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Locally Advanced Ovarian Carcinoma

MedGen UID:
1716639
•Concept ID:
C5238240
•
Neoplastic Process

Definition

Ovarian carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Ovarian Carcinoma

Professional guidelines

PubMed

Advances in Ovarian Cancer Care and Unmet Treatment Needs for Patients With Platinum Resistance: A Narrative Review.
Richardson DL, Eskander RN, O'Malley DM
JAMA Oncol 2023 Jun 1;9(6):851-859. doi: 10.1001/jamaoncol.2023.0197. PMID: 37079311
Epithelial ovarian cancer: Evolution of management in the era of precision medicine.
Lheureux S, Braunstein M, Oza AM
CA Cancer J Clin 2019 Jul;69(4):280-304. Epub 2019 May 17 doi: 10.3322/caac.21559. PMID: 31099893
ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease†.
Colombo N, Sessa C, du Bois A, Ledermann J, McCluggage WG, McNeish I, Morice P, Pignata S, Ray-Coquard I, Vergote I, Baert T, Belaroussi I, Dashora A, Olbrecht S, Planchamp F, Querleu D; ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Ann Oncol 2019 May 1;30(5):672-705. doi: 10.1093/annonc/mdz062. PMID: 31046081

Recent clinical studies

Etiology

PARP inhibitor era in ovarian cancer treatment: a systematic review and meta-analysis of randomized controlled trials.
Baradács I, Teutsch B, Váradi A, Bilá A, Vincze Á, Hegyi P, Fazekas T, Komoróczy B, Nyirády P, Ács N, Bánhidy F, Lintner B
J Ovarian Res 2024 Feb 26;17(1):53. doi: 10.1186/s13048-024-01362-y. PMID: 38409030Free PMC Article
Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment.
Schoutrop E, Moyano-Galceran L, Lheureux S, Mattsson J, Lehti K, Dahlstrand H, Magalhaes I
Semin Cancer Biol 2022 Nov;86(Pt 3):207-223. Epub 2022 Apr 5 doi: 10.1016/j.semcancer.2022.03.027. PMID: 35395389
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease†.
Colombo N, Sessa C, du Bois A, Ledermann J, McCluggage WG, McNeish I, Morice P, Pignata S, Ray-Coquard I, Vergote I, Baert T, Belaroussi I, Dashora A, Olbrecht S, Planchamp F, Querleu D; ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Ann Oncol 2019 May 1;30(5):672-705. doi: 10.1093/annonc/mdz062. PMID: 31046081
Epithelial ovarian cancer.
Lheureux S, Gourley C, Vergote I, Oza AM
Lancet 2019 Mar 23;393(10177):1240-1253. doi: 10.1016/S0140-6736(18)32552-2. PMID: 30910306

Diagnosis

Advances in Ovarian Cancer Care and Unmet Treatment Needs for Patients With Platinum Resistance: A Narrative Review.
Richardson DL, Eskander RN, O'Malley DM
JAMA Oncol 2023 Jun 1;9(6):851-859. doi: 10.1001/jamaoncol.2023.0197. PMID: 37079311
Epithelial ovarian cancer: Review article.
Sambasivan S
Cancer Treat Res Commun 2022;33:100629. Epub 2022 Sep 8 doi: 10.1016/j.ctarc.2022.100629. PMID: 36127285
Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment.
Schoutrop E, Moyano-Galceran L, Lheureux S, Mattsson J, Lehti K, Dahlstrand H, Magalhaes I
Semin Cancer Biol 2022 Nov;86(Pt 3):207-223. Epub 2022 Apr 5 doi: 10.1016/j.semcancer.2022.03.027. PMID: 35395389
Epithelial ovarian cancer: Evolution of management in the era of precision medicine.
Lheureux S, Braunstein M, Oza AM
CA Cancer J Clin 2019 Jul;69(4):280-304. Epub 2019 May 17 doi: 10.3322/caac.21559. PMID: 31099893
Epithelial ovarian cancer.
Lheureux S, Gourley C, Vergote I, Oza AM
Lancet 2019 Mar 23;393(10177):1240-1253. doi: 10.1016/S0140-6736(18)32552-2. PMID: 30910306

