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Locally Advanced Pancreatobiliary Carcinoma

MedGen UID:
1759922
•Concept ID:
C5418565
•
Neoplastic Process

Definition

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer.
Boggi U, Kauffmann E, Napoli N, Barreto SG, Besselink MG, Fusai GK, Hackert T, Abu Hilal M, Marchegiani G, Salvia R, Shrikhande SV, Truty M, Werner J, Wolfgang CL, Bannone E, Capretti G, Cattelani A, Coppola A, Cucchetti A, De Sio D, Di Dato A, Di Meo G, Fiorillo C, Gianfaldoni C, Ginesini M, Hidalgo Salinas C, Lai Q, Miccoli M, Montorsi R, Pagnanelli M, Poli A, Ricci C, Sucameli F, Tamburrino D, Viti V, Addeo PF, Alfieri S, Bachellier P, Baiocchi GL, Balzano G, Barbarello L, Brolese A, Busquets J, Butturini G, Caniglia F, Caputo D, Casadei R, Chunhua X, Colangelo E, Coratti A, Costa F, Crafa F, Dalla Valle R, De Carlis L, de Wilde RF, Del Chiaro M, Di Benedetto F, Di Sebastiano P, Dokmak S, Hogg M, Egorov VI, Ercolani G, Ettorre GM, Falconi M, Ferrari G, Ferrero A, Filauro M, Giardino A, Grazi GL, Gruttadauria S, Izbicki JR, Jovine E, Katz M, Keck T, Khatkov I, Kiguchi G, Kooby D, Lang H, Lombardo C, Malleo G, Massani M, Mazzaferro V, Memeo R, Miao Y, Mishima K, Molino C, Nagakawa Y, Nakamura M, Nardo B, Panaro F, Pasquali C, Perrone V, Rangelova E, Liu R, Romagnoli R, Romito R, Rosso E, Schulick R, Siriwardena A, Spampinato MG, Strobel O, Testini M, Troisi RI, Uzunoglo FG, Valente R, Veneroni L, Zerbi A, Vicente E, Vistoli F, Vivarelli M, Wakabayashi G, Zanus G, Zureikat A, Zyromski NJ, Coppola R, D'Andrea V, Davide J, Dervenis C, Frigerio I, Konlon KC, Michelassi F, Montorsi M, Nealon W, Portolani N, Sousa Silva D, Bozzi G, Ferrari V, Trivella MG, Cameron J, Clavien PA, Asbun HJ; REDISCOVER Multidisciplinary Advisory Board
Ann Surg 2024 Jul 1;280(1):56-65. Epub 2024 Feb 26 doi: 10.1097/SLA.0000000000006248. PMID: 38407228Free PMC Article

Recent clinical studies

Etiology

Comparison of the two histological subtypes of ampullary adenocarcinoma: a retrospective study.
Xu ZY, Guan J, Zhang ZY, Liu DW, Li XD, Zhou ZQ
Cir Cir 2024;92(2):159-164. doi: 10.24875/CIRU.23000021. PMID: 38782386
REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer.
Boggi U, Kauffmann E, Napoli N, Barreto SG, Besselink MG, Fusai GK, Hackert T, Abu Hilal M, Marchegiani G, Salvia R, Shrikhande SV, Truty M, Werner J, Wolfgang CL, Bannone E, Capretti G, Cattelani A, Coppola A, Cucchetti A, De Sio D, Di Dato A, Di Meo G, Fiorillo C, Gianfaldoni C, Ginesini M, Hidalgo Salinas C, Lai Q, Miccoli M, Montorsi R, Pagnanelli M, Poli A, Ricci C, Sucameli F, Tamburrino D, Viti V, Addeo PF, Alfieri S, Bachellier P, Baiocchi GL, Balzano G, Barbarello L, Brolese A, Busquets J, Butturini G, Caniglia F, Caputo D, Casadei R, Chunhua X, Colangelo E, Coratti A, Costa F, Crafa F, Dalla Valle R, De Carlis L, de Wilde RF, Del Chiaro M, Di Benedetto F, Di Sebastiano P, Dokmak S, Hogg M, Egorov VI, Ercolani G, Ettorre GM, Falconi M, Ferrari G, Ferrero A, Filauro M, Giardino A, Grazi GL, Gruttadauria S, Izbicki JR, Jovine E, Katz M, Keck T, Khatkov I, Kiguchi G, Kooby D, Lang H, Lombardo C, Malleo G, Massani M, Mazzaferro V, Memeo R, Miao Y, Mishima K, Molino C, Nagakawa Y, Nakamura M, Nardo B, Panaro F, Pasquali C, Perrone V, Rangelova E, Liu R, Romagnoli R, Romito R, Rosso E, Schulick R, Siriwardena A, Spampinato MG, Strobel O, Testini M, Troisi RI, Uzunoglo FG, Valente R, Veneroni L, Zerbi A, Vicente E, Vistoli F, Vivarelli M, Wakabayashi G, Zanus G, Zureikat A, Zyromski NJ, Coppola R, D'Andrea V, Davide J, Dervenis C, Frigerio I, Konlon KC, Michelassi F, Montorsi M, Nealon W, Portolani N, Sousa Silva D, Bozzi G, Ferrari V, Trivella MG, Cameron J, Clavien PA, Asbun HJ; REDISCOVER Multidisciplinary Advisory Board
Ann Surg 2024 Jul 1;280(1):56-65. Epub 2024 Feb 26 doi: 10.1097/SLA.0000000000006248. PMID: 38407228Free PMC Article
Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis.
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Histopathologic differentiation as a prognostic factor in patients with carcinoma of the hepatopancreatic ampulla of Vater.
Radojkovic M, Stojanovic M, Radojković D, Jeremic L, Mihailovic D, Ilic I
J Int Med Res 2018 Nov;46(11):4634-4639. Epub 2018 Jul 20 doi: 10.1177/0300060518786920. PMID: 30027790Free PMC Article

