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Locally Advanced Gastric Adenocarcinoma

MedGen UID:
1689661
•Concept ID:
C5206810
•
Neoplastic Process

Definition

A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Gastric Adenocarcinoma

Professional guidelines

PubMed

ApoA-I and ApoB levels, and ApoB-to-ApoA-I ratio as candidate pre-treatment biomarkers of pathomorphological response to neoadjuvant therapy in gastric and esophago-gastric junction adenocarcinoma.
Nurczyk K, Nowak N, Orczykowski T, Bojar P, Duma D, Gieroba R, Wallner G, Skoczylas T
Pol Przegl Chir 2023 Sep 20;96(2):44-49. doi: 10.5604/01.3001.0053.8925. PMID: 38629280
Approach to Resectable Gastric Cancer: Evolving Paradigm of Neoadjuvant and Adjuvant Treatment.
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
Oxaliplatin plus Capecitabine in the Perioperative Treatment of Locally Advanced Gastric Adenocarcinoma in Combination with D2 Gastrectomy: NEO-CLASSIC Study.
Yu Y, Fang Y, Shen Z, Wang Y, Yan M, Cao H, Liu Y, Wang X, Cui Y, Liu F, Chen W, Li W, Li Q, Jiang H, Sun Y, Liu T
Oncologist 2019 Oct;24(10):1311-e989. Epub 2019 Jun 25 doi: 10.1634/theoncologist.2019-0416. PMID: 31239311Free PMC Article

Recent clinical studies

Etiology

Neoadjuvant docetaxel, oxaliplatin plus capecitabine versus oxaliplatin plus capecitabine for patients with locally advanced gastric adenocarcinoma: long-term results of a phase III randomized controlled trial.
Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
Neoadjuvant Gastric Score: How Response to Neoadjuvant Chemotherapy Affects Overall Survival and Adjuvant Benefit.
Wehrle CJ, Seavey CN, Chang J, Stackhouse K, Woo K, Augustin T, Joyce D, Simon R, Walsh RM, Naffouje SA
Ann Surg Oncol 2023 Nov;30(12):7240-7250. Epub 2023 Sep 2 doi: 10.1245/s10434-023-14259-9. PMID: 37659978
Survival of Locally Advanced MSI-high Gastric Cancer Patients Treated With Perioperative Chemotherapy: A Retrospective Cohort Study.
Vos EL, Maron SB, Krell RW, Nakauchi M, Fiasconaro M, Capanu M, Walch HS, Chatila WK, Schultz N, Ilson DH, Janjigian YY, Ku GY, Yoon SS, Coit DG, Vanderbilt CM, Tang LH, Strong VE
Ann Surg 2023 May 1;277(5):798-805. Epub 2022 Jun 29 doi: 10.1097/SLA.0000000000005501. PMID: 35766391Free PMC Article
Benefit for single-agent adjuvant chemotherapy in elderly patients with locally advanced gastric adenocarcinoma.
Margalit O, Yu S, Shacham-Shmueli E, Strauss G, Yang YX, Lawrence YR, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Mamtani R, Boursi B
J Cancer Res Clin Oncol 2022 Jul;148(7):1703-1708. Epub 2022 Jan 23 doi: 10.1007/s00432-021-03911-0. PMID: 35066662
The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma.
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934

Diagnosis

Approach to Resectable Gastric Cancer: Evolving Paradigm of Neoadjuvant and Adjuvant Treatment.
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma.
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934
Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma.
Tong Y, Zhu Y, Zhao Y, Shan Z, Liu D, Zhang J
Cancer Res Treat 2021 Jan;53(1):112-122. Epub 2020 Aug 10 doi: 10.4143/crt.2020.516. PMID: 32777876Free PMC Article
Development and validation of a staging system for gastric adenocarcinoma after neoadjuvant chemotherapy and gastrectomy with D2 lymphadenectomy.
Lin JX, Yoon C, Desiderio J, Yi BC, Li P, Zheng CH, Parisi A, Huang CM, Strong VE, Yoon SS
Br J Surg 2019 Aug;106(9):1187-1196. Epub 2019 Jun 13 doi: 10.1002/bjs.11181. PMID: 31197829Free PMC Article
Neoadjuvant chemotherapy for locally advanced gastric adenocarcinoma.
Alexander HR, Grem JL, Pass HI, Hamilton M, McAtee N, Fraker DL, Allegra CJ
Oncology (Williston Park) 1993 May;7(5):37-42; discussion 42-4, 49-50, 53. PMID: 8512781

