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Locally Advanced Esophageal Carcinoma

MedGen UID:
1718968
•Concept ID:
C5239283
•
Neoplastic Process

Definition

Esophageal carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259
Preoperative treatment of locally advanced esophageal carcinoma (Review).
Orditura M, Galizia G, Fabozzi A, Lieto E, Gambardella V, Morgillo F, Del Genio GM, Fei L, Di Martino N, Renda A, Ciardiello F, De Vita F
Int J Oncol 2013 Dec;43(6):1745-53. Epub 2013 Oct 2 doi: 10.3892/ijo.2013.2118. PMID: 24100679

Recent clinical studies

Etiology

Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma.
Tsukamoto Y, Kurogi S, Fujishima H, Shibata T, Fumoto S, Nishiki K, Suzuki K, Etoh T, Shiraishi N, Fuchino T, Hirashita Y, Nakada C, Uchida T, Inomata M, Moriyama M, Hijiya N
Cancer Sci 2023 Nov;114(11):4459-4474. Epub 2023 Sep 15 doi: 10.1111/cas.15942. PMID: 37715346Free PMC Article
Supercharged cervical anastomosis for esophagectomy and gastric pull-up.
Takeda FR, Tutihashi R, Tustumi F, Sallum RAA, de Freitas Busnardo F, Ribeiro U Jr, Cecconello I
J Thorac Cardiovasc Surg 2021 Sep;162(3):688-697.e3. Epub 2020 Jun 26 doi: 10.1016/j.jtcvs.2020.06.021. PMID: 32739161
Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.
Wang Y, Xu G, Wang J, Li XH, Sun P, Zhang W, Li JX, Wu CY
Anticancer Res 2017 Aug;37(8):4643-4647. doi: 10.21873/anticanres.11866. PMID: 28739765
Leukocytosis and neutrophilia predict outcome in locally advanced esophageal cancer treated with definitive chemoradiation.
Schernberg A, Moureau-Zabotto L, Rivin Del Campo E, Escande A, Ducreux M, Nguyen F, Goere D, Chargari C, Deutsch E
Oncotarget 2017 Feb 14;8(7):11579-11588. doi: 10.18632/oncotarget.14584. PMID: 28086222Free PMC Article
Long-term Treatment Outcomes for Locally Advanced Esophageal Cancer: A Single-Institution Experience.
Sio TT, Wilson ZC, Stauder MC, Bhatia S, Martenson JA, Quevedo JF, Schomas DA, Miller RC
Am J Clin Oncol 2016 Oct;39(5):448-52. doi: 10.1097/COC.0000000000000089. PMID: 24879469

Diagnosis

Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus.
Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma.
Tsukamoto Y, Kurogi S, Fujishima H, Shibata T, Fumoto S, Nishiki K, Suzuki K, Etoh T, Shiraishi N, Fuchino T, Hirashita Y, Nakada C, Uchida T, Inomata M, Moriyama M, Hijiya N
Cancer Sci 2023 Nov;114(11):4459-4474. Epub 2023 Sep 15 doi: 10.1111/cas.15942. PMID: 37715346Free PMC Article
Treatment utilization and outcomes in elderly patients with locally advanced esophageal carcinoma: a review of the National Cancer Database.
Vlacich G, Samson PP, Perkins SM, Roach MC, Parikh PJ, Bradley JD, Lockhart AC, Puri V, Meyers BF, Kozower B, Robinson CG
Cancer Med 2017 Dec;6(12):2886-2896. Epub 2017 Nov 15 doi: 10.1002/cam4.1250. PMID: 29139215Free PMC Article
Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.
Wang Y, Xu G, Wang J, Li XH, Sun P, Zhang W, Li JX, Wu CY
Anticancer Res 2017 Aug;37(8):4643-4647. doi: 10.21873/anticanres.11866. PMID: 28739765
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259

Therapy

Immunotherapy for Resectable Locally Advanced Esophageal Carcinoma.
Fick CN, Dunne EG, Sihag S, Molena D, Cytryn SL, Janjigian YY, Wu AJ, Worrell SG, Hofstetter WL, Jones DR, Gray KD
Ann Thorac Surg 2024 Jul;118(1):130-140. Epub 2024 Feb 24 doi: 10.1016/j.athoracsur.2024.02.021. PMID: 38408631Free PMC Article
Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma.
Tsukamoto Y, Kurogi S, Fujishima H, Shibata T, Fumoto S, Nishiki K, Suzuki K, Etoh T, Shiraishi N, Fuchino T, Hirashita Y, Nakada C, Uchida T, Inomata M, Moriyama M, Hijiya N
Cancer Sci 2023 Nov;114(11):4459-4474. Epub 2023 Sep 15 doi: 10.1111/cas.15942. PMID: 37715346Free PMC Article
Supercharged cervical anastomosis for esophagectomy and gastric pull-up.
Takeda FR, Tutihashi R, Tustumi F, Sallum RAA, de Freitas Busnardo F, Ribeiro U Jr, Cecconello I
J Thorac Cardiovasc Surg 2021 Sep;162(3):688-697.e3. Epub 2020 Jun 26 doi: 10.1016/j.jtcvs.2020.06.021. PMID: 32739161
Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259

