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Locally Advanced Breast Carcinoma

MedGen UID:
1703295
•Concept ID:
C5205659
•
Neoplastic Process

Definition

A breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Surgical management of locally advanced breast cancer: Recommendations of the Brazilian Society of Surgical Oncology.
da Costa Vieira RA, Andrade WP, Vieira SC, Romano M, Iglesias G, Oliveira AF
J Surg Oncol 2022 Jul;126(1):57-67. doi: 10.1002/jso.26890. PMID: 35689588
Central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment.
Gonzalez-Angulo AM, Cristofanilli M, Strom EA, Buzdar AU, Kau SW, Broglio KR, Smith TL, Hortobagyi GN
Cancer 2004 Oct 15;101(8):1760-6. doi: 10.1002/cncr.20530. PMID: 15386311
Treatment of locally advanced breast carcinoma with high-dose external beam supervoltage radiotherapy.
Brufman G, Weshler Z, Prosnitz LR, Fuks Z
Isr J Med Sci 1981 Sep-Oct;17(9-10):940-5. PMID: 6796541

Recent clinical studies

Etiology

Surgical management of locally advanced breast cancer: Recommendations of the Brazilian Society of Surgical Oncology.
da Costa Vieira RA, Andrade WP, Vieira SC, Romano M, Iglesias G, Oliveira AF
J Surg Oncol 2022 Jul;126(1):57-67. doi: 10.1002/jso.26890. PMID: 35689588
Diffusion-weighted MR imaging of locally advanced breast carcinoma: the optimal time window of predicting the early response to neoadjuvant chemotherapy.
Yuan L, Li JJ, Li CQ, Yan CG, Cheng ZL, Wu YK, Hao P, Lin BQ, Xu YK
Cancer Imaging 2018 Oct 29;18(1):38. doi: 10.1186/s40644-018-0173-5. PMID: 30373679Free PMC Article
Inflammatory breast carcinoma and locally advanced breast carcinoma: characterisation with MR imaging.
Girardi V, Carbognin G, Camera L, Bonetti F, Manfrin E, Pollini G, Pozzi Mucelli R
Radiol Med 2011 Feb;116(1):71-83. Epub 2010 Oct 6 doi: 10.1007/s11547-010-0590-4. PMID: 20927653
Inflammatory breast carcinoma in magnetic resonance imaging: a comparison with locally advanced breast cancer.
Renz DM, Baltzer PA, Böttcher J, Thaher F, Gajda M, Camara O, Runnebaum IB, Kaiser WA
Acad Radiol 2008 Feb;15(2):209-21. doi: 10.1016/j.acra.2007.09.011. PMID: 18206620
Multimodal therapy in locally advanced breast carcinoma.
Lopez MJ, Andriole DP, Kraybill WG, Khojasteh A
Am J Surg 1990 Dec;160(6):669-74; discussion 674-5. doi: 10.1016/s0002-9610(05)80772-x. PMID: 2252134

Diagnosis

Clinical Internal Dosimetry and Biodistribution of 177 Lu-DOTA-Trastuzumab in HER2-Positive Metastatic and Locally Advanced Breast Carcinoma.
Narwadkar YS, Parghane RV, Sahu S, Lad S, Deep K, Wanage G, Suralkar T, Banerjee S, Gupta S, Basu S, Badwe RA
Clin Nucl Med 2024 Apr 1;49(4):e149-e155. Epub 2024 Feb 1 doi: 10.1097/RLU.0000000000005067. PMID: 38350067
Inflammatory breast carcinoma and locally advanced breast carcinoma: characterisation with MR imaging.
Girardi V, Carbognin G, Camera L, Bonetti F, Manfrin E, Pollini G, Pozzi Mucelli R
Radiol Med 2011 Feb;116(1):71-83. Epub 2010 Oct 6 doi: 10.1007/s11547-010-0590-4. PMID: 20927653
Inflammatory breast carcinoma in magnetic resonance imaging: a comparison with locally advanced breast cancer.
Renz DM, Baltzer PA, Böttcher J, Thaher F, Gajda M, Camara O, Runnebaum IB, Kaiser WA
Acad Radiol 2008 Feb;15(2):209-21. doi: 10.1016/j.acra.2007.09.011. PMID: 18206620
FDG PET, PET/CT, and breast cancer imaging.
Rosen EL, Eubank WB, Mankoff DA
Radiographics 2007 Oct;27 Suppl 1:S215-29. doi: 10.1148/rg.27si075517. PMID: 18180228
Multimodal therapy in locally advanced breast carcinoma.
Lopez MJ, Andriole DP, Kraybill WG, Khojasteh A
Am J Surg 1990 Dec;160(6):669-74; discussion 674-5. doi: 10.1016/s0002-9610(05)80772-x. PMID: 2252134