Therapy

Neoadjuvant docetaxel, oxaliplatin plus capecitabine versus oxaliplatin plus capecitabine for patients with locally advanced gastric adenocarcinoma: long-term results of a phase III randomized controlled trial.
Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or gastroesophageal junction.
Tang Z, Wang Y, Liu D, Wang X, Xu C, Yu Y, Cui Y, Tang C, Li Q, Sun J, Zhang Q, Ji Y, Ma G, Li H, Shen Z, Shen K, Zheng R, Hou Z, Liu T, Wang J, Sun Y
Nat Commun 2022 Nov 10;13(1):6807. doi: 10.1038/s41467-022-34403-5. PMID: 36357415Free PMC Article
Approach to Resectable Gastric Cancer: Evolving Paradigm of Neoadjuvant and Adjuvant Treatment.
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
Benefit for single-agent adjuvant chemotherapy in elderly patients with locally advanced gastric adenocarcinoma.
Margalit O, Yu S, Shacham-Shmueli E, Strauss G, Yang YX, Lawrence YR, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Mamtani R, Boursi B
J Cancer Res Clin Oncol 2022 Jul;148(7):1703-1708. Epub 2022 Jan 23 doi: 10.1007/s00432-021-03911-0. PMID: 35066662
Long-Term Outcomes of Laparoscopic Distal Gastrectomy for Locally Advanced Gastric Cancer: The KLASS-02-RCT Randomized Clinical Trial.
Hyung WJ, Yang HK, Park YK, Lee HJ, An JY, Kim W, Kim HI, Kim HH, Ryu SW, Hur H, Kim MC, Kong SH, Cho GS, Kim JJ, Park DJ, Ryu KW, Kim YW, Kim JW, Lee JH, Han SU; Korean Laparoendoscopic Gastrointestinal Surgery Study Group
J Clin Oncol 2020 Oct 1;38(28):3304-3313. Epub 2020 Aug 20 doi: 10.1200/JCO.20.01210. PMID: 32816629

Prognosis

Neoadjuvant docetaxel, oxaliplatin plus capecitabine versus oxaliplatin plus capecitabine for patients with locally advanced gastric adenocarcinoma: long-term results of a phase III randomized controlled trial.
Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
Patient-Derived Organoids from Locally Advanced Gastric Adenocarcinomas Can Predict Resistance to Neoadjuvant Chemotherapy.
Yoon C, Lu J, Kim BJ, Cho SJ, Kim JH, Moy RH, Ryeom SW, Yoon SS
J Gastrointest Surg 2023 Apr;27(4):666-676. Epub 2023 Jan 10 doi: 10.1007/s11605-022-05568-7. PMID: 36627466
Survival of Locally Advanced MSI-high Gastric Cancer Patients Treated With Perioperative Chemotherapy: A Retrospective Cohort Study.
Vos EL, Maron SB, Krell RW, Nakauchi M, Fiasconaro M, Capanu M, Walch HS, Chatila WK, Schultz N, Ilson DH, Janjigian YY, Ku GY, Yoon SS, Coit DG, Vanderbilt CM, Tang LH, Strong VE
Ann Surg 2023 May 1;277(5):798-805. Epub 2022 Jun 29 doi: 10.1097/SLA.0000000000005501. PMID: 35766391Free PMC Article
Approach to Resectable Gastric Cancer: Evolving Paradigm of Neoadjuvant and Adjuvant Treatment.
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma.
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934

Clinical prediction guides

Neoadjuvant Gastric Score: How Response to Neoadjuvant Chemotherapy Affects Overall Survival and Adjuvant Benefit.
Wehrle CJ, Seavey CN, Chang J, Stackhouse K, Woo K, Augustin T, Joyce D, Simon R, Walsh RM, Naffouje SA
Ann Surg Oncol 2023 Nov;30(12):7240-7250. Epub 2023 Sep 2 doi: 10.1245/s10434-023-14259-9. PMID: 37659978
Patient-Derived Organoids from Locally Advanced Gastric Adenocarcinomas Can Predict Resistance to Neoadjuvant Chemotherapy.
Yoon C, Lu J, Kim BJ, Cho SJ, Kim JH, Moy RH, Ryeom SW, Yoon SS
J Gastrointest Surg 2023 Apr;27(4):666-676. Epub 2023 Jan 10 doi: 10.1007/s11605-022-05568-7. PMID: 36627466
Development of a staging system and survival prediction model for advanced gastric cancer patients without adjuvant treatment after curative gastrectomy: A retrospective multicenter cohort study.
Park KB, Jun KH, Song KY, Chin H, Lee HH
Int J Surg 2022 May;101:106629. Epub 2022 Apr 20 doi: 10.1016/j.ijsu.2022.106629. PMID: 35460886
Benefit for single-agent adjuvant chemotherapy in elderly patients with locally advanced gastric adenocarcinoma.
Margalit O, Yu S, Shacham-Shmueli E, Strauss G, Yang YX, Lawrence YR, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Mamtani R, Boursi B
J Cancer Res Clin Oncol 2022 Jul;148(7):1703-1708. Epub 2022 Jan 23 doi: 10.1007/s00432-021-03911-0. PMID: 35066662
The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma.
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934

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