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Locally Advanced Primary Malignant Central Nervous System Neoplasm

MedGen UID:
1712561
•Concept ID:
C5237760
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Primary Malignant Central Nervous System Neoplasm

Professional guidelines

PubMed

Surgical Management and Advances in the Treatment of Glioma.
Hardigan AA, Jackson JD, Patel AP
Semin Neurol 2023 Dec;43(6):810-824. Epub 2023 Nov 14 doi: 10.1055/s-0043-1776766. PMID: 37963582Free PMC Article
The evolving role of reirradiation in the management of recurrent brain tumors.
De Pietro R, Zaccaro L, Marampon F, Tini P, De Felice F, Minniti G
J Neurooncol 2023 Sep;164(2):271-286. Epub 2023 Aug 25 doi: 10.1007/s11060-023-04407-2. PMID: 37624529Free PMC Article
Treatment of Glioblastoma.
Nam JY, de Groot JF
J Oncol Pract 2017 Oct;13(10):629-638. doi: 10.1200/JOP.2017.025536. PMID: 29020535

Recent clinical studies

Etiology

Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study.
Solomon BJ, Bauer TM, Mok TSK, Liu G, Mazieres J, de Marinis F, Goto Y, Kim DW, Wu YL, Jassem J, López FL, Soo RA, Shaw AT, Polli A, Messina R, Iadeluca L, Toffalorio F, Felip E
Lancet Respir Med 2023 Apr;11(4):354-366. Epub 2022 Dec 16 doi: 10.1016/S2213-2600(22)00437-4. PMID: 36535300
Immune checkpoint blockades in gynecological cancers: A review of clinical trials.
Peng H, He X, Wang Q
Acta Obstet Gynecol Scand 2022 Sep;101(9):941-951. Epub 2022 Jun 25 doi: 10.1111/aogs.14412. PMID: 35751489Free PMC Article
Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer.
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177
Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials.
Drilon A, Siena S, Dziadziuszko R, Barlesi F, Krebs MG, Shaw AT, de Braud F, Rolfo C, Ahn MJ, Wolf J, Seto T, Cho BC, Patel MR, Chiu CH, John T, Goto K, Karapetis CS, Arkenau HT, Kim SW, Ohe Y, Li YC, Chae YK, Chung CH, Otterson GA, Murakami H, Lin CC, Tan DSW, Prenen H, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Doebele RC; trial investigators
Lancet Oncol 2020 Feb;21(2):261-270. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30690-4. PMID: 31838015Free PMC Article
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials.
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators
Lancet Oncol 2020 Feb;21(2):271-282. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30691-6. PMID: 31838007Free PMC Article

Diagnosis

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Neoplastic Myelopathies.
Pruitt AA
Continuum (Minneap Minn) 2021 Feb 1;27(1):121-142. doi: 10.1212/CON.0000000000000964. PMID: 33522739
Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma.
DeCordova S, Shastri A, Tsolaki AG, Yasmin H, Klein L, Singh SK, Kishore U
Front Immunol 2020;11:1402. Epub 2020 Jul 17 doi: 10.3389/fimmu.2020.01402. PMID: 32765498Free PMC Article
Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials.
Drilon A, Siena S, Dziadziuszko R, Barlesi F, Krebs MG, Shaw AT, de Braud F, Rolfo C, Ahn MJ, Wolf J, Seto T, Cho BC, Patel MR, Chiu CH, John T, Goto K, Karapetis CS, Arkenau HT, Kim SW, Ohe Y, Li YC, Chae YK, Chung CH, Otterson GA, Murakami H, Lin CC, Tan DSW, Prenen H, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Doebele RC; trial investigators
Lancet Oncol 2020 Feb;21(2):261-270. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30690-4. PMID: 31838015Free PMC Article

Therapy

Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study.
Solomon BJ, Bauer TM, Mok TSK, Liu G, Mazieres J, de Marinis F, Goto Y, Kim DW, Wu YL, Jassem J, López FL, Soo RA, Shaw AT, Polli A, Messina R, Iadeluca L, Toffalorio F, Felip E
Lancet Respir Med 2023 Apr;11(4):354-366. Epub 2022 Dec 16 doi: 10.1016/S2213-2600(22)00437-4. PMID: 36535300
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer.
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials.
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators
Lancet Oncol 2020 Feb;21(2):271-282. Epub 2019 Dec 11 doi: 10.1016/S1470-2045(19)30691-6. PMID: 31838007Free PMC Article
Current state of immunotherapy for glioblastoma.
Lim M, Xia Y, Bettegowda C, Weller M
Nat Rev Clin Oncol 2018 Jul;15(7):422-442. doi: 10.1038/s41571-018-0003-5. PMID: 29643471

