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Lymphoid neoplasm

MedGen UID:
108626
•Concept ID:
C0598798
•
Neoplastic Process
Synonyms: Lymphocytic and Plasma Cell Neoplasm; lymphocytic and plasma cell neoplasm; Lymphocytic and Plasma Cell Tumor; lymphocytic and plasma cell tumor; Lymphocytic and Plasma Cell Tumour; lymphocytic and plasma cell tumour; Lymphocytic and Plasmacytic Neoplasm; lymphocytic and plasmacytic neoplasm; Lymphocytic Neoplasm; lymphocytic neoplasm; Lymphocytic Tumor; lymphocytic tumor; lymphocytic tumour; Lymphoid and Plasma Cell Tumor; lymphoid and plasma cell tumor; Lymphoid and Plasma Cell Tumour; lymphoid and plasma cell tumour; Lymphoid and Plasmacytic Neoplasm; lymphoid and plasmacytic neoplasm; Lymphoid and Plasmacytic Tumor; lymphoid and plasmacytic tumor; Lymphoid and Plasmacytic Tumour; lymphoid and plasmacytic tumour; Lymphoid Neoplasm; lymphoid neoplasm; Lymphoid Tumor; lymphoid tumor; lymphoid tumour
SNOMED CT: Lymphoid neoplasm (414628006)
 
Monarch Initiative: MONDO:0005157

Definition

A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoid neoplasm

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Differences in the diagnosis and treatment of hematologic malignancies attributable to health insurance coverage.
Song EY, Shin S, Park H, Kim N, Yoon JH, Roh EY
Medicine (Baltimore) 2022 Mar 4;101(9):e29020. doi: 10.1097/MD.0000000000029020. PMID: 35244084Free PMC Article
Waldenström Macroglobulinemia: Review of Pathogenesis and Management.
Yun S, Johnson AC, Okolo ON, Arnold SJ, McBride A, Zhang L, Baz RC, Anwer F
Clin Lymphoma Myeloma Leuk 2017 May;17(5):252-262. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.028. PMID: 28366781Free PMC Article

Recent clinical studies

Etiology

The 2022 classifications of lymphoid neoplasms : Keynote.
Campo E
Pathologie (Heidelb) 2023 Dec;44(Suppl 3):121-127. Epub 2023 Nov 13 doi: 10.1007/s00292-023-01247-9. PMID: 37957421
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies.
Appiah-Kubi K, Lan T, Wang Y, Qian H, Wu M, Yao X, Wu Y, Chen Y
Crit Rev Oncol Hematol 2017 Jan;109:20-34. Epub 2016 Nov 21 doi: 10.1016/j.critrevonc.2016.11.008. PMID: 28010895
Genetic abnormalities associated with acute lymphoblastic leukemia.
Yokota T, Kanakura Y
Cancer Sci 2016 Jun;107(6):721-5. Epub 2016 Apr 27 doi: 10.1111/cas.12927. PMID: 26991355Free PMC Article
Targeting CD30 in anaplastic large cell lymphoma.
Vadakara J, Pro B
Curr Hematol Malig Rep 2012 Dec;7(4):285-91. doi: 10.1007/s11899-012-0137-y. PMID: 23065407

Diagnosis

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
The 2022 classifications of lymphoid neoplasms : Keynote.
Campo E
Pathologie (Heidelb) 2023 Dec;44(Suppl 3):121-127. Epub 2023 Nov 13 doi: 10.1007/s00292-023-01247-9. PMID: 37957421
Updates on eosinophilic disorders.
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA
Virchows Arch 2023 Jan;482(1):85-97. Epub 2022 Sep 7 doi: 10.1007/s00428-022-03402-8. PMID: 36068374
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
Waldenström macroglobulinaemia.
Ghobrial IM, Gertz MA, Fonseca R
Lancet Oncol 2003 Nov;4(11):679-85. doi: 10.1016/s1470-2045(03)01246-4. PMID: 14602248