Therapy

Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review).
Yang L, Xie HJ, Li YY, Wang X, Liu XX, Mai J
Oncol Rep 2022 Apr;47(4) Epub 2022 Feb 25 doi: 10.3892/or.2022.8293. PMID: 35211759Free PMC Article
Epithelial ovarian cancer: Evolution of management in the era of precision medicine.
Lheureux S, Braunstein M, Oza AM
CA Cancer J Clin 2019 Jul;69(4):280-304. Epub 2019 May 17 doi: 10.3322/caac.21559. PMID: 31099893
ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease†.
Colombo N, Sessa C, du Bois A, Ledermann J, McCluggage WG, McNeish I, Morice P, Pignata S, Ray-Coquard I, Vergote I, Baert T, Belaroussi I, Dashora A, Olbrecht S, Planchamp F, Querleu D; ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Ann Oncol 2019 May 1;30(5):672-705. doi: 10.1093/annonc/mdz062. PMID: 31046081
Epithelial ovarian cancer.
Lheureux S, Gourley C, Vergote I, Oza AM
Lancet 2019 Mar 23;393(10177):1240-1253. doi: 10.1016/S0140-6736(18)32552-2. PMID: 30910306

Prognosis

Advances in Ovarian Cancer Care and Unmet Treatment Needs for Patients With Platinum Resistance: A Narrative Review.
Richardson DL, Eskander RN, O'Malley DM
JAMA Oncol 2023 Jun 1;9(6):851-859. doi: 10.1001/jamaoncol.2023.0197. PMID: 37079311
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Epithelial ovarian cancer: Evolution of management in the era of precision medicine.
Lheureux S, Braunstein M, Oza AM
CA Cancer J Clin 2019 Jul;69(4):280-304. Epub 2019 May 17 doi: 10.3322/caac.21559. PMID: 31099893
ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease†.
Colombo N, Sessa C, du Bois A, Ledermann J, McCluggage WG, McNeish I, Morice P, Pignata S, Ray-Coquard I, Vergote I, Baert T, Belaroussi I, Dashora A, Olbrecht S, Planchamp F, Querleu D; ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Ann Oncol 2019 May 1;30(5):672-705. doi: 10.1093/annonc/mdz062. PMID: 31046081
Epithelial ovarian cancer.
Lheureux S, Gourley C, Vergote I, Oza AM
Lancet 2019 Mar 23;393(10177):1240-1253. doi: 10.1016/S0140-6736(18)32552-2. PMID: 30910306

Clinical prediction guides

Advances in Ovarian Cancer Care and Unmet Treatment Needs for Patients With Platinum Resistance: A Narrative Review.
Richardson DL, Eskander RN, O'Malley DM
JAMA Oncol 2023 Jun 1;9(6):851-859. doi: 10.1001/jamaoncol.2023.0197. PMID: 37079311
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Epithelial ovarian cancer: Evolution of management in the era of precision medicine.
Lheureux S, Braunstein M, Oza AM
CA Cancer J Clin 2019 Jul;69(4):280-304. Epub 2019 May 17 doi: 10.3322/caac.21559. PMID: 31099893
Epithelial ovarian cancer.
Lheureux S, Gourley C, Vergote I, Oza AM
Lancet 2019 Mar 23;393(10177):1240-1253. doi: 10.1016/S0140-6736(18)32552-2. PMID: 30910306

Recent systematic reviews

PARP inhibitor era in ovarian cancer treatment: a systematic review and meta-analysis of randomized controlled trials.
Baradács I, Teutsch B, Váradi A, Bilá A, Vincze Á, Hegyi P, Fazekas T, Komoróczy B, Nyirády P, Ács N, Bánhidy F, Lintner B
J Ovarian Res 2024 Feb 26;17(1):53. doi: 10.1186/s13048-024-01362-y. PMID: 38409030Free PMC Article
Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer: a systematic review and meta-analysis of randomized trials.
Filis P, Mauri D, Markozannes G, Tolia M, Filis N, Tsilidis K
ESMO Open 2022 Oct;7(5):100586. Epub 2022 Sep 16 doi: 10.1016/j.esmoop.2022.100586. PMID: 36116421Free PMC Article
Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer.
Tattersall A, Ryan N, Wiggans AJ, Rogozińska E, Morrison J
Cochrane Database Syst Rev 2022 Feb 16;2(2):CD007929. doi: 10.1002/14651858.CD007929.pub4. PMID: 35170751Free PMC Article
Progress in the management of ovarian granulosa cell tumor: A review.
Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996
Breast cancer (non-metastatic).
Stebbing J, Delaney G, Thompson A
BMJ Clin Evid 2011 Feb 8;2011 PMID: 21718560Free PMC Article

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