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Locally Advanced Liver Carcinoma

MedGen UID:
1756794
•Concept ID:
C5419077
•
Neoplastic Process

Definition

Liver carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD).
European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu; European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO); European Association for the Study of the Liver (EASL)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Treatment landscape of metastatic pancreatic cancer.
De Dosso S, Siebenhüner AR, Winder T, Meisel A, Fritsch R, Astaras C, Szturz P, Borner M
Cancer Treat Rev 2021 May;96:102180. Epub 2021 Mar 17 doi: 10.1016/j.ctrv.2021.102180. PMID: 33812339
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR
Nat Rev Gastroenterol Hepatol 2019 Oct;16(10):589-604. Epub 2019 Aug 22 doi: 10.1038/s41575-019-0186-y. PMID: 31439937Free PMC Article

Recent clinical studies

Etiology

Hepatocellular Carcinoma: a Narrative Review on Current Knowledge and Future Prospects.
Alawyia B, Constantinou C
Curr Treat Options Oncol 2023 Jul;24(7):711-724. Epub 2023 Apr 27 doi: 10.1007/s11864-023-01098-9. PMID: 37103744
Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR
Nat Rev Gastroenterol Hepatol 2019 Oct;16(10):589-604. Epub 2019 Aug 22 doi: 10.1038/s41575-019-0186-y. PMID: 31439937Free PMC Article
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Diagnosis

Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Systemic therapy of advanced hepatocellular carcinoma.
Galle PR, Dufour JF, Peck-Radosavljevic M, Trojan J, Vogel A
Future Oncol 2021 Apr;17(10):1237-1251. Epub 2020 Dec 14 doi: 10.2217/fon-2020-0758. PMID: 33307782
Hepatocellular carcinoma.
Forner A, Reig M, Bruix J
Lancet 2018 Mar 31;391(10127):1301-1314. Epub 2018 Jan 5 doi: 10.1016/S0140-6736(18)30010-2. PMID: 29307467
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Therapy

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Hepatocellular carcinoma.
Forner A, Reig M, Bruix J
Lancet 2018 Mar 31;391(10127):1301-1314. Epub 2018 Jan 5 doi: 10.1016/S0140-6736(18)30010-2. PMID: 29307467
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749

Prognosis

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma.
Zhou H, Song T
Biosci Trends 2021 Jul 6;15(3):155-160. Epub 2021 May 27 doi: 10.5582/bst.2021.01091. PMID: 34039818
Advances in immunotherapy for hepatocellular carcinoma.
Sangro B, Sarobe P, Hervás-Stubbs S, Melero I
Nat Rev Gastroenterol Hepatol 2021 Aug;18(8):525-543. Epub 2021 Apr 13 doi: 10.1038/s41575-021-00438-0. PMID: 33850328Free PMC Article
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Clinical prediction guides

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Sequential transarterial chemoembolisation and stereotactic body radiotherapy followed by immunotherapy as conversion therapy for patients with locally advanced, unresectable hepatocellular carcinoma (START-FIT): a single-arm, phase 2 trial.
Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Advances in immunotherapy for hepatocellular carcinoma.
Sangro B, Sarobe P, Hervás-Stubbs S, Melero I
Nat Rev Gastroenterol Hepatol 2021 Aug;18(8):525-543. Epub 2021 Apr 13 doi: 10.1038/s41575-021-00438-0. PMID: 33850328Free PMC Article
Fontan-associated liver disease: A review.
Gordon-Walker TT, Bove K, Veldtman G
J Cardiol 2019 Sep;74(3):223-232. Epub 2019 Mar 28 doi: 10.1016/j.jjcc.2019.02.016. PMID: 30928109

Recent systematic reviews

Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.
Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
The evolution of immune checkpoint inhibitor combinations in advanced hepatocellular carcinoma - A systematic review.
Meyers BM, Knox JJ, Liu DM, McLeod D, Ramjeesingh R, Tam VC, Lim HJ
Cancer Treat Rev 2023 Jul;118:102584. Epub 2023 May 27 doi: 10.1016/j.ctrv.2023.102584. PMID: 37336142
Sarcomatoid hepatocellular carcinoma versus conventional hepatocellular carcinoma: a systematic review and meta-analysis.
Lv TR, Hu HJ, Regmi P, Liu F, Li FY
J Cancer Res Clin Oncol 2022 Jul;148(7):1685-1696. Epub 2022 Feb 24 doi: 10.1007/s00432-022-03949-8. PMID: 35201426
Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.
Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, Engelmann C, Zhang P, Jeong JY, van Vugt JLA, Xiao H, Deng H, Gao X, Ye Q, Zhang J, Yang L, Cai Y, Liu Y, Liu N, Li Z, Han T, Kaido T, Sohn JH, Strassburg C, Berg T, Trebicka J, Hsu YC, IJzermans JNM, Wang J, Su GL, Ji F, Nguyen MH
J Hepatol 2022 Mar;76(3):588-599. Epub 2021 Nov 14 doi: 10.1016/j.jhep.2021.11.006. PMID: 34785325
Systematic review of novel ablative methods in locally advanced pancreatic cancer.
Keane MG, Bramis K, Pereira SP, Fusai GK
World J Gastroenterol 2014 Mar 7;20(9):2267-78. doi: 10.3748/wjg.v20.i9.2267. PMID: 24605026Free PMC Article

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