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Locally Advanced Malignant Neoplasm

MedGen UID:
195665
•Concept ID:
C0677984
•
Neoplastic Process
Synonyms: Locally advanced cancer; Locally Advanced Cancer; Locally advanced malignant neoplasm; Locally advanced malignant tumor; Locally Metastatic Malignant Neoplasm
SNOMED CT: Locally advanced cancer (1255249000); Locally advanced malignant tumor (1255249000); Locally advanced malignant neoplasm (1255249000)

Definition

A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Malignant Neoplasm

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023.
Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E
Eur J Cancer 2023 Oct;192:113254. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113254. PMID: 37604067
Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches.
Sekhoacha M, Riet K, Motloung P, Gumenku L, Adegoke A, Mashele S
Molecules 2022 Sep 5;27(17) doi: 10.3390/molecules27175730. PMID: 36080493Free PMC Article
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement.
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

Modern paradigms for prostate cancer detection and management.
Williams IS, McVey A, Perera S, O'Brien JS, Kostos L, Chen K, Siva S, Azad AA, Murphy DG, Kasivisvanathan V, Lawrentschuk N, Frydenberg M
Med J Aust 2022 Oct 17;217(8):424-433. Epub 2022 Oct 2 doi: 10.5694/mja2.51722. PMID: 36183329Free PMC Article
Technical advances in surgery for pancreatic cancer.
Schneider M, Hackert T, Strobel O, Büchler MW
Br J Surg 2021 Jul 23;108(7):777-785. doi: 10.1093/bjs/znab133. PMID: 34046668
Pancreatic cancer.
Mizrahi JD, Surana R, Valle JW, Shroff RT
Lancet 2020 Jun 27;395(10242):2008-2020. doi: 10.1016/S0140-6736(20)30974-0. PMID: 32593337
Cutaneous Melanoma-A Review in Detection, Staging, and Management.
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article

Diagnosis

Modern paradigms for prostate cancer detection and management.
Williams IS, McVey A, Perera S, O'Brien JS, Kostos L, Chen K, Siva S, Azad AA, Murphy DG, Kasivisvanathan V, Lawrentschuk N, Frydenberg M
Med J Aust 2022 Oct 17;217(8):424-433. Epub 2022 Oct 2 doi: 10.5694/mja2.51722. PMID: 36183329Free PMC Article
Pancreatic cancer.
Mizrahi JD, Surana R, Valle JW, Shroff RT
Lancet 2020 Jun 27;395(10242):2008-2020. doi: 10.1016/S0140-6736(20)30974-0. PMID: 32593337
Cutaneous Melanoma-A Review in Detection, Staging, and Management.
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675
Retinoblastoma.
Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article

Therapy

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
An Updated Systematic Review on Focal Therapy in Localized Prostate Cancer: What Has Changed over the Past 5 Years?
Hopstaken JS, Bomers JGR, Sedelaar MJP, Valerio M, Fütterer JJ, Rovers MM
Eur Urol 2022 Jan;81(1):5-33. Epub 2021 Sep 4 doi: 10.1016/j.eururo.2021.08.005. PMID: 34489140
Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data.
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group
Lancet 2020 Oct 31;396(10260):1422-1431. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31952-8. PMID: 33002431Free PMC Article
CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study.
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Brachytherapy: An overview for clinicians.
Chargari C, Deutsch E, Blanchard P, Gouy S, Martelli H, Guérin F, Dumas I, Bossi A, Morice P, Viswanathan AN, Haie-Meder C
CA Cancer J Clin 2019 Sep;69(5):386-401. Epub 2019 Jul 30 doi: 10.3322/caac.21578. PMID: 31361333

Prognosis

Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Multidisciplinary treatment of malignant thymoma.
Spaggiari L, Casiraghi M, Guarize J
Curr Opin Oncol 2012 Mar;24(2):117-22. doi: 10.1097/CCO.0b013e32834ea6bb. PMID: 22143371
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261
Non-Hodgkin's lymphoma.
Maloney DG
Curr Opin Hematol 1995 Jul;2(4):255-61. doi: 10.1097/00062752-199502040-00004. PMID: 9372005

Clinical prediction guides

Development and Validation of a Computed Tomography-Based Radiomics Signature to Predict Response to Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer.
Wang W, Peng Y, Feng X, Zhao Y, Seeruttun SR, Zhang J, Cheng Z, Li Y, Liu Z, Zhou Z
JAMA Netw Open 2021 Aug 2;4(8):e2121143. doi: 10.1001/jamanetworkopen.2021.21143. PMID: 34410397Free PMC Article
Ultrasound-based deep learning radiomics in the assessment of pathological complete response to neoadjuvant chemotherapy in locally advanced breast cancer.
Jiang M, Li CL, Luo XM, Chuan ZR, Lv WZ, Li X, Cui XW, Dietrich CF
Eur J Cancer 2021 Apr;147:95-105. Epub 2021 Feb 24 doi: 10.1016/j.ejca.2021.01.028. PMID: 33639324
Liquid biopsy to monitor melanoma patients.
Gaiser MR, von Bubnoff N, Gebhardt C, Utikal JS
J Dtsch Dermatol Ges 2018 Apr;16(4):405-414. Epub 2018 Mar 7 doi: 10.1111/ddg.13461. PMID: 29512873
The immune contexture in cancer prognosis and treatment.
Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer G
Nat Rev Clin Oncol 2017 Dec;14(12):717-734. Epub 2017 Jul 25 doi: 10.1038/nrclinonc.2017.101. PMID: 28741618
ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer.
Offersen BV, Boersma LJ, Kirkove C, Hol S, Aznar MC, Biete Sola A, Kirova YM, Pignol JP, Remouchamps V, Verhoeven K, Weltens C, Arenas M, Gabrys D, Kopek N, Krause M, Lundstedt D, Marinko T, Montero A, Yarnold J, Poortmans P
Radiother Oncol 2015 Jan;114(1):3-10. Epub 2015 Jan 24 doi: 10.1016/j.radonc.2014.11.030. PMID: 25630428

Recent systematic reviews

MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.
Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review and meta-analysis.
Gosavi R, Chia C, Michael M, Heriot AG, Warrier SK, Kong JC
Int J Colorectal Dis 2021 Oct;36(10):2063-2070. Epub 2021 May 4 doi: 10.1007/s00384-021-03945-3. PMID: 33945007
Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis.
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article
Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data.
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group
Lancet 2020 Oct 31;396(10260):1422-1431. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31952-8. PMID: 33002431Free PMC Article

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