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Locally Advanced Unresectable Malignant Neoplasm

MedGen UID:
1661950
Concept ID:
C4727142
Neoplastic Process
Synonym: Locally Advanced Unresectable Malignant Tumor

Definition

A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Moris D, Palta M, Kim C, Allen PJ, Morse MA, Lidsky ME
CA Cancer J Clin 2023 Mar;73(2):198-222. Epub 2022 Oct 19 doi: 10.3322/caac.21759. PMID: 36260350
Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Fanta P, Farjah F, Gerdes H, Gibson MK, Hochwald S, Hofstetter WL, Ilson DH, Keswani RN, Kim S, Kleinberg LR, Klempner SJ, Lacy J, Ly QP, Matkowskyj KA, McNamara M, Mulcahy MF, Outlaw D, Park H, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian N, Pluchino LA
J Natl Compr Canc Netw 2022 Feb;20(2):167-192. doi: 10.6004/jnccn.2022.0008. PMID: 35130500
Biller LH, Schrag D
JAMA 2021 Feb 16;325(7):669-685. doi: 10.1001/jama.2021.0106. PMID: 33591350

Recent clinical studies

Etiology

Cerreto M, Cardone F, Cerrito L, Stella L, Santopaolo F, Pallozzi M, Gasbarrini A, Ponziani FR
Curr Oncol 2023 Sep 26;30(10):8774-8792. doi: 10.3390/curroncol30100633. PMID: 37887533Free PMC Article
Oh S, Botros GN, Patel M, Haigentz M, Patel E, Kontopidis I, Langenfeld J, Deek MP, Jabbour SK
Hematol Oncol Clin North Am 2023 Jun;37(3):533-555. Epub 2023 Apr 4 doi: 10.1016/j.hoc.2023.02.007. PMID: 37024391
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Mazzaferro V, Gorgen A, Roayaie S, Droz Dit Busset M, Sapisochin G
J Hepatol 2020 Feb;72(2):364-377. doi: 10.1016/j.jhep.2019.11.020. PMID: 31954498
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Diagnosis

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Fanta P, Farjah F, Gerdes H, Gibson MK, Hochwald S, Hofstetter WL, Ilson DH, Keswani RN, Kim S, Kleinberg LR, Klempner SJ, Lacy J, Ly QP, Matkowskyj KA, McNamara M, Mulcahy MF, Outlaw D, Park H, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian N, Pluchino LA
J Natl Compr Canc Netw 2022 Feb;20(2):167-192. doi: 10.6004/jnccn.2022.0008. PMID: 35130500
Miller M, Hanna N
BMJ 2021 Nov 9;375:n2363. doi: 10.1136/bmj.n2363. PMID: 34753715
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Therapy

Miller M, Hanna N
BMJ 2021 Nov 9;375:n2363. doi: 10.1136/bmj.n2363. PMID: 34753715
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Kwapisz D
Cancer Immunol Immunother 2021 Mar;70(3):607-617. Epub 2020 Oct 5 doi: 10.1007/s00262-020-02736-z. PMID: 33015734Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Strobel O, Neoptolemos J, Jäger D, Büchler MW
Nat Rev Clin Oncol 2019 Jan;16(1):11-26. doi: 10.1038/s41571-018-0112-1. PMID: 30341417

Prognosis

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Lu S, Casarini I, Kato T, Cobo M, Özgüroğlu M, Hodge R, van der Gronde T, Saggese M, Ramalingam SS
Clin Lung Cancer 2021 Jul;22(4):371-375. Epub 2021 Jan 6 doi: 10.1016/j.cllc.2020.11.004. PMID: 33558193
Schmid P, Rugo HS, Adams S, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Henschel V, Molinero L, Chui SY, Maiya V, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Investigators
Lancet Oncol 2020 Jan;21(1):44-59. Epub 2019 Nov 27 doi: 10.1016/S1470-2045(19)30689-8. PMID: 31786121
Boku N, Ryu MH, Kato K, Chung HC, Minashi K, Lee KW, Cho H, Kang WK, Komatsu Y, Tsuda M, Yamaguchi K, Hara H, Fumita S, Azuma M, Chen LT, Kang YK
Ann Oncol 2019 Feb 1;30(2):250-258. doi: 10.1093/annonc/mdy540. PMID: 30566590Free PMC Article
Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JÁ, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD
Lancet Oncol 2017 Mar;18(3):312-322. Epub 2017 Jan 26 doi: 10.1016/S1470-2045(17)30065-7. PMID: 28131785

Clinical prediction guides

Lee YB, Nam JY, Cho EJ, Lee JH, Yu SJ, Kim HC, Paeng JC, Yoon JH, Kim YJ
Clin Cancer Res 2023 Sep 15;29(18):3650-3658. doi: 10.1158/1078-0432.CCR-23-0581. PMID: 37459133
Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Chin RI, Wu FS, Menda Y, Kim H
Semin Radiat Oncol 2021 Jan;31(1):60-70. doi: 10.1016/j.semradonc.2020.07.007. PMID: 33246637
Ge L, Pan B, Song F, Ma J, Zeraatkar D, Zhou J, Tian J
BMJ Open 2017 Dec 26;7(12):e018175. doi: 10.1136/bmjopen-2017-018175. PMID: 29282264Free PMC Article

Recent systematic reviews

Huang D, Sun F, Ke L, Li S
Int Immunopharmacol 2024 Sep 10;138:112576. Epub 2024 Jun 27 doi: 10.1016/j.intimp.2024.112576. PMID: 38941672
Eshmuminov D, Aminjonov B, Palm RF, Malleo G, Schmocker RK, Abdallah R, Yoo C, Shaib WL, Schneider MA, Rangelova E, Choi YJ, Kim H, Rose JB, Patel S, Wilson GC, Maloney S, Timmermann L, Sahora K, Rössler F, Lopez-Lopez V, Boyer E, Maggino L, Malinka T, Park JY, Katz MHG, Prakash L, Ahmad SA, Helton S, Jang JY, Hoffe SE, Salvia R, Taieb J, He J, Clavien PA, Held U, Lehmann K
Ann Surg Oncol 2023 Jul;30(7):4417-4428. Epub 2023 Apr 5 doi: 10.1245/s10434-023-13353-2. PMID: 37020094Free PMC Article
Li X, Wang F, Jia H, Lian Z, Ren K, Yuan Z, Wang P, Zhao L
Future Oncol 2022 Sep;18(27):3055-3065. Epub 2022 Aug 10 doi: 10.2217/fon-2022-0491. PMID: 35947522
Suker M, Beumer BR, Sadot E, Marthey L, Faris JE, Mellon EA, El-Rayes BF, Wang-Gillam A, Lacy J, Hosein PJ, Moorcraft SY, Conroy T, Hohla F, Allen P, Taieb J, Hong TS, Shridhar R, Chau I, van Eijck CH, Koerkamp BG
Lancet Oncol 2016 Jun;17(6):801-810. Epub 2016 May 6 doi: 10.1016/S1470-2045(16)00172-8. PMID: 27160474Free PMC Article
Fegrachi S, Besselink MG, van Santvoort HC, van Hillegersberg R, Molenaar IQ
HPB (Oxford) 2014 Feb;16(2):119-23. Epub 2013 Apr 18 doi: 10.1111/hpb.12097. PMID: 23600801Free PMC Article

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