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Locally Advanced Pancreatic Adenocarcinoma

MedGen UID:
1664239
Concept ID:
C4744700
Neoplastic Process

Definition

A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Attiyeh MA, Amini A, Chung V, Melstrom LG
J Surg Oncol 2021 May;123(6):1395-1404. doi: 10.1002/jso.26415. PMID: 33831247
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Pollom EL, Koong AC, Ko AH
Hematol Oncol Clin North Am 2015 Aug;29(4):741-59. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.005. PMID: 26226908

Recent clinical studies

Etiology

Ejlsmark MW, Schytte T, Bernchou U, Bahij R, Weber B, Mortensen MB, Pfeiffer P
Curr Oncol 2023 Jul 18;30(7):6820-6837. doi: 10.3390/curroncol30070499. PMID: 37504359Free PMC Article
Temraz S, Nassar F, Hammoud MS, Mukherji D, O'Reilly EM, Dbouk H, Farhat F, Charafeddine M, Faraj W, Khalifeh MJ, Abou-Alfa GK, Shamseddine A
Asia Pac J Clin Oncol 2022 Dec;18(6):735-742. Epub 2022 Mar 31 doi: 10.1111/ajco.13775. PMID: 35362216
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Rashid MF, Hecht EM, Steinman JA, Kluger MD
Abdom Radiol (NY) 2018 Feb;43(2):457-466. doi: 10.1007/s00261-017-1349-3. PMID: 29051982

Diagnosis

Polyakov AN, Patyutko YI, Kudashkin NE, Kantieva DM, Romanova KA, Nasonova EA, Korshak AV, Egenov OA, Podluzhnyi DV
Khirurgiia (Mosk) 2023;(10):29-38. doi: 10.17116/hirurgia202310129. PMID: 37916555
Sindayigaya R, Barat M, Tzedakis S, Dautry R, Dohan A, Belle A, Coriat R, Soyer P, Fuks D, Marchese U
Diagn Interv Imaging 2023 Oct;104(10):455-464. Epub 2023 Jun 8 doi: 10.1016/j.diii.2023.05.008. PMID: 37301694
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Mian OY, Ram AN, Tuli R, Herman JM
Curr Oncol Rep 2014 Jun;16(6):388. doi: 10.1007/s11912-014-0388-y. PMID: 24740136

Therapy

Ejlsmark MW, Schytte T, Bernchou U, Bahij R, Weber B, Mortensen MB, Pfeiffer P
Curr Oncol 2023 Jul 18;30(7):6820-6837. doi: 10.3390/curroncol30070499. PMID: 37504359Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Pollom EL, Koong AC, Ko AH
Hematol Oncol Clin North Am 2015 Aug;29(4):741-59. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.005. PMID: 26226908

Prognosis

Sindayigaya R, Barat M, Tzedakis S, Dautry R, Dohan A, Belle A, Coriat R, Soyer P, Fuks D, Marchese U
Diagn Interv Imaging 2023 Oct;104(10):455-464. Epub 2023 Jun 8 doi: 10.1016/j.diii.2023.05.008. PMID: 37301694
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Salgado M, Arévalo S, Hernando O, Martínez A, Yaya R, Hidalgo M
Clin Transl Oncol 2018 Feb;20(2):113-118. Epub 2017 Jun 13 doi: 10.1007/s12094-017-1679-1. PMID: 28612202
Mian OY, Ram AN, Tuli R, Herman JM
Curr Oncol Rep 2014 Jun;16(6):388. doi: 10.1007/s11912-014-0388-y. PMID: 24740136
Rossi M, Orgera G, Hatzidakis A, Krokidis M
Cardiovasc Intervent Radiol 2014 Jun;37(3):586-91. Epub 2013 Aug 30 doi: 10.1007/s00270-013-0724-x. PMID: 23989503

Clinical prediction guides

Polyakov AN, Patyutko YI, Kudashkin NE, Kantieva DM, Romanova KA, Nasonova EA, Korshak AV, Egenov OA, Podluzhnyi DV
Khirurgiia (Mosk) 2023;(10):29-38. doi: 10.17116/hirurgia202310129. PMID: 37916555
Temraz S, Nassar F, Hammoud MS, Mukherji D, O'Reilly EM, Dbouk H, Farhat F, Charafeddine M, Faraj W, Khalifeh MJ, Abou-Alfa GK, Shamseddine A
Asia Pac J Clin Oncol 2022 Dec;18(6):735-742. Epub 2022 Mar 31 doi: 10.1111/ajco.13775. PMID: 35362216
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Granata V, Fusco R, Piccirillo M, Palaia R, Petrillo A, Lastoria S, Izzo F
Int J Surg 2015 Jun;18:230-6. Epub 2015 Apr 24 doi: 10.1016/j.ijsu.2015.04.055. PMID: 25917204
Mian OY, Ram AN, Tuli R, Herman JM
Curr Oncol Rep 2014 Jun;16(6):388. doi: 10.1007/s11912-014-0388-y. PMID: 24740136

Recent systematic reviews

Vornhülz M, Anton S, Eross B, Szakács Z, Hegyi P, Regel I, Belka C, Niyazi M, Mayerle J, Beyer G
Radiat Oncol 2022 Jun 17;17(1):108. doi: 10.1186/s13014-022-02076-5. PMID: 35715808Free PMC Article
Sugumar K, Hurtado A, Naik I, Hue JJ, Rothermel LD, Ammori JB, Hardacre JM, Winter JM, Ocuin LM
HPB (Oxford) 2022 May;24(5):586-595. Epub 2021 Dec 24 doi: 10.1016/j.hpb.2021.12.014. PMID: 35000842
Attard JA, Farrugia A, Pathanki A, Roberts KJ, Dasari B, Isaac J, Ma YT, Chatzizacharias NA
Pancreas 2020 Nov/Dec;49(10):1264-1275. doi: 10.1097/MPA.0000000000001694. PMID: 33122513

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