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Locally Advanced Unresectable Bone Sarcoma

MedGen UID:
1653732
Concept ID:
C4727282
Neoplastic Process

Definition

A bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Bone Sarcoma

Professional guidelines

PubMed

Qu G, Zhang C, Tian Z, Yao W
Curr Treat Options Oncol 2024 Oct;25(10):1289-1296. Epub 2024 Sep 20 doi: 10.1007/s11864-024-01262-9. PMID: 39302575
Locquet MA, Brahmi M, Blay JY, Dutour A
BMC Cancer 2023 Aug 11;23(1):742. doi: 10.1186/s12885-023-11232-3. PMID: 37563551Free PMC Article
Rutkowski P, Debiec-Rychter M
Expert Rev Anticancer Ther 2015;15(8):901-9. Epub 2015 May 31 doi: 10.1586/14737140.2015.1052799. PMID: 26027711

Recent clinical studies

Etiology

Qu G, Zhang C, Tian Z, Yao W
Curr Treat Options Oncol 2024 Oct;25(10):1289-1296. Epub 2024 Sep 20 doi: 10.1007/s11864-024-01262-9. PMID: 39302575
Zhang QS, Hayes JP, Gondi V, Pollack SM
Semin Radiat Oncol 2024 Apr;34(2):229-242. doi: 10.1016/j.semradonc.2023.12.005. PMID: 38508787
Gounder MM, Merriam P, Ratan R, Patel SR, Chugh R, Villalobos VM, Thornton M, Van Tine BA, Abdelhamid AH, Whalen J, Yang J, Rajarethinam A, Duh MS, Bobbili PJ, Huynh L, Totev TI, Lax AK, Agarwal S, Demetri GD
Cancer 2021 Apr 15;127(8):1311-1317. Epub 2020 Dec 9 doi: 10.1002/cncr.33365. PMID: 33296083Free PMC Article
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöffski P, Blay JY, Kerst JM, Sufliarsky J, Whelan J, Hohenberger P, Krarup-Hansen A, Alcindor T, Marreaud S, Litière S, Hermans C, Fisher C, Hogendoorn PC, dei Tos AP, van der Graaf WT; European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Lancet Oncol 2014 Apr;15(4):415-23. Epub 2014 Mar 5 doi: 10.1016/S1470-2045(14)70063-4. PMID: 24618336

Diagnosis

Qu G, Zhang C, Tian Z, Yao W
Curr Treat Options Oncol 2024 Oct;25(10):1289-1296. Epub 2024 Sep 20 doi: 10.1007/s11864-024-01262-9. PMID: 39302575
Oesterreich R, Varela MF, Moldes J, Lobos P
Pediatr Surg Int 2022 Oct;38(10):1435-1444. Epub 2022 Jul 25 doi: 10.1007/s00383-022-05188-x. PMID: 35876904
Gounder MM, Merriam P, Ratan R, Patel SR, Chugh R, Villalobos VM, Thornton M, Van Tine BA, Abdelhamid AH, Whalen J, Yang J, Rajarethinam A, Duh MS, Bobbili PJ, Huynh L, Totev TI, Lax AK, Agarwal S, Demetri GD
Cancer 2021 Apr 15;127(8):1311-1317. Epub 2020 Dec 9 doi: 10.1002/cncr.33365. PMID: 33296083Free PMC Article
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055
Mavrogenis AF, Rossi G, Palmerini E, Errani C, Rimondi E, Ruggieri P, Soucacos PN, Papagelopoulos PJ
J BUON 2012 Jul-Sep;17(3):436-45. PMID: 23033278

Therapy

Schadendorf D, Tawbi H, Lipson EJ, Stephen Hodi F, Rutkowski P, Gogas H, Lao CD, Grob JJ, Moshyk A, Lord-Bessen J, Hamilton M, Guo S, Shi L, Keidel S, Long GV
Eur J Cancer 2023 Jul;187:164-173. Epub 2023 Mar 22 doi: 10.1016/j.ejca.2023.03.014. PMID: 37167764
Dong M, Liu R, Zhang Q, Luo H, Wang D, Wang Y, Chen J, Ou Y, Wang X
Radiat Oncol 2022 Oct 25;17(1):172. doi: 10.1186/s13014-022-02089-0. PMID: 36284346Free PMC Article
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöffski P, Blay JY, Kerst JM, Sufliarsky J, Whelan J, Hohenberger P, Krarup-Hansen A, Alcindor T, Marreaud S, Litière S, Hermans C, Fisher C, Hogendoorn PC, dei Tos AP, van der Graaf WT; European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Lancet Oncol 2014 Apr;15(4):415-23. Epub 2014 Mar 5 doi: 10.1016/S1470-2045(14)70063-4. PMID: 24618336
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055

Prognosis

Qu G, Zhang C, Tian Z, Yao W
Curr Treat Options Oncol 2024 Oct;25(10):1289-1296. Epub 2024 Sep 20 doi: 10.1007/s11864-024-01262-9. PMID: 39302575
Anzar I, Malone B, Samarakoon P, Vardaxis I, Simovski B, Fontenelle H, Meza-Zepeda LA, Stratford R, Keung EZ, Burgess M, Tawbi HA, Myklebost O, Clancy T
Front Immunol 2023;14:1226445. Epub 2023 Sep 20 doi: 10.3389/fimmu.2023.1226445. PMID: 37799721Free PMC Article
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055
Mavrogenis AF, Rossi G, Palmerini E, Errani C, Rimondi E, Ruggieri P, Soucacos PN, Papagelopoulos PJ
J BUON 2012 Jul-Sep;17(3):436-45. PMID: 23033278

Clinical prediction guides

Probst U, Fuhrmann I, Beyer L, Wiggermann P
Technol Cancer Res Treat 2018 Jan 1;17:1533033818785329. doi: 10.1177/1533033818785329. PMID: 29986632Free PMC Article
Rutkowski P, Gaston L, Borkowska A, Stacchiotti S, Gelderblom H, Baldi GG, Palmerini E, Casali P, Gronchi A, Parry M, Campanacci DA, Scoccianti G, Wagrodzki M, Ferrari S, Dijkstra S, Pieńkowski A, Grimer R
Eur J Surg Oncol 2018 Sep;44(9):1384-1390. Epub 2018 Mar 31 doi: 10.1016/j.ejso.2018.03.020. PMID: 29650420
Takahashi M, Komine K, Imai H, Okada Y, Saijo K, Takahashi M, Shirota H, Ohori H, Takahashi S, Chiba N, Mori T, Shimodaira H, Ishioka C
PLoS One 2017;12(5):e0176972. Epub 2017 May 10 doi: 10.1371/journal.pone.0176972. PMID: 28489919Free PMC Article
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055
Mavrogenis AF, Rossi G, Altimari G, Calabrò T, Angelini A, Palmerini E, Rimondi E, Ruggieri P
Radiol Med 2013 Dec;118(8):1344-59. Epub 2012 Aug 9 doi: 10.1007/s11547-012-0868-3. PMID: 22872460

Recent systematic reviews

Dong M, Liu R, Zhang Q, Luo H, Wang D, Wang Y, Chen J, Ou Y, Wang X
Radiat Oncol 2022 Oct 25;17(1):172. doi: 10.1186/s13014-022-02089-0. PMID: 36284346Free PMC Article

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