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Locally Advanced Unresectable Colorectal Adenocarcinoma

MedGen UID:
1692082
•Concept ID:
C5206478
•
Neoplastic Process

Definition

A colorectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Colorectal Adenocarcinoma

Professional guidelines

PubMed

Multidisciplinary Approach to the Treatment of Advanced Hepatocellular Carcinoma in the Era of New Biologic Agents.
Shindoh J
J Nippon Med Sch 2022 May 12;89(2):145-153. Epub 2021 Nov 26 doi: 10.1272/jnms.JNMS.2022_89-223. PMID: 34840212
The role of IVS14+1 G > A genotype detection in the dihydropyrimidine dehydrogenase gene and pharmacokinetic monitoring of 5-fluorouracil in the individualized adjustment of 5-fluorouracil for patients with local advanced and metastatic colorectal cancer: a preliminary report.
Cai X, Fang JM, Xue P, Song WF, Hu J, Gu HL, Yang HY, Wang LW
Eur Rev Med Pharmacol Sci 2014;18(8):1247-58. PMID: 24817302
Current management of colorectal liver metastases.
Martin LW, Warren RS
Surg Oncol Clin N Am 2000 Oct;9(4):853-76; discussion 877-8. PMID: 11008255

Recent clinical studies

Etiology

5-fluorouracil with oxaliplatin and/or irinotecan for advanced sinonasal intestinal-type adenocarcinoma (ITAC).
Sarradin V, Betrian S, Chaltiel L, Brac De La Perriere C, Delord JP
Bull Cancer 2023 Feb;110(2):168-173. Epub 2022 Nov 10 doi: 10.1016/j.bulcan.2022.10.004. PMID: 36372589
Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
The role of IVS14+1 G > A genotype detection in the dihydropyrimidine dehydrogenase gene and pharmacokinetic monitoring of 5-fluorouracil in the individualized adjustment of 5-fluorouracil for patients with local advanced and metastatic colorectal cancer: a preliminary report.
Cai X, Fang JM, Xue P, Song WF, Hu J, Gu HL, Yang HY, Wang LW
Eur Rev Med Pharmacol Sci 2014;18(8):1247-58. PMID: 24817302
Colorectal cancer in young and elderly patients.
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055

Diagnosis

Downstaging strategies for unresectable hepatocellular carcinoma.
Karachaliou GS, Dimitrokallis N, Moris DP
World J Gastroenterol 2024 May 28;30(20):2731-2733. doi: 10.3748/wjg.v30.i20.2731. PMID: 38855157Free PMC Article
Colorectal cancer in young and elderly patients.
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Preoperative evaluation of pancreatic adenocarcinoma.
Parsons CM, Sutcliffe JL, Bold RJ
J Hepatobiliary Pancreat Surg 2008;15(4):429-35. Epub 2008 Aug 1 doi: 10.1007/s00534-007-1240-7. PMID: 18670846
Hepatic arterial infusion of chemotherapy: the role of diagnostic and interventional radiology.
Ganeshan A, Upponi S, Hon LQ, Warakaulle D, Uberoi R
Ann Oncol 2008 May;19(5):847-51. Epub 2007 Nov 20 doi: 10.1093/annonc/mdm528. PMID: 18029972
Current management of colorectal liver metastases.
Martin LW, Warren RS
Surg Oncol Clin N Am 2000 Oct;9(4):853-76; discussion 877-8. PMID: 11008255

Therapy

5-fluorouracil with oxaliplatin and/or irinotecan for advanced sinonasal intestinal-type adenocarcinoma (ITAC).
Sarradin V, Betrian S, Chaltiel L, Brac De La Perriere C, Delord JP
Bull Cancer 2023 Feb;110(2):168-173. Epub 2022 Nov 10 doi: 10.1016/j.bulcan.2022.10.004. PMID: 36372589
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
Hepatic arterial infusion of chemotherapy: the role of diagnostic and interventional radiology.
Ganeshan A, Upponi S, Hon LQ, Warakaulle D, Uberoi R
Ann Oncol 2008 May;19(5):847-51. Epub 2007 Nov 20 doi: 10.1093/annonc/mdm528. PMID: 18029972
Current management of colorectal liver metastases.
Martin LW, Warren RS
Surg Oncol Clin N Am 2000 Oct;9(4):853-76; discussion 877-8. PMID: 11008255
Radioimmunoguided Surgery system improves survival for patients with recurrent colorectal cancer.
Bertsch DJ, Burak WE Jr, Young DC, Arnold MW, Martin EW Jr
Surgery 1995 Oct;118(4):634-8; discussion 638-9. doi: 10.1016/s0039-6060(05)80029-7. PMID: 7570316

Prognosis

Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Role of pelvic radiotherapy for locally advanced rectal cancer and synchronous unresectable distant metastases.
Liu KT, Wan JF, Zhu J, Li GC, Sun WJ, Shen LJ, Cai SJ, Gu WL, Lian P, Zhang Z
Cancer Radiother 2016 Dec;20(8):805-810. Epub 2016 Oct 21 doi: 10.1016/j.canrad.2016.06.009. PMID: 27777027
The role of IVS14+1 G > A genotype detection in the dihydropyrimidine dehydrogenase gene and pharmacokinetic monitoring of 5-fluorouracil in the individualized adjustment of 5-fluorouracil for patients with local advanced and metastatic colorectal cancer: a preliminary report.
Cai X, Fang JM, Xue P, Song WF, Hu J, Gu HL, Yang HY, Wang LW
Eur Rev Med Pharmacol Sci 2014;18(8):1247-58. PMID: 24817302
Colorectal cancer in young and elderly patients.
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Current management of colorectal liver metastases.
Martin LW, Warren RS
Surg Oncol Clin N Am 2000 Oct;9(4):853-76; discussion 877-8. PMID: 11008255

Clinical prediction guides

Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
The role of IVS14+1 G > A genotype detection in the dihydropyrimidine dehydrogenase gene and pharmacokinetic monitoring of 5-fluorouracil in the individualized adjustment of 5-fluorouracil for patients with local advanced and metastatic colorectal cancer: a preliminary report.
Cai X, Fang JM, Xue P, Song WF, Hu J, Gu HL, Yang HY, Wang LW
Eur Rev Med Pharmacol Sci 2014;18(8):1247-58. PMID: 24817302
Colorectal cancer in young and elderly patients.
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Treatment of carcinoma of the esophagus with 5-fluorouracil and recombinant alfa-2a-interferon.
Wadler S, Fell S, Haynes H, Katz HJ, Rozenblit A, Kaleya R, Wiernik PH
Cancer 1993 Mar 1;71(5):1726-30. doi: 10.1002/1097-0142(19930301)71:5<1726::aid-cncr2820710504>3.0.co;2-m. PMID: 8448736
Cisplatin and 5-fluorouracil combination chemotherapy in advanced and/or metastatic colorectal carcinoma: a phase II study.
Galligioni E, Canobbio L, Figoli F, Fassio T, Frustaci S, Crivellari D, Vaccher E, Lo Re G, Gasparini G, Veronesi A
Eur J Cancer Clin Oncol 1987 Jun;23(6):657-61. doi: 10.1016/0277-5379(87)90260-4. PMID: 3653187

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