal tumours and thyrotroph adenomas.
Nf L, Ai M
Pituitary 2023 Apr;26(2):182-186. Epub 2023 Apr 29 doi: 10.1007/s11102-023-01312-9. PMID: 37117845Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116

Diagnosis

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Visual loss in pregnancy.
Bachmeier CAE, Snell C, Morton A
BMJ Case Rep 2019 May 5;12(5) doi: 10.1136/bcr-2018-228323. PMID: 31061177Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Primary amenorrhea: diagnosis and management.
Marsh CA, Grimstad FW
Obstet Gynecol Surv 2014 Oct;69(10):603-12. doi: 10.1097/OGX.0000000000000111. PMID: 25336070
Pituitary tumors.
Ontjes DA, Ney RL
CA Cancer J Clin 1976 Nov-Dec;26(6):330-50. doi: 10.3322/canjclin.26.6.330. PMID: 186163

Therapy

Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators.
Mallick S, Chakrabarti J, Eschbacher J, Moraitis AG, Greenstein AE, Churko J, Pond KW, Livolsi A, Thorne CA, Little AS, Yuen KCJ, Zavros Y
Transl Res 2023 Jun;256:56-72. Epub 2023 Jan 12 doi: 10.1016/j.trsl.2023.01.002. PMID: 36640905Free PMC Article
Treatment Options for Gonadotroph Tumors: Current State and Perspectives.
Ilie MD, Raverot G
J Clin Endocrinol Metab 2020 Oct 1;105(10) doi: 10.1210/clinem/dgaa497. PMID: 32735647
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Resistant prolactinomas.
Vasilev V, Daly AF, Vroonen L, Zacharieva S, Beckers A
J Endocrinol Invest 2011 Apr;34(4):312-6. Epub 2011 Mar 15 doi: 10.1007/BF03347092. PMID: 21406957
Diet and epithelial cancer of the thyroid gland.
Franceschi S, Talamini R, Fassina A, Bidoli E
Tumori 1990 Aug 31;76(4):331-8. doi: 10.1177/030089169007600406. PMID: 2205027

Prognosis

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Gonadotrope Tumors.
Asa SL, Ezzat S
Prog Mol Biol Transl Sci 2016;143:187-210. Epub 2016 Sep 7 doi: 10.1016/bs.pmbts.2016.08.005. PMID: 27697203
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116

Clinical prediction guides

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Surgical approach for suprasellar hemangioblastomas preserving the pituitary stalk: Review of the literature and report of a further case.
Alshafai N, Maduri R, Shail M, Chirchiglia D, Meyronet D, Signorelli F
Clin Neurol Neurosurg 2018 May;168:147-152. Epub 2018 Mar 10 doi: 10.1016/j.clineuro.2018.03.010. PMID: 29550691
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116
Pituitary image: pituicytoma.
Teti C, Castelletti L, Allegretti L, Talco M, Zona G, Minuto F, Boschetti M, Ferone D
Pituitary 2015 Oct;18(5):592-7. doi: 10.1007/s11102-014-0612-7. PMID: 25311104

Recent systematic reviews

The clinicopathological features and prognosis of silent corticotroph tumors: an updated systematic review and meta-analysis.
Vuong HG, Dunn IF
Endocrine 2023 Dec;82(3):527-535. Epub 2023 Jul 18 doi: 10.1007/s12020-023-03449-w. PMID: 37462809
The effect of endoscopic transsphenoidal somatotroph tumors resection on pituitary hormones: systematic review and meta-analysis.
Nie D, Fang Q, Wong W, Gui S, Zhao P, Li C, Zhang Y
World J Surg Oncol 2023 Mar 1;21(1):71. doi: 10.1186/s12957-023-02958-2. PMID: 36859291Free PMC Article
Endocrinological outcomes after transcranial resection of tuberculum sellae meningiomas: a systematic review and meta-analysis.
Martinez-Perez R, Kortz MW, Florez-Perdomo W, Ung TH, Youssef AS
Neurosurg Rev 2022 Jun;45(3):1965-1975. Epub 2022 Feb 12 doi: 10.1007/s10143-022-01744-0. PMID: 35149901
Primary pituitary lymphoma: an update of the literature.
Tarabay A, Cossu G, Berhouma M, Levivier M, Daniel RT, Messerer M
J Neurooncol 2016 Dec;130(3):383-395. Epub 2016 Aug 31 doi: 10.1007/s11060-016-2249-z. PMID: 27581598
Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis.
He W, Chen F, Dalm B, Kirby PA, Greenlee JD
Pituitary 2015 Feb;18(1):159-68. doi: 10.1007/s11102-014-0552-2. PMID: 24445565

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