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Locally Advanced Pancreatobiliary Carcinoma

MedGen UID:
1759922
Concept ID:
C5418565
Neoplastic Process

Definition

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Boggi U, Kauffmann E, Napoli N, Barreto SG, Besselink MG, Fusai GK, Hackert T, Abu Hilal M, Marchegiani G, Salvia R, Shrikhande SV, Truty M, Werner J, Wolfgang CL, Bannone E, Capretti G, Cattelani A, Coppola A, Cucchetti A, De Sio D, Di Dato A, Di Meo G, Fiorillo C, Gianfaldoni C, Ginesini M, Hidalgo Salinas C, Lai Q, Miccoli M, Montorsi R, Pagnanelli M, Poli A, Ricci C, Sucameli F, Tamburrino D, Viti V, Addeo PF, Alfieri S, Bachellier P, Baiocchi GL, Balzano G, Barbarello L, Brolese A, Busquets J, Butturini G, Caniglia F, Caputo D, Casadei R, Chunhua X, Colangelo E, Coratti A, Costa F, Crafa F, Dalla Valle R, De Carlis L, de Wilde RF, Del Chiaro M, Di Benedetto F, Di Sebastiano P, Dokmak S, Hogg M, Egorov VI, Ercolani G, Ettorre GM, Falconi M, Ferrari G, Ferrero A, Filauro M, Giardino A, Grazi GL, Gruttadauria S, Izbicki JR, Jovine E, Katz M, Keck T, Khatkov I, Kiguchi G, Kooby D, Lang H, Lombardo C, Malleo G, Massani M, Mazzaferro V, Memeo R, Miao Y, Mishima K, Molino C, Nagakawa Y, Nakamura M, Nardo B, Panaro F, Pasquali C, Perrone V, Rangelova E, Liu R, Romagnoli R, Romito R, Rosso E, Schulick R, Siriwardena A, Spampinato MG, Strobel O, Testini M, Troisi RI, Uzunoglo FG, Valente R, Veneroni L, Zerbi A, Vicente E, Vistoli F, Vivarelli M, Wakabayashi G, Zanus G, Zureikat A, Zyromski NJ, Coppola R, D'Andrea V, Davide J, Dervenis C, Frigerio I, Konlon KC, Michelassi F, Montorsi M, Nealon W, Portolani N, Sousa Silva D, Bozzi G, Ferrari V, Trivella MG, Cameron J, Clavien PA, Asbun HJ; REDISCOVER Multidisciplinary Advisory Board
Ann Surg 2024 Jul 1;280(1):56-65. Epub 2024 Feb 26 doi: 10.1097/SLA.0000000000006248. PMID: 38407228Free PMC Article

Recent clinical studies

Etiology

Song Y, Jiang L, Han Y, Zhang S, Li S
J Transl Med 2024 Jul 30;22(1):708. doi: 10.1186/s12967-024-05524-w. PMID: 39080703Free PMC Article
Xu ZY, Guan J, Zhang ZY, Liu DW, Li XD, Zhou ZQ
Cir Cir 2024;92(2):159-164. doi: 10.24875/CIRU.23000021. PMID: 38782386
Boggi U, Kauffmann E, Napoli N, Barreto SG, Besselink MG, Fusai GK, Hackert T, Abu Hilal M, Marchegiani G, Salvia R, Shrikhande SV, Truty M, Werner J, Wolfgang CL, Bannone E, Capretti G, Cattelani A, Coppola A, Cucchetti A, De Sio D, Di Dato A, Di Meo G, Fiorillo C, Gianfaldoni C, Ginesini M, Hidalgo Salinas C, Lai Q, Miccoli M, Montorsi R, Pagnanelli M, Poli A, Ricci C, Sucameli F, Tamburrino D, Viti V, Addeo PF, Alfieri S, Bachellier P, Baiocchi GL, Balzano G, Barbarello L, Brolese A, Busquets J, Butturini G, Caniglia F, Caputo D, Casadei R, Chunhua X, Colangelo E, Coratti A, Costa F, Crafa F, Dalla Valle R, De Carlis L, de Wilde RF, Del Chiaro M, Di Benedetto F, Di Sebastiano P, Dokmak S, Hogg M, Egorov VI, Ercolani G, Ettorre GM, Falconi M, Ferrari G, Ferrero A, Filauro M, Giardino A, Grazi GL, Gruttadauria S, Izbicki JR, Jovine E, Katz M, Keck T, Khatkov I, Kiguchi G, Kooby D, Lang H, Lombardo C, Malleo G, Massani M, Mazzaferro V, Memeo R, Miao Y, Mishima K, Molino C, Nagakawa Y, Nakamura M, Nardo B, Panaro F, Pasquali C, Perrone V, Rangelova E, Liu R, Romagnoli R, Romito R, Rosso E, Schulick R, Siriwardena A, Spampinato MG, Strobel O, Testini M, Troisi RI, Uzunoglo FG, Valente R, Veneroni L, Zerbi A, Vicente E, Vistoli F, Vivarelli M, Wakabayashi G, Zanus G, Zureikat A, Zyromski NJ, Coppola R, D'Andrea V, Davide J, Dervenis C, Frigerio I, Konlon KC, Michelassi F, Montorsi M, Nealon W, Portolani N, Sousa Silva D, Bozzi G, Ferrari V, Trivella MG, Cameron J, Clavien PA, Asbun HJ; REDISCOVER Multidisciplinary Advisory Board
Ann Surg 2024 Jul 1;280(1):56-65. Epub 2024 Feb 26 doi: 10.1097/SLA.0000000000006248. PMID: 38407228Free PMC Article
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720

