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Locally Advanced Prostate Neuroendocrine Carcinoma

MedGen UID:
1694377
•Concept ID:
C5204071
•
Neoplastic Process

Definition

A prostate neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Prostate Neuroendocrine Carcinoma

Professional guidelines

PubMed

Treatment-related Neuroendocrine Prostate Carcinoma-Diagnostic and Molecular Correlates.
Gopalan A
Adv Anat Pathol 2024 Mar 1;31(2):70-79. Epub 2024 Jan 15 doi: 10.1097/PAP.0000000000000431. PMID: 38223983
Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. I. Molecular Biomarkers in Prostate Cancer.
Lotan TL, Tomlins SA, Bismar TA, Van der Kwast TH, Grignon D, Egevad L, Kristiansen G, Pritchard CC, Rubin MA, Bubendorf L
Am J Surg Pathol 2020 Jul;44(7):e15-e29. doi: 10.1097/PAS.0000000000001450. PMID: 32044806

Recent clinical studies

Etiology

Clinical Significance of Extracellular Vesicles in Prostate and Renal Cancer.
Chen TY, Mihalopoulos M, Zuluaga L, Rich J, Ganta T, Mehrazin R, Tsao CK, Tewari A, Gonzalez-Kozlova E, Badani K, Dogra N, Kyprianou N
Int J Mol Sci 2023 Sep 28;24(19) doi: 10.3390/ijms241914713. PMID: 37834162Free PMC Article
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma.
Wenzel M, Siron N, Collà Ruvolo C, Nocera L, Würnschimmel C, Tian Z, Shariat SF, Saad F, Briganti A, Tilki D, Banek S, Kluth LA, Roos FC, Chun FKH, Karakiewicz PI
Cancer Causes Control 2022 Jan;33(1):25-35. Epub 2021 Sep 2 doi: 10.1007/s10552-021-01493-3. PMID: 34476653Free PMC Article
Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. I. Molecular Biomarkers in Prostate Cancer.
Lotan TL, Tomlins SA, Bismar TA, Van der Kwast TH, Grignon D, Egevad L, Kristiansen G, Pritchard CC, Rubin MA, Bubendorf L
Am J Surg Pathol 2020 Jul;44(7):e15-e29. doi: 10.1097/PAS.0000000000001450. PMID: 32044806
Neuroendocrine differentiation in prostate carcinoma: focusing on its pathophysiologic mechanisms and pathological features.
Alberti C
G Chir 2010 Nov-Dec;31(11-12):568-74. PMID: 21232206

Diagnosis

Treatment-related Neuroendocrine Prostate Carcinoma-Diagnostic and Molecular Correlates.
Gopalan A
Adv Anat Pathol 2024 Mar 1;31(2):70-79. Epub 2024 Jan 15 doi: 10.1097/PAP.0000000000000431. PMID: 38223983
Clinical Significance of Extracellular Vesicles in Prostate and Renal Cancer.
Chen TY, Mihalopoulos M, Zuluaga L, Rich J, Ganta T, Mehrazin R, Tsao CK, Tewari A, Gonzalez-Kozlova E, Badani K, Dogra N, Kyprianou N
Int J Mol Sci 2023 Sep 28;24(19) doi: 10.3390/ijms241914713. PMID: 37834162Free PMC Article
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma.
Wenzel M, Siron N, Collà Ruvolo C, Nocera L, Würnschimmel C, Tian Z, Shariat SF, Saad F, Briganti A, Tilki D, Banek S, Kluth LA, Roos FC, Chun FKH, Karakiewicz PI
Cancer Causes Control 2022 Jan;33(1):25-35. Epub 2021 Sep 2 doi: 10.1007/s10552-021-01493-3. PMID: 34476653Free PMC Article