Therapy

Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.
Yi S, Yan Y, Jin M, Bhattacharya S, Wang Y, Wu Y, Yang L, Gine E, Clot G, Chen L, Yu Y, Zou D, Wang J, Phan AT, Cui R, Li F, Sun Q, Zhai Q, Wang T, Yu Z, Liu L, Liu W, Lyv R, Sui W, Huang W, Xiong W, Wang H, Li C, Xiao Z, Hao M, Wang J, Cheng T, Bea S, Herrera AF, Danilov A, Campo E, Ngo VN, Qiu L, Wang L
J Clin Invest 2022 Feb 1;132(3) doi: 10.1172/JCI153283. PMID: 34882582Free PMC Article
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Waldenström Macroglobulinemia: Review of Pathogenesis and Management.
Yun S, Johnson AC, Okolo ON, Arnold SJ, McBride A, Zhang L, Baz RC, Anwer F
Clin Lymphoma Myeloma Leuk 2017 May;17(5):252-262. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.028. PMID: 28366781Free PMC Article
Targeting CD30 in anaplastic large cell lymphoma.
Vadakara J, Pro B
Curr Hematol Malig Rep 2012 Dec;7(4):285-91. doi: 10.1007/s11899-012-0137-y. PMID: 23065407

Prognosis

The hepatic niche leads to aggressive natural killer cell leukemia proliferation through the transferrin-transferrin receptor 1 axis.
Kameda K, Yanagiya R, Miyatake Y, Carreras J, Higuchi H, Murayama H, Ishida T, Ito A, Iida S, Fukuhara N, Harigae H, Fujioka Y, Takahashi N, Wada H, Ishida F, Nakazawa H, Ishihara R, Murakami Y, Tagawa H, Matsuura T, Nakagawa S, Iwabuchi S, Hashimoto S, Imadome KI, Nakamura N, Ishizawa K, Kanda Y, Ando K, Kotani A
Blood 2023 Jul 27;142(4):352-364. doi: 10.1182/blood.2022018597. PMID: 37146246
Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.
Yi S, Yan Y, Jin M, Bhattacharya S, Wang Y, Wu Y, Yang L, Gine E, Clot G, Chen L, Yu Y, Zou D, Wang J, Phan AT, Cui R, Li F, Sun Q, Zhai Q, Wang T, Yu Z, Liu L, Liu W, Lyv R, Sui W, Huang W, Xiong W, Wang H, Li C, Xiao Z, Hao M, Wang J, Cheng T, Bea S, Herrera AF, Danilov A, Campo E, Ngo VN, Qiu L, Wang L
J Clin Invest 2022 Feb 1;132(3) doi: 10.1172/JCI153283. PMID: 34882582Free PMC Article
Pseudolymphomatous Atypical Fibroxanthoma.
Garcia Castro R, Viñolas-Cuadros A, Moyano-Bueno D, Conde-Ferreiros A, Cardeñoso E, Santos-Briz A
Am J Dermatopathol 2020 Dec;42(12):972-976. doi: 10.1097/DAD.0000000000001761. PMID: 32769551
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Waldenström macroglobulinaemia.
Ghobrial IM, Gertz MA, Fonseca R
Lancet Oncol 2003 Nov;4(11):679-85. doi: 10.1016/s1470-2045(03)01246-4. PMID: 14602248

Clinical prediction guides

Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF).
Ye X, Tuo Z, Chen K, Wu R, Wang J, Yu Q, Ye L, Miyamoto A, Yoo KH, Zhang C, Wei W, Li D, Feng D
Oncol Res 2024;32(3):503-515. Epub 2024 Feb 6 doi: 10.32604/or.2024.045050. PMID: 38361753Free PMC Article
Pseudolymphomatous Atypical Fibroxanthoma.
Garcia Castro R, Viñolas-Cuadros A, Moyano-Bueno D, Conde-Ferreiros A, Cardeñoso E, Santos-Briz A
Am J Dermatopathol 2020 Dec;42(12):972-976. doi: 10.1097/DAD.0000000000001761. PMID: 32769551
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Genetic alterations and their clinical implications in DLBCL.
Miao Y, Medeiros LJ, Li Y, Li J, Young KH
Nat Rev Clin Oncol 2019 Oct;16(10):634-652. doi: 10.1038/s41571-019-0225-1. PMID: 31127191
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.
Nadeu F, Delgado J, Royo C, Baumann T, Stankovic T, Pinyol M, Jares P, Navarro A, Martín-García D, Beà S, Salaverria I, Oldreive C, Aymerich M, Suárez-Cisneros H, Rozman M, Villamor N, Colomer D, López-Guillermo A, González M, Alcoceba M, Terol MJ, Colado E, Puente XS, López-Otín C, Enjuanes A, Campo E
Blood 2016 Apr 28;127(17):2122-30. Epub 2016 Feb 2 doi: 10.1182/blood-2015-07-659144. PMID: 26837699Free PMC Article

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