Therapy

Clinical Internal Dosimetry and Biodistribution of 177 Lu-DOTA-Trastuzumab in HER2-Positive Metastatic and Locally Advanced Breast Carcinoma.
Narwadkar YS, Parghane RV, Sahu S, Lad S, Deep K, Wanage G, Suralkar T, Banerjee S, Gupta S, Basu S, Badwe RA
Clin Nucl Med 2024 Apr 1;49(4):e149-e155. Epub 2024 Feb 1 doi: 10.1097/RLU.0000000000005067. PMID: 38350067
Label-free multiphoton imaging to assess neoadjuvant therapy responses in breast carcinoma.
Li L, Han Z, Qiu L, Kang D, Zhan Z, Tu H, Chen J
Int J Biol Sci 2020;16(8):1376-1387. Epub 2020 Feb 21 doi: 10.7150/ijbs.41579. PMID: 32210726Free PMC Article
Axillary reverse mapping: Is it feasible in locally advanced breast cancer patients?
Khandelwal R, Poovamma CU, Shilpy C, Prema M, Anthony P
Breast Dis 2014 Jan 1;34(4):151-5. doi: 10.3233/BD-140371. PMID: 24934169
Docetaxel and cisplatin as primary chemotherapy for treatment of locally advanced breast cancers.
Lee YJ, Doliny P, Gomez-Fernandez C, Powell J, Reis I, Hurley J
Clin Breast Cancer 2004 Dec;5(5):371-6. doi: 10.3816/cbc.2004.n.044. PMID: 15585076
Multimodal therapy in locally advanced breast carcinoma.
Lopez MJ, Andriole DP, Kraybill WG, Khojasteh A
Am J Surg 1990 Dec;160(6):669-74; discussion 674-5. doi: 10.1016/s0002-9610(05)80772-x. PMID: 2252134

Prognosis

Diffusion-weighted MR imaging of locally advanced breast carcinoma: the optimal time window of predicting the early response to neoadjuvant chemotherapy.
Yuan L, Li JJ, Li CQ, Yan CG, Cheng ZL, Wu YK, Hao P, Lin BQ, Xu YK
Cancer Imaging 2018 Oct 29;18(1):38. doi: 10.1186/s40644-018-0173-5. PMID: 30373679Free PMC Article
Docetaxel and cisplatin as primary chemotherapy for treatment of locally advanced breast cancers.
Lee YJ, Doliny P, Gomez-Fernandez C, Powell J, Reis I, Hurley J
Clin Breast Cancer 2004 Dec;5(5):371-6. doi: 10.3816/cbc.2004.n.044. PMID: 15585076
Inflammatory breast carcinoma and noninflammatory locally advanced breast carcinoma: distinct clinicopathologic entities?
Anderson WF, Chu KC, Chang S
J Clin Oncol 2003 Jun 15;21(12):2254-9. doi: 10.1200/JCO.2003.07.082. PMID: 12805323
Multimodal therapy in locally advanced breast carcinoma.
Lopez MJ, Andriole DP, Kraybill WG, Khojasteh A
Am J Surg 1990 Dec;160(6):669-74; discussion 674-5. doi: 10.1016/s0002-9610(05)80772-x. PMID: 2252134
Locally advanced breast carcinoma: results with combined regional therapy.
Toonkel LM, Fix I, Jacobson LH, Bamberg N, Wallach CB
Int J Radiat Oncol Biol Phys 1986 Sep;12(9):1583-7. doi: 10.1016/0360-3016(86)90281-6. PMID: 3759583

Clinical prediction guides

Diffusion-weighted MR imaging of locally advanced breast carcinoma: the optimal time window of predicting the early response to neoadjuvant chemotherapy.
Yuan L, Li JJ, Li CQ, Yan CG, Cheng ZL, Wu YK, Hao P, Lin BQ, Xu YK
Cancer Imaging 2018 Oct 29;18(1):38. doi: 10.1186/s40644-018-0173-5. PMID: 30373679Free PMC Article
Axillary reverse mapping: Is it feasible in locally advanced breast cancer patients?
Khandelwal R, Poovamma CU, Shilpy C, Prema M, Anthony P
Breast Dis 2014 Jan 1;34(4):151-5. doi: 10.3233/BD-140371. PMID: 24934169
Clinical and radiological predictors of nipple-areola complex involvement in breast cancer patients.
D'Alonzo M, Martincich L, Biglia N, Pisacane A, Maggiorotto F, Rosa GD, Montemurro F, Kubatzki F, Sismondi P, Ponzone R
Eur J Cancer 2012 Oct;48(15):2311-8. Epub 2012 May 28 doi: 10.1016/j.ejca.2012.04.017. PMID: 22647686
Inflammatory breast carcinoma and noninflammatory locally advanced breast carcinoma: distinct clinicopathologic entities?
Anderson WF, Chu KC, Chang S
J Clin Oncol 2003 Jun 15;21(12):2254-9. doi: 10.1200/JCO.2003.07.082. PMID: 12805323
Locally advanced breast carcinoma: accuracy of mammography versus clinical examination in the prediction of residual disease after chemotherapy.
Helvie MA, Joynt LK, Cody RL, Pierce LJ, Adler DD, Merajver SD
Radiology 1996 Feb;198(2):327-32. doi: 10.1148/radiology.198.2.8596826. PMID: 8596826

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