Therapy

Treatment-related Neuroendocrine Prostate Carcinoma-Diagnostic and Molecular Correlates.
Gopalan A
Adv Anat Pathol 2024 Mar 1;31(2):70-79. Epub 2024 Jan 15 doi: 10.1097/PAP.0000000000000431. PMID: 38223983
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer.
Puca L, Gavyert K, Sailer V, Conteduca V, Dardenne E, Sigouros M, Isse K, Kearney M, Vosoughi A, Fernandez L, Pan H, Motanagh S, Hess J, Donoghue AJ, Sboner A, Wang Y, Dittamore R, Rickman D, Nanus DM, Tagawa ST, Elemento O, Mosquera JM, Saunders L, Beltran H
Sci Transl Med 2019 Mar 20;11(484) doi: 10.1126/scitranslmed.aav0891. PMID: 30894499Free PMC Article
Neuroendocrine differentiation in prostate carcinoma: focusing on its pathophysiologic mechanisms and pathological features.
Alberti C
G Chir 2010 Nov-Dec;31(11-12):568-74. PMID: 21232206
Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancer.
Evans AJ, Humphrey PA, Belani J, van der Kwast TH, Srigley JR
Am J Surg Pathol 2006 Jun;30(6):684-93. doi: 10.1097/00000478-200606000-00003. PMID: 16723845
Immunoassay and immunohistology studies of chromogranin A as a neuroendocrine marker in patients with carcinoma of the prostate.
Deftos LJ, Nakada S, Burton DW, di Sant'Agnese PA, Cockett AT, Abrahamsson PA
Urology 1996 Jul;48(1):58-62. doi: 10.1016/s0090-4295(96)00089-1. PMID: 8693652

Prognosis

AKAP2-anchored protein phosphatase 1 controls prostatic neuroendocrine carcinoma cell migration and invasion.
Reggi E, Kaiser S, Sahnane N, Uccella S, La Rosa S, Diviani D
Biochim Biophys Acta Mol Basis Dis 2024 Jan;1870(1):166916. Epub 2023 Oct 11 doi: 10.1016/j.bbadis.2023.166916. PMID: 37827203
Clinical Significance of Extracellular Vesicles in Prostate and Renal Cancer.
Chen TY, Mihalopoulos M, Zuluaga L, Rich J, Ganta T, Mehrazin R, Tsao CK, Tewari A, Gonzalez-Kozlova E, Badani K, Dogra N, Kyprianou N
Int J Mol Sci 2023 Sep 28;24(19) doi: 10.3390/ijms241914713. PMID: 37834162Free PMC Article
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Genetics of Prostate Carcinoma.
Krušlin B, Škara L, Vodopić T, Vrhovec B, Murgić J, Štimac G, Fröbe A, Lež C, Ulamec M, Gall-Trošelj K
Acta Med Acad 2021 Apr;50(1):71-87. doi: 10.5644/ama2006-124.327. PMID: 34075765

Clinical prediction guides

Clinical Significance of Extracellular Vesicles in Prostate and Renal Cancer.
Chen TY, Mihalopoulos M, Zuluaga L, Rich J, Ganta T, Mehrazin R, Tsao CK, Tewari A, Gonzalez-Kozlova E, Badani K, Dogra N, Kyprianou N
Int J Mol Sci 2023 Sep 28;24(19) doi: 10.3390/ijms241914713. PMID: 37834162Free PMC Article
Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma.
Wenzel M, Siron N, Collà Ruvolo C, Nocera L, Würnschimmel C, Tian Z, Shariat SF, Saad F, Briganti A, Tilki D, Banek S, Kluth LA, Roos FC, Chun FKH, Karakiewicz PI
Cancer Causes Control 2022 Jan;33(1):25-35. Epub 2021 Sep 2 doi: 10.1007/s10552-021-01493-3. PMID: 34476653Free PMC Article
Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. I. Molecular Biomarkers in Prostate Cancer.
Lotan TL, Tomlins SA, Bismar TA, Van der Kwast TH, Grignon D, Egevad L, Kristiansen G, Pritchard CC, Rubin MA, Bubendorf L
Am J Surg Pathol 2020 Jul;44(7):e15-e29. doi: 10.1097/PAS.0000000000001450. PMID: 32044806
Evaluation and clinical value of neuroendocrine differentiation in human prostatic tumors.
Cussenot O, Villette JM, Cochand-Priollet B, Berthon P
Prostate Suppl 1998;8:43-51. PMID: 9690663

Recent systematic reviews

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 1: Focus on Immunohistochemical Results with Discussion of Pre-Analytical and Interpretation Variables.
Palicelli A, Bonacini M, Croci S, Magi-Galluzzi C, Cañete-Portillo S, Chaux A, Bisagni A, Zanetti E, De Biase D, Melli B, Sanguedolce F, Ragazzi M, Bonasoni MP, Soriano A, Ascani S, Zizzo M, Castro Ruiz C, De Leo A, Giordano G, Landriscina M, Carrieri G, Cormio L, Berney DM, Athanazio D, Gandhi J, Cavazza A, Santandrea G, Tafuni A, Zanelli M
Cells 2021 Nov 14;10(11) doi: 10.3390/cells10113166. PMID: 34831389Free PMC Article

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