Diagnosis

Triglyceride-glucose index and glycemic dynamics in pancreatic ductal adenocarcinoma: implications for disease progression and prognosis.
Song Y, Jiang L, Han Y, Zhang S, Li S
J Transl Med 2024 Jul 30;22(1):708. doi: 10.1186/s12967-024-05524-w. PMID: 39080703Free PMC Article
The prognostic role of epidermal growth factor receptor mutation in completely resected ampullary adenocarcinoma.
Varol U, Cakır E, Aktas S, Altun ZS, Dilek FH, Butun O, Salman T, Unlu AGD, Alacacioglu A, Somali I
Pol J Pathol 2023;74(1):18-28. doi: 10.5114/pjp.2023.127044. PMID: 37306349
Impact of biliary stent-related events in patients diagnosed with advanced pancreatobiliary tumours receiving palliative chemotherapy.
Lamarca A, Rigby C, McNamara MG, Hubner RA, Valle JW
World J Gastroenterol 2016 Jul 14;22(26):6065-75. doi: 10.3748/wjg.v22.i26.6065. PMID: 27468198Free PMC Article
Twenty-six cases of advanced ampullary adenocarcinoma treated with systemic chemotherapy.
Shoji H, Morizane C, Hiraoka N, Kondo S, Ueno H, Ohno I, Shimizu S, Mitsunaga S, Ikeda M, Okusaka T
Jpn J Clin Oncol 2014 Apr;44(4):324-30. Epub 2014 Jan 30 doi: 10.1093/jjco/hyt237. PMID: 24482413
Mitochondrial DNA D-loop in pancreatic cancer: somatic mutations are epiphenomena while the germline 16519 T variant worsens metabolism and outcome.
Navaglia F, Basso D, Fogar P, Sperti C, Greco E, Zambon CF, Stranges A, Falda A, Pizzi S, Parenti A, Pedrazzoli S, Plebani M
Am J Clin Pathol 2006 Oct;126(4):593-601. doi: 10.1309/GQFCCJMH5KHNVX73. PMID: 16938655

Therapy

Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Current evidence and the potential role of proton beam therapy for hepatocellular carcinoma.
Lee SU, Kim TH
Clin Mol Hepatol 2023 Oct;29(4):958-968. Epub 2023 Aug 29 doi: 10.3350/cmh.2023.0274. PMID: 37822213Free PMC Article
Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis.
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Safety and efficacy of single-day GemOx regimen in patients with pancreatobiliary cancer: a single institution experience.
Li J, Merl M, Lee MX, Kaley K, Saif MW
Expert Opin Drug Saf 2010 Mar;9(2):207-13. doi: 10.1517/14740330903555181. PMID: 20095915

Prognosis

Triglyceride-glucose index and glycemic dynamics in pancreatic ductal adenocarcinoma: implications for disease progression and prognosis.
Song Y, Jiang L, Han Y, Zhang S, Li S
J Transl Med 2024 Jul 30;22(1):708. doi: 10.1186/s12967-024-05524-w. PMID: 39080703Free PMC Article
Comparison of the two histological subtypes of ampullary adenocarcinoma: a retrospective study.
Xu ZY, Guan J, Zhang ZY, Liu DW, Li XD, Zhou ZQ
Cir Cir 2024;92(2):159-164. doi: 10.24875/CIRU.23000021. PMID: 38782386
Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
The prognostic role of epidermal growth factor receptor mutation in completely resected ampullary adenocarcinoma.
Varol U, Cakır E, Aktas S, Altun ZS, Dilek FH, Butun O, Salman T, Unlu AGD, Alacacioglu A, Somali I
Pol J Pathol 2023;74(1):18-28. doi: 10.5114/pjp.2023.127044. PMID: 37306349
Histopathologic differentiation as a prognostic factor in patients with carcinoma of the hepatopancreatic ampulla of Vater.
Radojkovic M, Stojanovic M, Radojković D, Jeremic L, Mihailovic D, Ilic I
J Int Med Res 2018 Nov;46(11):4634-4639. Epub 2018 Jul 20 doi: 10.1177/0300060518786920. PMID: 30027790Free PMC Article

Clinical prediction guides

Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis.
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Histopathologic differentiation as a prognostic factor in patients with carcinoma of the hepatopancreatic ampulla of Vater.
Radojkovic M, Stojanovic M, Radojković D, Jeremic L, Mihailovic D, Ilic I
J Int Med Res 2018 Nov;46(11):4634-4639. Epub 2018 Jul 20 doi: 10.1177/0300060518786920. PMID: 30027790Free PMC Article
Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer.
Kim WS, Choi DW, Choi SH, Heo JS, You DD, Lee HG
J Surg Oncol 2012 Mar;105(3):266-72. Epub 2011 Aug 31 doi: 10.1002/jso.22090. PMID: 21882202

Recent systematic reviews

Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720

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