Diagnosis

Song Y, Jiang L, Han Y, Zhang S, Li S
J Transl Med 2024 Jul 30;22(1):708. doi: 10.1186/s12967-024-05524-w. PMID: 39080703Free PMC Article
Varol U, Cakır E, Aktas S, Altun ZS, Dilek FH, Butun O, Salman T, Unlu AGD, Alacacioglu A, Somali I
Pol J Pathol 2023;74(1):18-28. doi: 10.5114/pjp.2023.127044. PMID: 37306349
Lamarca A, Rigby C, McNamara MG, Hubner RA, Valle JW
World J Gastroenterol 2016 Jul 14;22(26):6065-75. doi: 10.3748/wjg.v22.i26.6065. PMID: 27468198Free PMC Article
Shoji H, Morizane C, Hiraoka N, Kondo S, Ueno H, Ohno I, Shimizu S, Mitsunaga S, Ikeda M, Okusaka T
Jpn J Clin Oncol 2014 Apr;44(4):324-30. Epub 2014 Jan 30 doi: 10.1093/jjco/hyt237. PMID: 24482413
Navaglia F, Basso D, Fogar P, Sperti C, Greco E, Zambon CF, Stranges A, Falda A, Pizzi S, Parenti A, Pedrazzoli S, Plebani M
Am J Clin Pathol 2006 Oct;126(4):593-601. doi: 10.1309/GQFCCJMH5KHNVX73. PMID: 16938655

Therapy

Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Lee SU, Kim TH
Clin Mol Hepatol 2023 Oct;29(4):958-968. Epub 2023 Aug 29 doi: 10.3350/cmh.2023.0274. PMID: 37822213Free PMC Article
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Kim JW, Cho Y, Kim HS, Choi WH, Park JS, Lee IJ
BMC Surg 2019 Mar 7;19(1):31. doi: 10.1186/s12893-019-0492-x. PMID: 30845939Free PMC Article

Prognosis

Song Y, Jiang L, Han Y, Zhang S, Li S
J Transl Med 2024 Jul 30;22(1):708. doi: 10.1186/s12967-024-05524-w. PMID: 39080703Free PMC Article
Xu ZY, Guan J, Zhang ZY, Liu DW, Li XD, Zhou ZQ
Cir Cir 2024;92(2):159-164. doi: 10.24875/CIRU.23000021. PMID: 38782386
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Varol U, Cakır E, Aktas S, Altun ZS, Dilek FH, Butun O, Salman T, Unlu AGD, Alacacioglu A, Somali I
Pol J Pathol 2023;74(1):18-28. doi: 10.5114/pjp.2023.127044. PMID: 37306349
Kim WS, Choi DW, Choi SH, Heo JS, You DD, Lee HG
J Surg Oncol 2012 Mar;105(3):266-72. Epub 2011 Aug 31 doi: 10.1002/jso.22090. PMID: 21882202

Clinical prediction guides

Song Y, Jiang L, Han Y, Zhang S, Li S
J Transl Med 2024 Jul 30;22(1):708. doi: 10.1186/s12967-024-05524-w. PMID: 39080703Free PMC Article
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Kim WS, Choi DW, Choi SH, Heo JS, You DD, Lee HG
J Surg Oncol 2012 Mar;105(3):266-72. Epub 2011 Aug 31 doi: 10.1002/jso.22090. PMID: 21882202

Recent systematic reviews

Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720

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