Prognosis

Emerging therapies for glioblastoma: current state and future directions.
Rong L, Li N, Zhang Z
J Exp Clin Cancer Res 2022 Apr 15;41(1):142. doi: 10.1186/s13046-022-02349-7. PMID: 35428347Free PMC Article
Brain metastases: the role of clinical imaging.
Derks SHAE, van der Veldt AAM, Smits M
Br J Radiol 2022 Feb 1;95(1130):20210944. Epub 2021 Dec 14 doi: 10.1259/bjr.20210944. PMID: 34808072Free PMC Article
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
A review of glioblastoma immunotherapy.
Medikonda R, Dunn G, Rahman M, Fecci P, Lim M
J Neurooncol 2021 Jan;151(1):41-53. Epub 2020 Apr 6 doi: 10.1007/s11060-020-03448-1. PMID: 32253714
Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma.
DeCordova S, Shastri A, Tsolaki AG, Yasmin H, Klein L, Singh SK, Kishore U
Front Immunol 2020;11:1402. Epub 2020 Jul 17 doi: 10.3389/fimmu.2020.01402. PMID: 32765498Free PMC Article

Clinical prediction guides

Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study.
Solomon BJ, Bauer TM, Mok TSK, Liu G, Mazieres J, de Marinis F, Goto Y, Kim DW, Wu YL, Jassem J, López FL, Soo RA, Shaw AT, Polli A, Messina R, Iadeluca L, Toffalorio F, Felip E
Lancet Respir Med 2023 Apr;11(4):354-366. Epub 2022 Dec 16 doi: 10.1016/S2213-2600(22)00437-4. PMID: 36535300
Safety and efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer including as first-line therapy: update from the ARROW trial.
Griesinger F, Curigliano G, Thomas M, Subbiah V, Baik CS, Tan DSW, Lee DH, Misch D, Garralda E, Kim DW, van der Wekken AJ, Gainor JF, Paz-Ares L, Liu SV, Kalemkerian GP, Houvras Y, Bowles DW, Mansfield AS, Lin JJ, Smoljanovic V, Rahman A, Kong S, Zalutskaya A, Louie-Gao M, Boral AL, Mazières J
Ann Oncol 2022 Nov;33(11):1168-1178. Epub 2022 Aug 13 doi: 10.1016/j.annonc.2022.08.002. PMID: 35973665
Central Nervous System Lymphoma: Novel Therapies.
Fortin Ensign SP, Gathers D, Wiedmeier JE, Mrugala MM
Curr Treat Options Oncol 2022 Jan;23(1):117-136. Epub 2022 Feb 19 doi: 10.1007/s11864-021-00921-5. PMID: 35182298
A molecularly integrated grade for meningioma.
Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi WL
Neuro Oncol 2022 May 4;24(5):796-808. doi: 10.1093/neuonc/noab213. PMID: 34508644Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Recent systematic reviews

Glioblastoma Immunotherapy: A Systematic Review of the Present Strategies and Prospects for Advancements.
Agosti E, Zeppieri M, De Maria L, Tedeschi C, Fontanella MM, Panciani PP, Ius T
Int J Mol Sci 2023 Oct 10;24(20) doi: 10.3390/ijms242015037. PMID: 37894718Free PMC Article
Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review.
Ius T, Sabatino G, Panciani PP, Fontanella MM, Rudà R, Castellano A, Barbagallo GMV, Belotti F, Boccaletti R, Catapano G, Costantino G, Della Puppa A, Di Meco F, Gagliardi F, Garbossa D, Germanò AF, Iacoangeli M, Mortini P, Olivi A, Pessina F, Pignotti F, Pinna G, Raco A, Sala F, Signorelli F, Sarubbo S, Skrap M, Spena G, Somma T, Sturiale C, Angileri FF, Esposito V
J Neurooncol 2023 Apr;162(2):267-293. Epub 2023 Mar 24 doi: 10.1007/s11060-023-04274-x. PMID: 36961622Free PMC Article
Efficacy of radiotherapy and stereotactic radiosurgery as adjuvant or salvage treatment in atypical and anaplastic (WHO grade II and III) meningiomas: a systematic review and meta-analysis.
Gagliardi F, De Domenico P, Snider S, Pompeo E, Roncelli F, Barzaghi LR, Acerno S, Mortini P
Neurosurg Rev 2023 Mar 17;46(1):71. doi: 10.1007/s10143-023-01969-7. PMID: 36928326
Targeted therapy for advanced anaplastic lymphoma kinase (<I>ALK</I>)-rearranged non-small cell lung cancer.
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Whole brain radiotherapy for the treatment of multiple brain metastases.
Tsao MN, Lloyd N, Wong R, Chow E, Rakovitch E, Laperriere N
Cochrane Database Syst Rev 2006 Jul 19;(3):CD003869. doi: 10.1002/14651858.CD003869.pub2. PMID: 16856022

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