Prognosis

Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus.
Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma.
Tsukamoto Y, Kurogi S, Fujishima H, Shibata T, Fumoto S, Nishiki K, Suzuki K, Etoh T, Shiraishi N, Fuchino T, Hirashita Y, Nakada C, Uchida T, Inomata M, Moriyama M, Hijiya N
Cancer Sci 2023 Nov;114(11):4459-4474. Epub 2023 Sep 15 doi: 10.1111/cas.15942. PMID: 37715346Free PMC Article
Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.
Wang Y, Xu G, Wang J, Li XH, Sun P, Zhang W, Li JX, Wu CY
Anticancer Res 2017 Aug;37(8):4643-4647. doi: 10.21873/anticanres.11866. PMID: 28739765
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259
Preoperative treatment of locally advanced esophageal carcinoma (Review).
Orditura M, Galizia G, Fabozzi A, Lieto E, Gambardella V, Morgillo F, Del Genio GM, Fei L, Di Martino N, Renda A, Ciardiello F, De Vita F
Int J Oncol 2013 Dec;43(6):1745-53. Epub 2013 Oct 2 doi: 10.3892/ijo.2013.2118. PMID: 24100679

Clinical prediction guides

Immunotherapy for Resectable Locally Advanced Esophageal Carcinoma.
Fick CN, Dunne EG, Sihag S, Molena D, Cytryn SL, Janjigian YY, Wu AJ, Worrell SG, Hofstetter WL, Jones DR, Gray KD
Ann Thorac Surg 2024 Jul;118(1):130-140. Epub 2024 Feb 24 doi: 10.1016/j.athoracsur.2024.02.021. PMID: 38408631Free PMC Article
Association of immune-related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma.
Tsukamoto Y, Kurogi S, Fujishima H, Shibata T, Fumoto S, Nishiki K, Suzuki K, Etoh T, Shiraishi N, Fuchino T, Hirashita Y, Nakada C, Uchida T, Inomata M, Moriyama M, Hijiya N
Cancer Sci 2023 Nov;114(11):4459-4474. Epub 2023 Sep 15 doi: 10.1111/cas.15942. PMID: 37715346Free PMC Article
Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.
Wang Y, Xu G, Wang J, Li XH, Sun P, Zhang W, Li JX, Wu CY
Anticancer Res 2017 Aug;37(8):4643-4647. doi: 10.21873/anticanres.11866. PMID: 28739765
Leukocytosis and neutrophilia predict outcome in locally advanced esophageal cancer treated with definitive chemoradiation.
Schernberg A, Moureau-Zabotto L, Rivin Del Campo E, Escande A, Ducreux M, Nguyen F, Goere D, Chargari C, Deutsch E
Oncotarget 2017 Feb 14;8(7):11579-11588. doi: 10.18632/oncotarget.14584. PMID: 28086222Free PMC Article
Preoperative treatment of locally advanced esophageal carcinoma (Review).
Orditura M, Galizia G, Fabozzi A, Lieto E, Gambardella V, Morgillo F, Del Genio GM, Fei L, Di Martino N, Renda A, Ciardiello F, De Vita F
Int J Oncol 2013 Dec;43(6):1745-53. Epub 2013 Oct 2 doi: 10.3892/ijo.2013.2118. PMID: 24100679

Recent systematic reviews

Esophagectomy in the Older Adult: A Systematic Review.
Schiller S, Carmeli I, Orgad R, Kashtan H, Cooper L, Solomon D
J Laparoendosc Adv Surg Tech A 2024 Jun;34(6):464-478. Epub 2024 Apr 8 doi: 10.1089/lap.2024.0087. PMID: 38587375
Liver Injury in Patients With Distal Esophageal Carcinoma After Precision Radiation Therapy: Systematic Review of FDG-PET/CT Patterns.
Betancourt Cuellar SL, Benveniste MF, Truong M, Nguyen QN, Atiyah A, Hofstetter WL, Erasmus JJ
Am J Clin Oncol 2023 Jan 1;46(1):25-30. Epub 2022 Nov 16 doi: 10.1097/COC.0000000000000960. PMID: 36562692
The impact of radiation dose on the efficacy of definitive chemoradiotherapy in patients with locally advanced esophageal carcinoma: a systematic review and meta-analysis.
Luo D, Zhong Q, Zhu X
Cancer Biol Ther 2023 Dec 31;24(1):1-10. doi: 10.1080/15384047.2022.2156246. PMID: 36519807Free PMC Article
Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Clinical complete response after chemoradiotherapy for carcinoma of thoracic esophagus: Is esophagectomy always necessary? A systematic review and meta-analysis.
Wang J, Qin J, Jing S, Liu Q, Cheng Y, Wang Y, Cao F
Thorac Cancer 2018 Dec;9(12):1638-1647. Epub 2018 Oct 1 doi: 10.1111/1759-7714.12874. PMID: 30277016Free PMC Article

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