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Pleomorphic adenoma

MedGen UID:
44467
•Concept ID:
C0026277
•
Neoplastic Process
Synonyms: Adenoma, Pleomorphic; Adenomas, Pleomorphic; Chondroid Syringoma; Chondroid Syringomas; Mixed Salivary Gland Tumor; Pleomorphic Adenoma; Pleomorphic Adenomas; Salivary Gland Tumor, Mixed; Syringoma, Chondroid; Syringomas, Chondroid
SNOMED CT: Mixed salivary gland tumor (8360001); Pleomorphic adenoma (8360001); Mixed tumor (8360001); Mixed tumor, salivary gland type (8360001)

Definition

A benign or malignant neoplasm that arises from the salivary glands. It is characterized by the presence of epithelial and mesenchymal elements. This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Recent clinical studies

Etiology

Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881
Pleomorphic adenoma.
Wasylik K, Kim JC, Amedee RG
J La State Med Soc 2001 Jan;153(1):12-6. PMID: 11272444

Diagnosis

Pleomorphic adenoma of hard palate: a case report.
Yousra Z, Saliha C
Pan Afr Med J 2021;38:146. Epub 2021 Feb 9 doi: 10.11604/pamj.2021.38.146.26508. PMID: 33912316Free PMC Article
Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Pleomorphic adenoma.
Wasylik K, Kim JC, Amedee RG
J La State Med Soc 2001 Jan;153(1):12-6. PMID: 11272444

Therapy

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Pleomorphic adenoma of the epiglottis.
Alzate Amaya F, Invencio da Costa L, Álvarez-Buylla Blanco M
Acta Otorrinolaringol Esp (Engl Ed) 2019 Nov-Dec;70(6):376-377. Epub 2018 Dec 24 doi: 10.1016/j.otorri.2018.07.002. PMID: 30591211
Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis.
Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Parotid pleomorphic and non-pleomorphic adenomas: a mono-institutional series of 512 patients.
Lombardi D, Tomasoni M, Nicolai A, Paderno A, Grammatica A, Arcuri M, Lancini D, Battocchio S, Ardighieri L, Bozzola A, Pittiani F, Farina D, Redaelli de Zinis LO, Nicolai P, Piazza C
Eur Arch Otorhinolaryngol 2022 May;279(5):2543-2551. Epub 2021 Aug 5 doi: 10.1007/s00405-021-07018-7. PMID: 34355271
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Recent systematic reviews

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis.
Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

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